DK175532B1 - Lipid-osmotisk pumpe - Google Patents

Lipid-osmotisk pumpe Download PDF

Info

Publication number: DK175532B1
Authority: DK; Denmark
Prior art keywords: lipid; water; wall; osmotic; agent
Prior art date: 1985-02-01

Application number

DK198600485A

Other languages

Danish (da)

English (en)

Other versions

DK48586D0 (da

DK48586A (da

Inventor

Gordon L Amidon

Takeru Higuchi

Jennifer B Dressman

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-01

Filing date

1986-01-31

Publication date

2004-11-22

1986-01-31 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1986-01-31 Publication of DK48586D0 publication Critical patent/DK48586D0/da

1986-08-02 Publication of DK48586A publication Critical patent/DK48586A/da

2004-11-22 Application granted granted Critical

2004-11-22 Publication of DK175532B1 publication Critical patent/DK175532B1/da

Links

150000002632 lipids Chemical class 0.000 title claims abstract description 134
230000003204 osmotic effect Effects 0.000 title claims abstract description 47
239000002357 osmotic agent Substances 0.000 claims abstract description 67
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 49
239000013543 active substance Substances 0.000 claims abstract description 48
229920000642 polymer Polymers 0.000 claims abstract description 43
239000007788 liquid Substances 0.000 claims abstract description 29
230000035699 permeability Effects 0.000 claims abstract description 17
239000007864 aqueous solution Substances 0.000 claims abstract description 11
-1 alkali metal salts Chemical class 0.000 claims description 57
229920002301 cellulose acetate Polymers 0.000 claims description 47
238000000034 method Methods 0.000 claims description 32
239000000203 mixture Substances 0.000 claims description 25
239000003795 chemical substances by application Substances 0.000 claims description 24
239000002904 solvent Substances 0.000 claims description 14
150000002148 esters Chemical class 0.000 claims description 13
239000000654 additive Substances 0.000 claims description 10
239000008346 aqueous phase Substances 0.000 claims description 6
229920006217 cellulose acetate butyrate Polymers 0.000 claims description 6
108010051201 lipid I Proteins 0.000 claims description 5
229920005862 polyol Polymers 0.000 claims description 5
230000008569 process Effects 0.000 claims description 5
229920002284 Cellulose triacetate Polymers 0.000 claims description 4
NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 4
230000015572 biosynthetic process Effects 0.000 claims description 4
150000001720 carbohydrates Chemical class 0.000 claims description 4
229930195733 hydrocarbon Natural products 0.000 claims description 4
239000002480 mineral oil Substances 0.000 claims description 4
150000003077 polyols Chemical class 0.000 claims description 4
239000004215 Carbon black (E152) Substances 0.000 claims description 3
230000000996 additive effect Effects 0.000 claims description 3
239000008366 buffered solution Substances 0.000 claims description 3
238000006243 chemical reaction Methods 0.000 claims description 3
235000014113 dietary fatty acids Nutrition 0.000 claims description 3
229930195729 fatty acid Natural products 0.000 claims description 3
239000000194 fatty acid Substances 0.000 claims description 3
150000004665 fatty acids Chemical class 0.000 claims description 3
235000010446 mineral oil Nutrition 0.000 claims description 3
150000007524 organic acids Chemical class 0.000 claims description 3
235000005985 organic acids Nutrition 0.000 claims description 3
229920008347 Cellulose acetate propionate Polymers 0.000 claims description 2
229920001747 Cellulose diacetate Polymers 0.000 claims description 2
229910052783 alkali metal Inorganic materials 0.000 claims description 2
229910052784 alkaline earth metal Inorganic materials 0.000 claims description 2
235000014121 butter Nutrition 0.000 claims description 2
229940110456 cocoa butter Drugs 0.000 claims description 2
235000019868 cocoa butter Nutrition 0.000 claims description 2
238000005342 ion exchange Methods 0.000 claims description 2
235000019271 petrolatum Nutrition 0.000 claims description 2
229910052723 transition metal Inorganic materials 0.000 claims description 2
150000003626 triacylglycerols Chemical group 0.000 claims description 2
HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical group C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims 1
230000002349 favourable effect Effects 0.000 claims 1
238000000935 solvent evaporation Methods 0.000 claims 1
230000009286 beneficial effect Effects 0.000 abstract description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 73
239000000243 solution Substances 0.000 description 71
238000000576 coating method Methods 0.000 description 58
239000011248 coating agent Substances 0.000 description 56
