DK1828166T3 - Hydantoinderivater, der kan anvendes som metalloproteinase-inhibitorer - Google Patents

Hydantoinderivater, der kan anvendes som metalloproteinase-inhibitorer

Info

Publication number
DK1828166T3
DK1828166T3 DK05818265T DK05818265T DK1828166T3 DK 1828166 T3 DK1828166 T3 DK 1828166T3 DK 05818265 T DK05818265 T DK 05818265T DK 05818265 T DK05818265 T DK 05818265T DK 1828166 T3 DK1828166 T3 DK 1828166T3
Authority
DK
Denmark
Prior art keywords
metalloproteinase inhibitors
hydantoin derivatives
hydantoin
derivatives
metalloproteinase
Prior art date
Application number
DK05818265T
Other languages
Danish (da)
English (en)
Inventor
David Waterson
David J Persson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1828166T3 publication Critical patent/DK1828166T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK05818265T 2004-12-15 2005-12-14 Hydantoinderivater, der kan anvendes som metalloproteinase-inhibitorer DK1828166T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0427403.1A GB0427403D0 (en) 2004-12-15 2004-12-15 Novel compounds I
PCT/GB2005/004811 WO2006064218A1 (en) 2004-12-15 2005-12-14 Hydantoin derivatives useful as metalloproteinase inhibitors

Publications (1)

Publication Number Publication Date
DK1828166T3 true DK1828166T3 (da) 2009-10-05

Family

ID=34090044

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05818265T DK1828166T3 (da) 2004-12-15 2005-12-14 Hydantoinderivater, der kan anvendes som metalloproteinase-inhibitorer

Country Status (29)

Country Link
US (1) US8129412B2 (pt)
EP (1) EP1828166B1 (pt)
JP (1) JP5042849B2 (pt)
KR (1) KR20070090921A (pt)
CN (1) CN101080402B (pt)
AR (1) AR051797A1 (pt)
AU (1) AU2005315459B2 (pt)
BR (1) BRPI0519057A2 (pt)
CA (1) CA2589525A1 (pt)
CY (1) CY1109376T1 (pt)
DE (1) DE602005015617D1 (pt)
DK (1) DK1828166T3 (pt)
ES (1) ES2328836T3 (pt)
GB (1) GB0427403D0 (pt)
HR (1) HRP20090489T1 (pt)
IL (1) IL183590A0 (pt)
MX (1) MX2007006744A (pt)
NO (1) NO20073550L (pt)
NZ (1) NZ555684A (pt)
PL (1) PL1828166T3 (pt)
PT (1) PT1828166E (pt)
RS (1) RS51193B (pt)
RU (1) RU2388758C2 (pt)
SA (1) SA05260406B1 (pt)
SI (1) SI1828166T1 (pt)
TW (1) TW200634001A (pt)
UA (1) UA89067C2 (pt)
WO (1) WO2006064218A1 (pt)
ZA (1) ZA200705068B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010004026A (es) 2007-10-19 2010-04-30 Boehringer Ingelheim Int Piperidino-dihidrotienopirimidinas sustituidas.
WO2009138777A1 (en) * 2008-05-12 2009-11-19 Astrazeneca Ab Process for the preparation of alkoxy-phenoxy-pi peridine
US7759512B2 (en) 2008-07-21 2010-07-20 3M Innovative Properties Company Aqueous methods for making fluorinated sulfonate esters
CN102234287B (zh) 2010-04-26 2015-08-05 上海阳帆医药科技有限公司 硝基咪唑类化合物、其制备方法和用途
CA2805748A1 (en) 2010-07-16 2012-01-19 Shashank Shekhar Process for preparing n-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2h)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
SG187103A1 (en) 2010-07-16 2013-02-28 Abbvie Inc Phosphine ligands for catalytic reactions
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
HUP1300139A2 (en) 2013-03-06 2014-09-29 Richter Gedeon Nyrt Phenoxypiperidine h3 antagonists
US20160364553A1 (en) * 2015-06-09 2016-12-15 Intel Corporation System, Apparatus And Method For Providing Protected Content In An Internet Of Things (IOT) Network
GB201610056D0 (en) * 2016-06-09 2016-07-27 Galapagos Nv And Laboratoires Servier Les Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders and osteoarthritis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9919776D0 (en) 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
JP2003501414A (ja) 1999-06-04 2003-01-14 アストラゼネカ・アクチエボラーグ メタロプロテイナーゼの阻害剤
WO2001062742A1 (en) 2000-02-21 2001-08-30 Astrazeneca Ab Piperidine- and piperazine substituted n-hydroxyformamides as inhibitors of metalloproteinases
SE0100902D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
SE0301922D0 (sv) 2003-06-27 2003-06-27 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
RS51193B (sr) 2010-10-31
ES2328836T3 (es) 2009-11-18
CN101080402B (zh) 2010-12-08
CA2589525A1 (en) 2006-06-22
PT1828166E (pt) 2009-09-16
UA89067C2 (ru) 2009-12-25
SI1828166T1 (sl) 2009-12-31
WO2006064218A1 (en) 2006-06-22
DE602005015617D1 (de) 2009-09-03
NZ555684A (en) 2009-11-27
NO20073550L (no) 2007-09-11
US20080280950A1 (en) 2008-11-13
AR051797A1 (es) 2007-02-07
KR20070090921A (ko) 2007-09-06
TW200634001A (en) 2006-10-01
AU2005315459A1 (en) 2006-06-22
RU2388758C2 (ru) 2010-05-10
BRPI0519057A2 (pt) 2008-12-23
RU2007121222A (ru) 2009-01-27
AU2005315459B2 (en) 2009-01-08
EP1828166A1 (en) 2007-09-05
CN101080402A (zh) 2007-11-28
IL183590A0 (en) 2007-09-20
MX2007006744A (es) 2007-07-09
SA05260406B1 (ar) 2009-02-02
ZA200705068B (en) 2008-10-29
HRP20090489T1 (hr) 2009-10-31
JP2008524184A (ja) 2008-07-10
GB0427403D0 (en) 2005-01-19
HK1108435A1 (en) 2008-05-09
CY1109376T1 (el) 2014-07-02
EP1828166B1 (en) 2009-07-22
US8129412B2 (en) 2012-03-06
JP5042849B2 (ja) 2012-10-03
PL1828166T3 (pl) 2009-12-31

