DK170630B1 - Topisk, antibakteriel creme - Google Patents

Topisk, antibakteriel creme Download PDF

Info

Publication number: DK170630B1
Authority: DK; Denmark
Prior art keywords: cream; topical; iodine; component; base
Prior art date: 1984-12-12

Application number

DK574185A

Other languages

Danish (da)

English (en)

Other versions

DK574185A (da

DK574185D0 (da

Inventor

Peter David Holtshousen

Original Assignee

Euro Celtique Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-12

Filing date

1985-12-11

Publication date

1995-11-20

1985-12-11 Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa

1985-12-11 Publication of DK574185D0 publication Critical patent/DK574185D0/da

1986-06-13 Publication of DK574185A publication Critical patent/DK574185A/da

1995-11-20 Application granted granted Critical

1995-11-20 Publication of DK170630B1 publication Critical patent/DK170630B1/da

Links

239000006071 cream Substances 0.000 title claims abstract description 81
230000000699 topical effect Effects 0.000 title claims abstract description 19
230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 15
CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims abstract description 26
239000004215 Carbon black (E152) Substances 0.000 claims abstract description 26
229930195733 hydrocarbon Natural products 0.000 claims abstract description 26
150000002430 hydrocarbons Chemical class 0.000 claims abstract description 26
229920000153 Povidone-iodine Polymers 0.000 claims abstract description 24
229960001621 povidone-iodine Drugs 0.000 claims abstract description 23
239000000203 mixture Substances 0.000 claims abstract description 21
229920005862 polyol Polymers 0.000 claims abstract description 19
150000003077 polyols Chemical class 0.000 claims abstract description 19
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 17
235000019271 petrolatum Nutrition 0.000 claims abstract description 16
239000003871 white petrolatum Substances 0.000 claims abstract description 10
239000007788 liquid Substances 0.000 claims abstract description 9
239000002674 ointment Substances 0.000 claims description 23
238000009736 wetting Methods 0.000 claims description 19
229940100611 topical cream Drugs 0.000 claims description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
239000004264 Petrolatum Substances 0.000 claims description 8
229940066842 petrolatum Drugs 0.000 claims description 8
239000003995 emulsifying agent Substances 0.000 claims description 4
239000007764 o/w emulsion Substances 0.000 claims description 3
239000002480 mineral oil Substances 0.000 claims description 2
235000010446 mineral oil Nutrition 0.000 claims 1
239000003242 anti bacterial agent Substances 0.000 abstract description 18
235000011187 glycerol Nutrition 0.000 abstract description 5
DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 32
239000011630 iodine Substances 0.000 description 22
229910052740 iodine Inorganic materials 0.000 description 22
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 21
239000002585 base Substances 0.000 description 17
PBQGHMHRLALUEN-UHFFFAOYSA-N benzoic acid;2-hydroxybenzoic acid;2-hydroxybutanedioic acid Chemical compound OC(=O)C(O)CC(O)=O.OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1O PBQGHMHRLALUEN-UHFFFAOYSA-N 0.000 description 17
239000001259 polydextrose Substances 0.000 description 16
229940035035 polydextrose Drugs 0.000 description 16
235000013856 polydextrose Nutrition 0.000 description 16
229920001100 Polydextrose Polymers 0.000 description 15
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
206010052428 Wound Diseases 0.000 description 9
208000027418 Wounds and injury Diseases 0.000 description 9
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 9
239000003795 chemical substances by application Substances 0.000 description 8
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 8
239000000243 solution Substances 0.000 description 8
230000035876 healing Effects 0.000 description 7
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
239000007864 aqueous solution Substances 0.000 description 6
238000000034 method Methods 0.000 description 6
230000035515 penetration Effects 0.000 description 6
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
230000002378 acidificating effect Effects 0.000 description 5
229920000620 organic polymer Polymers 0.000 description 5
229920000642 polymer Polymers 0.000 description 5
229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
238000003756 stirring Methods 0.000 description 5
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
229960000541 cetyl alcohol Drugs 0.000 description 4
239000003599 detergent Substances 0.000 description 4
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 4
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 4
239000000047 product Substances 0.000 description 4
238000012360 testing method Methods 0.000 description 4
RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 3
229920001214 Polysorbate 60 Polymers 0.000 description 3
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 3
230000001580 bacterial effect Effects 0.000 description 3
229940064804 betadine Drugs 0.000 description 3
230000008033 biological extinction Effects 0.000 description 3
239000000839 emulsion Substances 0.000 description 3
239000000463 material Substances 0.000 description 3
239000003921 oil Substances 0.000 description 3
-1 poly (ethyleneoxy) ethanol Chemical class 0.000 description 3
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 3
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 3
229940113124 polysorbate 60 Drugs 0.000 description 3
239000001267 polyvinylpyrrolidone Substances 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
238000002560 therapeutic procedure Methods 0.000 description 3
230000029663 wound healing Effects 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
239000005711 Benzoic acid Substances 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
241000191967 Staphylococcus aureus Species 0.000 description 2
235000010233 benzoic acid Nutrition 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
238000009472 formulation Methods 0.000 description 2
230000002070 germicidal effect Effects 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
239000000155 melt Substances 0.000 description 2
230000003641 microbiacidal effect Effects 0.000 description 2
238000002156 mixing Methods 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
229940069328 povidone Drugs 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
208000017520 skin disease Diseases 0.000 description 2
239000001587 sorbitan monostearate Substances 0.000 description 2
229940035048 sorbitan monostearate Drugs 0.000 description 2
235000011076 sorbitan monostearate Nutrition 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
230000000153 supplemental effect Effects 0.000 description 2
238000004347 surface barrier Methods 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
108010076119 Caseins Proteins 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
241000588697 Enterobacter cloacae Species 0.000 description 1
BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
102000007530 Neurofibromin 1 Human genes 0.000 description 1
108010085793 Neurofibromin 1 Proteins 0.000 description 1
239000005662 Paraffin oil Substances 0.000 description 1
241000588770 Proteus mirabilis Species 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
206010040047 Sepsis Diseases 0.000 description 1
241000607715 Serratia marcescens Species 0.000 description 1
241000191940 Staphylococcus Species 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
239000003377 acid catalyst Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000008272 agar Substances 0.000 description 1
229910001516 alkali metal iodide Inorganic materials 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
235000013871 bee wax Nutrition 0.000 description 1
239000012166 beeswax Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
229940082500 cetostearyl alcohol Drugs 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
238000002485 combustion reaction Methods 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
238000012864 cross contamination Methods 0.000 description 1
235000015142 cultured sour cream Nutrition 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
230000008029 eradication Effects 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
239000008103 glucose Substances 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
238000002169 hydrotherapy Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000007794 irritation Effects 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229940124561 microbicide Drugs 0.000 description 1
239000002855 microbicide agent Substances 0.000 description 1
244000005700 microbiome Species 0.000 description 1
230000001338 necrotic effect Effects 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
239000012071 phase Substances 0.000 description 1
238000012643 polycondensation polymerization Methods 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940012831 stearyl alcohol Drugs 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
230000000451 tissue damage Effects 0.000 description 1
231100000827 tissue damage Toxicity 0.000 description 1
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
229960000707 tobramycin Drugs 0.000 description 1
239000003860 topical agent Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
108010050327 trypticase-soy broth Proteins 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
230000035899 viability Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Dairy Products (AREA)
Cosmetics (AREA)
Medicines Containing Plant Substances (AREA)

