DK1763534T3 - Nye 2-substituerede D-homo-estra-1,3,5(10)-triener som inhibitorer af 17beta-hydroxysteroiddehydrogenasen type 1 - Google Patents

Nye 2-substituerede D-homo-estra-1,3,5(10)-triener som inhibitorer af 17beta-hydroxysteroiddehydrogenasen type 1

Info

Publication number
DK1763534T3
DK1763534T3 DK05768705.5T DK05768705T DK1763534T3 DK 1763534 T3 DK1763534 T3 DK 1763534T3 DK 05768705 T DK05768705 T DK 05768705T DK 1763534 T3 DK1763534 T3 DK 1763534T3
Authority
DK
Denmark
Prior art keywords
sub
sup
trienes
estra
homo
Prior art date
Application number
DK05768705.5T
Other languages
English (en)
Inventor
Christian Gege
Wilko Regenhardt
Olaf Peters
Alexander Hillisch
Jerzy Adamski
Gabriele Moeller
Walter Elger
Birgitt Schneider
Dominga Deluca
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Application granted granted Critical
Publication of DK1763534T3 publication Critical patent/DK1763534T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK05768705.5T 2004-07-02 2005-07-04 Nye 2-substituerede D-homo-estra-1,3,5(10)-triener som inhibitorer af 17beta-hydroxysteroiddehydrogenasen type 1 DK1763534T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004032673A DE102004032673A1 (de) 2004-07-02 2004-07-02 Neue 2-substituierte D-Homo-estra-1,3,5(10)-triene als Inhibitoren der 17ß-Hydroxysteroiddehydrogenase Typ 1
PCT/EP2005/007314 WO2006003012A1 (de) 2004-07-02 2005-07-04 NEUE 2-SUBSTITUIERTE D-HOMO ESTRA-1,3,5(10)-TRIENE ALS INHIBITOREN DER 17ß-HYDROXYSTEROIDDEHYDROGENASE TYP 1

Publications (1)

Publication Number Publication Date
DK1763534T3 true DK1763534T3 (da) 2010-05-17

Family

ID=35106828

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05768705.5T DK1763534T3 (da) 2004-07-02 2005-07-04 Nye 2-substituerede D-homo-estra-1,3,5(10)-triener som inhibitorer af 17beta-hydroxysteroiddehydrogenasen type 1

Country Status (24)

