|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
IL166241A0
(en)
|
2002-07-29 |
2006-01-15 |
Rigel Pharmaceuticals Inc |
Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds
|
|
ES2421139T3
(es)
|
2003-07-30 |
2013-08-29 |
Rigel Pharmaceuticals, Inc. |
Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias
|
|
WO2006042102A2
(en)
*
|
2004-10-05 |
2006-04-20 |
Neurogen Corporation |
Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
|
|
BRPI0517272A
(pt)
|
2004-10-29 |
2008-10-07 |
Tibotec Pharm Ltd |
derivados de pirimidina bicìclicos de inibição de hiv
|
|
WO2006133426A2
(en)
|
2005-06-08 |
2006-12-14 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
JP5102771B2
(ja)
*
|
2005-10-28 |
2012-12-19 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
タンパク質キナーゼとしての化合物および組成物
|
|
EP4424838A3
(en)
*
|
2005-11-23 |
2024-12-04 |
Gerard M. Housey |
Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators
|
|
WO2007098507A2
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US8168383B2
(en)
|
2006-04-14 |
2012-05-01 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
PL2450437T3
(pl)
|
2006-04-14 |
2017-12-29 |
Cell Signaling Technology Inc |
Defekty genu i zmutowana kinaza ALK w ludzkich guzach litych
|
|
TWI398252B
(zh)
*
|
2006-05-26 |
2013-06-11 |
諾華公司 |
吡咯并嘧啶化合物及其用途
|
|
CA2663401C
(en)
|
2006-09-15 |
2011-07-12 |
Pfizer Products Inc. |
Pyrido (2, 3-d) pyrimidinone compounds and their use as pi3 inhibitors
|
|
MX2009004426A
(es)
|
2006-10-23 |
2009-08-12 |
Cephalon Inc |
Derivados biciclicos fusionados de 2,4-diaminopirimidina como inhibidores alk y c-met.
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
CN101611035A
(zh)
*
|
2006-12-28 |
2009-12-23 |
大正制药株式会社 |
吡唑并嘧啶化合物
|
|
EP2188292B1
(en)
*
|
2007-08-08 |
2013-05-29 |
GlaxoSmithKline Intellectual Property Development Limited |
2- [ (2-{phenylamino}-1h-pyrrolo [2, 3-d]pyrimidin-4-yl) amino]benzamide derivatives as igf-1r inhibitors for the treatment of cancer
|
|
EP2215091B1
(en)
*
|
2007-12-04 |
2016-03-30 |
Nerviano Medical Sciences S.r.l. |
Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
|
|
UY31631A1
(es)
*
|
2008-02-06 |
2009-09-30 |
|
Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicaciones
|
|
JP2011523646A
(ja)
|
2008-05-21 |
2011-08-18 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
キナーゼ阻害剤としてのリン誘導体
|
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
|
AU2009284098B2
(en)
|
2008-08-22 |
2012-03-29 |
Astex Therapeutics Ltd. |
Pyrrolopyrimidine compounds as CDK inhibitors
|
|
WO2010071885A1
(en)
|
2008-12-19 |
2010-06-24 |
Cephalon, Inc. |
Pyrrolotriazines as alk and jak2 inhibitors
|
|
GB0903759D0
(en)
|
2009-03-04 |
2009-04-15 |
Medical Res Council |
Compound
|
|
CA2738573C
(en)
|
2009-04-03 |
2013-02-19 |
F. Hoffmann-La Roche Ag |
Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
|
|
EA022120B1
(ru)
*
|
2009-10-20 |
2015-11-30 |
Целльзом Лимитид |
Аналоги гетероциклил пиразолопиримидина в качестве ингибиторов jak
|
|
JP2013510166A
(ja)
|
2009-11-06 |
2013-03-21 |
プレキシコン インコーポレーテッド |
キナーゼ調節のための化合物、方法およびその適用
|
|
JP2011148751A
(ja)
*
|
2010-01-25 |
2011-08-04 |
Konica Minolta Holdings Inc |
含窒素縮合複素環化合物の製造方法
|
|
TWI518325B
(zh)
*
|
2010-02-04 |
2016-01-21 |