Similar Documents

Publication Publication Date Title
DK1789041T3 (da) Aryl-pyridinderivater som 11-beta-HSD1-inhibitorer
LTC1907382I2 (lt) Nitrokatechnolio dariniai, kaip COMT inhibitoriai
DK1797042T3 (da) Indozolonderivater som 11B-HSD1-inhibitorer
DK1940813T3 (da) Heterocykliske amidderivater, der kan anvendes som mikrobiocider
DK2094263T3 (da) 2-adamantyl-butyramidderivater som selektive 11 beta-hsd1-inhibitorer
DK1492785T3 (da) 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DK1926722T3 (da) Substituerede benzimidazoler som kinaseinhibitorer
DK1960352T3 (da) 2-adamantylurinstof-derivater som selektive 11beta-hsd1 inhibitorer
DK1586319T3 (da) Thiadiazolidinoner som GSK-3-inhibitorer
NO20053775D0 (no) Diazepinoindol derivater som kinaseinhibitorer.
DK1959951T3 (da) Heteroaryl-substituerede piperidinderivater som L-CPT1-inhibitorer
DK1962830T3 (da) Azaindolhæmmere af aurorakinaser.
DK2086939T3 (da) Pyridiacarboxamid som II-beta-HSDI-inhibitorer
DK1979356T3 (da) Carbonylaminopyrrolopyrazoler, kraftige kinaseinhibitorer
DK1868999T3 (da) Pyridin-3-carboxamidderivater som omvendte CB1-agonister
DK2125748T3 (da) Acylaminopyrazol som FGFR inhibitorer
DK1846394T3 (da) Pyrazolylaminopyridinderivater, der er egnede som kinaseinhibitorer
DK2078001T3 (da) Diazepan-acetamidderivater som selektive 11-HSD1-inhibitorer
DK2003120T3 (da) Azapeptidderivater som HIV-proteaseinhibitorer
ZA200705075B (en) Novel hydantoin derivatives as metalloproteinase inhibitors
DK1937671T3 (da) Benzimidazolthiophenforbindelser som PLK-inhibitorer
ATE538092T1 (de) Asparaginsäureproteaseinhibitoren
IL183667A0 (en) Novel hydantoin derivatives as metalloproteinase inhibitors
NO20051236L (no) Heterobiarylderivater som matriksmetalloproteinaseinhibitorer
DK1740569T3 (da) Imidazol-derivater som TAFla-inhibitorer