DK182386A - Carbapenemmellemprodukter - Google Patents

Carbapenemmellemprodukter Download PDF

Info

Publication number: DK182386A
Authority: DK; Denmark
Prior art keywords: carbapenes; intermediate products; products; alkyl; useful
Prior art date: 1985-04-22

Application number

DK182386A

Other languages

Danish (da)

English (en)

Other versions

DK182386D0 (da

Inventor

Yasutsugu Ueda

Guy Roberge

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-22

Filing date

1986-04-21

Publication date

1986-10-23

1986-04-21 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1986-04-21 Publication of DK182386D0 publication Critical patent/DK182386D0/da

1986-10-23 Publication of DK182386A publication Critical patent/DK182386A/da

Links

239000013067 intermediate product Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 description 3
YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 description 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
0 CC(C1)=CC(C)=C(*)C1C1C=CC1 Chemical compound CC(C1)=CC(C)=C(*)C1C1C=CC1 0.000 description 1
WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 description 1
WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
- C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/12—Organo silicon halides
- C07F7/16—Preparation thereof from silicon and halogenated hydrocarbons direct synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK182386A 1985-04-22 1986-04-21 Carbapenemmellemprodukter DK182386A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/725,594 US4683296A (en)	1983-03-07	1985-04-22	Carbapenem intermediates
US72559485		1985-04-22

Publications (2)

Publication Number	Publication Date
DK182386D0 DK182386D0 (da)	1986-04-21
DK182386A true DK182386A (da)	1986-10-23

Family

ID=24915191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK182386A DK182386A (da)	1985-04-22	1986-04-21	Carbapenemmellemprodukter

Country Status (35)