自治醫科大學 |
對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
|
|
UY33227A
(es)
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
|
TWI510487B
(zh)
*
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
|
EP2571361A4
(en)
|
2010-05-19 |
2013-11-13 |
Univ North Carolina |
PYRAZOLOPYRIMIDINE COMPOUNDS FOR CANCER TREATMENT
|
|
EP2616441B1
(en)
|
2010-09-17 |
2019-08-07 |
Purdue Pharma L.P. |
Pyridine compounds and the uses thereof
|
|
AR083797A1
(es)
*
|
2010-11-10 |
2013-03-20 |
Novartis Ag |
Succinato de dimetil-amida del acido 7-ciclopentil-2-(5-piperazin-1-il-piridin-2-il-amino)-7h-pirrolo-[2,3-d]pirimidin-6-carboxilico, proceso para prepararla, intermediarios de dicha sintesis y proceso de preparacion de los mismos
|
|
KR20140009259A
(ko)
*
|
2010-11-19 |
2014-01-22 |
에프. 호프만-라 로슈 아게 |
피라졸로피리딘 및 tyk2 억제제로서 이의 용도
|
|
WO2012088266A2
(en)
|
2010-12-22 |
2012-06-28 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
|
|
CN102093364B
(zh)
|
2011-01-07 |
2015-01-28 |
北京赛林泰医药技术有限公司 |
作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物
|
|
CN103476776B
(zh)
*
|
2011-01-07 |
2016-09-28 |
北京赛林泰医药技术有限公司 |
作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物
|
|
PE20141360A1
(es)
|
2011-02-07 |
2014-10-13 |
Plexxikon Inc |
Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
|
|
WO2012143320A1
(en)
|
2011-04-18 |
2012-10-26 |
Cellzome Limited |
(7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
|
|
AU2012250517B2
(en)
|
2011-05-04 |
2016-05-19 |
Takeda Pharmaceutical Company Limited |
Compounds for inhibiting cell proliferation in EGFR-driven cancers
|
|
CA2836474A1
(en)
*
|
2011-05-17 |
2012-11-22 |
Plexxikon Inc. |
Kinase modulation and indications therefor
|
|
KR20140063700A
(ko)
*
|
2011-09-20 |
2014-05-27 |
셀좀 리미티드 |
키나제 억제제로서의 피라졸로[4,3-c]피리딘 유도체
|
|
BR112014007788A2
(pt)
|
2011-10-03 |
2017-04-18 |
Univ North Carolina Chapel Hill |
compostos de pirrolopirimidina para tratamento do câncer
|
|
US20140343128A1
(en)
|
2011-11-15 |
2014-11-20 |
Novartis Ag |
Combination of a phosphoinositide 3-kinase inhibitor and a modulator of the Janus Kinase 2 - Signal Transducer and Activator of Transcription 5 pathway
|
|
KR102068374B1
(ko)
*
|
2012-03-06 |
2020-01-20 |
세파론, 인코포레이티드 |
이중 alk 및 fak 억제제로서의 융합된 비시클릭 2,4-디아미노피리미딘 유도체
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
JP6469567B2
(ja)
|
2012-05-05 |
2019-02-13 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
Egfr発動性がんの細胞増殖阻害用化合物
|
|
CN106008511B
(zh)
*
|
2012-05-14 |
2018-08-14 |
华东理工大学 |
蝶啶酮衍生物及其作为egfr、blk、flt3抑制剂的应用
|
|
JP2015517574A
(ja)
|
2012-05-22 |
2015-06-22 |
ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル |
がん治療のためのピリミジン化合物
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
CA2876689C
(en)
|
2012-06-13 |
2022-04-26 |
Incyte Corporation |
Substituted tricyclic compounds as fgfr inhibitors
|
|
US9388185B2
(en)
|
2012-08-10 |
2016-07-12 |
Incyte Holdings Corporation |
Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
|
|
WO2014062774A1
(en)
|
2012-10-17 |
2014-04-24 |
The University Of North Carolina At Chapel Hill |
Pyrazolopyrimidine compounds for the treatment of cancer
|
|
CN104854101B
(zh)
*
|
2012-11-06 |
2018-05-01 |
上海复尚慧创医药研究有限公司 |
Alk激酶抑制剂
|
|
WO2014085225A1
(en)
|
