DK174196B1 - Co-vaccinationspræparat - Google Patents

Co-vaccinationspræparat Download PDF

Info

Publication number: DK174196B1
Authority: DK; Denmark
Prior art keywords: coli; composition according; bacterin; gram; cells
Prior art date: 1986-05-23

Application number

DK198800307A

Other languages

Danish (da)

English (en)

Other versions

DK30788D0 (da

DK30788A (da

Inventor

Ralph Nelson

Gerald Schlink

Original Assignee

Sanofi Animal Health Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-23

Filing date

1988-01-22

Publication date

2002-09-16

1988-01-22 Application filed by Sanofi Animal Health Inc filed Critical Sanofi Animal Health Inc

1988-01-22 Publication of DK30788D0 publication Critical patent/DK30788D0/da

1988-01-22 Publication of DK30788A publication Critical patent/DK30788A/da

2002-09-16 Application granted granted Critical

2002-09-16 Publication of DK174196B1 publication Critical patent/DK174196B1/da

Links

238000002360 preparation method Methods 0.000 title description 9
238000002255 vaccination Methods 0.000 title description 4
241000588724 Escherichia coli Species 0.000 claims description 35
239000002158 endotoxin Substances 0.000 claims description 19
229920006008 lipopolysaccharide Polymers 0.000 claims description 18
241000606856 Pasteurella multocida Species 0.000 claims description 17
230000001580 bacterial effect Effects 0.000 claims description 17
241001465754 Metazoa Species 0.000 claims description 15
229940051027 pasteurella multocida Drugs 0.000 claims description 15
239000000203 mixture Substances 0.000 claims description 14
241000588622 Moraxella bovis Species 0.000 claims description 9
241001138501 Salmonella enterica Species 0.000 claims description 7
241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims description 7
230000028993 immune response Effects 0.000 claims description 6
244000052769 pathogen Species 0.000 claims description 5
244000000058 gram-negative pathogen Species 0.000 claims description 4
230000001717 pathogenic effect Effects 0.000 claims description 4
241000588779 Bordetella bronchiseptica Species 0.000 claims description 3
241000589893 Brachyspira hyodysenteriae Species 0.000 claims description 3
241000606807 Glaesserella parasuis Species 0.000 claims description 3
241000589926 Leptospira interrogans serovar Hardjo Species 0.000 claims description 3
241001518154 Leptospira kirschneri serovar Grippotyphosa Species 0.000 claims description 3
241000589517 Pseudomonas aeruginosa Species 0.000 claims description 3
241000392514 Salmonella enterica subsp. enterica serovar Dublin Species 0.000 claims description 3
241000589876 Campylobacter Species 0.000 claims description 2
241000589872 Campylobacter hyointestinalis Species 0.000 claims description 2
241001550390 Leptospira interrogans serovar Canicola Species 0.000 claims description 2
241000606748 Actinobacillus pleuropneumoniae Species 0.000 claims 2
241000894006 Bacteria Species 0.000 description 18
229960005486 vaccine Drugs 0.000 description 17
239000012895 dilution Substances 0.000 description 15
238000010790 dilution Methods 0.000 description 15
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 12
238000000034 method Methods 0.000 description 9
241000699670 Mus sp. Species 0.000 description 8
238000002474 experimental method Methods 0.000 description 6
241000283690 Bos taurus Species 0.000 description 5
239000000427 antigen Substances 0.000 description 5
108091007433 antigens Proteins 0.000 description 5
102000036639 antigens Human genes 0.000 description 5
230000004913 activation Effects 0.000 description 4
239000000969 carrier Substances 0.000 description 4
229960004279 formaldehyde Drugs 0.000 description 4
235000019256 formaldehyde Nutrition 0.000 description 4
230000012010 growth Effects 0.000 description 4
239000002609 medium Substances 0.000 description 4
239000000243 solution Substances 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
238000004113 cell culture Methods 0.000 description 3
108010038854 colibacterin Proteins 0.000 description 3
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
239000002953 phosphate buffered saline Substances 0.000 description 3
238000012360 testing method Methods 0.000 description 3
241000282472 Canis lupus familiaris Species 0.000 description 2
102000019040 Nuclear Antigens Human genes 0.000 description 2
108010051791 Nuclear Antigens Proteins 0.000 description 2
241000282887 Suidae Species 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
244000309466 calf Species 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
230000002349 favourable effect Effects 0.000 description 2
239000000835 fiber Substances 0.000 description 2
238000011081 inoculation Methods 0.000 description 2
244000144977 poultry Species 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
241000894007 species Species 0.000 description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
241000589877 Campylobacter coli Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
101710146739 Enterotoxin Proteins 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
241000606790 Haemophilus Species 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
241001494479 Pecora Species 0.000 description 1
241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
229940024546 aluminum hydroxide gel Drugs 0.000 description 1
SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 1
230000003698 anagen phase Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
238000009835 boiling Methods 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
229940096529 carboxypolymethylene Drugs 0.000 description 1
239000012531 culture fluid Substances 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
239000000147 enterotoxin Substances 0.000 description 1
231100000655 enterotoxin Toxicity 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
239000012510 hollow fiber Substances 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
229940031551 inactivated vaccine Drugs 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
230000003902 lesion Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
239000001974 tryptic soy broth Substances 0.000 description 1
108010050327 trypticase-soy broth Proteins 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/104—Pseudomonadales, e.g. Pseudomonas
- A61K39/1045—Moraxella
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK198800307A 1986-05-23 1988-01-22 Co-vaccinationspræparat DK174196B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US86645186A	1986-05-23	1986-05-23
US86645186		1986-05-23
US8701222		1987-05-22
PCT/US1987/001222 WO1987007148A1 (fr)	1986-05-23	1987-05-22	Co-vaccination utilisant une preparation de bacteries gram-negatives sans chaines laterales o-hydrate de carbone

