DK1846384T3 - Monohydrochloridsalt af 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidin - Google Patents
Monohydrochloridsalt af 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidinInfo
- Publication number
- DK1846384T3 DK1846384T3 DK06708050T DK06708050T DK1846384T3 DK 1846384 T3 DK1846384 T3 DK 1846384T3 DK 06708050 T DK06708050 T DK 06708050T DK 06708050 T DK06708050 T DK 06708050T DK 1846384 T3 DK1846384 T3 DK 1846384T3
- Authority
- DK
- Denmark
- Prior art keywords
- chlorophenyl
- propoxy
- piperidine
- propyl
- monohydrochloride salt
- Prior art date
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
- NNACHAUCXXVJSP-UHFFFAOYSA-N pitolisant Chemical compound C1=CC(Cl)=CC=C1CCCOCCCN1CCCCC1 NNACHAUCXXVJSP-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Anesthesiology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05100942A EP1690858B1 (fr) | 2005-02-10 | 2005-02-10 | Sel de monohydrochloride de 1-[3-[3-(4-chlorophenyl)propoxy[propyl]-piperidine |
| PCT/EP2006/050703 WO2006084833A1 (fr) | 2005-02-10 | 2006-02-06 | Sel de monohydrochlorure de 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1846384T3 true DK1846384T3 (da) | 2008-11-17 |
Family
ID=34938687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06708050T DK1846384T3 (da) | 2005-02-10 | 2006-02-06 | Monohydrochloridsalt af 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidin |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8207197B2 (fr) |
| EP (2) | EP1690858B1 (fr) |
| JP (1) | JP5072604B2 (fr) |
| KR (1) | KR101344271B1 (fr) |
| CN (1) | CN101155793B (fr) |
| AR (1) | AR054734A1 (fr) |
| AT (2) | ATE391716T1 (fr) |
| CA (1) | CA2597016C (fr) |
| CY (1) | CY1108428T1 (fr) |
| DE (2) | DE602005005941D1 (fr) |
| DK (1) | DK1846384T3 (fr) |
| ES (1) | ES2309948T3 (fr) |
| HR (1) | HRP20080446T3 (fr) |
| ME (1) | ME01103B (fr) |
| MX (1) | MX2007009574A (fr) |
| PL (1) | PL1846384T3 (fr) |
| PT (1) | PT1846384E (fr) |
| RS (1) | RS50624B (fr) |
| SI (1) | SI1846384T1 (fr) |
| TW (1) | TWI393711B (fr) |
| UY (1) | UY29369A1 (fr) |
| WO (1) | WO2006084833A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2167096A4 (fr) * | 2007-06-13 | 2010-07-14 | Cypress Bioscience Inc | Amélioration de la tolérance à la mirtazapine et à un second principe actif par utilisation combinée de ces derniers |
| KR20110132564A (ko) | 2009-02-11 | 2011-12-08 | 선오비온 파마슈티컬스 인코포레이티드 | 히스타민 h3 역 작용제 및 길항제, 및 이의 사용 방법 |
| MX2011013437A (es) | 2009-06-10 | 2012-02-21 | Sunovion Pharmaceuticals Inc | Antagonista y agonistas inversos de histamina h3 y metodos para el uso de los mismos. |
| MX2012002898A (es) | 2009-09-11 | 2012-04-02 | Sunovion Pharmaceuticals Inc | Agonistas y antagonistas inversos de histamina h3 y metodos de uso para los mismos. |
| WO2014199935A1 (fr) * | 2013-06-10 | 2014-12-18 | 株式会社エム・エス・エス | Agent de prévention utilisé pour prévenir l'augmentation de la masse corporelle ou l'obésité en tant qu'effet indésirable d'un médicament, par la suppression du signal de stress du réticulum endoplasmique |
| CN103435575A (zh) * | 2013-08-06 | 2013-12-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 1-( 3-( 3-( 4-氯苯基)丙氧基)丙基)哌啶盐酸盐的制备方法 |
| CN104447620B (zh) * | 2014-11-28 | 2016-05-04 | 瑞阳制药有限公司 | 1-[3-[3-(4-氯苯基)丙氧基]丙基]-哌啶盐酸盐的制备方法 |
| EP3239138A1 (fr) | 2016-04-25 | 2017-11-01 | Sandoz Ag | Sel de fumarate d'hydrogène de 1-[3-[3-(4-chlorophényl)propoxy]propyl]pipéridine |
| WO2020092604A1 (fr) * | 2018-10-30 | 2020-05-07 | Concert Pharmaceuticals, Inc. | Pitolisant deutéré |
| IT201900013941A1 (it) | 2019-08-05 | 2021-02-05 | Procos Spa | PROCESSO PER LA SINTESI DI PITOLISANT HCl |
| CN110804026B (zh) * | 2019-11-18 | 2022-04-01 | 苏州永健生物医药有限公司 | 1- (3- (3-(4-氯苯基)丙氧基)丙基)哌啶盐酸盐的合成方法 |
