DK174151B1 - Monoklonalt antistof, hybridoma og reagens til immunoanalyse af alfa-hANP - Google Patents

Monoklonalt antistof, hybridoma og reagens til immunoanalyse af alfa-hANP Download PDF

Info

Publication number: DK174151B1
Authority: DK; Denmark
Prior art keywords: hanp; antibody; monoclonal antibody; anp; hybridoma
Prior art date: 1987-09-01

Application number

DK198804845A

Other languages

Danish (da)

English (en)

Other versions

DK484588A (da

DK484588D0 (da

Inventor

Hiroo Imura

Kazuwa Nakao

Eiji Ishikawa

Masao Kono

Ken Inouye

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-01

Filing date

1988-08-31

Publication date

2002-07-22

1987-09-01 Priority claimed from JP62218662A external-priority patent/JPS6461500A/ja

1988-08-31 Application filed by Shionogi & Co filed Critical Shionogi & Co

1988-08-31 Publication of DK484588D0 publication Critical patent/DK484588D0/da

1989-03-02 Publication of DK484588A publication Critical patent/DK484588A/da

2002-07-22 Application granted granted Critical

2002-07-22 Publication of DK174151B1 publication Critical patent/DK174151B1/da

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230000028993 immune response Effects 0.000 description 1
230000005847 immunogenicity Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 description 1
239000003550 marker Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
208000009928 nephrosis Diseases 0.000 description 1
231100001027 nephrosis Toxicity 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 1
125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
VRNSNXRNJUCZIN-UHFFFAOYSA-N potassium;7h-purine Chemical compound [K].C1=NC=C2NC=NC2=N1 VRNSNXRNJUCZIN-UHFFFAOYSA-N 0.000 description 1
230000008569 process Effects 0.000 description 1
229960000948 quinine Drugs 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
AHTFMWCHTGEJHA-UHFFFAOYSA-N s-(2,5-dioxooxolan-3-yl) ethanethioate Chemical compound CC(=O)SC1CC(=O)OC1=O AHTFMWCHTGEJHA-UHFFFAOYSA-N 0.000 description 1
238000012216 screening Methods 0.000 description 1
238000010187 selection method Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007974 sodium acetate buffer Substances 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
241000894007 species Species 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
238000011191 terminal modification Methods 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
229960002175 thyroglobulin Drugs 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
239000003643 water by type Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
General Engineering & Computer Science (AREA)
Cell Biology (AREA)
Hematology (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK198804845A 1987-09-01 1988-08-31 Monoklonalt antistof, hybridoma og reagens til immunoanalyse af alfa-hANP DK174151B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP62218662A JPS6461500A (en)	1987-09-01	1987-09-01	Alpha-hanp recognizing monoclonal antibody and immunologically measuring reagent for alpha-hanp
JP21866287		1987-09-01

Publications (3)

Publication Number	Publication Date
DK484588D0 DK484588D0 (da)	1988-08-31
DK484588A DK484588A (da)	1989-03-02
DK174151B1 true DK174151B1 (da)	2002-07-22

Family

ID=16723458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198804845A DK174151B1 (da)	1987-09-01	1988-08-31	Monoklonalt antistof, hybridoma og reagens til immunoanalyse af alfa-hANP

Country Status (9)

Country	Link
EP (1)	EP0306309B1 (de)
KR (1)	KR940009281B1 (de)
AT (1)	ATE97959T1 (de)
CA (1)	CA1335082C (de)
DE (1)	DE3885975T2 (de)
DK (1)	DK174151B1 (de)
ES (1)	ES2061664T3 (de)
HK (1)	HK1003795A1 (de)
NO (1)	NO174005C (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2724315B2 (ja) *	1988-02-29	1998-03-09	塩野義製薬株式会社	α−ＡＮＰを認識するモノクローナル抗体およびα−ＡＮＰの免疫学的測定法
JP2561513B2 (ja) *	1988-07-04	1996-12-11	塩野義製薬株式会社	γ−ＡＮＰを認識するモノクローナル抗体
JP2873586B2 (ja) *	1988-07-15	1999-03-24	武田薬品工業株式会社	抗体およびこれを用いる免疫化学的測定方法
JPH0667319B2 (ja) *	1989-04-19	1994-08-31	塩野義製薬株式会社	Ａｎｐのｃ端側を認識するモノクローナル抗体
TW205096B (de) *	1991-05-29	1993-05-01	Shionogi & Co
JP2665850B2 (ja)	1991-11-14	1997-10-22	塩野義製薬株式会社	ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体
AT407674B (de) *	1998-09-29	2001-05-25	Biomedica Gmbh	Verfahren zur bestimmung von atrialem natriuretischem peptid (anp)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3509958A1 (de) *	1985-03-20	1986-09-25	Bayer Ag, 5090 Leverkusen	Monoklonale antikoerper gegen atriale, natriuretische peptide vom menschen

