DK179586A - Griseolsyrederivater og fremgangsmaade til fremstilling deraf samt derivaternes anvendelse - Google Patents

Griseolsyrederivater og fremgangsmaade til fremstilling deraf samt derivaternes anvendelse Download PDF

Info

Publication number: DK179586A
Authority: DK; Denmark
Prior art keywords: derivatives; acid; griseoic; procedures; preparation
Prior art date: 1985-04-19

Application number

DK179586A

Other languages

English (en)

Other versions

DK179586D0 (da

DK167878B1 (da

Inventor

Masakatsu Kaneko

Yoshinobu Murofushi

Misako Kimura

Mitsuo Yamazaki

Yasuteru Iijima

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-19

Filing date

1986-04-18

Publication date

1986-10-20

1986-04-18 Application filed by Sankyo Co filed Critical Sankyo Co

1986-04-18 Publication of DK179586D0 publication Critical patent/DK179586D0/da

1986-10-20 Publication of DK179586A publication Critical patent/DK179586A/da

1993-12-27 Application granted granted Critical

1993-12-27 Publication of DK167878B1 publication Critical patent/DK167878B1/da

Links

239000002253 acid Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
IAPZXUKYTCQQFE-QZKDJMESSA-N (2r,3r,3as,5s)-2-(6-aminopurin-9-yl)-5-[carboxy(hydroxy)methyl]-3-hydroxy-3,3a-dihydro-2h-furo[3,2-b]furan-5-carboxylic acid Chemical class NC1=NC=NC2=C1N=CN2[C@H]1[C@H](O)[C@@H]2O[C@](C(O)=O)(C(O)C(O)=O)C=C2O1 IAPZXUKYTCQQFE-QZKDJMESSA-N 0.000 abstract 3
IAPZXUKYTCQQFE-UHFFFAOYSA-N Griseolic acid Natural products NC1=NC=NC2=C1N=CN2C1C(O)C2OC(C(O)=O)(C(O)C(O)=O)C=C2O1 IAPZXUKYTCQQFE-UHFFFAOYSA-N 0.000 abstract 2
GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical group N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 2
150000003212 purines Chemical class 0.000 abstract 2
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
229940083251 peripheral vasodilators purine derivative Drugs 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK179586A 1985-04-19 1986-04-18 Griseolsyrederivater DK167878B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP8213285		1985-04-19
JP8213285		1985-04-19
JP9198785		1985-04-27
JP9198785		1985-04-27
JP9198985		1985-04-27
JP9198985		1985-04-27

Publications (3)

Publication Number	Publication Date
DK179586D0 DK179586D0 (da)	1986-04-18
DK179586A true DK179586A (da)	1986-10-20
DK167878B1 DK167878B1 (da)	1993-12-27

Family

ID=27303820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK179586A DK167878B1 (da)	1985-04-19	1986-04-18	Griseolsyrederivater

Country Status (10)