Country Link
EP (1) EP1763534B1 (da)
JP (1) JP4871274B2 (da)
KR (1) KR20070035059A (da)
CN (1) CN1980949B (da)
AT (1) ATE458744T1 (da)
AU (1) AU2005259329B8 (da)
BR (1) BRPI0511394A (da)
CA (1) CA2571760C (da)
CR (1) CR8854A (da)
DE (2) DE102004032673A1 (da)
DK (1) DK1763534T3 (da)
EA (1) EA011455B1 (da)
EC (1) ECSP077160A (da)
ES (1) ES2340401T3 (da)
HR (1) HRP20100230T1 (da)
IL (1) IL180171A0 (da)
MX (1) MX2007000108A (da)
NO (1) NO20070605L (da)
NZ (1) NZ552515A (da)
PL (1) PL1763534T3 (da)
PT (1) PT1763534E (da)
UA (1) UA92324C2 (da)
WO (1) WO2006003012A1 (da)
ZA (1) ZA200700958B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
US8080540B2 (en) 2006-09-19 2011-12-20 Abbott Products Gmbh Therapeutically active triazoles and their use
US8288367B2 (en) 2006-11-30 2012-10-16 Solvay Pharmaceuticals Gmbh Substituted estratriene derivatives as 17BETA HSD inhibitors
DE102007015169A1 (de) 2007-03-27 2008-10-02 Universität des Saarlandes Campus Saarbrücken 17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
DE102007040243A1 (de) 2007-08-25 2009-02-26 Universität des Saarlandes 17Beta-Hydroxysteriod-Dehydrogenase Typ1 Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
CN105518017B (zh) 2013-06-25 2020-07-14 佛恩多制药有限公司 治疗活性的作为1型17β-羟基类固醇脱氢酶抑制剂的雌三烯噻唑衍生物
MX2015017879A (es) 2013-06-25 2017-03-01 Forendo Pharma Ltd Derivados de estratrientiazol 17-nitrogeno substitutidos terapeuticamente activos como inhibidores de 17.beta-hidroxiestero ide deshidrogenasa.
AR096728A1 (es) 2013-06-25 2016-01-27 Forendo Pharma Ltd Derivados de estratrieno-tiazol terapéuticamente activos
CN107207562B (zh) 2014-12-23 2020-03-06 佛恩多制药有限公司 17β-HSD1抑制剂的前药
US10413557B2 (en) 2014-12-23 2019-09-17 Forendo Pharma Ltd. Prodrugs of 17.BETA.-HSD1-inhibitors
CZ307437B6 (cs) 2016-06-07 2018-08-22 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
WO2018224736A2 (en) 2017-06-08 2018-12-13 Forendo Pharma Ltd Therapeutically active steroidal derivatives
MX2021006452A (es) 2018-12-05 2021-09-28 Forendo Pharma Ltd Compuestos estra-1,3,5(10)-trieno condensados en posición 16(17) con un anillo de pirazol como inhibidores de 17-hsd1.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3005835A (en) * 1960-09-13 1961-10-24 Searle & Co D-homo-18-norestra-1, 3, 5(10)-trien-17alpha-ones and intermediates thereto
GB1346691A (en) * 1970-06-12 1974-02-13 Inst Khim Prirodnykh Soedineny Stereospecific method for preparing estrane compounds of natural configuration
JPH06279488A (ja) * 1993-03-29 1994-10-04 Kuraray Co Ltd 新規なステロイド誘導体および骨粗鬆症治療剤
RU2000125533A (ru) * 1998-03-11 2002-10-20 Эндорешерш, Инк. (Ca) Ингибиторы 17-бета-гидроксистероиддегидрогеназ 5 и 3 типа и способы их применения
DE10151365A1 (de) * 2001-10-17 2003-04-30 Schering Ag 17-Chlor-D-Homosteroide als selektive Estrogenrezeptorantagonisten
WO2003017973A1 (en) * 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. A method of treating benign gynaecological disorders and a drug delivery vehicle for use in such a method
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE102004032674A1 (de) * 2004-07-02 2006-01-26 Schering Ag Neue 2-substituierte Estra-1,3,5(10)-trien-17-one als Inhibitoren der 17β-Hydroxysteroiddehydrogenase Typ 1

Also Published As

Publication number Publication date
JP4871274B2 (ja) 2012-02-08
IL180171A0 (en) 2007-06-03
AU2005259329B2 (en) 2011-11-10
ES2340401T3 (es) 2010-06-02
HRP20100230T1 (hr) 2010-06-30
ECSP077160A (es) 2007-02-28
WO2006003012A1 (de) 2006-01-12
DE102004032673A1 (de) 2006-01-26
CA2571760A1 (en) 2006-01-12
BRPI0511394A (pt) 2007-12-04
AU2005259329B8 (en) 2011-11-24
ATE458744T1 (de) 2010-03-15
HK1103745A1 (en) 2007-12-28
CR8854A (es) 2007-08-28
EP1763534B1 (de) 2010-02-24
EA011455B1 (ru) 2009-04-28
MX2007000108A (es) 2007-03-09
CN1980949A (zh) 2007-06-13
NO20070605L (no) 2007-02-01
NZ552515A (en) 2010-07-30
CA2571760C (en) 2011-11-22
PL1763534T3 (pl) 2010-07-30
PT1763534E (pt) 2010-04-27
JP2008504337A (ja) 2008-02-14
ZA200700958B (en) 2008-07-30
EA200700103A1 (ru) 2007-08-31
DE502005009091D1 (de) 2010-04-08
UA92324C2 (en) 2010-10-25
KR20070035059A (ko) 2007-03-29
CN1980949B (zh) 2010-05-05
EP1763534A1 (de) 2007-03-21
AU2005259329A1 (en) 2006-01-12

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