DK1730147T3 - Substituerede 1,4,8-triazaspiro[4.5]decan-2-on-forbindelser til behandling af fedme - Google Patents

Substituerede 1,4,8-triazaspiro[4.5]decan-2-on-forbindelser til behandling af fedme

Info

Publication number: DK1730147T3
Authority: DK; Denmark
Prior art keywords: compounds; triazaspiro; decan; treatment; obesity
Prior art date: 2004-03-22

Application number

DK05716285.1T

Other languages

English (en)

Inventor

Corinna Sundermann

Bernd Sundermann

Stefan Oberboersch

Werner Englberger

Hagen-Heinrich Hennies

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-22

Filing date

2005-03-22

Publication date

2010-05-31

2005-03-22 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2010-05-31 Application granted granted Critical

2010-05-31 Publication of DK1730147T3 publication Critical patent/DK1730147T3/da

Links

HFPLVVCVTUVAPK-UHFFFAOYSA-N 1,4,8-triazaspiro[4.5]decan-3-one Chemical class N1C(=O)CNC11CCNCC1 HFPLVVCVTUVAPK-UHFFFAOYSA-N 0.000 title abstract 2
208000008589 Obesity Diseases 0.000 title 1
235000020824 obesity Nutrition 0.000 title 1
238000000034 method Methods 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Addiction (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Child & Adolescent Psychology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Seasonings (AREA)
Confectionery (AREA)
General Preparation And Processing Of Foods (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK05716285.1T 2004-03-22 2005-03-22 Substituerede 1,4,8-triazaspiro[4.5]decan-2-on-forbindelser til behandling af fedme DK1730147T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102004014296A DE102004014296A1 (de)	2004-03-22	2004-03-22	Substituierte 1,4,8-Triazaspiro[4.5]decan-2-on-Verbindingen
PCT/EP2005/003029 WO2005095402A1 (de)	2004-03-22	2005-03-22	Substituierte 1,4,8-triazaspiro [4.5]decan-2-on-verbindungen zur behandlung von fettsucht

Publications (1)

Publication Number	Publication Date
DK1730147T3 true DK1730147T3 (da)	2010-05-31

Family

ID=34961883

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05716285.1T DK1730147T3 (da)	2004-03-22	2005-03-22	Substituerede 1,4,8-triazaspiro[4.5]decan-2-on-forbindelser til behandling af fedme

Country Status (13)

Country	Link
US (1)	US7951815B2 (da)
EP (1)	EP1730147B1 (da)
JP (1)	JP2007529565A (da)
AT (1)	ATE457027T1 (da)
CA (1)	CA2560293C (da)
CY (1)	CY1109962T1 (da)
DE (2)	DE102004014296A1 (da)
DK (1)	DK1730147T3 (da)
ES (1)	ES2340502T3 (da)
PL (1)	PL1730147T3 (da)
PT (1)	PT1730147E (da)
SI (1)	SI1730147T1 (da)
WO (1)	WO2005095402A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7977358B2 (en)	2007-07-26	2011-07-12	Hoffmann-La Roche Inc.	Pyrazol derivatives
US9340558B2 (en)	2007-11-02	2016-05-17	Pain Therapeutics Inc.	Filamin a binding anti-inflammatory and analgesic
US8653068B2 (en) *	2009-10-30	2014-02-18	Pain Therapeutics, Inc.	Filamin A binding anti-inflammatory and analgesic
CA2779252C (en) *	2008-10-31	2015-05-05	Pain Therapeutics, Inc.	Filamin a-binding anti-inflammatory analgesic
US8580808B2 (en) *	2009-10-30	2013-11-12	Pain Therapeutic, Inc.	Filamin A-binding anti-inflammatory analgesic
EP2488177B1 (en) *	2008-10-31	2016-10-12	Pain Therapeutics, Inc.	Filamin a binding anti-inflammatory and analgesic
US8580809B2 (en) *	2009-10-30	2013-11-12	Pain Therapeutics, Inc.	Filamin A-binding anti-inflammatory analgesic
EP2872899B1 (en)	2012-07-13	2018-07-11	Pain Therapeutics, Inc.	Alzheimer's disease assay in a living patient
EP2882428B1 (en)	2012-07-13	2019-01-16	Pain Therapeutics, Inc.	A method of inhibiting tau phosphorylation
US10092574B2 (en)	2012-09-26	2018-10-09	Valorisation-Recherche, Limited Partnership	Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
US9433604B2 (en)	2013-10-08	2016-09-06	Pain Therapeutics Inc.	Method for inhibiting growth of cancer cells
WO2020048826A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048831A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
AR116020A1 (es)	2018-09-03	2021-03-25	Bayer Ag	COMPUESTOS DE 3,9-DIAZAESPIRO[5.5]UNDECANO COMO INHIBIDORES DE GGTasa I Y SU USO PARA EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS
WO2020048828A1 (en)	2018-09-03	2020-03-12	Bayer Pharma Aktiengesellschaft	5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds
WO2020048827A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	1, 3, 9-triazaspiro[5.5] undecan-2-one compounds
WO2020048830A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3725389A (en) *	1971-07-02	1973-04-03	American Home Prod	Adducts of delta-aminobenzylpenicillin and n-substituted-4-piperidones
JP2575446B2 (ja) *	1988-02-12	1997-01-22	武田薬品工業株式会社	トリアザスピロ化合物
SI0921125T1 (en) *	1997-12-05	2002-04-30	F. Hoffmann-La Roche Ag	1,3,8-Triazaspiro(4,5)decan-4-on derivatives
DE69905798T2 (de) *	1998-06-12	2004-02-12	F. Hoffmann-La Roche Ag	Di- oder Triazaspiro[4,5]decanderivate
WO2000034280A1 (en) *	1998-12-09	2000-06-15	Banyu Pharmaceutical Co., Ltd.	4-oxoimidazolidine-2-spiro-nitrogenous heterocycle compounds
WO2001096337A1 (en) *	2000-06-14	2001-12-20	Banyu Pharmaceutical Co.,Ltd	4-oxoimidazolidine-2-spiro-nitrogenous heterocycle compounds
CA2454785C (en) *	2001-07-23	2010-09-07	Banyu Pharmaceutical Co., Ltd.	4-oxoimidazolidine-2-spiropiperidine derivatives