2012-11-27 |
2014-06-05 |
The University Of North Carolina At Chapel Hill |
Pyrimidine compounds for the treatment of cancer
|
|
WO2014089913A1
(zh)
*
|
2012-12-12 |
2014-06-19 |
山东亨利医药科技有限责任公司 |
作为酪氨酸激酶抑制剂的并环化合物
|
|
CN103864792B
(zh)
*
|
2012-12-12 |
2017-01-18 |
山东亨利医药科技有限责任公司 |
作为酪氨酸激酶抑制剂的含氮并环类化合物
|
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
|
PH12015502383B1
(en)
|
2013-04-19 |
2023-02-03 |
Incyte Holdings Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
EP3004111A1
(en)
|
2013-05-29 |
2016-04-13 |
Cephalon, Inc. |
Pyrrolotriazines as alk inhibitors
|
|
EP4772247A2
(en)
|
2013-08-14 |
2026-07-08 |
Novartis AG |
Combination therapy comprising ribociclib and fulvestrant for the treatment of cancer
|
|
US20160222014A1
(en)
*
|
2013-09-10 |
2016-08-04 |
Asana Biosciences, Llc |
Compounds for regulating fak and/or src pathways
|
|
RU2550346C2
(ru)
|
2013-09-26 |
2015-05-10 |
Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" |
Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
|
|
EP3122900A1
(en)
|
2014-03-24 |
2017-02-01 |
F. Hoffmann-La Roche AG |
Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
|
|
US20170137426A1
(en)
*
|
2014-03-28 |
2017-05-18 |
Changzhou Jiekai Pharmatech Co., Ltd. |
Heterocyclic compounds as axl inhibitors
|
|
US9649309B2
(en)
|
2014-04-11 |
2017-05-16 |
The University Of North Carolina At Chapel Hill |
Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity
|
|
SG11201608299TA
(en)
|
2014-05-01 |
2016-11-29 |
Novartis Ag |
Compounds and compositions as toll-like receptor 7 agonists
|
|
WO2015168269A1
(en)
*
|
2014-05-01 |
2015-11-05 |
Novartis Ag |
Compounds and compositions as toll-like receptor 7 agonists
|
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
CN105111215B
(zh)
*
|
2014-12-12 |
2019-06-18 |
苏州晶云药物科技股份有限公司 |
一种周期蛋白依赖性激酶抑制剂的晶型及其制备方法
|
|
CN104610265A
(zh)
*
|
2014-12-31 |
2015-05-13 |
芜湖杨燕制药有限公司 |
一种化合物及其制备方法
|
|
CN104606197A
(zh)
*
|
2014-12-31 |
2015-05-13 |
芜湖杨燕制药有限公司 |
一种化合物的抗肿瘤用途
|
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
|
US9580423B2
(en)
|
2015-02-20 |
2017-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
CA2976790C
(en)
|
2015-02-20 |
2024-02-27 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
CR20180229A
(es)
|
2015-10-29 |
2018-08-24 |
Novartis Ag |
Conjugados de anticuerpos que comprenden un agonista del receptor tipo toll
|
|
CN106831780A
(zh)
*
|
2015-12-03 |
2017-06-13 |
南开大学 |
具有cdk4/6和hdac抑制活性的新型杂环衍生物
|
|
US10709708B2
(en)
|
2016-03-17 |
2020-07-14 |
The University Of North Carolina At Chapel Hill |
Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor
|
|
CN108658854A
(zh)
*
|
2017-03-28 |
2018-10-16 |
中国海洋大学 |
一种生物碱化合物及其制备方法和作为海洋防污剂的应用
|
|
CN108658855A
(zh)
*
|
2017-03-28 |
2018-10-16 |
中国海洋大学 |
一种含氮双环化合物及其制备方法和用途
|
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
|
JP7234142B2
(ja)
|
2017-06-02 |
2023-03-07 |
ファイザー・インク |
Flt3に特異的な抗体およびその使用
|
|
RS66310B1
(sr)
|
2018-05-04 |
2025-01-31 |
Incyte Corp |
Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu
|
|
KR102956194B1
(ko)
|
2018-05-04 |
2026-04-23 |
인사이트 코포레이션 |
Fgfr 억제제의 염
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
CN111484496B
(zh)
*
|
2019-01-29 |
2022-11-29 |
江苏开元药业有限公司 |