1988
- 1988-08-24 CA CA000575613A patent/CA1335082C/en not_active Expired - Lifetime
- 1988-08-30 NO NO883854A patent/NO174005C/no not_active IP Right Cessation
- 1988-08-31 DK DK198804845A patent/DK174151B1/da active IP Right Grant
- 1988-09-01 AT AT88308100T patent/ATE97959T1/de not_active IP Right Cessation
- 1988-09-01 EP EP19880308100 patent/EP0306309B1/de not_active Expired - Lifetime
- 1988-09-01 ES ES88308100T patent/ES2061664T3/es not_active Expired - Lifetime
- 1988-09-01 DE DE88308100T patent/DE3885975T2/de not_active Expired - Lifetime
- 1988-09-01 KR KR1019880011311A patent/KR940009281B1/ko not_active Expired - Lifetime
1998
- 1998-04-09 HK HK98102977A patent/HK1003795A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK484588A (da)	1989-03-02
DK484588D0 (da)	1988-08-31
KR940009281B1 (ko)	1994-10-06
EP0306309B1 (de)	1993-12-01
DE3885975T2 (de)	1994-04-14
DE3885975D1 (de)	1994-01-13
KR890005519A (ko)	1989-05-15
EP0306309A3 (en)	1990-03-14
NO174005B (no)	1993-11-22
NO174005C (no)	1994-03-02
NO883854L (no)	1989-03-02
CA1335082C (en)	1995-04-04
ATE97959T1 (de)	1993-12-15
NO883854D0 (no)	1988-08-30
EP0306309A2 (de)	1989-03-08
ES2061664T3 (es)	1994-12-16
HK1003795A1 (en)	1998-11-06

Legal Events

Date	Code	Title	Description
2002-07-22	B1	Patent granted (law 1993)

Publication	Publication Date	Title
US6677124B2 (en)	2004-01-13	Monoclonal antibody recognizing C-terminus of hBNP
EP2292662A2 (de)	2011-03-09	Testverfahren und Reagenzien zur Quantifizierung von hBNP
US4797473A (en)	1989-01-10	Monoclonal antibodies to unreduced, nonenzymatically-glycated proteins
US5643735A (en)	1997-07-01	Anti-thymosin α1 monoclonal antibody-producing hybridoma
US5501988A (en)	1996-03-26	Anti hCG-β core monoclonal antibody, its production and use
DK174151B1 (da)	2002-07-22	Monoklonalt antistof, hybridoma og reagens til immunoanalyse af alfa-hANP
JPH04503006A (ja)	1992-06-04	血液凝固ＸＩＩａ因子βモノクローナル抗体およびイムノアッセイ
HK1003795B (en)	1998-11-06	Monoclonal antibodies recognizing alpha-hanp and corresponding hybridomas, their preparation and use
US5124264A (en)	1992-06-23	Monoclonal antibody recognizing atrial natriuretic polypeptide
US5124248A (en)	1992-06-23	Monoclonal antibody recognizing gamma atrial natriuretic polypeptide
JPH0746999B2 (ja)	1995-05-24	ヒトの心房ナトリウム排泄増加性ペプチドに対するモノクローナル抗体産生ハイブリドーマ
JP3076640B2 (ja)	2000-08-14	ヒト９２ｋＤａゼラチナーゼの免疫学的定量法
CA2012740C (en)	2000-07-11	A monoclonal antibody recognizing c-terminus of anp
JPWO1992011384A1 (ja)	1993-01-14	抗ヒトプラスミン−α↓２−プラスミンインヒビター複合体抗体、ハイブリドーマ及び免疫学的測定方法
JPH0570436B2 (de)	1993-10-05
JP2558956B2 (ja)	1996-11-27	ヒト・オステオカルシンの免疫学的測定方法、そのための試薬及びキツト、ヒト・オステオカルシンに対する抗体、それを産生するハイブリドーマ及びそれを産生する方法
CA1334077C (en)	1995-01-24	Monoclonal antibody recognizing human psti, hybridoma producing the antibody, and determination of human psti
JPH11276167A (ja)	1999-10-12	新規なモノクローナル抗体及び癌遺伝子産物ｃ−Ｓｋｉタンパク質の免疫学的分析方法
JPH08157500A (ja)	1996-06-18	Ｆａｓ抗原の定量法
JPH03183497A (ja)	1991-08-09	四環式化合物に対するモノクローナル抗体、それらの生産方法および応用