DK1848744T3 - Humane anti-interferon-gamma-antistoffer og fremgangsmåder til anvendelse heraf - Google Patents

Humane anti-interferon-gamma-antistoffer og fremgangsmåder til anvendelse heraf

Info

Publication number: DK1848744T3
Authority: DK; Denmark
Prior art keywords: interferon gamma; ifnγ; methods; human anti; gamma antibodies
Prior art date: 2005-01-27

Application number

DK06765483.0T

Other languages

English (en)

Inventor

Walter Ferlin

Nicolas Fischer

Greg Elson

Olivier Leger

Original Assignee

Novimmune Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-27

Filing date

2006-01-27

Publication date

2012-03-19

2006-01-27 Application filed by Novimmune Sa filed Critical Novimmune Sa

2012-03-19 Application granted granted Critical

2012-03-19 Publication of DK1848744T3 publication Critical patent/DK1848744T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

DK06765483.0T 2005-01-27 2006-01-27 Humane anti-interferon-gamma-antistoffer og fremgangsmåder til anvendelse heraf DK1848744T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US64821905P	2005-01-27	2005-01-27
PCT/IB2006/001514 WO2006109191A2 (en)	2005-01-27	2006-01-27	Human anti-interferon gamma antibodies and methods of use thereof

Publications (1)

Publication Number	Publication Date
DK1848744T3 true DK1848744T3 (da)	2012-03-19

Family

ID=37087400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06765483.0T DK1848744T3 (da)	2005-01-27	2006-01-27	Humane anti-interferon-gamma-antistoffer og fremgangsmåder til anvendelse heraf

Country Status (20)

Country	Link
US (4)	US7700098B2 (da)
EP (1)	EP1848744B1 (da)
JP (1)	JP5173437B2 (da)
KR (1)	KR101380570B1 (da)
CN (1)	CN101151277B (da)
AT (1)	ATE541859T1 (da)
AU (1)	AU2006233353B2 (da)
BR (1)	BRPI0607238B8 (da)
CA (1)	CA2595276C (da)
DK (1)	DK1848744T3 (da)
EA (1)	EA013118B1 (da)
ES (1)	ES2381203T3 (da)
IL (1)	IL184749A0 (da)
MX (1)	MX2007008719A (da)
NO (1)	NO340445B1 (da)
PL (1)	PL1848744T3 (da)
PT (1)	PT1848744E (da)
UA (1)	UA92337C2 (da)
WO (1)	WO2006109191A2 (da)
ZA (1)	ZA200706169B (da)