Publications (3)

Publication Number	Publication Date
DK30788D0 DK30788D0 (da)	1988-01-22
DK30788A DK30788A (da)	1988-01-22
DK174196B1 true DK174196B1 (da)	2002-09-16

Family

ID=25347657

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198800307A DK174196B1 (da)	1986-05-23	1988-01-22	Co-vaccinationspræparat

Country Status (8)

Country	Link
EP (1)	EP0367757B1 (fr)
CA (1)	CA1305667C (fr)
DE (1)	DE3750725T2 (fr)
DK (1)	DK174196B1 (fr)
IE (1)	IE66690B1 (fr)
IL (1)	IL82624A (fr)
WO (1)	WO1987007148A1 (fr)
ZA (1)	ZA873698B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2082155C (fr) †	1990-05-29	2008-04-15	Krishnaswamy I. Dayalu	Vaccin contre la pneumonie du porc et methode de preparation
ATE173634T1 (de) *	1994-04-20	1998-12-15	Us Army	Impfstoff gegen gram-negative bakterielle infektionen
US6749831B1 (en)	1997-05-16	2004-06-15	Medical Defense Technology, Llc	Vaccine against lipopolysaccharide core

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1085956A (en) *	1963-09-10	1967-10-04	Nat Res Dev	Improvements relating to vaccines
US4016253A (en) *	1975-04-02	1977-04-05	Iowa State University Research Foundation, Inc.	Vaccine for immunization of swine against Bordetella bronchiseptica infection and method of use
US4167560A (en) *	1977-04-12	1979-09-11	Texas Vet Lab, Inc.	Polyvalent shipping fever vaccine
DK138379A (da) *	1979-04-04	1980-10-05	Nordisk Droge & Kemikalie	Vaccine imod pleuropneumonia (ondartet lungesyge) hos svin dens anvendelse samt fremgangsmaade og substat til dyrkning specielt aerob fermentering af mikroorganismen haemophilus pleuropneumoniae
IL59663A (en) *	1980-03-19	1983-02-23	Univ Ramot	Vaccines obtained from bacterial mutant strains of enterobacteriaceae and pseudomonaceae
US4455142A (en) *	1980-07-07	1984-06-19	Alza Corporation	Method of coadministering an antigen and an immunopotentiator
US4428931A (en) *	1982-03-15	1984-01-31	Merck & Co., Inc.	Bacterial toxoids and gram-negative immune globulin therefrom
US4469672A (en) *	1983-04-07	1984-09-04	Iowa State University Research Foundation	Method of combined parenteral and oral vaccination for swine dysentery
IE940698L (en) *	1984-04-05	1985-10-05	Univ Missouri	Vaccine and serum for endotoxin associated disease and method of preparing same as well as to methods of immunization and treatment of such disease and to a detoxified endotoxin and bacterial mutant

