DK1701698T3 - Direkte komprimerbart farmaceutisk præparat til oral indgivelse af CCI-779 - Google Patents

Direkte komprimerbart farmaceutisk præparat til oral indgivelse af CCI-779

Info

Publication number: DK1701698T3
Authority: DK; Denmark
Prior art keywords: cci; pharmaceutical composition; oral administration; directly compressible; compressible pharmaceutical
Prior art date: 2004-01-08

Application number

DK04814371T

Other languages

Danish (da)

English (en)

Inventor

Muhammad Ashraf

Eric J Benjamin

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-08

Filing date

2004-12-14

Publication date

2008-05-05

2004-12-14 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-05-05 Application granted granted Critical

2008-05-05 Publication of DK1701698T3 publication Critical patent/DK1701698T3/da

Links

CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229960000235 temsirolimus Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK04814371T 2004-01-08 2004-12-14 Direkte komprimerbart farmaceutisk præparat til oral indgivelse af CCI-779 DK1701698T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53495104P	2004-01-08	2004-01-08
PCT/US2004/042178 WO2005070393A2 (en)	2004-01-08	2004-12-14	Directly compressible pharmaceutical composition of the rapamycin ester cci-779

Publications (1)

Publication Number	Publication Date
DK1701698T3 true DK1701698T3 (da)	2008-05-05

Family

ID=34806893

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04814371T DK1701698T3 (da)	2004-01-08	2004-12-14	Direkte komprimerbart farmaceutisk præparat til oral indgivelse af CCI-779

Country Status (30)

Country	Link
US (1)	US20050152983A1 (de)
EP (1)	EP1701698B1 (de)
JP (1)	JP2007517879A (de)
KR (1)	KR20060130162A (de)
CN (1)	CN1921861A (de)
AR (1)	AR047180A1 (de)
AT (1)	ATE383859T1 (de)
AU (1)	AU2004314213A1 (de)
BR (1)	BRPI0418373A (de)
CA (1)	CA2552595A1 (de)
CR (1)	CR8491A (de)
CY (1)	CY1107373T1 (de)
DE (1)	DE602004011398T2 (de)
DK (1)	DK1701698T3 (de)
EC (1)	ECSP066757A (de)
ES (1)	ES2298861T3 (de)
GT (1)	GT200500003A (de)
HN (1)	HN2005000005A (de)
IL (1)	IL176519A0 (de)
MX (1)	MXPA06007829A (de)
NO (1)	NO20062930L (de)
PA (1)	PA8621201A1 (de)
PE (1)	PE20050683A1 (de)
PL (1)	PL1701698T3 (de)
PT (1)	PT1701698E (de)
RU (1)	RU2006122517A (de)
TW (1)	TW200526213A (de)
UA (1)	UA84903C2 (de)
WO (1)	WO2005070393A2 (de)
ZA (1)	ZA200605631B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1660081A1 (de)	2003-09-03	2006-05-31	Wyeth	Amorphe rapamycin 42-ester mit 3-hydroxy-2-(hydroxymethyl)-2-methylpropionsäure und diese enthaltende pharmazeutische zusammensetzungen
KR20070015544A (ko) *	2004-04-14	2007-02-05	와이어쓰	라파마이신 42-에스테르 유도체의 위치특이성 합성
CN1946852A (zh) *	2004-04-27	2007-04-11	惠氏公司	利用雷帕霉素特异性甲基化酶标记雷帕霉素
JP2008530145A (ja) *	2005-02-15	2008-08-07	ワイス	経口投与可能なｃｃｉ−７７９製剤
AU2006315512B2 (en)	2005-11-14	2012-11-01	Ariad Pharmaceuticals, Inc.	Administration of an mTOR inhibitor to treat patients with cancer
WO2008003050A2 (en) *	2006-06-28	2008-01-03	Emisphere Technologies, Inc.	Gallium nitrate formulations
US8414910B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US8998846B2 (en)	2006-11-20	2015-04-07	Lutonix, Inc.	Drug releasing coatings for balloon catheters
US9700704B2 (en)	2006-11-20	2017-07-11	Lutonix, Inc.	Drug releasing coatings for balloon catheters
US9737640B2 (en)	2006-11-20	2017-08-22	Lutonix, Inc.	Drug releasing coatings for medical devices
US8414909B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
US8414526B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8430055B2 (en)	2008-08-29	2013-04-30	Lutonix, Inc.	Methods and apparatuses for coating balloon catheters
US20080276935A1 (en)	2006-11-20	2008-11-13	Lixiao Wang	Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8425459B2 (en)	2006-11-20	2013-04-23	Lutonix, Inc.	Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414525B2 (en)	2006-11-20	2013-04-09	Lutonix, Inc.	Drug releasing coatings for medical devices
WO2011151704A2 (en)	2010-06-02	2011-12-08	Fresenius Kabi Oncology Ltd.	Stable pharmaceutical compositions of rapamycin esters
MX380504B (es)	2010-06-03	2025-03-12	Pharmacyclics Llc	El uso de inhibidores de la tirosina quinasa de bruton (btk).
MA37711A1 (fr)	2012-06-04	2017-05-31	Pharmacyclics Inc	Formes cristallines d'un inhibiteur de tyrosine kinase de bruton
HK1206073A1 (en)	2012-07-24	2015-12-31	药品循环有限责任公司	Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
US10682415B2 (en)	2013-07-22	2020-06-16	Wisconsin Alumni Research Foundation	Thermogel formulation for combination drug delivery
CN104721158B (zh) *	2013-12-24	2018-01-30	正大天晴药业集团股份有限公司	一种稳定的依维莫司片剂
IL315294A (en)	2015-03-03	2024-10-01	Pharmacyclics Llc	Pharmaceutical formulations of proton tyrosine kinase inhibitor
US20190022073A1 (en) *	2015-09-03	2019-01-24	Nippon Kayaku Kabushiki Kaisha	Pharmaceutical composition comprising rapamycin or derivative thereof
WO2017129772A1 (en)	2016-01-29	2017-08-03	Xellia Phamaceuticals Aps	Stable pharmaceutical compositions of temsirolimus