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AU2008323206B2 (en) *	2007-11-12	2014-08-14	U3 Pharma Gmbh	AXL antibodies
ES2360334T3 (es) *	2008-06-27	2011-06-03	Theranor Sprl	Composiciones farmacéuticas de anticuerpos para enfermedades causadas por virus.
EP2356140A2 (en)	2008-10-07	2011-08-17	Novimmune Sa	Il-17-mediated transfection methods
HUE047173T2 (hu)	2010-03-01	2020-04-28	Bayer Healthcare Llc	Optimalizált monoklonális ellenanyagok szöveti faktor útvonal inhibitor (TFPI) ellen
US20130142809A1 (en) *	2011-11-23	2013-06-06	Andrew A. Welcher	METHODS OF TREATMENT USING AN IFN gamma INHIBITOR
PL3489261T3 (pl)	2012-08-24	2021-08-16	The Regents Of The University Of California	Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu
CN121588213A (zh) *	2015-05-07	2026-03-03	瑞典孤儿比奥维特鲁姆股份公司	用于诊断和治疗cxcl9和其它生物标志物水平升高的患者的病症
US11091543B2 (en)	2015-05-07	2021-08-17	Swedish Orphan Biovitrum Ag	Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications
WO2016200627A1 (en)	2015-06-09	2016-12-15	Children's Hospital Medical Center	Dosing algorithm for complement inhibitor
CN105695405A (zh) *	2016-03-29	2016-06-22	深圳爱生再生医学科技有限公司	Cik细胞扩增方法
IL299099B2 (en)	2016-06-27	2025-07-01	Univ California	Cancer treatment combinations
EP3528845A2 (en)	2016-10-24	2019-08-28	Novimmune S.A.	Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications
TWI797124B (zh)	2017-05-05	2023-04-01	香港商安立璽榮生醫(香港)有限公司	抗干擾素-γ之抗體及其應用
US11672877B2 (en) *	2017-08-23	2023-06-13	Wayne State University	In vivo immunoimaging of interferon-gamma
EP3717004A4 (en)	2017-12-01	2021-12-01	Children's Hospital Medical Center	COMPOSITIONS FOR BLOCKING INTERERONS AND THEIR METHODS OF USE
CN112105373B (zh) *	2018-03-29	2024-04-05	安立玺荣(上海)生物医药科技有限公司	治疗b型肝炎病毒感染的方法
CA3113223A1 (en) *	2018-09-19	2020-03-26	Totient, Inc.	Cancer associated antibody compositions and methods of use
WO2021185832A1 (en)	2020-03-16	2021-09-23	Swedish Orphan Biovitrum Ag	New therapeutic treatment
WO2022132710A1 (en) *	2020-12-15	2022-06-23	Vanderbilt University	Human hendra virus and nipah virus antibodies and methods of use therefor
CA3204552A1 (en)	2021-01-08	2022-07-14	Joseph M. LUETTGEN	Antibodies and antigen binding peptides for factor xia inhibitors and uses thereof
CN112794903B (zh) *	2021-04-14	2021-06-25	广州市雷德生物科技有限公司	一种特异性结合IFN-γ的抗体及其应用
JP7359457B2 (ja) *	2021-10-11	2023-10-11	タグシクス・バイオ株式会社	自己免疫性疾患治療薬
US20250320288A1 (en) *	2022-06-02	2025-10-16	Elixiron Immunotherapeutics (Hong Kong)	Method of treating vitiligo with interferon-gamma antibody
JP2024021165A (ja) *	2022-08-03	2024-02-16	タグシクス・バイオ株式会社	ＩＦＮ－γへ選択的に結合するＤＮＡオリゴヌクレオチドを含有するドライアイ治療薬
JP2024021164A (ja) *	2022-08-03	2024-02-16	タグシクス・バイオ株式会社	ＩＦＮ－γへ選択的に結合するＤＮＡオリゴヌクレオチドを含有するハンナ型間質性膀胱炎治療薬
WO2024254401A1 (en)	2023-06-09	2024-12-12	Children's Hospital Medical Center	Treatment of stem cell graft failure
KR20260047586A (ko) *	2023-07-24	2026-04-08	벤더르빌트 유니버시티	인플루엔자 b 바이러스에 대한 광범위 반응성 항체
CN121889422A (zh) *	2023-07-25	2026-04-17	西马布有限公司	能够结合干扰素γ的抗原结合分子
TW202525846A (zh)	2023-08-25	2025-07-01	美商普羅特歐拉吉克適美國公司	抗ｉｌ—１３多特異性抗體構築體及其用途
WO2025224314A1 (en)	2024-04-26	2025-10-30	Swedish Orphan Biovitrum Ag	Use of emapalumab for treatment