| US11623920B2 (en) | 2021-06-07 | 2023-04-11 | Nuray Chemicals Private Limited | Process for preparing pitolisant hydrochloride and solid-state forms thereof |
| US11945788B2 (en) | 2021-06-07 | 2024-04-02 | Nuray Chemicals Private Limited | Process for preparing pitolisant hydrochloride and solid-state forms thereof |
| WO2023126865A1 (fr) * | 2021-12-29 | 2023-07-06 | Biophore India Pharmaceuticals Pvt Ltd | Formes solides de chlorhydrate de 1-3-[3-(4-chlorophényl) propoxy] propyl} pipéridine et leur procédé de préparation |
| US20250281475A1 (en) * | 2022-05-04 | 2025-09-11 | Msn Laboratories Private Limited, R & D Center | A pharmaceutical composition of pitolisant hydrochloride and their process for the preparation |
| WO2024084379A1 (fr) * | 2022-10-17 | 2024-04-25 | Biophore India Pharmaceuticals Pvt. Ltd | Nouveau procédé de préparation d'une dispersion solide amorphe de 1-3-[3- (4-chlorophenyl)propoxy] propyl} pipéridine, chlorhydrate avec de l'hydroxypropyl bêta-cyclodextrine (hpβcd) |
| EP4374854A1 (fr) * | 2022-11-28 | 2024-05-29 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Mélange pharmaceutique comprenant un pitolisant amorphe |
| CN121175294A (zh) | 2023-03-31 | 2025-12-19 | 生物计划制药公司 | 盐酸替洛利生的多晶型形式 |
| EP4681704A1 (fr) | 2024-07-18 | 2026-01-21 | BIOPROJET Pharma | Nouvelles formulations de pitolisant |
| WO2025082972A1 (fr) | 2023-10-16 | 2025-04-24 | Bioprojet Pharma | Formulations de pitolisant à enrobage entérique et procédés d'utilisation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0982300A3 (fr) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines comme antagonistes du recepteur histamine H3 et leur application thérapeutique |
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2005
- 2005-02-10 AT AT05100942T patent/ATE391716T1/de not_active IP Right Cessation
- 2005-02-10 EP EP05100942A patent/EP1690858B1/fr not_active Expired - Lifetime
- 2005-02-10 DE DE602005005941T patent/DE602005005941D1/de not_active Expired - Lifetime
-
2006
- 2006-02-06 ES ES06708050T patent/ES2309948T3/es not_active Expired - Lifetime
- 2006-02-06 ME MEP-2008-394A patent/ME01103B/fr unknown
- 2006-02-06 EP EP06708050A patent/EP1846384B1/fr not_active Expired - Lifetime
- 2006-02-06 US US11/815,736 patent/US8207197B2/en active Active
- 2006-02-06 AT AT06708050T patent/ATE402154T1/de active
- 2006-02-06 HR HR20080446T patent/HRP20080446T3/xx unknown
- 2006-02-06 RS RSP-2008/0482A patent/RS50624B/sr unknown
- 2006-02-06 DK DK06708050T patent/DK1846384T3/da active
- 2006-02-06 MX MX2007009574A patent/MX2007009574A/es active IP Right Grant
- 2006-02-06 DE DE602006001938T patent/DE602006001938D1/de not_active Expired - Lifetime
- 2006-02-06 CN CN200680008857.1A patent/CN101155793B/zh not_active Expired - Lifetime
- 2006-02-06 PT PT06708050T patent/PT1846384E/pt unknown
- 2006-02-06 PL PL06708050T patent/PL1846384T3/pl unknown
- 2006-02-06 SI SI200630073T patent/SI1846384T1/sl unknown
- 2006-02-06 JP JP2007554541A patent/JP5072604B2/ja not_active Expired - Lifetime
- 2006-02-06 CA CA2597016A patent/CA2597016C/fr not_active Expired - Lifetime
- 2006-02-06 WO PCT/EP2006/050703 patent/WO2006084833A1/fr not_active Ceased
- 2006-02-08 AR ARP060100448A patent/AR054734A1/es not_active Application Discontinuation
- 2006-02-08 TW TW095104184A patent/TWI393711B/zh not_active IP Right Cessation
- 2006-02-09 UY UY29369A patent/UY29369A1/es not_active Application Discontinuation
-
2007
- 2007-09-06 KR KR1020077020422A patent/KR101344271B1/ko not_active Expired - Lifetime
-
2008
- 2008-10-21 CY CY20081101174T patent/CY1108428T1/el unknown
-
2012
- 2012-06-07 US US13/491,229 patent/US8354430B2/en not_active Expired - Lifetime
Also Published As
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|---|---|---|
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