Country	Link
US (1)	US4683296A (fr)
JP (1)	JPS61275284A (fr)
KR (1)	KR890004347B1 (fr)
CN (1)	CN86102077A (fr)
AR (1)	AR244236A1 (fr)
AT (1)	AT386208B (fr)
AU (1)	AU599022B2 (fr)
BE (1)	BE904645A (fr)
CA (1)	CA1302426C (fr)
CH (1)	CH667273A5 (fr)
CS (1)	CS266585B2 (fr)
DD (1)	DD251352A5 (fr)
DE (1)	DE3613366A1 (fr)
DK (1)	DK182386A (fr)
ES (1)	ES8708234A1 (fr)
FI (1)	FI861633A7 (fr)
FR (1)	FR2580653B1 (fr)
GB (1)	GB2173801B (fr)
GR (1)	GR861064B (fr)
HU (1)	HU195824B (fr)
IE (1)	IE59042B1 (fr)
IL (1)	IL78533A (fr)
IT (1)	IT1213061B (fr)
LU (1)	LU86401A1 (fr)
MY (1)	MY102926A (fr)
NL (1)	NL8601010A (fr)
NO (1)	NO861558L (fr)
NZ (1)	NZ215263A (fr)
OA (1)	OA08235A (fr)
PT (1)	PT82435B (fr)
SE (1)	SE8601824L (fr)
YU (1)	YU43696B (fr)
ZA (1)	ZA862987B (fr)
ZM (1)	ZM6286A1 (fr)
ZW (1)	ZW8986A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4772683A (en) *	1986-02-24	1988-09-20	Bristol-Myers Company	High percentage beta-yield synthesis of carbapenem intermediates
JP2675625B2 (ja) *	1989-01-12	1997-11-12	鐘淵化学工業株式会社	エノールシリルエーテル化合物の製造方法
NZ234411A (en) *	1989-07-18	1991-05-28	Merck & Co Inc	Preparation of 2-diazo-3-silyloxy-3-butenoate esters
US5340927A (en) *	1989-07-18	1994-08-23	Merck & Co., Inc.	Process for the preparation of 2-diazo-3-trisubstituted silyloxy 3-butenoates
DE4014649A1 (de) *	1990-05-08	1991-11-14	Hoechst Ag	Neue mehrfunktionelle verbindungen mit (alpha)-diazo-ss-ketoester- und sulfonsaeureester-einheiten, verfahren zu ihrer herstellung und deren verwendung
JP2000166962A (ja) *	1998-12-08	2000-06-20	Tatsu Ifukube	触覚刺激装置及び方法
EP1670806B9 (fr)	2003-08-28	2010-06-02	Ranbaxy Laboratories Limited	Procede pour la preparation d'esters d'acide 2-diazo-3-trimethylsilyloxy-3 butenoique
US20070037971A1 (en) *	2005-07-29	2007-02-15	Meeran Hashim Nizar P N	Process for desilylation of carbapenem intermediates
AU2009277936B2 (en) *	2008-07-30	2014-11-27	Sun Pharmaceutical Industries Limited	Process for the preparation of carbapenem compounds
WO2011048583A1 (fr)	2009-10-23	2011-04-28	Ranbaxy Laboratories Limited	Procédé pour la préparation de composés de carbapénème
CN102690282A (zh) *	2011-07-07	2012-09-26	深圳市海滨制药有限公司	晶体形式的1β甲基碳青霉烯类抗生素中间体及其制备方法
CN102643211A (zh) *	2012-04-10	2012-08-22	平顶山佳瑞高科实业有限公司	一种2-重氮乙酰乙酸对硝基苄酯的制备方法
US10695322B2 (en)	2016-01-29	2020-06-30	The Johns Hopkins University	Inhibitors of bacterial growth
CN106565535B (zh) *	2016-11-15	2018-07-17	山西师范大学	2-重氮-1-芳基酮类化合物的制备方法
CN107556212B (zh) *	2017-09-14	2020-03-24	台州昌霖化工科技有限公司	一种制备2-重氮乙酰乙酸对硝基苄酯的方法
CN114516820A (zh) *	2022-02-25	2022-05-20	山东艾孚特科技有限公司	一种制备2-重氮乙酰乙酸对硝基苄酯的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1982003445A1 (fr) *	1981-04-03	1982-10-14	Nagamoto Shunichi	Unite d'affichage d'un dispositif de cuisson permettant d'afficher de maniere selective des signaux d'images provenant de plusieurs sources de signaux d'images
US4444685A (en) *	1981-04-27	1984-04-24	Merck & Co., Inc.	Stereospecific synthesis of thienamycin from penicillin
CA1190236A (fr) *	1981-10-23	1985-07-09	Edward J.J. Grabowski	Synthese d'un antibiotique
US4525582A (en) *	1982-06-22	1985-06-25	Merck & Co., Inc.	Silyl, benzyl, p-nitrobenyl, or methyl esters of diazoacetate, a synthon used in the conversion of penicillin to thienamycin
NZ205626A (en) *	1982-09-28	1986-12-05	Bristol Myers Co	Carbapenem antibiotics
CA1220215A (fr) *	1983-03-07	1987-04-07	Yasutsugu Ueda	Intermediaires du carbapenem

