DK171440B1 - Fremgangsmåde til undertrykkelse af uønskede thio-reaktioner under spaltning af peptider med cyanogenbromid - Google Patents

Fremgangsmåde til undertrykkelse af uønskede thio-reaktioner under spaltning af peptider med cyanogenbromid Download PDF

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Publication number
DK171440B1
DK171440B1 DK219684A DK219684A DK171440B1 DK 171440 B1 DK171440 B1 DK 171440B1 DK 219684 A DK219684 A DK 219684A DK 219684 A DK219684 A DK 219684A DK 171440 B1 DK171440 B1 DK 171440B1
Authority
DK
Denmark
Prior art keywords
process according
cnbr
cleavage
thiosulfate
thiol
Prior art date
Application number
DK219684A
Other languages
Danish (da)
English (en)
Other versions
DK219684D0 (da
DK219684A (da
Inventor
Richard Dennis Dimarchi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK219684D0 publication Critical patent/DK219684D0/da
Publication of DK219684A publication Critical patent/DK219684A/da
Application granted granted Critical
Publication of DK171440B1 publication Critical patent/DK171440B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK219684A 1983-08-01 1984-05-03 Fremgangsmåde til undertrykkelse af uønskede thio-reaktioner under spaltning af peptider med cyanogenbromid DK171440B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/519,169 US4451396A (en) 1983-08-01 1983-08-01 Process for inhibiting undesired thiol reactions during cyanogen bromide cleavage of peptides
US51916983 1983-08-01

Publications (3)

Publication Number Publication Date
DK219684D0 DK219684D0 (da) 1984-05-03
DK219684A DK219684A (da) 1985-02-02
DK171440B1 true DK171440B1 (da) 1996-10-28

Family

ID=24067162

Family Applications (1)

Application Number Title Priority Date Filing Date
DK219684A DK171440B1 (da) 1983-08-01 1984-05-03 Fremgangsmåde til undertrykkelse af uønskede thio-reaktioner under spaltning af peptider med cyanogenbromid

Country Status (13)

Country Link
US (1) US4451396A (cs)
EP (1) EP0134070B1 (cs)
JP (1) JPS6042395A (cs)
AU (1) AU575562B2 (cs)
CA (1) CA1251899A (cs)
DE (1) DE3473278D1 (cs)
DK (1) DK171440B1 (cs)
FI (1) FI841726A7 (cs)
GB (1) GB2144429B (cs)
GR (1) GR82069B (cs)
HU (1) HU191310B (cs)
IE (1) IE57353B1 (cs)
IL (1) IL71736A (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3625378A1 (de) * 1986-07-26 1988-02-04 Hoechst Ag Verfahren zur entfernung von halogencyanen und phosgen aus abgasen
DE3709432A1 (de) * 1987-03-21 1988-10-06 Fresenius Ag Kapillarfilteranordnung zur sterilisation von fluessigen medien
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
US5736363A (en) * 1991-07-29 1998-04-07 British Bio-Technology Limited IGF-II analogues
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
AU4380599A (en) * 1998-06-26 2000-01-17 Ppl Therapeutics (Scotland) Limited Methods for production of recombinant polypeptides
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
YU76981A (en) * 1980-03-27 1983-09-30 Lilly Co Eli Process for bonding the a-chain of insulin or insulin analogues and the b-chain of insulin or insulin analogues in order to obtain insulin or insulin analogues

Also Published As

Publication number Publication date
HU191310B (en) 1987-02-27
EP0134070A2 (en) 1985-03-13
GB2144429A (en) 1985-03-06
IL71736A (en) 1986-12-31
DK219684D0 (da) 1984-05-03
JPS6042395A (ja) 1985-03-06
GB8411367D0 (en) 1984-06-06
EP0134070A3 (en) 1987-04-08
JPH0542439B2 (cs) 1993-06-28
FI841726L (fi) 1985-02-02
EP0134070B1 (en) 1988-08-10
FI841726A7 (fi) 1985-02-02
AU2764184A (en) 1985-02-07
IE57353B1 (en) 1992-08-12
FI841726A0 (fi) 1984-05-02
GB2144429B (en) 1987-05-13
DK219684A (da) 1985-02-02
US4451396A (en) 1984-05-29
IL71736A0 (en) 1984-09-30
GR82069B (cs) 1984-12-13
IE841089L (en) 1985-02-01
DE3473278D1 (en) 1988-09-15
AU575562B2 (en) 1988-08-04
CA1251899A (en) 1989-03-28
HUT37441A (en) 1985-12-28

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired