DK185584A - Enzymatisk fremstilling af sphingophospholipidderivater - Google Patents

Enzymatisk fremstilling af sphingophospholipidderivater Download PDF

Info

Publication number: DK185584A
Authority: DK; Denmark
Prior art keywords: sphingophospholipid; derivatives; enzymatic preparation; alcohol compounds; group
Prior art date: 1983-04-11

Application number

DK185584A

Other languages

English (en)

Other versions

DK185584D0 (da

Inventor

Yoshitaka Kokusho

Shigeaki Kato

Haruo Machida

Original Assignee

Meito Sangyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-11

Filing date

1984-04-10

Publication date

1984-10-12

1984-04-10 Application filed by Meito Sangyo Kk filed Critical Meito Sangyo Kk

1984-04-10 Publication of DK185584D0 publication Critical patent/DK185584D0/da

1984-10-12 Publication of DK185584A publication Critical patent/DK185584A/da

Links

230000002255 enzymatic effect Effects 0.000 title 1
-1 primary alcohol compounds Chemical class 0.000 description 6
125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
230000001476 alcoholic effect Effects 0.000 description 3
125000001931 aliphatic group Chemical group 0.000 description 3
150000002402 hexoses Chemical class 0.000 description 3
150000002972 pentoses Chemical class 0.000 description 3
229920006395 saturated elastomer Polymers 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
150000001720 carbohydrates Chemical class 0.000 description 2
229910052736 halogen Inorganic materials 0.000 description 2
150000002367 halogens Chemical class 0.000 description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
125000001424 substituent group Chemical group 0.000 description 2
UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 1
ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
239000002126 C01EB10 - Adenosine Substances 0.000 description 1
UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 1
102000015439 Phospholipases Human genes 0.000 description 1
108010064785 Phospholipases Proteins 0.000 description 1
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
229960005305 adenosine Drugs 0.000 description 1
125000002723 alicyclic group Chemical group 0.000 description 1
150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
125000002029 aromatic hydrocarbon group Chemical group 0.000 description 1
150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 description 1
125000004663 dialkyl amino group Chemical group 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
125000000623 heterocyclic group Chemical group 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
235000008160 pyridoxine Nutrition 0.000 description 1
239000011677 pyridoxine Substances 0.000 description 1
229940011671 vitamin b6 Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

Description

hvori R betyder en mættet eller umættet aliphatisk carbon-hydridgruppe, og B betyder - (CH2) 2N+(CH2) 3, -(CH2)2NH2 e^-“ ler -CH2CH(OH)CH2(OH), med en forbindelse indeholdende en alkoholisk hydroxylgruppe og valgt blandt (1) primære alkoholforbindelser indeholdende en mættet eller umættet, aliphatisk eller aromatisk carbonhydridgruppe R', der kan være substitueret med en substituent valgt blandt halogen, amino, carboxyl og hydroxyl; primære alkoholforbindelser indeholdende en gruppe R' af et mættet eller umættet, aliphatisk eller aromatisk carbonhydrid, der i molekylet indeholder en binding valgt blandt ether-, ester- og amidbindinger; og heterocycliske primære alkoholforbindelser indeholdende en heterocyclisk gruppe R' valgt blandt pyridoxin, cytidin, arabino-cytidin og adenosin; (2) sekundære alkoholforbindelser med en aliphatisk carbonhydridgruppe R', der kan være substitueret med en substituent valgt blandt halogen, amino, mono- eller dialkyl-amino og phenyl; og sekundære alkoholforbindelser med en alicyclisk carbonhydridgruppe R*; og (3) saccharider valgt blandt pentoser indeholdende en pentoserest R* og en primær alkoholisk hydroxylgruppe og hexoser indeholdende en hexoserest R1 og en primær alkoholisk hydroxylgruppe, hvori pentoseresten R* eller hexose-resten R' kan være substitueret med amino eller acetyl-amino; og phenylglycosider af de nævnte saccharider; i nærværelse af phospholipase DM.

DK185584A 1983-04-11 1984-04-10 Enzymatisk fremstilling af sphingophospholipidderivater DK185584A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP58063307A JPS59187787A (ja)	1983-04-11	1983-04-11	酵素法スフインゴリン脂質誘導体の製法
JP6330783		1983-04-11

Publications (2)

Publication Number	Publication Date
DK185584D0 DK185584D0 (da)	1984-04-10
DK185584A true DK185584A (da)	1984-10-12

Family

ID=13225497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK185584A DK185584A (da)	1983-04-11	1984-04-10	Enzymatisk fremstilling af sphingophospholipidderivater

Country Status (5)

