DK172590A - Nye aminer og anvendelse og fremstilling deraf - Google Patents

Nye aminer og anvendelse og fremstilling deraf Download PDF

Info

Publication number: DK172590A
Authority: DK; Denmark
Prior art keywords: illegible; diphenylpropylamines; preparing; producing; pharmaceutical preparations
Prior art date: 1988-01-22

Application number

DK172590A

Other languages

English (en)

Other versions

DK172103B1 (da

DK172590D0 (da

Inventor

Nils Aake Joensson

Bengt Aake Sparf

Lembit Mikiver

Pinchas Moses

Lisbet Nilvebrant

Gunilla Glas

Original Assignee

Kabivitrum Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-22

Filing date

1990-07-19

Publication date

1990-07-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20371146&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK172590(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-07-19 Application filed by Kabivitrum Ab filed Critical Kabivitrum Ab

1990-07-19 Publication of DK172590A publication Critical patent/DK172590A/da

1990-07-19 Publication of DK172590D0 publication Critical patent/DK172590D0/da

1997-10-27 Application granted granted Critical

1997-10-27 Publication of DK172103B1 publication Critical patent/DK172103B1/da

Links

239000003814 drug Substances 0.000 title abstract 3
KISZTEOELCMZPY-UHFFFAOYSA-N 3,3-diphenylpropylamine Chemical class C=1C=CC=CC=1C(CCN)C1=CC=CC=C1 KISZTEOELCMZPY-UHFFFAOYSA-N 0.000 title abstract 2
230000001078 anti-cholinergic effect Effects 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
150000001412 amines Chemical class 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
-1 methoxy, hydroxyl Chemical group 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000002029 aromatic hydrocarbon group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000000812 cholinergic antagonist Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001302 tertiary amino group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Lubricants (AREA)
Steroid Compounds (AREA)

DK172590A 1988-01-22 1990-07-19 Hidtil ukendte 3,3-difenylpropylaminer, farmaceutiske præparater indeholdende disse, deres anvendelse til fremstilling af et anticholinergt lægemiddel samt fremgangsmåde til deres fremstilling DK172103B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
SE8800207		1988-01-22
SE8800207A SE8800207D0 (sv)	1988-01-22	1988-01-22	Nya aminer, deras anvendning och framstellning
SE8900016		1989-01-20
PCT/SE1989/000016 WO1989006644A1 (en)	1988-01-22	1989-01-20	New amines, their use and preparation

Publications (3)

Publication Number	Publication Date
DK172590A true DK172590A (da)	1990-07-19
DK172590D0 DK172590D0 (da)	1990-07-19
DK172103B1 DK172103B1 (da)	1997-10-27

Family

ID=20371146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK172590A DK172103B1 (da)	1988-01-22	1990-07-19	Hidtil ukendte 3,3-difenylpropylaminer, farmaceutiske præparater indeholdende disse, deres anvendelse til fremstilling af et anticholinergt lægemiddel samt fremgangsmåde til deres fremstilling

Country Status (17)

Country	Link
EP (2)	EP0325571B1 (da)
JP (1)	JP2664503B2 (da)
AT (1)	ATE65990T1 (da)
AU (1)	AU635493B2 (da)
CA (1)	CA1340223C (da)
DE (2)	DE19875024I2 (da)
DK (1)	DK172103B1 (da)
ES (1)	ES2029384T4 (da)
FI (1)	FI109900B (da)
GR (1)	GR3002854T3 (da)
HK (1)	HK64494A (da)
HU (2)	HU212729B (da)
LU (1)	LU90259I2 (da)
NL (1)	NL980020I2 (da)
NO (2)	NO173496C (da)
SE (1)	SE8800207D0 (da)
WO (1)	WO1989006644A1 (da)

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SE9701144D0 (sv)	1997-03-27	1997-03-27	Pharmacia & Upjohn Ab	Novel compounds, their use and preparation
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AU2002347552A1 (en)	2002-12-23	2004-07-14	Ranbaxy Laboratories Limited	1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
MXPA05007767A (es)	2003-01-22	2006-01-31	Pfizer Health Ab	Dosis reducida de tolterodina y otros agentes antimuscarinicos para tratar trastornos urinarios.
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WO2004096751A1 (en)	2003-04-25	2004-11-11	Pharmacia & Upjohn Company Llc	Halogen substituted 3,3-diphenylpropylamines (tolterodine) having antimuscarinic activity
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EP2044001B1 (en)	2006-06-20	2016-11-23	LEK Pharmaceuticals d.d.	Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-n-alkyl-3-phenylpropylamines
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ITMI20082055A1 (it) *	2008-11-19	2009-02-18	Dipharma Francis Srl	Procedimento per la preparazione di (r)-tolterodina base libera
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Publication number	Priority date	Publication date	Assignee	Title
DK111894A (da) *	1962-11-15
GB1169945A (en) *	1966-08-25	1969-11-05	Geistlich Soehne Ag	Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives
GB1169944A (en) *	1966-08-25	1969-11-05	Geistlich Soehne Ag	Novel 3,3-Diphenylpropylamines and processes for the preparation thereof