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA737247B (en) *	1972-09-29	1975-04-30	Ayerst Mckenna & Harrison	Rapamycin and process of preparation
JP2642486B2 (ja) *	1989-08-04	1997-08-20	田辺製薬株式会社	難溶性薬物の超微粒子化法
US5536729A (en) *	1993-09-30	1996-07-16	American Home Products Corporation	Rapamycin formulations for oral administration
US5928668A (en) *	1993-12-21	1999-07-27	Applied Analytical Industries, Inc.	Method for dry blend compression of medicaments
US5362718A (en) *	1994-04-18	1994-11-08	American Home Products Corporation	Rapamycin hydroxyesters
FR2736550B1 (fr) *	1995-07-14	1998-07-24	Sandoz Sa	Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
RU2186562C2 (ru) *	1996-08-22	2002-08-10	Ресеч Трайангл Фармасьютикалс Лтд.	Композиции, представляющие собой микрочастицы веществ, нерастворимых в воде, и способ их изготовления
US5989591A (en) *	1997-03-14	1999-11-23	American Home Products Corporation	Rapamycin formulations for oral administration
US5985325A (en) *	1997-06-13	1999-11-16	American Home Products Corporation	Rapamycin formulations for oral administration
US6277983B1 (en) *	2000-09-27	2001-08-21	American Home Products Corporation	Regioselective synthesis of rapamycin derivatives
TWI286074B (en) *	2000-11-15	2007-09-01	Wyeth Corp	Pharmaceutical composition containing CCI-779 as an antineoplastic agent
UA77200C2 (en) *	2001-08-07	2006-11-15	Wyeth Corp	Antineoplastic combination of cci-779 and bkb-569
UA81265C2 (en) *	2002-09-17	2007-12-25	Wyeth Corp	Granulate formulation of the rapamycin ester cci-779 and process for the preparation thereof
UA83484C2 (uk) *	2003-03-05	2008-07-25	Уайт	Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
KR20060052880A (ko) *	2003-07-25	2006-05-19	와이어쓰	동결건조된 ｃｃｉ- 779 제형
JP4227649B2 (ja) *	2003-08-07	2009-02-18	ワイス	Ｃｃｉ−７７９の位置選択的合成
EP1660081A1 (de) *	2003-09-03	2006-05-31	Wyeth	Amorphe rapamycin 42-ester mit 3-hydroxy-2-(hydroxymethyl)-2-methylpropionsäure und diese enthaltende pharmazeutische zusammensetzungen
US20060142422A1 (en) *	2004-12-07	2006-06-29	Toshikazu Kobayashi	Hydrolysis resistant polyester compositions and articles made therefrom
JP2008530145A (ja) *	2005-02-15	2008-08-07	ワイス	経口投与可能なｃｃｉ−７７９製剤