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 51
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 49
239000011148 porous material Substances 0.000 description 38
239000011780 sodium chloride Substances 0.000 description 35
239000000463 material Substances 0.000 description 33
RCTGMCJBQGBLKT-PAMTUDGESA-N scarlet red Chemical compound CC1=CC=CC=C1\N=N\C(C=C1C)=CC=C1\N=N\C1=C(O)C=CC2=CC=CC=C12 RCTGMCJBQGBLKT-PAMTUDGESA-N 0.000 description 31
229960005369 scarlet red Drugs 0.000 description 31
239000011162 core material Substances 0.000 description 29
239000011324 bead Substances 0.000 description 25
229920002678 cellulose Polymers 0.000 description 25
239000003814 drug Substances 0.000 description 25
239000001913 cellulose Substances 0.000 description 24
235000010980 cellulose Nutrition 0.000 description 24
229940079593 drug Drugs 0.000 description 24
TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 description 22
229960004605 timolol Drugs 0.000 description 22
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 15
239000004014 plasticizer Substances 0.000 description 15
229940068918 polyethylene glycol 400 Drugs 0.000 description 13
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 11
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 11
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 11
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
150000001875 compounds Chemical class 0.000 description 10
238000005086 pumping Methods 0.000 description 10
239000007787 solid Substances 0.000 description 9
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 8
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 8
229930195725 Mannitol Natural products 0.000 description 8
239000000594 mannitol Substances 0.000 description 8
235000010355 mannitol Nutrition 0.000 description 8
210000000056 organ Anatomy 0.000 description 8
ANRBLZZRYMCUQR-UHFFFAOYSA-N butyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate Chemical compound C12=CC=C(OC)C=C2C(CC(=O)OCCCC)=C(C)N1C(=O)C1=CC=C(Cl)C=C1 ANRBLZZRYMCUQR-UHFFFAOYSA-N 0.000 description 7
238000009736 wetting Methods 0.000 description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
241001465754 Metazoa Species 0.000 description 6
239000008187 granular material Substances 0.000 description 6
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 6
239000001103 potassium chloride Substances 0.000 description 6
235000011164 potassium chloride Nutrition 0.000 description 6
239000005720 sucrose Substances 0.000 description 6
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
229930006000 Sucrose Natural products 0.000 description 5
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 5
230000036760 body temperature Effects 0.000 description 5
125000004432 carbon atom Chemical group C* 0.000 description 5
239000012530 fluid Substances 0.000 description 5
150000002334 glycols Chemical class 0.000 description 5
239000008101 lactose Substances 0.000 description 5
229960001375 lactose Drugs 0.000 description 5
239000002609 medium Substances 0.000 description 5
229910052757 nitrogen Inorganic materials 0.000 description 5
239000008188 pellet Substances 0.000 description 5
229920000728 polyester Polymers 0.000 description 5
239000000126 substance Substances 0.000 description 5
229930091371 Fructose Natural products 0.000 description 4
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 4
239000005715 Fructose Substances 0.000 description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
239000002202 Polyethylene glycol Substances 0.000 description 4
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 4
239000002253 acid Substances 0.000 description 4
125000002947 alkylene group Chemical group 0.000 description 4
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 4
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 4
150000002009 diols Chemical class 0.000 description 4
239000002552 dosage form Substances 0.000 description 4
235000019441 ethanol Nutrition 0.000 description 4
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 4
239000002245 particle Substances 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
239000012047 saturated solution Substances 0.000 description 4
239000002511 suppository base Substances 0.000 description 4
239000011975 tartaric acid Substances 0.000 description 4
235000002906 tartaric acid Nutrition 0.000 description 4
238000012360 testing method Methods 0.000 description 4
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
239000001856 Ethyl cellulose Substances 0.000 description 3
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
229910019142 PO4 Inorganic materials 0.000 description 3
229920005372 Plexiglas® Polymers 0.000 description 3
SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 description 3