Country	Link
US (5)	US5498819A (da)
EP (1)	EP0214708B1 (da)
KR (1)	KR930007385B1 (da)
AT (2)	ATE121097T1 (da)
CA (1)	CA1267409A (da)
DE (3)	DE3650297T2 (da)
DK (1)	DK167878B1 (da)
ES (4)	ES8802054A1 (da)
FI (1)	FI94133C (da)
NO (1)	NO169901C (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0319316A3 (en) *	1987-12-02	1990-11-28	Sankyo Company Limited	Griseolic acid monoesters, their preparation and use
US5091431A (en) *	1988-02-08	1992-02-25	Schering Corporation	Phosphodiesterase inhibitors
US4971972A (en) *	1989-03-23	1990-11-20	Schering Corporation	Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
JPH04112889A (ja) *	1990-09-04	1992-04-14	Kyowa Hakko Kogyo Co Ltd	Ｋｓ―５０５誘導体
US5866702A (en) *	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2
CA2238283C (en) *	1997-05-30	2002-08-20	Cell Pathways, Inc.	Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions
US6558787B1 (en) *	1999-12-27	2003-05-06	Kodak Polychrome Graphics Llc	Relation to manufacture of masks and electronic parts
EP1312363A1 (en) *	2001-09-28	2003-05-21	Pfizer Products Inc.	Methods of treatment and kits comprising a growth hormone secretagogue
US7342884B2 (en) *	2002-03-13	2008-03-11	Harmonic, Inc.	Method and apparatus for one directional communications in bidirectional communications channel
US20040043014A1 (en) *	2002-08-30	2004-03-04	Hiroyoshi Moriyama	Platelet aggregation inhibitor and supplement food effective for inhibiting platelet aggregation
WO2005018563A2 (en) *	2003-08-22	2005-03-03	Pharmacia Corporation	Compositions of a cyclooxygenase-2 selective inhibitor and a phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury
GB0601951D0 (en)	2006-01-31	2006-03-15	Novartis Ag	Organic compounds
WO2011081915A2 (en) *	2009-12-15	2011-07-07	Cebix Inc.	Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
WO2015022298A1 (en)	2013-08-12	2015-02-19	Saudi Basic Industries Corporation	Catalyst system for polymerisation of an olefin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4035370A (en) *	1971-11-03	1977-07-12	Richter Gedeon Vegyeszeti Gyar Rt.	Alkaloid esters
US4167565A (en) *	1976-11-08	1979-09-11	Abbott Laboratories	Adenosine-5'-carboxamides and method of use
JPS5668695A (en) *	1979-11-10	1981-06-09	Sankyo Co Ltd	Enzyme inhibitor griseolic acid and its preparation
US4803271A (en) *	1982-02-01	1989-02-07	Syntex (U.S.A.) Inc.	Process for preparing guanine derivatives
US4783532A (en) *	1983-10-28	1988-11-08	Sankyo Company Limited	Process for preparing griseolic acid derivatives
JPS6094992A (ja) *	1983-10-28	1985-05-28	Sankyo Co Ltd	グリゼオ−ル酸誘導体
JPS60246396A (ja) *	1984-05-22	1985-12-06	Sankyo Co Ltd	酵素阻害物質ジヒドロデスオキシグリゼオ−ル酸及びその塩類
US4788190A (en) *	1986-12-24	1988-11-29	Schering Corporation	2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds
US5091431A (en) *	1988-02-08	1992-02-25	Schering Corporation	Phosphodiesterase inhibitors
US4966912A (en) *	1989-09-29	1990-10-30	Uniroyal Chemical Company, Inc.	Fungicidal 3-imino-1,4-oxathiins
JPH0559085A (ja) *	1990-12-27	1993-03-09	Nippon Kayaku Co Ltd	イミダゾール塩基を有するオキセタノシン誘導体
JPH0639472B2 (ja) *	1991-12-21	1994-05-25	メルシャン株式会社	アゾール誘導体

1986
- 1986-04-18 DK DK179586A patent/DK167878B1/da not_active IP Right Cessation
- 1986-04-18 FI FI861655A patent/FI94133C/fi not_active IP Right Cessation
- 1986-04-18 NO NO861533A patent/NO169901C/no not_active IP Right Cessation
- 1986-04-19 ES ES554178A patent/ES8802054A1/es not_active Expired
- 1986-04-19 KR KR1019860003049A patent/KR930007385B1/ko not_active Expired - Fee Related
- 1986-04-21 EP EP86303000A patent/EP0214708B1/en not_active Expired
- 1986-04-21 CA CA000507140A patent/CA1267409A/en not_active Expired - Fee Related
- 1986-04-21 DE DE3650297T patent/DE3650297T2/de not_active Expired - Fee Related
- 1986-04-21 DE DE3650429T patent/DE3650429T2/de not_active Expired - Fee Related
- 1986-04-21 AT AT88121486T patent/ATE121097T1/de not_active IP Right Cessation
- 1986-04-21 AT AT88121487T patent/ATE129501T1/de not_active IP Right Cessation
- 1986-04-21 DE DE8686303000T patent/DE3667470D1/de not_active Expired - Fee Related
1987
- 1987-05-21 ES ES557558A patent/ES8801664A1/es not_active Expired
- 1987-05-21 ES ES557560A patent/ES8801666A1/es not_active Expired
- 1987-05-21 ES ES557559A patent/ES8801665A1/es not_active Expired
1993
- 1993-09-30 US US08/130,154 patent/US5498819A/en not_active Expired - Fee Related
1994
- 1994-10-06 US US08/319,413 patent/US5760042A/en not_active Expired - Fee Related
1995
- 1995-05-09 US US08/437,644 patent/US5616600A/en not_active Expired - Fee Related
- 1995-05-09 US US08/437,634 patent/US5556975A/en not_active Expired - Fee Related
- 1995-05-09 US US08/437,632 patent/US5532369A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR860008206A (ko)	1986-11-14
ES8802054A1 (es)	1988-03-16
ES557558A0 (es)	1988-02-16
ES557560A0 (es)	1988-02-16
DE3650429D1 (de)	1995-11-30
ATE121097T1 (de)	1995-04-15
DE3650297D1 (de)	1995-05-18
US5498819A (en)	1996-03-12
FI94133C (fi)	1995-07-25
EP0214708B1 (en)	1989-12-13
US5532369A (en)	1996-07-02
US5556975A (en)	1996-09-17
EP0214708A2 (en)	1987-03-18
DK179586D0 (da)	1986-04-18
NO861533L (no)	1986-11-21
NO169901C (no)	1992-08-19
HK1005738A1 (en)	1999-01-22
FI94133B (fi)	1995-04-13
DE3650297T2 (de)	1996-01-25
ES554178A0 (es)	1988-03-16
KR930007385B1 (ko)	1993-08-09
ES8801666A1 (es)	1988-02-16
CA1267409A (en)	1990-04-03
US5616600A (en)	1997-04-01
ES8801664A1 (es)	1988-02-16
DK167878B1 (da)	1993-12-27
FI861655L (fi)	1986-10-20
FI861655A0 (fi)	1986-04-18
ATE129501T1 (de)	1995-11-15
NO169901B (no)	1992-05-11
DE3667470D1 (de)	1990-01-18
HK1005739A1 (en)	1999-01-22
DE3650429T2 (de)	1996-06-13
US5760042A (en)	1998-06-02
ES557559A0 (es)	1988-02-16
EP0214708A3 (en)	1987-08-26
ES8801665A1 (es)	1988-02-16

