DK187785A - Chartreusinderivater og salte deraf, fremgangsmaade til fremstillingaf disse og antitumorpraeparater indeholdende saadanne forbindelser - Google Patents
Chartreusinderivater og salte deraf, fremgangsmaade til fremstillingaf disse og antitumorpraeparater indeholdende saadanne forbindelser Download PDFInfo
- Publication number
- DK187785A DK187785A DK187785A DK187785A DK187785A DK 187785 A DK187785 A DK 187785A DK 187785 A DK187785 A DK 187785A DK 187785 A DK187785 A DK 187785A DK 187785 A DK187785 A DK 187785A
- Authority
- DK
- Denmark
- Prior art keywords
- chartreus
- relationships
- derivatives
- salts
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
hvori X-^ er H eller en eventuelt substitueret alkylgruppe; X2 er en eventuelt substitueret alkyl-, alkylcarbonylalkyl-, phenyl-, phenylalkyl-, furyl- eller thienylgruppe; dersom X-j^ og X2 er eventuelt substituerede alkylgrupper samtidig, er det totale antal carbonatomer i alkylgrupperne 4 eller mindre; X1 er H, dersom X2 er en eventuelt substitueret phenyl-, phenylalkyl-, furyl- eller thienylgruppe, X.^ og X2 kan sammen med det nabostillede carbonatom danne en cycloalkyliden-
gruppe, gruppe, og Q er en
gruppe, en en
gruppe (hvor R, R’ og R" er even tuelt substituerede alkandiyl-, alkendiyl-, alkyndiyl-, cyclo-alkandiyl-, cycloalkendiyl- eller phenylengrupper; Z^, Z'^ og Z,r^ er H eller eventuelt substitueret alkyl; Z2 er H, en for-mylgruppe, en eventuelt substitueret alkyl-, alkylcarbonyl-, benzoyl- eller benzyloxycarbonylgruppe; Z1 og Z2 kan sammen med nitrogenatomet danne en eventuelt substitueret nitro gen-holdig heterocyclisk gruppe), en eventuelt substitueret alkyl-, alkenyl-, cycloalkyl-, cycloalkenyl-, alkylcarbonyl-, alkoxycarbonyl- eller phenylgruppe, idet det totale antal atomer i Q bortset fra H er 30 eller mindre.
Forbindelserne er lægemidler med kraftig antitumorvirkning. Præparater indeholdende ovennævnte forbindelser som den aktive be standdel.
Forbindelserne fremstilles ved forskellige fremgangsmåder. Chartreusinderivat som mellemprodukt med den almene formel
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59085719A JPS60228496A (ja) | 1984-04-27 | 1984-04-27 | チヤ−トルシン誘導体及びそれらを含有する抗癌剤 |
| JP8571984 | 1984-04-27 | ||
| JP26801284 | 1984-12-19 | ||
| JP59268012A JPS61145195A (ja) | 1984-12-19 | 1984-12-19 | エンド型チヤ−トルシン誘導体及びそれらを含有する抗癌剤 |
| JP60027708A JPS61189291A (ja) | 1985-02-15 | 1985-02-15 | チヤ−トルシン誘導体及びそれらを含有する抗癌剤 |
| JP2770885 | 1985-02-15 | ||
| JP60032391A JPS61191691A (ja) | 1985-02-20 | 1985-02-20 | エキソ型チヤ−トルシン誘導体及びそれらを含有する抗癌剤 |
| JP3239185 | 1985-02-20 | ||
| JP4057085 | 1985-03-01 | ||
| JP60040570A JPS61200997A (ja) | 1985-03-01 | 1985-03-01 | チヤ−トルシン誘導体及びそれらを含有する抗癌剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK187785D0 DK187785D0 (da) | 1985-04-26 |
| DK187785A true DK187785A (da) | 1985-10-28 |
| DK172675B1 DK172675B1 (da) | 1999-05-17 |
Family
ID=27520960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198501877A DK172675B1 (da) | 1984-04-27 | 1985-04-26 | Chartreusinderivater og salte deraf, fremgangsmåde til fremstilling af disse og antitumorpræparater indeholdende sådanne fo |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4760136A (da) |
| EP (1) | EP0159708B1 (da) |