125000002252 acyl group Chemical group 0.000 description 3
230000008901 benefit Effects 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000004927 clay Substances 0.000 description 3
JURKNVYFZMSNLP-UHFFFAOYSA-N cyclobenzaprine Chemical compound C1=CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 JURKNVYFZMSNLP-UHFFFAOYSA-N 0.000 description 3
229960003572 cyclobenzaprine Drugs 0.000 description 3
239000008121 dextrose Substances 0.000 description 3
SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Chemical compound CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 description 3
IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 3
229960002768 dipyridamole Drugs 0.000 description 3
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 3
239000000975 dye Substances 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
229920001249 ethyl cellulose Polymers 0.000 description 3
235000019325 ethyl cellulose Nutrition 0.000 description 3
238000001704 evaporation Methods 0.000 description 3
230000008020 evaporation Effects 0.000 description 3
239000007789 gas Substances 0.000 description 3
239000007903 gelatin capsule Substances 0.000 description 3
239000011521 glass Substances 0.000 description 3
229960001680 ibuprofen Drugs 0.000 description 3
229960000905 indomethacin Drugs 0.000 description 3
230000003993 interaction Effects 0.000 description 3
238000005259 measurement Methods 0.000 description 3
231100000252 nontoxic Toxicity 0.000 description 3
230000003000 nontoxic effect Effects 0.000 description 3
235000021317 phosphate Nutrition 0.000 description 3
OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 3
229910052939 potassium sulfate Inorganic materials 0.000 description 3
235000011151 potassium sulphates Nutrition 0.000 description 3
239000000843 powder Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000008279 sol Substances 0.000 description 3
239000000725 suspension Substances 0.000 description 3
229960003188 temazepam Drugs 0.000 description 3
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 2
OVOUKWFJRHALDD-UHFFFAOYSA-N 2-[2-(2-acetyloxyethoxy)ethoxy]ethyl acetate Chemical compound CC(=O)OCCOCCOCCOC(C)=O OVOUKWFJRHALDD-UHFFFAOYSA-N 0.000 description 2
JTXMVXSTHSMVQF-UHFFFAOYSA-N 2-acetyloxyethyl acetate Chemical compound CC(=O)OCCOC(C)=O JTXMVXSTHSMVQF-UHFFFAOYSA-N 0.000 description 2
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
241000251468 Actinopterygii Species 0.000 description 2
229920002498 Beta-glucan Polymers 0.000 description 2
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
108091006146 Channels Proteins 0.000 description 2
JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 2
241000938605 Crocodylia Species 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 description 2
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
241000282412 Homo Species 0.000 description 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
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241000700159 Rattus Species 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
238000002835 absorbance Methods 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
DRFCSTAUJQILHC-UHFFFAOYSA-N acetic acid;benzoic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1 DRFCSTAUJQILHC-UHFFFAOYSA-N 0.000 description 2
238000004026 adhesive bonding Methods 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
125000000217 alkyl group Chemical group 0.000 description 2
239000003435 antirheumatic agent Substances 0.000 description 2
230000004888 barrier function Effects 0.000 description 2
239000002585 base Substances 0.000 description 2
BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 2
DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 2
239000011575 calcium Substances 0.000 description 2
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
235000014633 carbohydrates Nutrition 0.000 description 2
239000000969 carrier Substances 0.000 description 2
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150000003710 vitamin D derivatives Chemical class 0.000 description 1
235000019168 vitamin K Nutrition 0.000 description 1
239000011712 vitamin K Substances 0.000 description 1
150000003721 vitamin K derivatives Chemical class 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
229940046010 vitamin k Drugs 0.000 description 1
229960005080 warfarin Drugs 0.000 description 1
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
OYPPVKRFBIWMSX-SXGWCWSVSA-N zimeldine Chemical compound C=1C=CN=CC=1C(=C/CN(C)C)\C1=CC=C(Br)C=C1 OYPPVKRFBIWMSX-SXGWCWSVSA-N 0.000 description 1
229960002791 zimeldine Drugs 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Preparation (AREA)
Fats And Perfumes (AREA)
External Artificial Organs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

