NO20080865L - Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer - Google Patents

Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer

Info

Publication number
NO20080865L
NO20080865L NO20080865A NO20080865A NO20080865L NO 20080865 L NO20080865 L NO 20080865L NO 20080865 A NO20080865 A NO 20080865A NO 20080865 A NO20080865 A NO 20080865A NO 20080865 L NO20080865 L NO 20080865L
Authority
NO
Norway
Prior art keywords
acc
carboxylase
coenzyme
acetyl
inhibitors
Prior art date
Application number
NO20080865A
Other languages
English (en)
Inventor
Takeru Yamakawa
Hideki Jona
Kenji Niiyama
Koji Yamada
Tomoharu Iino
Mitsuru Ohkubo
Hideaki Imamura
Jun Kusunoki
Lihu Yang
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of NO20080865L publication Critical patent/NO20080865L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oppfinnelsen vedrører en forbindelse med formel (I): (i) eller et farmasøytisk akseptabelt salt eller ester derav, som er nyttig som terapeutisk middel for ulike ACC-relaterte forstyrrelser.
NO20080865A 2005-07-19 2008-02-18 Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer NO20080865L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70038205P 2005-07-19 2005-07-19
PCT/US2006/027546 WO2007011811A1 (en) 2005-07-19 2006-07-14 Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors

Publications (1)

Publication Number Publication Date
NO20080865L true NO20080865L (no) 2008-04-18

Family

ID=37317248

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080865A NO20080865L (no) 2005-07-19 2008-02-18 Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer

Country Status (20)

Country Link
US (2) US7410976B2 (no)
EP (1) EP1910375B1 (no)
JP (1) JP5076159B2 (no)
KR (1) KR20080036041A (no)
CN (1) CN101238132A (no)
AR (1) AR054842A1 (no)
AT (1) ATE509023T1 (no)
AU (1) AU2006270145B2 (no)
BR (1) BRPI0613427A2 (no)
CA (1) CA2614963C (no)
DO (1) DOP2006000170A (no)
IL (1) IL188417A0 (no)
MX (1) MX2008000966A (no)
NO (1) NO20080865L (no)
NZ (1) NZ564591A (no)
PE (1) PE20070527A1 (no)
RU (1) RU2422446C2 (no)
TW (1) TW200728307A (no)
WO (2) WO2007011811A1 (no)
ZA (1) ZA200711119B (no)

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EP2097420B1 (en) * 2006-11-29 2012-04-04 Pfizer Products Inc. Spiroketone inhibitors of acetyl-coa carboxylase
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US8138197B2 (en) 2007-01-12 2012-03-20 Msd K.K. Spirochromanon derivatives
JPWO2008102749A1 (ja) 2007-02-20 2010-05-27 武田薬品工業株式会社 複素環化合物
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US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
HRP20161178T1 (hr) 2010-09-30 2016-11-04 Pfizer Inc. N1-PIRAZOLOSPIROKETONSKI INHIBITORI ACETIL-CoA-KARBOKSILAZE
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BR112013019211A2 (pt) 2011-02-02 2021-07-06 Vertex Pharma amidas de piperidina espirocíclicas de pirrolopirazina como moduladores de canais de íon
CN103443105A (zh) * 2011-02-18 2013-12-11 沃泰克斯药物股份有限公司 作为离子通道调节剂的苯并二氢吡喃-螺环哌啶酰胺
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Also Published As

Publication number Publication date
JP2009502785A (ja) 2009-01-29
ZA200711119B (en) 2009-12-30
CA2614963C (en) 2014-10-07
DOP2006000170A (es) 2007-03-31
AR054842A1 (es) 2007-07-18
EP1910375A1 (en) 2008-04-16
US7410976B2 (en) 2008-08-12
RU2008106243A (ru) 2009-08-27
EP1910375B1 (en) 2011-05-11
RU2422446C2 (ru) 2011-06-27
MX2008000966A (es) 2008-03-26
BRPI0613427A2 (pt) 2012-10-30
CN101238132A (zh) 2008-08-06
US7935712B2 (en) 2011-05-03
IL188417A0 (en) 2008-11-03
WO2007011809A1 (en) 2007-01-25
CA2614963A1 (en) 2007-01-25
AU2006270145B2 (en) 2011-04-14
AU2006270145A1 (en) 2007-01-25
US20090131464A1 (en) 2009-05-21
US20070021453A1 (en) 2007-01-25
PE20070527A1 (es) 2007-06-14
JP5076159B2 (ja) 2012-11-21
WO2007011811A1 (en) 2007-01-25
KR20080036041A (ko) 2008-04-24
TW200728307A (en) 2007-08-01
ATE509023T1 (de) 2011-05-15
NZ564591A (en) 2010-01-29

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