|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
BR0313059B8
(pt)
|
2002-07-29 |
2021-07-27 |
Rigel Pharmaceuticals |
composto, e, composição farmacêutica
|
|
CN102358738A
(zh)
|
2003-07-30 |
2012-02-22 |
里格尔药品股份有限公司 |
2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途
|
|
US7906528B2
(en)
*
|
2004-10-05 |
2011-03-15 |
Novartis International Pharmaceutical Ltd. |
Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
|
|
US8153640B2
(en)
|
2004-10-29 |
2012-04-10 |
Tibotec Pharmaceuticals Ltd. |
HIV inhibiting bicyclic pyrimdine derivatives
|
|
EP1904457B1
(en)
|
2005-06-08 |
2017-09-06 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
AU2006309171A1
(en)
*
|
2005-10-28 |
2007-05-10 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
CA2631182C
(en)
*
|
2005-11-23 |
2019-08-06 |
Hmi, Inc. |
Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators
|
|
JP2009528295A
(ja)
|
2006-02-24 |
2009-08-06 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
Jak経路の阻害のための組成物および方法
|
|
US8168383B2
(en)
|
2006-04-14 |
2012-05-01 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
EP2447359B1
(en)
|
2006-04-14 |
2015-11-04 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
JO3235B1
(ar)
|
2006-05-26 |
2018-03-08 |
Astex Therapeutics Ltd |
مركبات بيررولوبيريميدين و استعمالاتها
|
|
AU2007297212B8
(en)
|
2006-09-15 |
2011-04-28 |
Pfizer Products Inc. |
Pyrido (2, 3-d) pyrimidinone compounds and their use as pi3 inhibitors
|
|
ES2555803T3
(es)
|
2006-10-23 |
2016-01-08 |
Cephalon, Inc. |
Fusión de derivados bicíclicos 2,4-diaminopirimidina como utilizar inhibidores ALK y c-Met
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
CA2673965A1
(en)
*
|
2006-12-28 |
2008-07-10 |
Taisho Pharmaceutical Co., Ltd. |
Pyrazolopyrimidine compound
|
|
RU2472797C2
(ru)
*
|
2007-08-08 |
2013-01-20 |
ГЛАКСОСМИТКЛАЙН ЭлЭлСи |
ПРОИЗВОДНЫЕ 2-[(2-(ФЕНИЛАМИНО)-1Н-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)АМИНО]БЕНЗАМИДА В КАЧЕСТВЕ ИНГИБИТОРОВ IGF-1R ДЛЯ ЛЕЧЕНИЯ РАКА
|
|
JP5400791B2
(ja)
*
|
2007-12-04 |
2014-01-29 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
置換ジヒドロプテリジン−6−オン誘導体、その製造方法及びキナーゼ阻害剤としてのその使用
|
|
BRPI0908433A2
(pt)
|
2008-02-06 |
2019-09-24 |
Novartis Ag |
pirrolo[2,3-d]piridinas e empregos destas como inibidores tirosina cinase
|
|
EP2300013B2
(en)
|
2008-05-21 |
2024-11-13 |
Takeda Pharmaceutical Company Limited |
Phosphorous derivatives as kinase inhibitors
|
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
|
EA019094B1
(ru)
|
2008-08-22 |
2014-01-30 |
Новартис Аг |
Пирролопиримидины и их применение
|
|
EP2376491B1
(en)
|
2008-12-19 |
2015-03-04 |
Cephalon, Inc. |
Pyrrolotriazines as alk and jak2 inhibitors
|
|
GB0903759D0
(en)
*
|
2009-03-04 |
2009-04-15 |
Medical Res Council |
Compound
|
|
HUE027598T2
(en)
|
2009-04-03 |
2016-10-28 |
Hoffmann La Roche |
Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses
|
|
NZ598907A
(en)
*
|
2009-10-20 |
2014-03-28 |
Cellzome Ltd |
Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors
|
|
ES2633317T3
(es)
|
2009-11-06 |
2017-09-20 |
Plexxikon, Inc. |
Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
|
|
JP2011148751A
