DK179682A - Fremgangsmaade til fremstilling af lysin-tryptofan-oligopeptider eller fysiologisk vaerdifulde derivater eller salte deraf - Google Patents

Fremgangsmaade til fremstilling af lysin-tryptofan-oligopeptider eller fysiologisk vaerdifulde derivater eller salte deraf Download PDF

Info

Publication number: DK179682A
Authority: DK; Denmark
Prior art keywords: trytophano; olegopeptides; lysin; salts; procedure
Prior art date: 1981-04-23

Application number

DK179682A

Other languages

English (en)

Inventor

J M J Puigsubira

Original Assignee

J M J Puigsubira

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-23

Filing date

1982-04-22

Publication date

1982-10-24

1982-04-22 Application filed by J M J Puigsubira filed Critical J M J Puigsubira

1982-10-24 Publication of DK179682A publication Critical patent/DK179682A/da

Links

108010038807 Oligopeptides Proteins 0.000 description 2
102000015636 Oligopeptides Human genes 0.000 description 2
OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 description 1
RCODLYOZQUAONI-UHFFFAOYSA-N C=C1C=CC2=CC=NC2=C1 Chemical group C=C1C=CC2=CC=NC2=C1 RCODLYOZQUAONI-UHFFFAOYSA-N 0.000 description 1
101710176384 Peptide 1 Proteins 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
230000000871 hypocholesterolemic effect Effects 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
150000003839 salts Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

(Trp) . (hvor c og/eller d>0), dog saledes at mindst en af grup-α 1 2 perne R og R er en 6-metylenindol- eller beskyttet e-amino-butylrest, hvorpå o-nitrosulfenylgruppen elimineres fra reaktionsproduktet til dannelse af en forbindelse

V

eller et syreadditionssalt deraf; fra dette fjernes alle tilstedeværende aminobeskyttelsesgrupper, og om ønsket forsæbes den dannede ester af det ønskede oligopeptid (Lys) -

Si (Trp)b (Dr hvor a og b begge er >0, efterfulgt af neutralisation til opnåelse af den fri peptid 1.

Disse oligopeptider har hypokolesterolæmisk virkning.

DK179682A 1981-04-23 1982-04-22 Fremgangsmaade til fremstilling af lysin-tryptofan-oligopeptider eller fysiologisk vaerdifulde derivater eller salte deraf DK179682A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES501583		1981-04-23
ES501583A ES501583A0 (es)	1981-04-23	1981-04-23	Un procedimiento para la preparacion de oligopeptidos lisi- na-triptofano y de sus derivados y sales fisiologicamente aprovechables

Publications (1)

Publication Number	Publication Date
DK179682A true DK179682A (da)	1982-10-24

Family

ID=8482278

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK179682A DK179682A (da)	1981-04-23	1982-04-22	Fremgangsmaade til fremstilling af lysin-tryptofan-oligopeptider eller fysiologisk vaerdifulde derivater eller salte deraf

Country Status (10)

Country	Link
BE (1)	BE892932A (da)
CH (1)	CH657861A5 (da)
DE (1)	DE3213501A1 (da)
DK (1)	DK179682A (da)
ES (1)	ES501583A0 (da)
FR (1)	FR2504525B1 (da)
GB (1)	GB2097404B (da)
IT (1)	IT1151728B (da)
NL (1)	NL8201649A (da)
SE (1)	SE8202414L (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3823464A1 (de) *	1988-07-11	1990-01-18	Asta Pharma Ag	Neue tryptophandipeptide
ITMI20061607A1 (it) *	2006-08-09	2008-02-10	Maria Vincenza Carriero	Peptidi con attivita farmacologica

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5116667A (da) *	1974-07-30	1976-02-10	Shionogi Seiyaku Kk

1981
- 1981-04-23 ES ES501583A patent/ES501583A0/es active Granted
1982
- 1982-04-10 DE DE19823213501 patent/DE3213501A1/de not_active Withdrawn
- 1982-04-15 CH CH2266/82A patent/CH657861A5/de not_active IP Right Cessation
- 1982-04-19 SE SE8202414A patent/SE8202414L/ not_active Application Discontinuation
- 1982-04-19 GB GB8211276A patent/GB2097404B/en not_active Expired
- 1982-04-20 IT IT20834/82A patent/IT1151728B/it active
- 1982-04-21 NL NL8201649A patent/NL8201649A/nl not_active Application Discontinuation
- 1982-04-22 FR FR8206966A patent/FR2504525B1/fr not_active Expired
- 1982-04-22 DK DK179682A patent/DK179682A/da not_active Application Discontinuation
- 1982-04-22 BE BE0/207896A patent/BE892932A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB2097404B (en)	1985-05-30
NL8201649A (nl)	1982-11-16
IT1151728B (it)	1986-12-24
GB2097404A (en)	1982-11-03
FR2504525B1 (fr)	1986-10-24
SE8202414L (sv)	1982-10-24
ES8202788A1 (es)	1982-02-16
IT8220834A0 (it)	1982-04-20
FR2504525A1 (fr)	1982-10-29
ES501583A0 (es)	1982-02-16
DE3213501A1 (de)	1982-11-11
BE892932A (fr)	1982-08-16
CH657861A5 (de)	1986-09-30

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Legal Events

Date	Code	Title	Description
1988-12-19	AHB	Application shelved due to non-payment