DK198600485A 1985-02-01 1986-01-31 Lipid-osmotisk pumpe DK175532B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/697,105 US4685918A (en)	1985-02-01	1985-02-01	Lipid osmotic pump
US69710585		1985-02-01

Publications (3)

Publication Number	Publication Date
DK48586D0 DK48586D0 (da)	1986-01-31
DK48586A DK48586A (da)	1986-08-02
DK175532B1 true DK175532B1 (da)	2004-11-22

Family

ID=24799818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198600485A DK175532B1 (da)	1985-02-01	1986-01-31	Lipid-osmotisk pumpe

Country Status (11)

Country	Link
US (1)	US4685918A (fr)
EP (1)	EP0190969B1 (fr)
JP (1)	JPH0655666B2 (fr)
AT (1)	ATE85889T1 (fr)
CA (1)	CA1264133A (fr)
CY (1)	CY1861A (fr)
DE (1)	DE3687799T2 (fr)
DK (1)	DK175532B1 (fr)
ES (1)	ES8801768A1 (fr)
HK (1)	HK102995A (fr)
IE (1)	IE59888B1 (fr)

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GB2189699A (en) *	1986-04-30	1987-11-04	Haessle Ab	Coated acid-labile medicaments
US4983400A (en) *	1986-06-16	1991-01-08	Merck & Co., Inc.	Controlled release combination of carbidopa/levodopa
CH668187A5 (de) *	1986-08-07	1988-12-15	Ciba Geigy Ag	Therapeutisches system mit systemischer wirkung.
USRE34990E (en) *	1986-08-07	1995-07-04	Ciba-Geigy Corporation	Oral therapeutic system having systemic action
US5030632A (en) *	1986-09-23	1991-07-09	Sandoz Pharm. Corp.	Low dose temazepam
US5211954A (en) *	1986-09-23	1993-05-18	Sandoz Ltd.	Low dose temazepam
US5629310A (en) *	1986-09-23	1997-05-13	Sterling; William R.	Low dose temazepam
EP0277092B1 (fr) *	1987-01-14	1992-01-29	Ciba-Geigy Ag	Système thérapeutique pour médicaments peu solubles
GB8717168D0 (en) *	1987-07-21	1987-08-26	Roussel Lab Ltd	Controlled-release device
CA1331563C (fr) *	1987-08-03	1994-08-23	Gaylen M. Zentner	Systeme de liberation controlee de medicaments avec modulation de type donnan par des resines chargees insolubles
AU608891B2 (en) *	1987-09-24	1991-04-18	Merck & Co., Inc.	Solubility modulated drug delivery device
US5030203A (en) *	1987-11-16	1991-07-09	Baxter International Inc.	Ampule for controlled administration of beneficial agent
US5510115A (en) *	1987-11-16	1996-04-23	Baxter Travenol Laboratories, Inc.	Method and composition for administration of beneficial agent by controlled dissolution
US5108756A (en) *	1989-01-12	1992-04-28	Pfizer Inc.	Dispensing devices powered by lyotropic liquid crystals
IL92966A (en) *	1989-01-12	1995-07-31	Pfizer	Dispensing devices powered by hydrogel
US5030452A (en) *	1989-01-12	1991-07-09	Pfizer Inc.	Dispensing devices powered by lyotropic liquid crystals