(ja)
*
|
2010-01-25 |
2011-08-04 |
Konica Minolta Holdings Inc |
含窒素縮合複素環化合物の製造方法
|
|
TWI518325B
(zh)
*
|
2010-02-04 |
2016-01-21 |
自治醫科大學 |
對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
|
|
UY33227A
(es)
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
|
TWI619713B
(zh)
|
2010-04-21 |
2018-04-01 |
普雷辛肯公司 |
用於激酶調節的化合物和方法及其適應症
|
|
WO2011146313A1
(en)
|
2010-05-19 |
2011-11-24 |
The University Of North Carolina At Chapel Hill |
Pyrazolopyrimidine compounds for the treatment of cancer
|
|
EP2616441B1
(en)
|
2010-09-17 |
2019-08-07 |
Purdue Pharma L.P. |
Pyridine compounds and the uses thereof
|
|
US20120115878A1
(en)
*
|
2010-11-10 |
2012-05-10 |
John Vincent Calienni |
Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof
|
|
EP2640722B1
(en)
*
|
2010-11-19 |
2015-11-04 |
F.Hoffmann-La Roche Ag |
Pyrazolopyridines and their use as tyk2 inhibitors
|
|
WO2012088266A2
(en)
|
2010-12-22 |
2012-06-28 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
|
|
CN102093364B
(zh)
|
2011-01-07 |
2015-01-28 |
北京赛林泰医药技术有限公司 |
作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物
|
|
CN103476776B
(zh)
*
|
2011-01-07 |
2016-09-28 |
北京赛林泰医药技术有限公司 |
作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物
|
|
MA34948B1
(fr)
|
2011-02-07 |
2014-03-01 |
Plexxikon Inc |
Composes et procedes de modulation de kinase, et leurs indications
|
|
WO2012143320A1
(en)
|
2011-04-18 |
2012-10-26 |
Cellzome Limited |
(7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
|
|
EP2704572B1
(en)
|
2011-05-04 |
2015-12-30 |
Ariad Pharmaceuticals, Inc. |
Compounds for inhibiting cell proliferation in egfr-driven cancers
|
|
EP2709622A4
(en)
*
|
2011-05-17 |
2015-03-04 |
Plexxikon Inc |
CINEMA MODULATION AND INDICATIONS THEREFOR
|
|
US20140323504A1
(en)
*
|
2011-09-20 |
2014-10-30 |
Cellzome Limited |
Pyrazolo[4,3-c]Pyridine Derivatives As Kinase Inhibitors
|
|
US9273056B2
(en)
*
|
2011-10-03 |
2016-03-01 |
The University Of North Carolina At Chapel Hill |
Pyrrolopyrimidine compounds for the treatment of cancer
|
|
WO2013072392A1
(en)
|
2011-11-15 |
2013-05-23 |
Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research |
Combination of a phosphoinositide 3-kinase inhibitor and a modulator of the janus kinase 2-signal transducer and activator of transcription 5 pathway
|
|
CA2865420C
(en)
|
2012-03-06 |
2020-06-02 |
Cephalon, Inc. |
Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
JP6469567B2
(ja)
|
2012-05-05 |
2019-02-13 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
Egfr発動性がんの細胞増殖阻害用化合物
|
|
DE112013002484B4
(de)
*
|
2012-05-14 |
2023-05-04 |
Shanghai Yidian Pharmaceutical Technology Development Co., Ltd. |
Pteridinketon-Derivat und Anwendungen desselben als EGFR-, BLK- und FLT3-Inhibitor
|
|
HK1206338A1
(en)
|
2012-05-22 |
2016-01-08 |
北卡罗来纳大学教堂山分校 |
Pyrimidine compounds for the treatment of cancer
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
LT3495367T
(lt)
|
2012-06-13 |
2021-02-25 |
Incyte Holdings Corporation |
Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai
|
|
WO2014026125A1
(en)
|
2012-08-10 |
2014-02-13 |
Incyte Corporation |
Pyrazine derivatives as fgfr inhibitors