1988
- 1988-01-22 SE SE8800207A patent/SE8800207D0/xx unknown
1989
- 1989-01-20 DE DE1998175024 patent/DE19875024I2/de active Active
- 1989-01-20 EP EP89850017A patent/EP0325571B1/en not_active Expired - Lifetime
- 1989-01-20 ES ES89850017T patent/ES2029384T4/es not_active Expired - Lifetime
- 1989-01-20 AU AU29329/89A patent/AU635493B2/en not_active Expired
- 1989-01-20 EP EP89901611A patent/EP0354234A1/en active Pending
- 1989-01-20 JP JP1501413A patent/JP2664503B2/ja not_active Expired - Lifetime
- 1989-01-20 WO PCT/SE1989/000016 patent/WO1989006644A1/en not_active Ceased
- 1989-01-20 CA CA000588821A patent/CA1340223C/en not_active Expired - Lifetime
- 1989-01-20 AT AT89850017T patent/ATE65990T1/de not_active IP Right Cessation
- 1989-01-20 DE DE8989850017T patent/DE68900180D1/de not_active Expired - Lifetime
- 1989-01-20 HU HU891069A patent/HU212729B/hu unknown
1990
- 1990-07-11 NO NO903085A patent/NO173496C/no not_active IP Right Cessation
- 1990-07-19 DK DK172590A patent/DK172103B1/da not_active IP Right Cessation
- 1990-07-20 FI FI903688A patent/FI109900B/fi not_active IP Right Cessation
1991
- 1991-10-08 GR GR91401499T patent/GR3002854T3/el unknown
1994
- 1994-07-07 HK HK64494A patent/HK64494A/en not_active IP Right Cessation
- 1994-12-15 HU HU94P/P00053P patent/HU210603A9/hu unknown
1998
- 1998-06-19 NL NL980020C patent/NL980020I2/nl unknown
- 1998-07-03 LU LU90259C patent/LU90259I2/fr unknown
- 1998-10-20 NO NO1998023C patent/NO1998023I1/no unknown

Also Published As

Publication number	Publication date
HU891069D0 (en)	1991-11-28
DK172103B1 (da)	1997-10-27
AU635493B2 (en)	1993-03-25
GR3002854T3 (en)	1993-01-25
NO903085D0 (no)	1990-07-11
NO173496C (no)	1993-12-22
EP0325571A1 (en)	1989-07-26
WO1989006644A1 (en)	1989-07-27
NO173496B (no)	1993-09-13
NO1998023I1 (no)	1998-10-20
FI903688A0 (fi)	1990-07-20
EP0354234A1 (en)	1990-02-14
LU90259I2 (fr)	1998-09-16
AU2932989A (en)	1989-08-11
ES2029384T4 (es)	2011-05-30
SE8800207D0 (sv)	1988-01-22
CA1340223C (en)	1998-12-15
ATE65990T1 (de)	1991-08-15
DE68900180D1 (de)	1991-09-12
ES2029384T3 (es)	1992-08-01
FI109900B (fi)	2002-10-31
NO903085L (no)	1990-07-11
JP2664503B2 (ja)	1997-10-15
EP0325571B1 (en)	1991-08-07
NL980020I2 (nl)	1999-02-01
HK64494A (en)	1994-07-15
JPH03503163A (ja)	1991-07-18
HUT58040A (en)	1992-01-28
NL980020I1 (nl)	1998-09-01
DK172590D0 (da)	1990-07-19
HU212729B (en)	1996-10-28
DE19875024I2 (de)	2002-09-26
HU210603A9 (en)	1995-05-29

Legal Events

Date	Code	Title	Description
1997-10-27	B1	Patent granted (law 1993)
1999-02-08	B1	Patent granted (law 1993)
1999-08-16	CTFF	Application for supplementary protection certificate (spc) filed	Free format text: CA 1998 00018, 19980611, EXPIRES: 20120905
2001-03-12	PBP	Patent lapsed
2009-02-09	PUP	Patent expired

Publication	Publication Date	Title
DK172590A (da)	1990-07-19	Nye aminer og anvendelse og fremstilling deraf
HUT72742A (en)	1996-05-28	Novel 3,3-diphenylpropylamines, pharmaceutical compositions containing them and preparation
ZA932168B (en)	1993-11-08	Naphthylalkylamines, process for preparing them and pharmaceutical compositions containing them
ZA936658B (en)	1994-04-26	Benzopyran compounds process for their preparation and the pharmaceutical compositions which contain them
PL305091A1 (en)	1995-04-03	Novel derivatives of 11-benzaldoxim-17beta-methoxy-17alpha methoxymethyl estradiene, method of obtaining them and therapeutic agents containing such compounds
PT99563A (pt)	1992-10-30	Processo para a preparacao de aminas biologicamente activas
ATE160784T1 (de)	1997-12-15	Neue 17-hydroxyiminomethyl-5beta, 14beta- androstan-derivate, kardioaktives verfahren zu ihrer herstellung und pharmazeutische präparate davon
GR3021765T3 (en)	1997-02-28	Aminoalkylchomones, process for their preparation and pharmaceutical compositions containing them.
ZA915407B (en)	1992-04-29	Disubstituted polymethyleneimines,a process for the preparation thereof,and pharmaceutical compositions containing them
DE69706502D1 (de)	2001-10-11	Substituierte 7,12-Dioxabenzo(a)anthracenderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
AU5511394A (en)	1994-08-18	New (cyclohexyl)alkene compounds, processes for preparing them and pharmaceutical compositions containing them