2004
- 2004-03-22 DE DE102004014296A patent/DE102004014296A1/de not_active Withdrawn
2005
- 2005-03-22 AT AT05716285T patent/ATE457027T1/de active
- 2005-03-22 DK DK05716285.1T patent/DK1730147T3/da active
- 2005-03-22 DE DE502005008971T patent/DE502005008971D1/de not_active Expired - Lifetime
- 2005-03-22 CA CA2560293A patent/CA2560293C/en not_active Expired - Fee Related
- 2005-03-22 PL PL05716285T patent/PL1730147T3/pl unknown
- 2005-03-22 PT PT05716285T patent/PT1730147E/pt unknown
- 2005-03-22 JP JP2007504340A patent/JP2007529565A/ja not_active Ceased
- 2005-03-22 SI SI200530982T patent/SI1730147T1/sl unknown
- 2005-03-22 EP EP05716285A patent/EP1730147B1/de not_active Expired - Lifetime
- 2005-03-22 ES ES05716285T patent/ES2340502T3/es not_active Expired - Lifetime
- 2005-03-22 WO PCT/EP2005/003029 patent/WO2005095402A1/de not_active Ceased
2006
- 2006-09-22 US US11/525,057 patent/US7951815B2/en not_active Expired - Fee Related
2010
- 2010-04-09 CY CY20101100325T patent/CY1109962T1/el unknown

Also Published As

Publication number	Publication date
EP1730147A1 (de)	2006-12-13
US20070015784A1 (en)	2007-01-18
WO2005095402A1 (de)	2005-10-13
ES2340502T3 (es)	2010-06-04
JP2007529565A (ja)	2007-10-25
PT1730147E (pt)	2010-04-16
CA2560293A1 (en)	2005-10-13
CY1109962T1 (el)	2014-09-10
US7951815B2 (en)	2011-05-31
DE502005008971D1 (de)	2010-03-25
EP1730147B1 (de)	2010-02-03
SI1730147T1 (sl)	2010-05-31
PL1730147T3 (pl)	2010-07-30
WO2005095402A9 (de)	2009-06-11
ATE457027T1 (de)	2010-02-15
DE102004014296A1 (de)	2005-10-06
CA2560293C (en)	2013-01-22

Publication	Publication Date	Title
CY1109962T1 (el)	2014-09-10	Υποκατεστημενες ενωσεις 1,4,8-τριαζασπειρο[4,5]δεκαν-2-ονης για τη θεραπεια παχυσαρκιας
CY1109366T1 (el)	2014-07-02	Υποκατεστημενες ενωσεις 1,4,8-τριαζασπειρο[4.5]δεκαν-2-ονης
NO20070224L (no)	2007-04-02	2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
SE0301700D0 (sv)	2003-06-10	Novel compounds
CY1108794T1 (el)	2014-04-09	Σπειροκυκλικα παραγωγα κυκλοεξανιου
EA200501332A1 (ru)	2006-06-30	Производные пиримидин-4-она и их применение в качестве модуляторов киназы p38
SE0300119D0 (sv)	2003-01-17	Novel compounds
SE0401762D0 (sv)	2004-07-05	Novel compounds
WO2004100865A3 (en)	2005-01-20	New benzimidazole derivatives
DK1517890T3 (da)	2008-11-10	Kationisk substituerede diphenylazetidinoner, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse
TW200612936A (en)	2006-05-01	Indole derivatives
SE0302546D0 (sv)	2003-09-24	New compounds
TW200738659A (en)	2007-10-16	Novel compounds
TW200626553A (en)	2006-08-01	Novel compounds
DE602004031410D1 (de)	2011-03-31	Inden derivate als pharmazeutika
TW200716529A (en)	2007-05-01	New compounds II
SE0401763D0 (sv)	2004-07-05	Compounds
SE0303280D0 (sv)	2003-12-05	Novel compounds
DK1869038T3 (da)	2009-11-16	Substituerede 5,6,7,8-tetrahydro-imidazol[1,2-a]pyridin-2-ylamin-forbindelser og deres anvendelse til fremstilling af lægemidler
SE0303090D0 (sv)	2003-11-20	Novel compounds
TW200740781A (en)	2007-11-01	Novel compounds
SE0302755D0 (sv)	2003-10-17	Novel compounds
SE0403118D0 (sv)	2004-12-21	New compounds 2
TW200745133A (en)	2007-12-16	New compounds II
TW200720262A (en)	2007-06-01	Novel compounds ii