1985
- 1985-04-22 US US06/725,594 patent/US4683296A/en not_active Expired - Fee Related
1986
- 1986-02-21 NZ NZ215263A patent/NZ215263A/xx unknown
- 1986-03-28 CN CN198686102077A patent/CN86102077A/zh active Pending
- 1986-04-16 AU AU56167/86A patent/AU599022B2/en not_active Ceased
- 1986-04-17 FI FI861633A patent/FI861633A7/fi not_active Application Discontinuation
- 1986-04-18 FR FR868605640A patent/FR2580653B1/fr not_active Expired
- 1986-04-18 AR AR86303698A patent/AR244236A1/es active
- 1986-04-18 IL IL78533A patent/IL78533A/xx not_active IP Right Cessation
- 1986-04-18 OA OA58839A patent/OA08235A/fr unknown
- 1986-04-21 DK DK182386A patent/DK182386A/da not_active Application Discontinuation
- 1986-04-21 DE DE19863613366 patent/DE3613366A1/de not_active Ceased
- 1986-04-21 ES ES554217A patent/ES8708234A1/es not_active Expired
- 1986-04-21 PT PT82435A patent/PT82435B/pt not_active IP Right Cessation
- 1986-04-21 CS CS862873A patent/CS266585B2/cs unknown
- 1986-04-21 CH CH1600/86A patent/CH667273A5/de not_active IP Right Cessation
- 1986-04-21 SE SE8601824A patent/SE8601824L/ unknown
- 1986-04-21 DD DD86289445A patent/DD251352A5/de not_active IP Right Cessation
- 1986-04-21 LU LU86401A patent/LU86401A1/fr unknown
- 1986-04-21 BE BE0/216571A patent/BE904645A/fr not_active IP Right Cessation
- 1986-04-21 IT IT8620164A patent/IT1213061B/it active
- 1986-04-21 GB GB8609662A patent/GB2173801B/en not_active Expired
- 1986-04-21 ZW ZW89/86A patent/ZW8986A1/xx unknown
- 1986-04-21 KR KR1019860003078A patent/KR890004347B1/ko not_active Expired
- 1986-04-21 NO NO861558A patent/NO861558L/no unknown
- 1986-04-21 NL NL8601010A patent/NL8601010A/nl not_active Application Discontinuation
- 1986-04-21 IE IE104786A patent/IE59042B1/en not_active IP Right Cessation
- 1986-04-21 ZM ZM62/86A patent/ZM6286A1/xx unknown
- 1986-04-21 ZA ZA862987A patent/ZA862987B/xx unknown
- 1986-04-22 CA CA000507256A patent/CA1302426C/fr not_active Expired - Fee Related
- 1986-04-22 HU HU861677A patent/HU195824B/hu not_active IP Right Cessation
- 1986-04-22 GR GR861064A patent/GR861064B/el unknown
- 1986-04-22 JP JP61091418A patent/JPS61275284A/ja active Granted
- 1986-04-22 YU YU658/86A patent/YU43696B/xx unknown
- 1986-04-22 AT AT0106886A patent/AT386208B/de not_active IP Right Cessation
1987
- 1987-09-29 MY MYPI87002268A patent/MY102926A/en unknown

Also Published As

Publication number	Publication date
IT8620164A0 (it)	1986-04-21
NO861558L (no)	1986-10-23
ZM6286A1 (en)	1987-04-30
DD251352A5 (de)	1987-11-11
JPS61275284A (ja)	1986-12-05
ZA862987B (en)	1987-12-30
SE8601824D0 (sv)	1986-04-21
IL78533A (en)	1992-05-25
CS287386A2 (en)	1989-04-14
ES8708234A1 (es)	1987-10-01
SE8601824L (sv)	1986-10-23
GR861064B (en)	1986-09-01
GB8609662D0 (en)	1986-05-29
MY102926A (en)	1993-03-31
IE59042B1 (en)	1993-12-15
FI861633A7 (fi)	1986-10-23
AT386208B (de)	1988-07-25
ES554217A0 (es)	1987-10-01
OA08235A (fr)	1987-10-30
YU43696B (en)	1989-10-31
IE861047L (en)	1986-10-22
IT1213061B (it)	1989-12-07
FR2580653A1 (fr)	1986-10-24
KR860008191A (ko)	1986-11-12
PT82435A (en)	1986-05-01
YU65886A (en)	1988-04-30
NZ215263A (en)	1989-03-29
JPS6358836B2 (fr)	1988-11-17
US4683296A (en)	1987-07-28
CA1302426C (fr)	1992-06-02
CN86102077A (zh)	1987-01-28
FR2580653B1 (fr)	1989-06-16
AU5616786A (en)	1986-11-06
GB2173801B (en)	1989-08-23
LU86401A1 (fr)	1986-11-05
AU599022B2 (en)	1990-07-12
CH667273A5 (de)	1988-09-30
PT82435B (pt)	1988-08-17
DK182386D0 (da)	1986-04-21
KR890004347B1 (ko)	1989-10-31
HUT41040A (en)	1987-03-30
GB2173801A (en)	1986-10-22
FI861633A0 (fi)	1986-04-17
HU195824B (en)	1988-07-28
NL8601010A (nl)	1986-11-17
IL78533A0 (en)	1986-08-31
DE3613366A1 (de)	1986-11-20
ATA106886A (de)	1987-12-15
BE904645A (fr)	1986-10-21
AR244236A1 (es)	1993-10-29
CS266585B2 (en)	1990-01-12
ZW8986A1 (en)	1986-12-03