1987
- 1987-05-22 ZA ZA873698A patent/ZA873698B/xx unknown
- 1987-05-22 IE IE134387A patent/IE66690B1/en not_active IP Right Cessation
- 1987-05-22 IL IL82624A patent/IL82624A/xx not_active IP Right Cessation
- 1987-05-22 DE DE3750725T patent/DE3750725T2/de not_active Expired - Lifetime
- 1987-05-22 EP EP87903666A patent/EP0367757B1/fr not_active Expired - Lifetime
- 1987-05-22 WO PCT/US1987/001222 patent/WO1987007148A1/fr not_active Ceased
- 1987-05-25 CA CA000537927A patent/CA1305667C/fr not_active Expired - Lifetime
1988
- 1988-01-22 DK DK198800307A patent/DK174196B1/da active IP Right Grant

Also Published As

Publication number	Publication date
EP0367757A1 (fr)	1990-05-16
CA1305667C (fr)	1992-07-28
ZA873698B (en)	1987-11-18
IL82624A (en)	1993-02-21
DE3750725D1 (de)	1994-12-08
IE66690B1 (en)	1996-01-24
DK30788D0 (da)	1988-01-22
IL82624A0 (en)	1987-11-30
DE3750725T2 (de)	1995-06-08
EP0367757B1 (fr)	1994-11-02
DK30788A (da)	1988-01-22
IE871343L (en)	1987-11-23
WO1987007148A1 (fr)	1987-12-03

Legal Events

Date	Code	Title	Description
2002-09-16	B1	Patent granted (law 1993)

Publication	Publication Date	Title
US4298597A (en)	1981-11-03	Vaccine for diarrhea caused by E. coli
Deb et al.	1976	Laboratory trials with inactivated vaccines against Escherichia coli (O78 K80) infection in fowls
Elliott et al.	1980	Streptococcal infection in young pigs. V. An immunogenic polysaccharide from Streptococcus suis type 2 with particular reference to vaccination against streptococcal meningitis in pigs
US4789544A (en)	1988-12-06	Co-vaccination using non-O-carbohydrate side-chain gram-negative bacteria preparation
AU667858B2 (en)	1996-04-18	Gram-negative bacterial vaccines
Deb et al.	1978	Laboratory trials with inactivated vaccines against Escherichia coli (O2: K1) infection in fowls
US4606919A (en)	1986-08-19	Vaccine for the treatment of urinary tract infections containing aluminum phosphate
DK174196B1 (da)	2002-09-16	Co-vaccinationspræparat
US5536496A (en)	1996-07-16	Pasteurella multocida toxoid vaccines
McCarthy et al.	1984	Immunization of rainbow trout, Salmo gairdneri Richardson, against bacterial kidney disease: preliminary efficacy evaluation
US4335106A (en)	1982-06-15	Processes for the growth of a modified Pasteurella multocida bacteria and preparation of a vaccine therefrom
PEDERSEN	1975	The serology of Bordetella bronchiseptica isolated from pigs compared with strains from other animal species
GB2023420A (en)	1980-01-03	Preparations containing antigen from pasteurella haemolytica
US3328252A (en)	1967-06-27	Pasteurella and salmonella vaccines
Ward et al.	1985	Factors influencing the efficacy of vaccines against vibriosis caused by Vibrio anguillarum
US8563005B2 (en)	2013-10-22	Actinobacillus suis antigens
JP2721218B2 (ja)	1998-03-04	ブタ赤痢ワクチン
Smith et al.	1982	Immunogenicity of killed Bordetella bronchiseptica vaccines in the mouse
US6096322A (en)	2000-08-01	Pathogenicity and protective attributes of major clones of Escherichia coli recovered from chickens during processing
CA2312296C (fr)	2007-10-09	Vaccins d'anatoxine pasteurella multocida
Claus et al.	1979	Immunogenicity of Clostridium septicum in guinea pigs
RU2018322C1 (ru)	1994-08-30	Вакцина против рожи свиней
Davis et al.	1976	Further observations on the use of a bivalent bacterin against Haemophilus gallinarum
CA2086258C (fr)	2007-10-23	Vaccins d'anatoxine pasteurella multocida
Šourek et al.	1980	Mouse-protection experience with monovalent Pseudomonas aeruginosa vaccine