| KR (1) | KR920002298B1 (da) |
| AU (1) | AU573334B2 (da) |
| CA (1) | CA1263645A (da) |
| DE (1) | DE3574706D1 (da) |
| DK (1) | DK172675B1 (da) |
| GR (1) | GR851018B (da) |
| IL (1) | IL75018A (da) |
| NZ (1) | NZ211872A (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3683822D1 (de) * | 1985-10-23 | 1992-03-19 | Ishihara Sangyo Kaisha | Chartreusinderivate und salze, diese enthaltende antitumorzusammensetzungen und verfahren zu ihrer herstellung. |
| EP0381138A3 (en) * | 1989-01-30 | 1991-11-06 | Banyu Pharmaceutical Co., Ltd. | Antitumor substance be-12406 |
| EP0381114B1 (en) * | 1989-01-30 | 1994-09-28 | Ishihara Sangyo Kaisha, Ltd. | Exo-3',4'-0-benzylidene-3"-demethylchartreusin and its salts |
| US5191073A (en) * | 1989-02-13 | 1993-03-02 | Miles Inc. | Chromogenic merocyanine enzyme substrates |
| US5122602A (en) * | 1989-02-13 | 1992-06-16 | Miles Inc. | Chromogenic merocyanine enzyme substrates |
| JPH02306947A (ja) * | 1989-05-01 | 1990-12-20 | Monsanto Co | キラルβ―アミノ酸の製造方法 |
| ZA923817B (en) * | 1991-05-30 | 1993-02-24 | Bristol Myers Squibb Co | Chemical modification of elsamicin a at the 3'and/or 4'oh groups |
| ZA923815B (en) * | 1991-05-30 | 1993-02-24 | Bristol Myers Squibb Co | Preparation of 6-o-acylelsamicin a derivatives |
| US5229371A (en) * | 1991-05-30 | 1993-07-20 | Bristol-Myers Squibb Company | Chemical modification of elsamicin A at the 3' and/or 4' OH groups |
| EP1768951A4 (en) * | 2004-06-17 | 2011-06-15 | Musc Found For Res Dev | NON-NATURAL AMINO ACIDS |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4565862A (en) * | 1982-11-29 | 1986-01-21 | Hoffmann-La Roche Inc. | Ethers of antibiotic X-14868A |
| US4521240A (en) * | 1983-04-29 | 1985-06-04 | Chevron Research Company | 5-C-Alkyl-3-O-arylmethyl or substituted arylmethyl-1,2-O-alkylidene-α- |
| US4518589A (en) * | 1983-10-03 | 1985-05-21 | Bristol-Myers Company | BBM-2478 Antibiotic complex |
-
1985
- 1985-04-23 US US06/726,384 patent/US4760136A/en not_active Expired - Lifetime
- 1985-04-23 CA CA000479767A patent/CA1263645A/en not_active Expired
- 1985-04-23 NZ NZ211872A patent/NZ211872A/xx unknown
- 1985-04-24 AU AU41688/85A patent/AU573334B2/en not_active Ceased
- 1985-04-24 IL IL75018A patent/IL75018A/xx not_active IP Right Cessation
- 1985-04-24 EP EP85104991A patent/EP0159708B1/en not_active Expired
- 1985-04-24 DE DE8585104991T patent/DE3574706D1/de not_active Expired - Fee Related
- 1985-04-26 DK DK198501877A patent/DK172675B1/da active
- 1985-04-26 KR KR1019850002848A patent/KR920002298B1/ko not_active Expired
- 1985-04-26 GR GR851018A patent/GR851018B/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL75018A0 (en) | 1985-08-30 |
| CA1263645A (en) | 1989-12-05 |
| GR851018B (da) | 1985-11-25 |
| AU573334B2 (en) | 1988-06-02 |
| EP0159708B1 (en) | 1989-12-13 |
| KR920002298B1 (ko) | 1992-03-21 |
| EP0159708A2 (en) | 1985-10-30 |
| DE3574706D1 (de) | 1990-01-18 |
| DK187785D0 (da) | 1985-04-26 |
| US4760136A (en) | 1988-07-26 |
| DK172675B1 (da) | 1999-05-17 |
| AU4168885A (en) | 1985-10-31 |
| IL75018A (en) | 1989-10-31 |
| EP0159708A3 (en) | 1986-10-01 |
| KR850007604A (ko) | 1985-12-07 |
| NZ211872A (en) | 1989-06-28 |
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