BRPI0820073A2 - Anticorpos anti-axl - Google Patents
Anticorpos anti-axlInfo
- Publication number
- BRPI0820073A2 BRPI0820073A2 BRPI0820073-4A BRPI0820073A BRPI0820073A2 BR PI0820073 A2 BRPI0820073 A2 BR PI0820073A2 BR PI0820073 A BRPI0820073 A BR PI0820073A BR PI0820073 A2 BRPI0820073 A2 BR PI0820073A2
- Authority
- BR
- Brazil
- Prior art keywords
- axl antibodies
- axl
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07021931 | 2007-11-12 | ||
| PCT/EP2008/009548 WO2009062690A1 (en) | 2007-11-12 | 2008-11-12 | Axl antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0820073A2 true BRPI0820073A2 (pt) | 2015-06-23 |
Family
ID=40280763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0820073-4A BRPI0820073A2 (pt) | 2007-11-12 | 2008-11-12 | Anticorpos anti-axl |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8933202B2 (pt) |
| EP (2) | EP2220121B1 (pt) |
| JP (2) | JP5769969B2 (pt) |
| KR (1) | KR20100097684A (pt) |
| CN (2) | CN101939336B (pt) |
| AU (1) | AU2008323206B2 (pt) |
| BR (1) | BRPI0820073A2 (pt) |
| CA (1) | CA2705164A1 (pt) |
| CO (1) | CO6280499A2 (pt) |
| DK (1) | DK2220121T3 (pt) |
| ES (1) | ES2556214T3 (pt) |
| IL (1) | IL205607A0 (pt) |
| MX (1) | MX2010005031A (pt) |
| MY (1) | MY155621A (pt) |
| NZ (2) | NZ585465A (pt) |
| RU (1) | RU2506276C2 (pt) |
| SG (2) | SG186000A1 (pt) |
| WO (1) | WO2009062690A1 (pt) |
| ZA (1) | ZA201003397B (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2705164A1 (en) | 2007-11-12 | 2009-05-22 | U3 Pharma Gmbh | Axl antibodies |
| KR101568051B1 (ko) | 2007-11-15 | 2015-11-10 | 추가이 세이야쿠 가부시키가이샤 | Ａｎｅｘｅｌｅｋｔｏ에 결합하는 단일클론항체, 및 그의 이용 |
| HRP20150965T1 (hr) | 2009-03-25 | 2015-11-06 | Genentech, Inc. | Anti-fgr3 protutijela i metode koje ih koriste |
| JP5909442B2 (ja) * | 2009-05-11 | 2016-04-26 | ユー３・ファーマ・ゲーエムベーハー | ヒト化ａｘｌ抗体 |
| EP2270053A1 (en) * | 2009-05-11 | 2011-01-05 | U3 Pharma GmbH | Humanized AXL antibodies |
| RU2011151069A (ru) | 2009-05-15 | 2013-06-20 | Чугаи Сейяку Кабусики Кайся | Анти-axl антитело |
| TW201106972A (en) | 2009-07-27 | 2011-03-01 | Genentech Inc | Combination treatments |
| EP2483289B2 (en) | 2009-10-02 | 2025-03-26 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
| PT3241840T (pt) * | 2010-01-22 | 2022-10-13 | Univ Leland Stanford Junior | Inibição da sinalização de axl em terapêutica anti-metastática |
| CN101858917B (zh) * | 2010-06-02 | 2013-03-27 | 成都创宜生物科技有限公司 | Axl单克隆抗体的应用及以Axl为检测指标的胎膜早破检测试剂盒和制备方法 |
| CA2794731C (en) * | 2010-06-18 | 2019-03-19 | Genentech, Inc. | Anti-axl antibodies and methods of use |
| EP2670426B1 (en) | 2011-01-31 | 2017-05-10 | The General Hospital Corporation | Multimodal trail molecules and uses in cellular therapies |
| RS58087B1 (sr) * | 2011-05-13 | 2019-02-28 | Ganymed Pharmaceuticals Gmbh | Antitela za lečenje kancera koji eksprimira klaudin 6 |
| US9562252B2 (en) | 2011-05-13 | 2017-02-07 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
| US9409988B2 (en) * | 2011-06-22 | 2016-08-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-Axl antibodies and uses thereof |
| JP6033293B2 (ja) | 2011-06-22 | 2016-11-30 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル）Ｉｎｓｅｒｍ（Ｉｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅｌａ Ｓａｎｔｅ Ｅｔ Ｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｍｅｄｉｃａｌｅ） | 抗Ａｘｌ抗体及びその使用 |