|
|
EP2909211A4
(en)
|
2012-10-17 |
2016-06-22 |
Univ North Carolina |
PYRAZOLOPYRIMIDINE COMPOUNDS FOR CANCER TREATMENT
|
|
CA2890006C
(en)
*
|
2012-11-06 |
2021-11-23 |
Shanghai Fochon Pharmaceutical Co Ltd |
Alk kinase inhibitors
|
|
WO2014085225A1
(en)
|
2012-11-27 |
2014-06-05 |
The University Of North Carolina At Chapel Hill |
Pyrimidine compounds for the treatment of cancer
|
|
CN104968664A
(zh)
*
|
2012-12-12 |
2015-10-07 |
山东亨利医药科技有限责任公司 |
作为酪氨酸激酶抑制剂的并环化合物
|
|
CN103864792B
(zh)
*
|
2012-12-12 |
2017-01-18 |
山东亨利医药科技有限责任公司 |
作为酪氨酸激酶抑制剂的含氮并环类化合物
|
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
|
LT2986610T
(lt)
|
2013-04-19 |
2018-04-10 |
Incyte Holdings Corporation |
Bicikliniai heterociklai, kaip fgfr inhibitoriai
|
|
HK1222848A1
(zh)
|
2013-05-29 |
2017-07-14 |
Cephalon, Inc. |
用作alk抑制剂的吡咯并三嗪
|
|
SI3033086T1
(sl)
|
2013-08-14 |
2022-01-31 |
Novartis Ag |
Kombinirana terapija za zdravljenje raka
|
|
US20160222014A1
(en)
*
|
2013-09-10 |
2016-08-04 |
Asana Biosciences, Llc |
Compounds for regulating fak and/or src pathways
|
|
RU2550346C2
(ru)
|
2013-09-26 |
2015-05-10 |
Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" |
Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
|
|
MX2016012285A
(es)
|
2014-03-24 |
2017-01-23 |
Genentech Inc |
Tratamiento de cáncer con antagonista de c-met y correlación de estos con la expresión de hgf.
|
|
US20170137426A1
(en)
*
|
2014-03-28 |
2017-05-18 |
Changzhou Jiekai Pharmatech Co., Ltd. |
Heterocyclic compounds as axl inhibitors
|
|
CN106459063A
(zh)
|
2014-04-11 |
2017-02-22 |
北卡罗来纳-查佩尔山大学 |
Mertk‑特异性嘧啶化合物
|
|
KR102139847B1
(ko)
*
|
2014-05-01 |
2020-07-31 |
노파르티스 아게 |
톨-유사 수용체 7 효능제로서의 화합물 및 조성물
|
|
SG11201608299TA
(en)
|
2014-05-01 |
2016-11-29 |
Novartis Ag |
Compounds and compositions as toll-like receptor 7 agonists
|
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
CN105111215B
(zh)
*
|
2014-12-12 |
2019-06-18 |
苏州晶云药物科技股份有限公司 |
一种周期蛋白依赖性激酶抑制剂的晶型及其制备方法
|
|
CN104610265A
(zh)
*
|
2014-12-31 |
2015-05-13 |
芜湖杨燕制药有限公司 |
一种化合物及其制备方法
|
|
CN104606197A
(zh)
*
|
2014-12-31 |
2015-05-13 |
芜湖杨燕制药有限公司 |
一种化合物的抗肿瘤用途
|
|
SG11201706287PA
(en)
|
2015-02-20 |
2017-09-28 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
|
WO2016134294A1
(en)
|
2015-02-20 |
2016-08-25 |
Incyte Corporation |
Bicyclic heterocycles as fgfr4 inhibitors
|
|
SG11201802769RA
(en)
|
2015-10-29 |
2018-05-30 |
Novartis Ag |
Antibody conjugates comprising toll-like receptor agonist
|
|
CN106831780A
(zh)
*
|
2015-12-03 |
2017-06-13 |
南开大学 |
具有cdk4/6和hdac抑制活性的新型杂环衍生物
|
|
US10709708B2
(en)
|
2016-03-17 |
2020-07-14 |
The University Of North Carolina At Chapel Hill |
Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor
|
|
CN108658855A
(zh)
*
|
2017-03-28 |
2018-10-16 |
中国海洋大学 |
一种含氮双环化合物及其制备方法和用途
|
|
CN108658854A
(zh)
*
|
2017-03-28 |
2018-10-16 |
中国海洋大学 |
一种生物碱化合物及其制备方法和作为海洋防污剂的应用
|
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
|
PE20242042A1
(es)
|
2017-06-02 |
2024-10-10 |
Pfizer |
Anticuerpos especificos para flt3 y sus usos
|
|
MX2020011718A
(es)
|
2018-05-04 |
2021-02-15 |
Incyte Corp |
Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas.
