DK1812385T3 - Fremgangsmåde til fremstilling af enantiomere af amidoacetonitrilforbindelser ud fra deres racemater - Google Patents

Fremgangsmåde til fremstilling af enantiomere af amidoacetonitrilforbindelser ud fra deres racemater

Info

Publication number
DK1812385T3
DK1812385T3 DK05803815.9T DK05803815T DK1812385T3 DK 1812385 T3 DK1812385 T3 DK 1812385T3 DK 05803815 T DK05803815 T DK 05803815T DK 1812385 T3 DK1812385 T3 DK 1812385T3
Authority
DK
Denmark
Prior art keywords
racemates
enantiomers
preparation
amidoacetonitrile compounds
amidoacetonitrile
Prior art date
Application number
DK05803815.9T
Other languages
English (en)
Inventor
Pierre Ducray
Noelle Gauvry
Thomas Goebel
Francois Pautrat
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK1812385T3 publication Critical patent/DK1812385T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK05803815.9T 2004-11-09 2005-11-07 Fremgangsmåde til fremstilling af enantiomere af amidoacetonitrilforbindelser ud fra deres racemater DK1812385T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04026510 2004-11-09
PCT/EP2005/011884 WO2006050887A1 (en) 2004-11-09 2005-11-07 Process for the preparation of enantiomers of amidoacetonitrile compounds from their racemates

Publications (1)

Publication Number Publication Date
DK1812385T3 true DK1812385T3 (da) 2012-10-15

Family

ID=34927294

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05803815.9T DK1812385T3 (da) 2004-11-09 2005-11-07 Fremgangsmåde til fremstilling af enantiomere af amidoacetonitrilforbindelser ud fra deres racemater

Country Status (17)

Country Link
US (1) US7485751B2 (da)
EP (1) EP1812385B1 (da)
JP (1) JP5112074B2 (da)
KR (1) KR20070084061A (da)
CN (1) CN101056849B (da)
AR (1) AR051761A1 (da)
AU (1) AU2005303993B2 (da)
BR (1) BRPI0517970B1 (da)
CA (1) CA2580247C (da)
DK (1) DK1812385T3 (da)
ES (1) ES2388869T3 (da)
MX (1) MX2007005548A (da)
NZ (1) NZ553887A (da)
RU (1) RU2408574C2 (da)
TW (1) TW200628439A (da)
WO (1) WO2006050887A1 (da)
ZA (1) ZA200702097B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402677D0 (en) * 2003-11-06 2004-03-10 Novartis Ag Organic compounds
ES2597083T3 (es) 2007-05-15 2017-01-13 Merial, Inc. Compuestos de ariloazol-2-il cianoetilamino, procedimiento de fabricación y procedimiento de utilización de los mismos
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
KR101782308B1 (ko) * 2008-10-21 2017-09-27 메리얼 인코포레이티드 티오아미드 화합물, 이의 제조 방법 및 사용 방법
MY153715A (en) 2008-11-14 2015-03-13 Merial Ltd Enantiomerically enriched aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
NZ592367A (en) 2008-12-03 2013-05-31 Novartis Ag Amidoacetonitrile compounds and pesticidal composition thereof
EP2314292A1 (en) 2009-10-20 2011-04-27 Novartis AG Endoparasiticidal compositions
UY32992A (es) * 2009-11-23 2011-04-29 Novartis Ag Compuestos orgánicos
UY33282A (es) 2010-03-25 2011-09-30 Novartis Ag Composiciones endoparasiticidas
EP2880014B1 (en) * 2012-08-06 2017-05-17 Pitney Pharmaceuticals Pty Limited Compounds for the treatment of mtor pathway related diseases
US8822689B2 (en) 2012-09-19 2014-09-02 Merial Limited Aryloazol-2-yl cyanoethylamino compounds, method of making and method of using thereof
WO2014090918A1 (en) 2012-12-13 2014-06-19 Novartis Ag Process for the enantiomeric enrichment of diaryloxazoline derivatives
CN103030575B (zh) * 2013-01-04 2014-10-01 中国农业大学 一类双氰基酰胺化合物及其合成方法与应用
AU2016224395A1 (en) * 2015-02-24 2017-08-31 Pitney Pharmaceuticals Pty Limited Anti cancer agent comprising aminoacetonitrile compound as active ingredient
JP7644444B2 (ja) * 2021-03-02 2025-03-12 学校法人東京理科大学 異性体調製装置
CN119504830B (zh) * 2023-12-29 2026-04-10 菏泽皓元医药科技有限公司 一种莫奈太尔关键中间体及其拆分方法
CN120098027B (zh) * 2025-05-09 2025-08-26 瑞普生物股份有限公司 一种氨基乙腈类化合物及其中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1062334A (en) * 1963-09-19 1967-03-22 Merck & Co Inc Racemization of compounds containing an asymmetric quaternary carbon atom
DE3814887C1 (da) * 1988-05-02 1989-09-21 Medice Chem.-Pharm. Fabrik Puetter Gmbh & Co Kg, 5860 Iserlohn, De
JPH05215736A (ja) * 1992-02-04 1993-08-24 Daicel Chem Ind Ltd クロマト分離法
DE69307908T2 (de) * 1992-10-07 1997-07-10 Akzo Nobel Nv Verfahren zur trennung von enantiomeren aus einer racemischen mischung
US6239077B1 (en) 1998-05-01 2001-05-29 Nihon Nohyaku Co., Ltd. Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof
RU2201420C2 (ru) * 1998-11-03 2003-03-27 Новартис Аг Нитрилы дипептидов
JP4234885B2 (ja) 2000-07-07 2009-03-04 日本航空電子工業株式会社 サニヤック干渉計型電流センサ
NZ526538A (en) * 2000-12-20 2005-12-23 Novartis Ag Anti-endoparasitic amidoacetonitrils
TW200400932A (en) * 2002-06-19 2004-01-16 Novartis Ag Organic compounds
GB0402677D0 (en) * 2003-11-06 2004-03-10 Novartis Ag Organic compounds
AR046757A1 (es) * 2003-12-10 2005-12-21 Novartis Ag Amidoacetonitrilos utiles como pesticidas

Also Published As

Publication number Publication date
CA2580247A1 (en) 2006-05-18
RU2408574C2 (ru) 2011-01-10
WO2006050887A1 (en) 2006-05-18
AU2005303993A1 (en) 2006-05-18
JP5112074B2 (ja) 2013-01-09
BRPI0517970A (pt) 2008-10-21
CA2580247C (en) 2014-06-17
US7485751B2 (en) 2009-02-03
KR20070084061A (ko) 2007-08-24
EP1812385B1 (en) 2012-07-18
EP1812385A1 (en) 2007-08-01
NZ553887A (en) 2010-09-30
BRPI0517970B1 (pt) 2017-01-31
CN101056849A (zh) 2007-10-17
ES2388869T3 (es) 2012-10-19
TW200628439A (en) 2006-08-16
CN101056849B (zh) 2012-10-17
RU2007121502A (ru) 2008-12-20
AR051761A1 (es) 2007-02-07
MX2007005548A (es) 2007-05-21
AU2005303993B2 (en) 2009-10-29
JP2008518997A (ja) 2008-06-05
US20080045601A1 (en) 2008-02-21
ZA200702097B (en) 2008-10-29

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