| CN103857700A (zh) | 2011-08-26 | 2014-06-11 | 梅里麦克制药股份有限公司 | 串联fc双特异性抗体 |
| EP2589609A1 (en) * | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
| WO2014018113A1 (en) | 2012-07-24 | 2014-01-30 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
| WO2014035474A1 (en) * | 2012-08-30 | 2014-03-06 | The General Hospital Corporation | Compositions and methods for treating cancer |
| US10669324B2 (en) | 2012-10-30 | 2020-06-02 | Suppremol Gmbh | Vector encoding an Fc gamma receptor IIB protein and composition of the encoded protein |
| JP6195716B2 (ja) * | 2013-02-15 | 2017-09-13 | 富士レビオ株式会社 | 抗癌剤耐性診断マーカー |
| CA2902505A1 (en) | 2013-03-06 | 2014-09-12 | Merrimack Pharmaceuticals, Inc. | Anti-c-met tandem fc bispecific antibodies |
| EP2837637A1 (en) * | 2013-08-16 | 2015-02-18 | SuppreMol GmbH | Novel anti-FcyRIIB IgG-type antibody |
| GB201410826D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
| GB201410825D0 (en) | 2014-06-18 | 2014-07-30 | Bergenbio As | Anti-axl antibodies |
| ES3034398T3 (en) | 2014-08-28 | 2025-08-18 | Bioatla Inc | Conditionally active chimeric antigen receptors for modified t-cells |
| EP3229836B1 (en) * | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Human monoclonal antibodies against axl |
| EP3233119A2 (en) | 2014-12-18 | 2017-10-25 | Bergen Teknologioverforing AS | Anti-axl antagonistic antibodies |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| US10787517B2 (en) | 2015-05-18 | 2020-09-29 | Agensys, Inc. | Antibodies that bind to AXL proteins |
| JP6857138B2 (ja) * | 2015-05-18 | 2021-04-14 | アジェンシス，インコーポレイテッド | Ａｘｌタンパク質に結合する抗体 |
| GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
| CA2991805A1 (en) * | 2015-07-10 | 2017-01-19 | Genmab A/S | Axl-specific antibody-drug conjugates for cancer treatment |
| AU2017248644B2 (en) | 2016-04-15 | 2019-10-31 | Bioatla, Llc | Anti-Axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
| TWI851939B (zh) | 2016-05-13 | 2024-08-11 | 美商拜奧亞特拉公司 | 抗-ror2抗體、抗體片段、其免疫結合物及其用途 |
| GB201610902D0 (en) * | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
| KR102905343B1 (ko) | 2017-01-18 | 2025-12-29 | 바이오아트라, 인코퍼레이티드 | Axl 또는 ror2에 대한 키메라 항원 수용체 및 이의 사용 방법 |
| CN110536703B (zh) | 2017-04-20 | 2024-07-12 | Adc治疗有限公司 | 使用抗axl抗体-药物缀合物的组合疗法 |
| CN110540592B (zh) * | 2018-05-29 | 2022-08-09 | 杭州尚健生物技术有限公司 | 结合axl蛋白的抗体及其应用 |
| CN109160941B (zh) * | 2018-09-29 | 2020-09-04 | 未名生物医药有限公司 | 蛋白序列17e11及其用途 |
| GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
| EP4087657A1 (en) | 2020-01-08 | 2022-11-16 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
| IL297132A (en) | 2020-04-08 | 2022-12-01 | Bergenbio Asa | axl inhibitors for antiviral therapy |
| GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
| GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
| EP4357365A4 (en) * | 2021-06-16 | 2025-06-04 | Shanghai Sinobay Biotechnology Co., Ltd. | Antibodies against AXL protein and antigen-binding fragment thereof, as well as methods of production and use thereof |
| WO2024145869A1 (en) * | 2023-01-05 | 2024-07-11 | Zhejiang Shimai Pharmaceutical Co., Ltd. | Antibodies against axl and uses thereof |