|
|
ES3061844T3
(en)
|
2018-05-04 |
2026-04-07 |
Incyte Corp |
Salts of an fgfr inhibitor
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
CN111484496B
(zh)
*
|
2019-01-29 |
2022-11-29 |
江苏开元药业有限公司 |
2-氨基-吡咯并嘧啶和吡唑并嘧啶类化合物及其制备方法和用途
|
|
US11384083B2
(en)
|
2019-02-15 |
2022-07-12 |
Incyte Corporation |
Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
|
|
TW202100520A
(zh)
|
2019-03-05 |
2021-01-01 |
美商英塞特公司 |
作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
|
|
US11628162B2
(en)
|
2019-03-08 |
2023-04-18 |
Incyte Corporation |
Methods of treating cancer with an FGFR inhibitor
|
|
JP2022528047A
(ja)
*
|
2019-03-22 |
2022-06-08 |
ショウヤオ ホールディングス(ベイジン) カンパニー, リミテッド |
Wee1阻害剤、その製造および用途
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
US11447494B2
(en)
|
2019-05-01 |
2022-09-20 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
CN116348458A
(zh)
|
2019-08-14 |
2023-06-27 |
因赛特公司 |
作为cdk2抑制剂的咪唑基嘧啶基胺化合物
|
|
US12122767B2
(en)
|
2019-10-01 |
2024-10-22 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
CN119930611A
(zh)
|
2019-10-11 |
2025-05-06 |
因赛特公司 |
作为cdk2抑制剂的双环胺
|
|
TWI891666B
(zh)
|
2019-10-14 |
2025-08-01 |
美商英塞特公司 |
作為fgfr抑制劑之雙環雜環
|
|
US11566028B2
(en)
|
2019-10-16 |
2023-01-31 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
CA3163875A1
(en)
|
2019-12-04 |
2021-06-10 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
WO2021113462A1
(en)
|
2019-12-04 |
2021-06-10 |
Incyte Corporation |
Derivatives of an fgfr inhibitor
|
|
MX2022007044A
(es)
*
|
2019-12-13 |
2022-06-24 |
Nippon Shinyaku Co Ltd |
Compuesto y composicion como inhibidor de cinasa del receptor de los factores de crecimiento derivados de las plaquetas (pdgf).
|
|
US12012409B2
(en)
|
2020-01-15 |
2024-06-18 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
WO2021188578A1
(en)
*
|
2020-03-16 |
2021-09-23 |
University Of Southern California |
Screening methods to identify small molecule compounds that promote or inhibit the growth of circulating tumor cells, and uses thereof
|
|
EP4186901A4
(en)
*
|
2020-07-23 |
2024-06-12 |
Cytosinlab Therapeutics Co., Ltd. |
COMPOUND HAVING KINASE INHIBITORY ACTIVITY
|
|
WO2022083560A1
(zh)
*
|
2020-10-19 |
2022-04-28 |
南京药石科技股份有限公司 |
Tyk2选择性抑制剂及其用途
|
|
TW202304459A
(zh)
|
2021-04-12 |
2023-02-01 |
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