Country	Link
US (1)	US4782019A (da)
EP (1)	EP0122152B1 (da)
JP (1)	JPS59187787A (da)
DE (1)	DE3477402D1 (da)
DK (1)	DK185584A (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6336791A (ja) *	1986-08-01	1988-02-17	Nippon Oil & Fats Co Ltd	酵素によるリン脂質の製造方法
JPH0714865B2 (ja) *	1986-10-28	1995-02-22	武田薬品工業株式会社	リポソ−ム製剤およびその製造法
US5053531A (en) *	1988-11-08	1991-10-01	Ppg Industries, Inc.	Quaternary ammonium antistatic compounds
JPH02250847A (ja) *	1989-03-22	1990-10-08	Sumitomo Chem Co Ltd	光学活性体混合物の分離方法
US5180674A (en)	1990-04-16	1993-01-19	The Trustees Of The University Of Pennsylvania	Saccharide compositions, methods and apparatus for their synthesis
DE69133122D1 (de)	1990-04-16	2002-11-07	Univ Pennsylvania	Saccharidzusammensetzungen, Verfahren und Apparate zu deren Synthese
BR9107032A (pt) *	1990-10-22	1994-01-25	Unilever Nv	Pseudoceramidas modificadas,composto,processo para sintetizar uma pseudoceramida modificada,composicao,uso e processo para o tratamento da pele,cabelo ou unhas
AU639373B2 (en) *	1990-10-22	1993-07-22	Unilever Plc	Cosmetic composition
GB9100816D0 (en) *	1991-01-15	1991-02-27	Unilever Plc	Cosmetic composition
US6518051B1 (en)	1991-04-11	2003-02-11	The Trustees Of The University Of Pennsylvania	Saccharide compositions, methods and apparatus for their synthesis
ES2123066T3 (es) *	1992-11-03	1999-01-01	Unilever Nv	Procedimiento para sintetizar ceramidas que contienen fitoesfingosina y composiciones cosmeticas que las contienen.
US5430169A (en) *	1994-02-14	1995-07-04	The United States Of America Represented By The Department Of Health And Human Services	Method for preparation of sphingoid bases
US5498527A (en) *	1994-02-18	1996-03-12	Ube Industries, Ltd.	Phosphorylcholine-containing glyceroglycolipid
RU2414905C2 (ru) *	2005-12-23	2011-03-27	Н.В. Нютрисиа	Применение питательных композиций с фосфолипидами, сфинголипидами и холестерином

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2717547A1 (de) *	1977-04-20	1978-11-02	Max Planck Gesellschaft	Verfahren zur umesterung von phospholipiden mit phospholipase d

1983
- 1983-04-11 JP JP58063307A patent/JPS59187787A/ja active Granted
1984
- 1984-04-10 DK DK185584A patent/DK185584A/da not_active Application Discontinuation
- 1984-04-10 DE DE8484302446T patent/DE3477402D1/de not_active Expired
- 1984-04-10 US US06/598,696 patent/US4782019A/en not_active Expired - Fee Related
- 1984-04-10 EP EP84302446A patent/EP0122152B1/en not_active Expired

Also Published As

Publication number	Publication date
DK185584D0 (da)	1984-04-10
JPH028717B2 (da)	1990-02-26
US4782019A (en)	1988-11-01
EP0122152A2 (en)	1984-10-17
DE3477402D1 (en)	1989-04-27
JPS59187787A (ja)	1984-10-24
EP0122152B1 (en)	1989-03-22
EP0122152A3 (en)	1986-03-12

Legal Events

Date	Code	Title	Description
1997-12-22	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
DK185584A (da)	1984-10-12	Enzymatisk fremstilling af sphingophospholipidderivater
SE8602738D0 (sv)	1986-06-19	Gasoline composition
BR0002089A (pt)	2001-01-02	Processo a sìntese de análogos de nucleosìdeos
SE8305535L (sv)	1983-10-07	Lekemedelspreparat med antinikotinverkan och forfarande for framstellning derav
SE8205698L (sv)	1983-04-09	N-(4-(3-aminopropyl)aminobutyl-2-(omega-guanidinofettsyra-amido)-2-substituerad-etanamid, salt derav och forfarande for framstellning derav
ATE5854T1 (de)	1984-02-15	Zusammensetzungen zur verwendung bei der verminderung des appetites auf kohlenhydratkalorien.
KR870010864A (ko)	1987-12-18	O/w 형 에멀젼 조성물
KR870006039A (ko)	1987-07-08	신규 티아졸 화합물, 그 제조방법 및 이 화합물을 함유하는 약학적 조성물
DE3765336D1 (de)	1990-11-08	Stosswellengenerator zur erzeugung eines akustischen stosswellenimpulses.
SE8204918D0 (sv)	1982-08-27	Nya 3-amino-pregn-5-en-derivat, deras salter, sett for framstellning och anvendning derav som lekemedel och kompositioner innehallande dem
DE59208058D1 (de)	1997-04-03	Neue Tetrazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE69531546D1 (de)	2003-09-25	Synthetische gangliosid-derivate
KR830006198A (ko)	1983-09-20	시클로헥산 유도체의 제조방법
FI895921A0 (fi)	1989-12-12	Enzymhaemmande aminosyraderivat, foerfarande foer deras framstaellning, dessa innehaollande aemnen och deras anvaendning.
NO963496L (no)	1996-08-22	Injiserbare emulsjoner inneholdende antifungale derivater
KR840005733A (ko)	1984-11-16	무라밀 펩타이드의 제조방법
ATE49955T1 (de)	1990-02-15	Substituierte derivate von n\|thyl(meth)acrylamid, und verfahren zu ihrer herstellung.
IE841653L (en)	1984-12-30	Rooperol and its derivatives
ATE151749T1 (de)	1997-05-15	Synthese von indolen durch dehydrierung von indolinen
ATE132873T1 (de)	1996-01-15	Amphiphile nucleosidphosphatanaloga
ES8800252A1 (es)	1987-10-16	Procedimiento para la obtencion de derivados de hexosa acilados
ATE227289T1 (de)	2002-11-15	Verfahren zur herstellung von azyklischen nukleosiden
BR8405079A (pt)	1985-08-20	Composicoes organicas de titanio para uso em pocos de petroleo e gas
PT80992A (fr)	1985-09-01	Procede de preparation d'un derive de 1-<n-(alpha-amino-alpha- -methylacetyl)-aminophenyl>-2-amino-propanone
ES511869A0 (es)	1983-10-01	Procedimiento para preparar derivados de acido 5-aminometil-2,3-dihidro-2-oxo-1h-imidazol-4-carboxilico.