DK574185A 1984-12-12 1985-12-11 Topisk, antibakteriel creme DK170630B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
ZA8409673		1984-12-12
ZA849673		1984-12-12
CN85109101A CN85109101A (zh)	1984-12-12	1985-12-12	抗菌膏的制备方法
CN85109101		1985-12-12

Publications (3)

Publication Number	Publication Date
DK574185D0 DK574185D0 (da)	1985-12-11
DK574185A DK574185A (da)	1986-06-13
DK170630B1 true DK170630B1 (da)	1995-11-20

Family

ID=36698676

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK574185A DK170630B1 (da)	1984-12-12	1985-12-11	Topisk, antibakteriel creme

Country Status (18)

Country	Link
US (1)	US4671957A (fr)
EP (1)	EP0185490B1 (fr)
JP (1)	JPH0699298B2 (fr)
KR (1)	KR890001881B1 (fr)
CN (1)	CN85109101A (fr)
AT (1)	ATE67668T1 (fr)
AU (1)	AU576278B2 (fr)
CA (1)	CA1260833A (fr)
DE (1)	DE3584236D1 (fr)
DK (1)	DK170630B1 (fr)
ES (1)	ES8706437A1 (fr)
FI (1)	FI91935C (fr)
GR (1)	GR852972B (fr)
IE (1)	IE59827B1 (fr)
IL (1)	IL77224A (fr)
NO (1)	NO171095C (fr)
NZ (1)	NZ214496A (fr)
PT (1)	PT81618B (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3711083A1 (de) *	1987-04-02	1988-10-13	Euro Celtique Sa	Pharmazeutisches praeparat
US4867967A (en) *	1987-06-04	1989-09-19	Crutcher Wilbert L	Method for the treatment of pseudofolliculitis barbae
US5622708A (en) *	1988-09-21	1997-04-22	Ecolab Inc.	Erodible sanitizing caulk
US5241925A (en) *	1988-12-27	1993-09-07	Dermamed	Apparatus and techniques for administering veterinary medicaments
US5332577A (en) *	1988-12-27	1994-07-26	Dermamed	Transdermal administration to humans and animals
IE63315B1 (en) *	1989-04-24	1995-04-05	Becton Dickinson Co	Radiation sterilizable antimicrobial ointment and process to manufacture
US5324521A (en) *	1989-12-18	1994-06-28	Dermamed	Systems for transdermal administration of medicaments
US5370876A (en) *	1993-01-08	1994-12-06	Microbarriers	Antimicrobial protective skin composition and method for protecting skin from body fluids
US5512278A (en) *	1994-01-11	1996-04-30	Phylomed Corporation	Ointment base useful for pharmaceutical preparations
US7566460B2 (en) *	1995-06-22	2009-07-28	3M Innovative Properties Company	Stable hydroalcoholic compositions
EP0833605A1 (fr)	1995-06-22	1998-04-08	Minnesota Mining And Manufacturing Company	Compositions hydro-alcooliques stables
EP1407761A1 (fr)	1995-06-22	2004-04-14	Minnesota Mining And Manufacturing Company	Compositions hydro-alcooliques stables
US6623744B2 (en) *	1995-06-22	2003-09-23	3M Innovative Properties Company	Stable hydroalcoholic compositions
EP0928187A4 (fr)	1996-06-24	2002-10-02	Bio Safe Entpr Inc	Composition antibacterienne
US6582711B1 (en)	1997-01-09	2003-06-24	3M Innovative Properties Company	Hydroalcoholic compositions thickened using polymers
US6019997A (en) *	1997-01-09	2000-02-01	Minnesota Mining And Manufacturing	Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents
US5908619A (en) *	1997-01-09	1999-06-01	Minnesota Mining And Manufacturing Company	Hydroalcoholic compositions thickened using surfactant/polymer complexes