2004
- 2004-12-14 DE DE602004011398T patent/DE602004011398T2/de not_active Expired - Lifetime
- 2004-12-14 AU AU2004314213A patent/AU2004314213A1/en not_active Abandoned
- 2004-12-14 CA CA002552595A patent/CA2552595A1/en not_active Abandoned
- 2004-12-14 RU RU2006122517/15A patent/RU2006122517A/ru not_active Application Discontinuation
- 2004-12-14 JP JP2006549291A patent/JP2007517879A/ja not_active Withdrawn
- 2004-12-14 UA UAA200608870A patent/UA84903C2/ru unknown
- 2004-12-14 PL PL04814371T patent/PL1701698T3/pl unknown
- 2004-12-14 ES ES04814371T patent/ES2298861T3/es not_active Expired - Lifetime
- 2004-12-14 EP EP04814371A patent/EP1701698B1/de not_active Expired - Lifetime
- 2004-12-14 BR BRPI0418373-8A patent/BRPI0418373A/pt not_active IP Right Cessation
- 2004-12-14 CN CNA2004800399872A patent/CN1921861A/zh active Pending
- 2004-12-14 DK DK04814371T patent/DK1701698T3/da active
- 2004-12-14 AT AT04814371T patent/ATE383859T1/de not_active IP Right Cessation
- 2004-12-14 MX MXPA06007829A patent/MXPA06007829A/es active IP Right Grant
- 2004-12-14 PT PT04814371T patent/PT1701698E/pt unknown
- 2004-12-14 WO PCT/US2004/042178 patent/WO2005070393A2/en not_active Ceased
- 2004-12-14 KR KR1020067015655A patent/KR20060130162A/ko not_active Ceased
- 2004-12-27 TW TW093140750A patent/TW200526213A/zh unknown
2005
- 2005-01-04 AR ARP050100016A patent/AR047180A1/es not_active Application Discontinuation
- 2005-01-05 GT GT200500003A patent/GT200500003A/es unknown
- 2005-01-06 PE PE2005000043A patent/PE20050683A1/es not_active Application Discontinuation
- 2005-01-06 US US11/030,685 patent/US20050152983A1/en not_active Abandoned
- 2005-01-06 HN HN2005000005A patent/HN2005000005A/es unknown
- 2005-01-07 PA PA20058621201A patent/PA8621201A1/es unknown
2006
- 2006-06-22 IL IL176519A patent/IL176519A0/en unknown
- 2006-06-22 NO NO20062930A patent/NO20062930L/no not_active Application Discontinuation
- 2006-06-28 CR CR8491A patent/CR8491A/es not_active Application Discontinuation
- 2006-07-07 ZA ZA200605631A patent/ZA200605631B/xx unknown
- 2006-08-08 EC EC2006006757A patent/ECSP066757A/es unknown
2008
- 2008-03-31 CY CY20081100359T patent/CY1107373T1/el unknown

Also Published As

Publication number	Publication date
JP2007517879A (ja)	2007-07-05
EP1701698B1 (de)	2008-01-16
CR8491A (es)	2008-08-21
WO2005070393A2 (en)	2005-08-04
GT200500003A (es)	2005-08-18
PA8621201A1 (es)	2005-12-23
RU2006122517A (ru)	2008-02-20
CA2552595A1 (en)	2005-08-04
AU2004314213A1 (en)	2005-08-04
DE602004011398T2 (de)	2009-01-15
CN1921861A (zh)	2007-02-28
IL176519A0 (en)	2006-10-05
ZA200605631B (en)	2010-01-27
ECSP066757A (es)	2006-11-16
TW200526213A (en)	2005-08-16
ES2298861T3 (es)	2008-05-16
CY1107373T1 (el)	2012-12-19
NO20062930L (no)	2006-10-02
UA84903C2 (ru)	2008-12-10
PE20050683A1 (es)	2005-11-04
AR047180A1 (es)	2006-01-11
KR20060130162A (ko)	2006-12-18
EP1701698A2 (de)	2006-09-20
PT1701698E (pt)	2008-03-27
HK1090308A1 (en)	2006-12-22
BRPI0418373A (pt)	2007-05-22
US20050152983A1 (en)	2005-07-14
WO2005070393A3 (en)	2006-09-28
PL1701698T3 (pl)	2008-03-31
ATE383859T1 (de)	2008-02-15
MXPA06007829A (es)	2006-09-01
HN2005000005A (es)	2009-04-17
DE602004011398D1 (de)	2008-03-06

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