DK1706414T3 - Fremgangsmåde til fluorcytidinderivater - Google Patents

Fremgangsmåde til fluorcytidinderivater

Info

Publication number
DK1706414T3
DK1706414T3 DK04803900T DK04803900T DK1706414T3 DK 1706414 T3 DK1706414 T3 DK 1706414T3 DK 04803900 T DK04803900 T DK 04803900T DK 04803900 T DK04803900 T DK 04803900T DK 1706414 T3 DK1706414 T3 DK 1706414T3
Authority
DK
Denmark
Prior art keywords
sup
fluorocytidine derivatives
fluorocytidine
derivatives
deoxy
Prior art date
Application number
DK04803900T
Other languages
English (en)
Inventor
Christopher R Roberts
Jim-Wah Wong
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1706414T3 publication Critical patent/DK1706414T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK04803900T 2003-12-22 2004-12-15 Fremgangsmåde til fluorcytidinderivater DK1706414T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53226603P 2003-12-22 2003-12-22
PCT/EP2004/014281 WO2005063786A2 (en) 2003-12-22 2004-12-15 Process for fluorocytidine derivatives

Publications (1)

Publication Number Publication Date
DK1706414T3 true DK1706414T3 (da) 2008-10-13

Family

ID=34738779

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04803900T DK1706414T3 (da) 2003-12-22 2004-12-15 Fremgangsmåde til fluorcytidinderivater

Country Status (13)

Country Link
US (1) US7365188B2 (da)
EP (1) EP1706414B1 (da)
JP (2) JP5350591B2 (da)
KR (2) KR100851272B1 (da)
CN (1) CN101128472B (da)
AT (1) ATE402185T1 (da)
CA (1) CA2550299C (da)
DE (1) DE602004015331D1 (da)
DK (1) DK1706414T3 (da)
ES (1) ES2310298T3 (da)
IL (1) IL176075A (da)
TW (1) TWI291962B (da)
WO (1) WO2005063786A2 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2550299C (en) 2003-12-22 2010-03-30 Christopher R. Roberts Process for fluorocytidine derivatives
KR100834711B1 (ko) * 2006-12-21 2008-06-02 광동제약 주식회사 엔-아실-5'-데옥시-5-플루오로시티딘 유도체의 제조 방법
ITMI20070435A1 (it) * 2007-03-05 2008-09-06 Innovate Biotechnology Srl 2',3'-di-o-acil-5-fluoronucleosidi
US20100130734A1 (en) * 2007-04-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Process for preparing capecitabine
EP2164856A1 (en) * 2007-06-01 2010-03-24 Synthon B.V. Processes related to making capecitabine
PL2300489T3 (pl) 2008-06-06 2016-11-30 Sposoby wytwarzania 17-alkinylo-7-hydroksysteroidów i związków pokrewnych
EP2324042B1 (en) * 2008-08-06 2012-11-28 Sicor, Inc. Process for preparing azacytidine intermediate
WO2010061402A2 (en) * 2008-11-25 2010-06-03 Vishwanath Kannan An improved process for the preparation of capecitabine
WO2010065586A2 (en) * 2008-12-02 2010-06-10 Dr. Reddy's Laboratories Ltd. Preparation of capecitabine
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
WO2011067588A1 (en) 2009-12-04 2011-06-09 Generics [Uk] Limited Cyclic sulphinyl esters of cytidine
WO2011104540A1 (en) 2010-02-24 2011-09-01 Generics [Uk] Limited One step process for the preparation of capecitabine
CN103570781B (zh) * 2012-07-02 2016-01-13 国药一心制药有限公司 一种卡培他滨的工业化制备方法
CN103159813A (zh) * 2013-04-02 2013-06-19 武汉邦伦医药科技有限公司 一种卡培他滨制备工艺中的中间体的制备方法
CN103193842A (zh) * 2013-04-23 2013-07-10 济宁高新技术开发区永丰化工厂 卡培他滨的合成方法
AU2019216531A1 (en) 2018-02-02 2020-09-24 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
CN113321693A (zh) * 2021-05-25 2021-08-31 神隆医药（常熟）有限公司 一种适用于工业化生产的卡培他滨中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6038395A (ja) 1983-08-10 1985-02-27 Daikin Ind Ltd ５−フルオロシチジン類の製法
JPS6038396A (ja) 1983-08-10 1985-02-27 Daikin Ind Ltd ５−フルオロシチジン化合物の製法
DE3883374T2 (de) * 1987-10-28 1993-12-09 Pro Neuron Inc Acylatiertes uridin und cytidin und deren verwendungen.
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (da) * 1992-12-18 1995-08-21 Hoffmann La Roche
US5476932A (en) * 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
GB2372742A (en) * 2001-03-03 2002-09-04 Univ Leiden C2,5'-Disubstituted and N6,C2,5'-trisubstituted adenosine derivatives and their different uses
EP2316493A3 (en) * 2002-11-07 2011-08-10 Board of Regents, The University of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
CA2550299C (en) 2003-12-22 2010-03-30 Christopher R. Roberts Process for fluorocytidine derivatives

Also Published As

Publication number Publication date
WO2005063786A2 (en) 2005-07-14
KR100851272B1 (ko) 2008-08-08
CN101128472B (zh) 2012-03-14
US20050137392A1 (en) 2005-06-23
ES2310298T3 (es) 2009-01-01
TWI291962B (en) 2008-01-01
EP1706414A2 (en) 2006-10-04
CA2550299C (en) 2010-03-30
EP1706414B1 (en) 2008-07-23
JP2007515440A (ja) 2007-06-14
CA2550299A1 (en) 2005-07-14
CN101128472A (zh) 2008-02-20
WO2005063786A3 (en) 2006-12-14
US7365188B2 (en) 2008-04-29
IL176075A (en) 2011-06-30
JP5350591B2 (ja) 2013-11-27
IL176075A0 (en) 2006-10-05
ATE402185T1 (de) 2008-08-15
KR20080046752A (ko) 2008-05-27
KR20060107803A (ko) 2006-10-16
TW200528464A (en) 2005-09-01
DE602004015331D1 (de) 2008-09-04
JP2012097095A (ja) 2012-05-24

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