Legal Events

Date	Code	Title	Description
1994-04-25	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK178979A (da)	1980-02-15	Fremgangsmaade til fremstilling af thienamycin og mellemprodukter til brug ved udoevelse af fremgangsmaaden
IL107897A0 (en)	1994-04-12	Pyrrolopyrimidines
EP0081247A3 (en)	1984-07-25	Ferrule, coupling and process
DZ1712A1 (fr)	2002-02-17	Materiau composite pour le filtrage de rayonnementet sont utilisation.
BG101105A (bg)	1998-04-30	Заместени бензамидини, тяхното получаване и използването им като лекарствени средства
GB2085436B (en)	1984-01-18	Spiro-quaternary ammonium halides and n-(2-pyrimidinyl) piperazinylalkyl-azaspiroalkanedione process
TR200600582A1 (tr)	2006-08-21	N-(4-tiriflormetilfenil)-5-metil-[zoksazol-4-karboksamidin kristal formu
EP0533804A4 (en)	1993-04-21	Sigma binding site agents
FI853624L (fi)	1986-03-23	1-substituerade tetralinderivat, deras framstaellning och anvaendning.
IT8019016A0 (it)	1980-01-03	Di attutimento. impugnatura di pistola con cavita'
IT1115787B (it)	1986-02-03	Perfezionamento nei preparari ant-acidita' in forma di compresse
DE3854486D1 (de)	1995-10-26	Herabsetzung des Rückstandsladungstransfers in einem asynchronen Rastereingangsabtaster.
FI830730A7 (fi)	1983-09-04	Vermikuliittituotteiden ja niiden valmistuksessa käytettävien suspensioiden valmistus.
BG35042A3 (en)	1983-01-16	Method for preparing benzodiazepinic compounds
BG37838A3 (bg)	1985-08-15	Метод за получаване на цефалоспорини
BR9102174A (pt)	1991-12-24	Processo de pos-tratamento de camadas de conversao e uso do processo
DE59305733D1 (de)	1997-04-17	Verfahren zur Herstellung von 1,3-Difluorbenzol
PH23525A (en)	1989-08-25	2-(5-phenyl-2-furanyl) imidazoles useful as cardiotonic agents
DE59104649D1 (de)	1995-03-30	Verfahren zur Herstellung von N,N,N',N'-Tetraglycidyl-3,3'-dialkyl-4,4'-diaminodiphenylmethanen.
JPS5692219A (en)	1981-07-25	Purification of biologically original particle* particularly antigen aghbs of b type hepatitis virus surface
BG35899A3 (bg)	1984-07-16	Метод за получаване на пеницилинови и цефалоспоринови иминохалогениди
GB2088874B (en)	1983-09-28	Substituted quinazolones for the treatment of hypertension and bradycardia and as cardiotonic agents
DE69104825D1 (de)	1994-12-01	Oberflächenbehandlung von verzinnten glatt- und tiefgezogenen dosen.
AU533666B2 (en)	1983-12-08	N-alkyl alkanolamines
ZA916313B (en)	1993-04-28	New use of a monoclonal antibody