Legal Events

Date	Code	Title	Description
2003-12-01	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK179586D0 (da)	1986-04-18	Griseolsyrederivater og fremgangsmaade til fremstilling deraf samt derivaternes anvendelse
PT89111A (pt)	1989-12-29	Processo de preparacao de analogos de camptotecina hidrossoluveis, dos seus intermediarios e de composicoes que os contem
AU573866B2 (en)	1988-06-23	Composition containing xanthine derivatives and o-acetylsalicylic acid
ES2130111T3 (es)	1999-07-01	Derivados de ciclohexano, preparaciones que los contienen y su utilizacion.
ES2009723T3 (es)	1993-02-16	Derivados de acidos biliares, procedimientos para la preparacion de los mismos y composiciones farmaceuticas conteniendolos.
IE43113L (en)	1977-01-10	Anhydro-vinca alkaloids
DK91692A (da)	1992-07-14	Halogenerede nucleosidderivater, saadanne forbindelser til anvendelse mod en adenovirusinfektion, anvendelse af forbindelserne til fremstilling af et laegemiddel mod en adenovirusinfektion, farmaceutiske praeparater indeholdende forbindelserne samt fremgangsmaade til fremstilling af forbindelserne
ES2013379A6 (es)	1990-05-01	Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales.
EP0318060A3 (en)	1990-10-24	Griseolic acid derivatives, their preparation and their use
DK72282A (da)	1982-08-21	Fremgangsmaade til fremstilling af bis-estere af 1,1-alkandioler med 2beta-acetoxymethyl-2alfa-methyl-(5r)penam-3alfa-carboxylsyre-1,1-dioxid og en 6-acylaminopenicillansyre eller farmaceutisk acceptable salte deraf
RU93005243A (ru)	1996-02-27	Производные гризеоловой кислоты
FI885638A7 (fi)	1989-06-03	Menetelmä lääkeaineina käyttökelpoisten griseoliinihappomonoesterijohdannaisten valmistamiseksi
IT1205114B (it)	1989-03-15	2-selenometil-1,4-diidropiridine,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
DK163985D0 (da)	1985-04-11	Antivirale purinderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
DK83488A (da)	1988-08-20	Phosphonsyre-derivater samt fremgangsmaade til fremstilling og anvendelse af saadanne derivater som mellemprodukter
IT1224404B (it)	1990-10-04	Composti attivi sul sistema cardiovascolare
IT8559836V0 (it)	1985-10-03	Scheda particolarmente adatta per i pronostici relativi al giuoco del calcio.
NO172391C (no)	1993-07-14	Mellomprodukt for fremstilling av vannloeselige camptothecin-analoger