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JP3887011B2 (ja) *	1992-12-29	2007-02-28	ジェネンテク，インコーポレイテッド	ＩＦＮ−γインヒビターによる炎症性腸疾患の処置
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JP2002531466A (ja)	1998-12-01	2002-09-24	プロテインデザインラブス，インコーポレイテッド	γ−インターフェロンに対するヒト化抗体
US6534059B2 (en) *	2001-06-05	2003-03-18	Advanced Biotherapy, Inc.	Compositions and methods for treating hyperimmune response in the eye
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US7084257B2 (en) *	2001-10-05	2006-08-01	Amgen Inc.	Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
EP1506002A4 (en) *	2002-05-17	2006-06-07	Protein Design Labs	TREATMENT OF CROHN'S DISEASE OR PSORIASIS FROM ANTI-INTERFERON GAMMA ANTIBODIES
MXPA04011375A (es)	2002-06-27	2005-02-14	Interdigital Tech Corp	Controlador de red de radio para intercambio de informacion de equipo.
AU2003285874A1 (en) *	2002-10-16	2004-05-04	Amgen Inc.	HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS
GB0314461D0 (en) *	2003-06-20	2003-07-23	Isis Innovation	Suppression of transplant rejection
US7504106B2 (en)	2006-03-14	2009-03-17	Boris Skurkovich	Method and composition for treatment of renal failure with antibodies and their equivalents as partial or complete replacement for dialysis

2006
- 2006-01-27 MX MX2007008719A patent/MX2007008719A/es active IP Right Grant
- 2006-01-27 PL PL06765483T patent/PL1848744T3/pl unknown
- 2006-01-27 CN CN2006800099627A patent/CN101151277B/zh not_active Expired - Lifetime
- 2006-01-27 ES ES06765483T patent/ES2381203T3/es not_active Expired - Lifetime
- 2006-01-27 DK DK06765483.0T patent/DK1848744T3/da active
- 2006-01-27 KR KR1020077019312A patent/KR101380570B1/ko not_active Expired - Lifetime
- 2006-01-27 US US11/342,020 patent/US7700098B2/en active Active
- 2006-01-27 AU AU2006233353A patent/AU2006233353B2/en not_active Expired
- 2006-01-27 BR BRPI0607238A patent/BRPI0607238B8/pt active IP Right Grant
- 2006-01-27 UA UAA200709558A patent/UA92337C2/uk unknown
- 2006-01-27 JP JP2007552757A patent/JP5173437B2/ja not_active Expired - Lifetime
- 2006-01-27 WO PCT/IB2006/001514 patent/WO2006109191A2/en not_active Ceased
- 2006-01-27 CA CA2595276A patent/CA2595276C/en not_active Expired - Lifetime
- 2006-01-27 EP EP06765483A patent/EP1848744B1/en not_active Expired - Lifetime
- 2006-01-27 PT PT06765483T patent/PT1848744E/pt unknown
- 2006-01-27 EA EA200701589A patent/EA013118B1/ru unknown
- 2006-01-27 AT AT06765483T patent/ATE541859T1/de active
2007
- 2007-07-19 IL IL184749A patent/IL184749A0/en active IP Right Grant
- 2007-07-24 NO NO20073882A patent/NO340445B1/no unknown
- 2007-07-25 ZA ZA200706169A patent/ZA200706169B/en unknown
2010
- 2010-02-08 US US12/702,013 patent/US20100158922A1/en not_active Abandoned
2013
- 2013-10-18 US US14/057,356 patent/US9682142B2/en active Active
2017
- 2017-06-20 US US15/628,037 patent/US20170291943A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PT1848744E (pt)	2012-04-24
IL184749A0 (en)	2007-12-03
BRPI0607238B1 (pt)	2019-10-15
KR101380570B1 (ko)	2014-04-01
NO340445B1 (no)	2017-04-24
HK1110601A1 (en)	2008-07-18
US20100158922A1 (en)	2010-06-24
ATE541859T1 (de)	2012-02-15
EA200701589A1 (ru)	2008-02-28
WO2006109191A3 (en)	2007-04-26
AU2006233353A1 (en)	2006-10-19
KR20070102566A (ko)	2007-10-18
UA92337C2 (uk)	2010-10-25
ZA200706169B (en)	2008-04-30
US20060263363A1 (en)	2006-11-23
AU2006233353B2 (en)	2011-12-15
CA2595276A1 (en)	2006-10-19
JP5173437B2 (ja)	2013-04-03
JP2008528569A (ja)	2008-07-31
PL1848744T3 (pl)	2012-06-29
ES2381203T3 (es)	2012-05-24
WO2006109191A2 (en)	2006-10-19
EP1848744B1 (en)	2012-01-18
CA2595276C (en)	2014-03-11
BRPI0607238B8 (pt)	2021-05-25
NO20073882L (no)	2007-10-24
US20140186362A1 (en)	2014-07-03
US9682142B2 (en)	2017-06-20
EA013118B1 (ru)	2010-02-26
CN101151277B (zh)	2013-11-13
BRPI0607238A2 (pt)	2009-08-25
MX2007008719A (es)	2007-09-11
US7700098B2 (en)	2010-04-20
CN101151277A (zh)	2008-03-26
US20170291943A1 (en)	2017-10-12
EP1848744A2 (en)	2007-10-31

