DK188183A - Thiomethylpyridinderivater, fremgangsmaade til deres fremstilling og laegemidler indeholdende disse forbindelser - Google Patents

Thiomethylpyridinderivater, fremgangsmaade til deres fremstilling og laegemidler indeholdende disse forbindelser Download PDF

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Publication number
DK188183A
DK188183A DK188183A DK188183A DK188183A DK 188183 A DK188183 A DK 188183A DK 188183 A DK188183 A DK 188183A DK 188183 A DK188183 A DK 188183A DK 188183 A DK188183 A DK 188183A
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group
compounds
procedures
preparation
optionally substituted
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DK188183A
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English (en)
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DK188183D0 (da
DK160500B (da
DK160500C (da
Inventor
Helmut Schickaneder
Heidrun Engler
Istvan Szelenyi
Original Assignee
Heumann Ludwig & Co Gmbh
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Application filed by Heumann Ludwig & Co Gmbh filed Critical Heumann Ludwig & Co Gmbh
Publication of DK188183D0 publication Critical patent/DK188183D0/da
Publication of DK188183A publication Critical patent/DK188183A/da
Publication of DK160500B publication Critical patent/DK160500B/da
Application granted granted Critical
Publication of DK160500C publication Critical patent/DK160500C/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Description

er en lavere alkylgruppe, et halogenatom eller en aminoalkyl= gruppe, n har værdien 0 til 4, samt deres terapeutisk anvendelige syreadditionssalte. De hidtil ukendte forbindelser udmærker sig ved en overraskende aktivitet sammenlignet med kendte forbindelser, såsom ambroxol.
DK188183A 1982-05-05 1983-04-27 Analogifremgangsmaade til fremstilling af 3-thiomethylpyridinderivater DK160500C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3216843 1982-05-05
DE3216843A DE3216843C2 (de) 1982-05-05 1982-05-05 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (4)

Publication Number Publication Date
DK188183D0 DK188183D0 (da) 1983-04-27
DK188183A true DK188183A (da) 1983-11-06
DK160500B DK160500B (da) 1991-03-18
DK160500C DK160500C (da) 1991-08-26

Family

ID=6162790

Family Applications (1)

Application Number Title Priority Date Filing Date
DK188183A DK160500C (da) 1982-05-05 1983-04-27 Analogifremgangsmaade til fremstilling af 3-thiomethylpyridinderivater

Country Status (19)

Country Link
US (2) US4866066A (da)
EP (1) EP0093252B1 (da)
JP (1) JPS58203965A (da)
KR (1) KR860001578B1 (da)
AT (1) ATE32894T1 (da)
AU (1) AU565518B2 (da)
CA (1) CA1213279A (da)
DD (1) DD208801A5 (da)
DE (2) DE3216843C2 (da)
DK (1) DK160500C (da)
ES (1) ES520774A0 (da)
GR (1) GR78961B (da)
HU (1) HU189272B (da)
IE (1) IE55263B1 (da)
IL (1) IL68228A (da)
MX (1) MX7122E (da)
PT (1) PT76614B (da)
YU (1) YU91483A (da)
ZA (1) ZA832203B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5025016A (en) * 1983-05-05 1991-06-18 Ludwig Heumann & Co. Gmbh Pyrimidine-thioalkyl pyridine derivatives, medicaments containing these compounds, and method of treatment

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
GB2161160B (en) * 1984-07-06 1989-05-24 Fisons Plc Heterocyclic sulphinyl compounds
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
EP1659881B1 (en) 2003-08-06 2019-04-03 Senomyx Inc. Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
JP2008530017A (ja) * 2005-02-04 2008-08-07 セノミックス インコーポレイテッド 食料用組成物のための風味調整剤として連結された有機部分を含む分子
CN101384183B (zh) * 2005-02-04 2012-07-04 西诺米克斯公司 包含连接有杂芳基部分的化合物及其作为用于食物组合物的新型鲜味调节剂、促味剂和味觉增强剂的应用
TW200715993A (en) * 2005-06-15 2007-05-01 Senomyx Inc Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers
DK3235811T3 (da) 2006-04-21 2018-11-12 Senomyx Inc Fremgangsmåde til fremstilling af oxalamider

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1239017A (da) * 1968-02-22 1971-07-14
GB1234058A (da) * 1968-10-21 1971-06-03
GB1406882A (en) * 1972-04-28 1975-09-17 Leo Pharm Prod Ltd Benzoic acid derivatives and benzisptjoaup'e 1.1 dopxode derovatoves
GB1434405A (en) * 1973-09-06 1976-05-05 Leo Pharm Prod Ltd Phenyl-benzoic acid derivatives
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
JPS52125170A (en) * 1976-04-12 1977-10-20 Yoshitomi Pharmaceut Ind Ltd Pyridine derivatives
IT1092343B (it) * 1978-02-02 1985-07-06 Poli Ind Chimica Spa Pirimidilsolfuri ad attivita' antisecretoria,processo per la loro preparazione e composizioni farmaceutiche che li contengono
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
GB2038825B (en) * 1978-12-16 1983-02-09 Wyeth John & Brother Ltd Heterocyclic compounds substituted by heterocyclyl-alkyl-thio groups
GB2069493B (en) * 1980-02-20 1984-02-29 Wyeth John & Brother Ltd Pyridine derivatives
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
IL66340A (en) * 1981-08-13 1986-08-31 Haessle Ab Pharmaceutical compositions comprising pyridylmethyl-thiobenzimidazole derivatives,certain such novel derivatives and their preparation
US4546113A (en) * 1983-04-14 1985-10-08 Pfizer Inc. Antiprotozoal diamidines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5025016A (en) * 1983-05-05 1991-06-18 Ludwig Heumann & Co. Gmbh Pyrimidine-thioalkyl pyridine derivatives, medicaments containing these compounds, and method of treatment

Also Published As

Publication number Publication date
US4866066A (en) 1989-09-12
JPS58203965A (ja) 1983-11-28
DK188183D0 (da) 1983-04-27
DK160500B (da) 1991-03-18
ATE32894T1 (de) 1988-03-15
ES8401755A1 (es) 1984-01-01
HU189272B (en) 1986-06-30
DK160500C (da) 1991-08-26
DE3375917D1 (en) 1988-04-14
PT76614B (de) 1986-01-17
EP0093252B1 (de) 1988-03-09
IL68228A0 (en) 1983-06-15
DE3216843C2 (de) 1986-10-23
US4810715A (en) 1989-03-07
EP0093252A2 (de) 1983-11-09
KR860001578B1 (ko) 1986-10-10
MX7122E (es) 1987-06-29
GR78961B (da) 1984-10-02
IE55263B1 (en) 1990-07-18
IE830976L (en) 1983-11-05
CA1213279A (en) 1986-10-28
DD208801A5 (de) 1984-04-11
PT76614A (de) 1983-05-01
ZA832203B (en) 1983-12-28
ES520774A0 (es) 1984-01-01
DE3216843A1 (de) 1983-11-17
YU91483A (en) 1986-02-28
AU1264883A (en) 1983-11-10
IL68228A (en) 1987-12-20
AU565518B2 (en) 1987-09-17
KR840004076A (ko) 1984-10-06
EP0093252A3 (en) 1984-08-22

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