| CN116715774B (zh) * | 2023-05-12 | 2023-11-24 | 武汉爱博泰克生物科技有限公司 | 针对人axl的兔单克隆抗体及其制备方法和应用 |
| CN118344446B (zh) * | 2024-04-20 | 2026-05-08 | 温州医科大学 | 一种对axl蛋白具有结合亲和力的多肽及其应用 |
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-
2008
- 2008-11-12 CA CA2705164A patent/CA2705164A1/en not_active Abandoned
- 2008-11-12 DK DK08850452.7T patent/DK2220121T3/en active
- 2008-11-12 SG SG2012084026A patent/SG186000A1/en unknown
- 2008-11-12 US US12/742,546 patent/US8933202B2/en not_active Expired - Fee Related
- 2008-11-12 JP JP2010532510A patent/JP5769969B2/ja not_active Expired - Fee Related
- 2008-11-12 AU AU2008323206A patent/AU2008323206B2/en not_active Ceased
- 2008-11-12 NZ NZ585465A patent/NZ585465A/xx unknown
- 2008-11-12 NZ NZ599628A patent/NZ599628A/xx unknown
- 2008-11-12 SG SG10201405835TA patent/SG10201405835TA/en unknown
- 2008-11-12 BR BRPI0820073-4A patent/BRPI0820073A2/pt not_active IP Right Cessation
- 2008-11-12 RU RU2010123888/10A patent/RU2506276C2/ru not_active IP Right Cessation
- 2008-11-12 KR KR1020107012747A patent/KR20100097684A/ko not_active Abandoned
- 2008-11-12 WO PCT/EP2008/009548 patent/WO2009062690A1/en not_active Ceased
- 2008-11-12 EP EP08850452.7A patent/EP2220121B1/en active Active
- 2008-11-12 MX MX2010005031A patent/MX2010005031A/es not_active Application Discontinuation
- 2008-11-12 MY MYPI2010002190A patent/MY155621A/en unknown
- 2008-11-12 ES ES08850452.7T patent/ES2556214T3/es active Active
- 2008-11-12 EP EP15162381.6A patent/EP2918605A1/en not_active Withdrawn
- 2008-11-12 CN CN200880123225.9A patent/CN101939336B/zh not_active Expired - Fee Related
- 2008-11-12 CN CN201310242420.6A patent/CN103275227B/zh not_active Expired - Fee Related
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2010
- 2010-05-06 IL IL205607A patent/IL205607A0/en unknown
- 2010-05-13 ZA ZA2010/03397A patent/ZA201003397B/en unknown
- 2010-06-04 CO CO10068105A patent/CO6280499A2/es active IP Right Grant
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2008323206A1 (en) | 2009-05-22 |
| CO6280499A2 (es) | 2011-05-20 |
| MY155621A (en) | 2015-11-13 |
| RU2010123888A (ru) | 2011-12-20 |
| JP2015221804A (ja) | 2015-12-10 |
| CN101939336A (zh) | 2011-01-05 |
| RU2506276C2 (ru) | 2014-02-10 |
| CA2705164A1 (en) | 2009-05-22 |
| IL205607A0 (en) | 2010-11-30 |
| JP2011505120A (ja) | 2011-02-24 |
| DK2220121T3 (en) | 2015-12-07 |
| ES2556214T3 (es) | 2016-01-14 |
| ZA201003397B (en) | 2011-04-28 |
| KR20100097684A (ko) | 2010-09-03 |
| WO2009062690A1 (en) | 2009-05-22 |
| EP2220121B1 (en) | 2015-08-19 |
| EP2918605A1 (en) | 2015-09-16 |
| HK1185622A1 (en) | 2014-02-21 |
| CN101939336B (zh) | 2014-05-14 |
| HK1147275A1 (en) | 2011-08-05 |
| EP2220121A1 (en) | 2010-08-25 |
| AU2008323206B2 (en) | 2014-08-14 |
| MX2010005031A (es) | 2010-06-25 |
| US20100330095A1 (en) | 2010-12-30 |
| SG186000A1 (en) | 2012-12-28 |
| NZ599628A (en) | 2013-11-29 |
| CN103275227B (zh) | 2015-02-11 |
| NZ585465A (en) | 2012-12-21 |
| US8933202B2 (en) | 2015-01-13 |
| JP5769969B2 (ja) | 2015-08-26 |
| CN103275227A (zh) | 2013-09-04 |
| SG10201405835TA (en) | 2014-10-30 |
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