2-氨基-吡咯并嘧啶和吡唑并嘧啶类化合物及其制备方法和用途
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
TW202100520A
(zh)
|
2019-03-05 |
2021-01-01 |
美商英塞特公司 |
作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
|
|
WO2020185532A1
(en)
|
2019-03-08 |
2020-09-17 |
Incyte Corporation |
Methods of treating cancer with an fgfr inhibitor
|
|
CN113614087B
(zh)
*
|
2019-03-22 |
2023-06-02 |
首药控股(北京)股份有限公司 |
Wee1抑制剂及其制备和用途
|
|
US11919904B2
(en)
|
2019-03-29 |
2024-03-05 |
Incyte Corporation |
Sulfonylamide compounds as CDK2 inhibitors
|
|
WO2020223469A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
|
|
WO2020223558A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
Tricyclic amine compounds as cdk2 inhibitors
|
|
WO2021007269A1
(en)
|
2019-07-09 |
2021-01-14 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
WO2021030537A1
(en)
|
2019-08-14 |
2021-02-18 |
Incyte Corporation |
Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
|
|
US12122767B2
(en)
|
2019-10-01 |
2024-10-22 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
CR20220170A
(es)
|
2019-10-11 |
2022-10-10 |
Incyte Corp |
Aminas bicíclicas como inhibidoras de la cdk2
|
|
GEP20247679B
(en)
|
2019-10-14 |
2024-10-10 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
US11566028B2
(en)
|
2019-10-16 |
2023-01-31 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
WO2021113479A1
(en)
|
2019-12-04 |
2021-06-10 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
MX2022006691A
(es)
|
2019-12-04 |
2022-09-19 |
Incyte Corp |
Derivados de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr).
|
|
CN119371371A
(zh)
*
|
2019-12-13 |
2025-01-28 |
日本新药株式会社 |
作为pdgf受体激酶抑制剂的化合物和组合物
|
|
US12012409B2
(en)
|
2020-01-15 |
2024-06-18 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
US20230184743A1
(en)
*
|
2020-03-16 |
2023-06-15 |
University Of Southern California |
Screening methods to identify small molecule compounds that promote or inhibit the growth of circulating tumor cells, and uses thereof
|
|
CN118955502A
(zh)
*
|
2020-07-23 |
2024-11-15 |
上海赛岚生物科技有限公司 |
一类具有激酶抑制活性的化合物
|
|
WO2022083560A1
(zh)
*
|
2020-10-19 |
2022-04-28 |
南京药石科技股份有限公司 |
Tyk2选择性抑制剂及其用途
|
|
EP4323405A1
(en)
|
2021-04-12 |
2024-02-21 |
Incyte Corporation |
Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
|
|
CA3220274A1
(en)
|
2021-06-09 |
2022-12-15 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
TW202313610A
(zh)
|
2021-06-09 |
2023-04-01 |
美商英塞特公司 |
作為fgfr抑制劑之三環雜環
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
WO2023030388A1
(zh)
*
|
2021-08-31 |
2023-03-09 |
微境生物医药科技(上海)有限公司 |
作为Wee-1抑制剂的5-氟-7H-吡咯并[2,3-d]嘧啶类化合物
|
|
WO2023036252A1
(zh)
*
|
2021-09-08 |
2023-03-16 |
希格生科(深圳)有限公司 |
吡咯并嘧啶类或吡咯并吡啶类衍生物及其医药用途
|
|
TW202329937A
(zh)
|
2021-12-03 |
2023-08-01 |
美商英塞特公司 |
雙環胺ck12抑制劑
|
|
US12084453B2
(en)
|
2021-12-10 |
2024-09-10 |
Incyte Corporation |
Bicyclic amines as CDK12 inhibitors
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
CN116514803A
(zh)
*
|
2022-01-21 |
2023-08-01 |
上海赛岚生物科技有限公司 |
一种激酶抑制剂的盐晶型和自由碱晶型
|
|
CN114957248B
(zh)
*
|
2022-05-09 |
2023-12-29 |
南开大学 |
一种吡咯并嘧啶化合物及其制备方法、药物组合物和应用
|
|
WO2025155777A1
(en)
*
|
2024-01-17 |
2025-07-24 |
Ohio State Innovation Foundation |
Compositions and methods of use for the inhibition of ttk kinase
|