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EP2287196A3 (en)	2011-05-04	Antibodies against thymic stromal lymphopoietin receptor for treating allergic diseases
MX2010001307A (es)	2010-07-30	Anticuerpos anti-proteína regulada con la activación, expresada y secretada por los linfocitos t normales y metodos de uso de los mismos.
ATE527365T1 (de)	2011-10-15	Il-15r alpha -sushi domäne als selektiver und effizienter verstärker der il-15-wirkung durch il-15rbeta/gamma , in hyperagonist il-15 ralpha sushi -il 15 fusionsproteine .
MA32982B1 (fr)	2012-01-02	Proteines de liaison au recepteur cgrp humain
NO20070950L (no)	2007-04-12	Preparater og fremgangsmater for anvendelse av angiopoietinlignende-4-protein.
EA201301072A1 (ru)	2014-06-30	Антитела против il-23p19 и их применение
MX2009013410A (es)	2010-03-22	Biomarcadores para predecir capacidad de respuesta anti-tnf o sin capacidad de respuesta.
CY1110843T1 (el)	2015-06-10	Αντισωματα εναντι il-22ra και εταιροι δεσμευσης και μεθοδοι χρησης σε φλεγμονη
ECSP088529A (es)	2008-07-30	Anticuerpos anti mn y métodos para su utilización
EP2118123A4 (en)	2011-04-20	STABILIZED P53 PEPTIDES AND ITS USES
WO2008156865A3 (en)	2009-03-12	Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease
WO2004113500A3 (en)	2005-08-25	B7s1: an immune modulator
NO20092743L (no)	2009-09-21	Antistoffer mot CD200R
DE602005027400D1 (de)	2011-05-19	Il-22 zur behandlung von fettleibigkeit, diabetes, hyperlipidämie, hyperglykämie und insulinresistenz
DK1802749T3 (da)	2012-11-26	KASPP (LRRK2)-gen, dets fremstilling og anvendelse til påvisning og behandling af neurodegenerative lidelser
MY141851A (en)	2010-07-16	Human monoclonal antibodies against human il-4
DK1051491T3 (da)	2010-08-16	Equin Fc Epsilon receptor-alfa-kæde-nukleinsyremolekyler, korresponderende proteiner og anvendelse heraf
WO2006029220A3 (en)	2007-03-01	Combination therapy with anti-ctla4 and anti-4-1bb antibodies
ATE544856T1 (de)	2012-02-15	Peptid- und nukleotidsequenzen von anisakis spp. und ihre verwendung
ATE489628T1 (de)	2010-12-15	Galk1s als modifikatoren des pten/akt-wegs
WO2007076422A3 (en)	2007-11-01	Antibodies against interleukin-22 binding protein and its uses
AR052618A1 (es)	2007-03-21	Anticuerpos anti- interferon gamma y metodos de utilizacion de los mismos
WO2005101013A3 (en)	2006-03-02	Materials and methods for screening modulators of neural regneration