US6582683B2 (en)	2000-01-04	2003-06-24	Skinvisible Pharmaceuticals, Inc.	Dermal barrier composition
AU2002314847A1 (en)	2001-05-31	2002-12-09	Upsher-Smith Laboratories, Inc.	Dermatological compositions and methods comprising alpha-hydroxy acids or derivatives
US6756059B2 (en) *	2001-08-20	2004-06-29	Skinvisible Pharmaceuticals, Inc.	Topical composition, topical composition precursor, and methods for manufacturing and using
JP4450406B2 (ja) *	2002-01-16	2010-04-14	学校法人日本大学	ベニカミキリフラスを有効成分とする皮膚外用薬
US20040101507A1 (en) *	2002-11-27	2004-05-27	Janco Predovan	Skin cream
US20040126339A1 (en) *	2002-12-31	2004-07-01	Roszell James A.	Sunscreen composition and methods for manufacturing and using a sunscreen composition
US20090041859A1 (en) *	2005-04-08	2009-02-12	Mie University	Wound Treatment Drugs for External Use
DE102005045145B4 (de) *	2005-09-15	2025-09-25	Schülke & Mayr GmbH	Verwendung von Octenidindihydrochlorid in halbfesten Zubereitungen
WO2008066618A2 (fr) *	2006-10-20	2008-06-05	Skinvisible Pharmaceuticals, Inc.	Composition antifongique et procédés d'utilisation
US8128913B1 (en)	2007-12-06	2012-03-06	Skinvisible Pharmaceuticals, Inc.	Sunscreen composition with enhanced UV-A absorber stability and methods
US8299122B2 (en) *	2008-04-14	2012-10-30	Skinvisible Pharmaceuticals, Inc.	Method for stabilizing retinoic acid, retinoic acid containing composition, and method of using a retinoic acid containing composition
DE102010004950A1 (de) *	2010-01-18	2011-07-21	Remis Gesellschaft für Entwicklung und Vertrieb von technischen Elementen mbH, 50829	Kühlregal mit Türvorrichtung
US20140348774A1 (en) *	2010-12-10	2014-11-27	Aurora Pharmaceutical, LLC	Method for treating wounds and tissue repair
MX345458B (es) *	2011-05-11	2017-02-01	Veloce Biopharma Llc	Composiciones antimicoticas para el tratamiento de piel y uñas.
TW201605444A (zh) *	2013-12-18	2016-02-16	阿爾米雷爾有限公司	包含奧替尼啶二鹽酸鹽之局部醫藥組成物或化妝品組成物
EP3967312A1 (fr)	2014-09-12	2022-03-16	UNION therapeutics A/S	Utilisation antibactérienne de salicylanilides halogénés
GB201509326D0 (en)	2015-05-29	2015-07-15	Antibio Tx Aps	Novel use
CA2990627A1 (fr)	2015-06-22	2016-12-29	Infection Containment Company, LLC	Systeme antiseptique topique
KR102564048B1 (ko) *	2015-09-30	2023-08-04	(주)아모레퍼시픽	수중유형 에멀젼 조성물
GB201604484D0 (en)	2016-03-16	2016-04-27	Antibiotx Aps And Københavns Uni University Of Copenhagen	Topical antibacterial compositions
US11419834B2 (en)	2019-02-25	2022-08-23	Rhode Island Hospital	Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide
CA3074150C (fr)	2020-02-18	2025-12-16	Ovation Science, Inc.	Composition et methode d`administration transdermique de cannabidiol (cbd) et de delta-9-tetrahydrocannabinol (thc)
US12472140B2 (en)	2020-02-18	2025-11-18	Ovation Science Inc.	Composition and method for transdermal delivery of cannabidiol (CBD) and tetrahydrocannabinol (THC)
WO2025243071A1 (fr)	2024-05-22	2025-11-27	Apex Laboratories Private Limited	Composition médicamenteuse de povidone iodée et de biopolymère, et son procédé de fabrication