CA2008775C (fr) *	1989-02-24	1998-12-22	Alberto Ferro	Vernis a ongles
EP0550641B1 (fr) *	1990-09-28	1994-05-25	Pfizer Inc.	Dispositif de distribution contenant un milieu hydrophobe
DE4101873C2 (de) *	1991-01-23	1993-12-09	Isis Pharma Gmbh	Peroral applizierbare Arzneiform zur Behandlung zentraler Dopaminmangelzustände
CA2082185C (fr) *	1991-11-26	2004-01-20	Alexander R. Pokora	Traitement catalytique de matieres lignocellulosiques a l'aide de protease
US5484607A (en) *	1993-10-13	1996-01-16	Horacek; H. Joseph	Extended release clonidine formulation
US5798119A (en) *	1995-06-13	1998-08-25	S. C. Johnson & Son, Inc.	Osmotic-delivery devices having vapor-permeable coatings
US5786022A (en) *	1996-10-31	1998-07-28	Ethicon, Inc.	Coating mixture for surgical articles
AR026148A1 (es) *	2000-01-21	2003-01-29	Osmotica Argentina S A	Dispositivo osmotico con pasaje preformado que aumenta de tamano
US6464688B1 (en)	2000-02-15	2002-10-15	Microsolutions, Inc.	Osmotic pump delivery system with flexible drug compartment
AU2002241538A1 (en) *	2000-12-01	2002-07-24	Nephros Therapeutics, Inc.	Intrasvascular drug delivery device and use therefor
IN190699B (fr)	2001-02-02	2003-08-16	Sun Pharmaceutical Ind Ltd
US6632217B2 (en)	2001-04-19	2003-10-14	Microsolutions, Inc.	Implantable osmotic pump
WO2003096968A2 (fr) *	2002-05-15	2003-11-27	Sun Pharmaceutical Industries Limited	Systeme de delivrance orale osmotique controlee de medicament
US20050249799A1 (en) *	2004-03-03	2005-11-10	Spherics, Inc.	Polymeric drug delivery system for hydrophobic drugs
US20060045891A1 (en) *	2004-08-24	2006-03-02	Lovalenti Phillip M	Density-matched suspension vehicles and pharmaceutical suspensions
US20060045865A1 (en) *	2004-08-27	2006-03-02	Spherics, Inc.	Controlled regional oral delivery
US20090081296A1 (en) *	2006-02-02	2009-03-26	Humes H David	Extracorporeal cell-based therapeutic device and delivery system
US8048419B2 (en)	2006-02-02	2011-11-01	Innovative Biotherapies, Inc.	Extracorporeal cell-based therapeutic device and delivery system
AU2008261957A1 (en) *	2007-06-08	2008-12-18	Addrenex Pharmaceuticals, Inc.	Extended release formulation and method of treating adrenergic dysregulation
US20100172991A1 (en) *	2007-06-08	2010-07-08	Henry Joseph Horacek	Extended Release Formulation and Methods of Treating Adrenergic Dysregulation
US20090148532A1 (en) *	2007-12-06	2009-06-11	Venkatesh Gopi M	Preparation of controlled release skeletal muscle relaxant dosage forms
AU2009327485A1 (en) *	2008-06-18	2010-06-24	Cytopherx, Inc.	Methods for propagation of renal precursor cells