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4017641A (en) *	1975-01-31	1977-04-12	The Procter & Gamble Company	Skin moisturizing compositions containing 2-pyrrolidinone
US4049802A (en) *	1975-03-19	1977-09-20	Research Corporation	Zinc sulfadiazine and its use in the treatment of burns
DE2851544C2 (de) *	1978-11-29	1985-09-26	Beiersdorf Ag, 2000 Hamburg	Fluocortolon-haltige Creme
US4271149A (en) *	1979-09-21	1981-06-02	West Agro-Chemical, Inc.	Germicidal iodine compositions with enhanced iodine stability
US4301145A (en) *	1980-07-28	1981-11-17	Cestari Joseph E	Antiseptic skin cream
EP0103911A1 (fr) *	1982-06-30	1984-03-28	THE PROCTER & GAMBLE COMPANY	Compositions pharmaceutiques topiques contenant un agent émollient
GR77517B (fr) *	1982-06-30	1984-09-24	Procter & Gamble

1985
- 1985-12-04 DE DE8585308814T patent/DE3584236D1/de not_active Expired - Lifetime
- 1985-12-04 IL IL8577224A patent/IL77224A/xx not_active IP Right Cessation
- 1985-12-04 EP EP85308814A patent/EP0185490B1/fr not_active Expired - Lifetime
- 1985-12-04 AT AT85308814T patent/ATE67668T1/de not_active IP Right Cessation
- 1985-12-05 PT PT81618A patent/PT81618B/pt unknown
- 1985-12-06 AU AU50859/85A patent/AU576278B2/en not_active Expired
- 1985-12-09 US US06/806,763 patent/US4671957A/en not_active Expired - Lifetime
- 1985-12-09 NO NO85854943A patent/NO171095C/no not_active IP Right Cessation
- 1985-12-10 CA CA000497275A patent/CA1260833A/fr not_active Expired
- 1985-12-10 NZ NZ214496A patent/NZ214496A/xx unknown
- 1985-12-11 FI FI854886A patent/FI91935C/fi not_active IP Right Cessation
- 1985-12-11 ES ES549814A patent/ES8706437A1/es not_active Expired
- 1985-12-11 KR KR1019850009330A patent/KR890001881B1/ko not_active Expired
- 1985-12-11 IE IE312685A patent/IE59827B1/en not_active IP Right Cessation
- 1985-12-11 JP JP60278845A patent/JPH0699298B2/ja not_active Expired - Fee Related
- 1985-12-11 GR GR852972A patent/GR852972B/el not_active IP Right Cessation
- 1985-12-11 DK DK574185A patent/DK170630B1/da not_active IP Right Cessation
- 1985-12-12 CN CN85109101A patent/CN85109101A/zh active Pending

Also Published As

Publication number	Publication date
ES549814A0 (es)	1987-07-01
CA1260833A (fr)	1989-09-26
IL77224A (en)	1989-09-10
JPH0699298B2 (ja)	1994-12-07
CN85109101A (zh)	1987-06-24
NO171095C (no)	1993-01-27
FI854886A0 (fi)	1985-12-11
ATE67668T1 (de)	1991-10-15
EP0185490B1 (fr)	1991-09-25
IE853126L (en)	1986-06-12
EP0185490A3 (en)	1987-07-15
ES8706437A1 (es)	1987-07-01
NZ214496A (en)	1989-03-29
AU5085985A (en)	1986-06-19
FI91935C (fi)	1994-09-12
GR852972B (fr)	1986-04-01
DE3584236D1 (de)	1991-10-31
IE59827B1 (en)	1994-04-06
NO854943L (no)	1986-06-13
DK574185A (da)	1986-06-13
FI91935B (fi)	1994-05-31
JPS61186312A (ja)	1986-08-20
DK574185D0 (da)	1985-12-11
PT81618A (en)	1986-01-01
US4671957A (en)	1987-06-09
NO171095B (no)	1992-10-19
EP0185490A2 (fr)	1986-06-25
PT81618B (pt)	1987-10-20
AU576278B2 (en)	1988-08-18
KR890001881B1 (ko)	1989-05-29
KR870005638A (ko)	1987-07-06
FI854886L (fi)	1986-06-13

Legal Events

Date	Code	Title	Description
1995-11-20	B1	Patent granted (law 1993)
2005-12-27	PUP	Patent expired

Publication	Publication Date	Title
DK170630B1 (da)	1995-11-20	Topisk, antibakteriel creme
US4401651A (en)	1983-08-30	Wound-healing compositions containing povidone-iodine
KR20150113035A (ko)	2015-10-07	표면 상처의 치료를 위한 조성물 및 방법
GB2048070A (en)	1980-12-10	Medication for Open Wounds
Wassermann et al.	1989	Use of topically applied silver sulphadiazine plus cerium nitrate in major burns
US11259521B2 (en)	2022-03-01	Topical antiseptic system
HU200103B (en)	1990-04-28	Process for producing pharmaceutical compositions for treating lack of epithelium
US4717737A (en)	1988-01-05	Anti-bacterial methods and agent
US9265793B2 (en)	2016-02-23	Compositions with antibacterial and wound healing activity
Gilchrist	1997	Should iodine be reconsidered in wound management?
JPH0476967B2 (fr)	1992-12-07
JPH08506336A (ja)	1996-07-09	ヨウ素および非還元性糖を含有する創傷治癒組成物
US20250144133A1 (en)	2025-05-08	Colestyramine for treating wounds, bacterial infections of the skin, and inflammatory skin lesions
JPH11512417A (ja)	1999-10-26	防腐性スキンケア用組成物およびその調製法
WO1989000850A1 (fr)	1989-02-09	Composition pharmaceutique
US20150064129A1 (en)	2015-03-05	Wound healing composition
CN120381433B (zh)	2025-10-28	一种促进烧烫伤及其他创面愈合的抗感染药膏及其制备方法
RU2851865C1 (ru)	2025-12-01	Антисептическая мазь на основе композиции хлорнитробензофуроксанов, обладающая противовоспалительным, антимикробным и регенерирующим действием, и способ ее получения
US10905729B1 (en)	2021-02-02	Formulations and methods for wound treatment
Miyachi et al.	1990	Use of sugar and povidone-iodine in the treatment of refractory cutaneous ulcers
UA147639U (uk)	2021-05-26	Спосіб виготовлення безводної композиції для зовнішнього застосування з протизапальною, знеболюючою, ранозагоювальною та регенеруючою дією
CZ295316B6 (cs)	2005-07-13	Léčivo k léčbě bércových vředů a proleženin