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Publication number	Priority date	Publication date	Assignee	Title
US3854480A (en) *	1969-04-01	1974-12-17	Alza Corp	Drug-delivery system
US3948254A (en) *	1971-11-08	1976-04-06	Alza Corporation	Novel drug delivery device
US3819390A (en) *	1972-01-24	1974-06-25	Anheuser Busch	Lipophilic cellulose sponges
US3995632A (en) *	1973-05-04	1976-12-07	Alza Corporation	Osmotic dispenser
US4111202A (en) *	1976-11-22	1978-09-05	Alza Corporation	Osmotic system for the controlled and delivery of agent over time
US4256108A (en) *	1977-04-07	1981-03-17	Alza Corporation	Microporous-semipermeable laminated osmotic system
US4200098A (en) *	1978-10-23	1980-04-29	Alza Corporation	Osmotic system with distribution zone for dispensing beneficial agent
US4350271A (en) *	1980-08-22	1982-09-21	Alza Corporation	Water absorbing fluid dispenser
US4522625A (en) *	1982-09-29	1985-06-11	Alza Corporation	Drug dispenser comprising wall formed of semipermeable member and enteric member

1985
- 1985-02-01 US US06/697,105 patent/US4685918A/en not_active Expired - Lifetime
1986
- 1986-01-24 IE IE21386A patent/IE59888B1/en not_active IP Right Cessation
- 1986-01-29 DE DE8686400180T patent/DE3687799T2/de not_active Expired - Lifetime
- 1986-01-29 AT AT86400180T patent/ATE85889T1/de not_active IP Right Cessation
- 1986-01-29 CA CA000500632A patent/CA1264133A/fr not_active Expired
- 1986-01-29 EP EP86400180A patent/EP0190969B1/fr not_active Expired - Lifetime
- 1986-01-31 DK DK198600485A patent/DK175532B1/da not_active IP Right Cessation
- 1986-01-31 ES ES551505A patent/ES8801768A1/es not_active Expired
- 1986-02-01 JP JP61019214A patent/JPH0655666B2/ja not_active Expired - Lifetime
1995
- 1995-06-22 HK HK102995A patent/HK102995A/en not_active IP Right Cessation
1996
- 1996-04-05 CY CY186196A patent/CY1861A/xx unknown

Also Published As

Publication number	Publication date
CY1861A (en)	1996-04-05
DE3687799T2 (de)	1993-07-01
ES8801768A1 (es)	1988-02-16
EP0190969A2 (fr)	1986-08-13
DK48586D0 (da)	1986-01-31
JPS61185272A (ja)	1986-08-18
IE860213L (en)	1986-08-01
DE3687799D1 (de)	1993-04-01
HK102995A (en)	1995-06-30
ATE85889T1 (de)	1993-03-15
IE59888B1 (en)	1994-04-20
DK48586A (da)	1986-08-02
ES551505A0 (es)	1988-02-16
CA1264133A (fr)	1990-01-02
EP0190969A3 (en)	1987-11-04
US4685918A (en)	1987-08-11
EP0190969B1 (fr)	1993-02-24
JPH0655666B2 (ja)	1994-07-27

Legal Events

Date	Code	Title	Description
2006-02-20	PUP	Patent expired

Publication	Publication Date	Title
DK175532B1 (da)	2004-11-22	Lipid-osmotisk pumpe
US4111202A (en)	1978-09-05	Osmotic system for the controlled and delivery of agent over time
US4326525A (en)	1982-04-27	Osmotic device that improves delivery properties of agent in situ
US4851228A (en)	1989-07-25	Multiparticulate controlled porosity osmotic
US4968507A (en)	1990-11-06	Controlled porosity osmotic pump
JPS6011887B2 (ja)	1985-03-28	浸透圧で放出するジスペンサ−およびその製造法
US4320759A (en)	1982-03-23	Dispenser with diffuser
CA1318825C (fr)	1993-06-08	Multitude de mini-pilules sous forme posologique liquide
US4203439A (en)	1980-05-20	Osmotic system with volume amplifier for increasing amount of agent delivered therefrom
KR0176724B1 (ko)	1999-03-20	액상 약물 전달용 삼투 투약 시스템
US4309996A (en)	1982-01-12	System with microporous releasing diffusor
RU2093147C1 (ru)	1997-10-20	Изделия для пролонгированного выделения одного или нескольких фармацевтически активных веществ
EP0180708B1 (fr)	1989-05-17	Dispositif osmotique pour libérer une substance active
IE44450B1 (en)	1981-12-02	Osmotically driven dispenser and process for making same
NL8601993A (nl)	1987-03-16	Afgifteinrichting voor herkauwers.
SE459847B (sv)	1989-08-14	Osmotiskt system med omedelbar laekemedelstillgaenglighet
JPH0155242B2 (fr)	1989-11-22
CA1266827A (fr)	1990-03-20	Pompe osmotique a porosite controlee
GB2174005A (en)	1986-10-29	Osmotic dispenser
JP2915416B2 (ja)	1999-07-05	溶解度を調節した医薬供給装置
NL8601971A (nl)	1987-03-02	Afgiftesysteem met een middel om de afgifte van een heilzaam middel uit het systeem te versnellen.
JPH0137367B2 (fr)	1989-08-07
US4484921A (en)	1984-11-27	Theophylline therapy utilizing osmotic delivery
US4439195A (en)	1984-03-27	Theophylline therapy
JPH025978A (ja)	1990-01-10	徐放デバイス