DK188384A - Fremgangsmaade til fremstilling af sekundaere aminer - Google Patents

Fremgangsmaade til fremstilling af sekundaere aminer Download PDF

Info

Publication number: DK188384A
Authority: DK; Denmark
Prior art keywords: procedure; preparation; secondary amines; lower alkyl; zepines
Prior art date: 1983-04-28

Application number

DK188384A

Other languages

English (en)

Other versions

DK188384D0 (da

DK162980B (da

DK162980C (da

Inventor

Alan William Tremper

Kathleen Laura Wert

Original Assignee

Smithkline Beckman Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-28

Filing date

1984-04-11

Publication date

1984-10-29

1984-04-11 Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp

1984-04-11 Publication of DK188384D0 publication Critical patent/DK188384D0/da

1984-10-29 Publication of DK188384A publication Critical patent/DK188384A/da

1992-01-06 Publication of DK162980B publication Critical patent/DK162980B/da

1992-06-01 Application granted granted Critical

1992-06-01 Publication of DK162980C publication Critical patent/DK162980C/da

Links

150000003335 secondary amines Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract description 3
YTKGUKHQYUHYTQ-UHFFFAOYSA-N 2-(2-chloro-3,4-dimethoxyphenyl)ethanamine Chemical compound COC1=CC=C(CCN)C(Cl)=C1OC YTKGUKHQYUHYTQ-UHFFFAOYSA-N 0.000 abstract 1
LNZBSIXPXJKKDF-UHFFFAOYSA-N 2-(4-methoxyphenyl)-2-oxoacetaldehyde Chemical compound COC1=CC=C(C(=O)C=O)C=C1 LNZBSIXPXJKKDF-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
-1 thio compound Chemical class 0.000 description 2
206010020772 Hypertension Diseases 0.000 description 1
125000003158 alcohol group Chemical group 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
229940005501 dopaminergic agent Drugs 0.000 description 1
125000000468 ketone group Chemical group 0.000 description 1
230000008085 renal dysfunction Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/50—Machine tool, machine tool null till machine tool work handling
- G05B2219/50103—Restart, reverse, return along machined path, stop

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

hvori R^ er som ovenfor defineret, med en p-methoxyphenyl-glyoxal-lavere alkylhemimercaptal til fremstilling af en thioforbindelse med formlen

hvori R er en lavere alkylgruppe, og R^ er som ovenfor defineret, og omsætning af nævnte thioforbindelse med et reducerende middel, der omdanner ketogruppen til en alkoholgruppe.

Forbindelserne kan anvendes som dopaminergiske midler til behandling af forhøjet blodtryk og nyredysfunktion.

DK188384A 1983-04-28 1984-04-11 Fremgangsmaade til fremstilling af sekundaere aminer DK162980C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/489,654 US4540819A (en)	1983-04-28	1983-04-28	Process for preparing secondary amines
US48965483		1983-04-28

Publications (4)

Publication Number	Publication Date
DK188384D0 DK188384D0 (da)	1984-04-11
DK188384A true DK188384A (da)	1984-10-29
DK162980B DK162980B (da)	1992-01-06
DK162980C DK162980C (da)	1992-06-01

Family

ID=23944726

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK188384A DK162980C (da)	1983-04-28	1984-04-11	Fremgangsmaade til fremstilling af sekundaere aminer

Country Status (13)

Country	Link
US (1)	US4540819A (da)
EP (1)	EP0125053B1 (da)
JP (1)	JPS59206339A (da)
AT (1)	ATE22285T1 (da)
AU (1)	AU573209B2 (da)
CA (1)	CA1210780A (da)
DE (1)	DE3460757D1 (da)
DK (1)	DK162980C (da)
ES (1)	ES8506584A1 (da)
GR (1)	GR81490B (da)
IE (1)	IE57250B1 (da)
PT (1)	PT78470B (da)
ZA (1)	ZA842474B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4579972A (en) *	1983-04-28	1986-04-01	Smithkline Beckman Corporation	Intermediates for preparing secondary amines
US4781173A (en) *	1985-06-28	1988-11-01	Juha Ven	Evaporating device and electric supply station provided with such an evaporating device
MX2007008849A (es) *	2005-01-24	2007-08-21	Sicor Inc	Proceso para la preparacion de mesilato de fenoldopam.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3345416A (en) *	1963-09-04	1967-10-03	Dept Of Chemistry	Preparation and rearrangement of beta-ketosulfoxides
AT338242B (de) *	1975-09-25	1977-08-10	Tanabe Seiyaku Co	Verfahren zur herstellung neuer racemischer und optisch aktiver 1-hydroxyphenyl-2-(3',4'-dimethoxyphenathyl)aminoathanole-(1)
US4197297A (en) *	1976-11-17	1980-04-08	Smithkline Corporation	6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
CH637383A5 (en) *	1978-01-01	1983-07-29	Smithkline Beckman Corp	Trisubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, and their salts
IT1148741B (it) *	1980-11-28	1986-12-03	Zambeletti Spa L	Procedimento per la preparazione dell'1-(3,5-dimetossi-4-idrossifenil)-2-(n-metilammino)etanolo cloridrato

1983
- 1983-04-28 US US06/489,654 patent/US4540819A/en not_active Expired - Fee Related
1984
- 1984-04-03 ZA ZA842474A patent/ZA842474B/xx unknown
- 1984-04-10 AU AU26680/84A patent/AU573209B2/en not_active Ceased
- 1984-04-11 CA CA000451717A patent/CA1210780A/en not_active Expired
- 1984-04-11 DK DK188384A patent/DK162980C/da active
- 1984-04-13 AT AT84302552T patent/ATE22285T1/de active
- 1984-04-13 DE DE8484302552T patent/DE3460757D1/de not_active Expired
- 1984-04-13 EP EP84302552A patent/EP0125053B1/en not_active Expired
- 1984-04-23 PT PT78470A patent/PT78470B/pt not_active IP Right Cessation
- 1984-04-25 JP JP59085080A patent/JPS59206339A/ja active Granted
- 1984-04-26 IE IE1022/84A patent/IE57250B1/en not_active IP Right Cessation
- 1984-04-26 GR GR74516A patent/GR81490B/el unknown
- 1984-04-27 ES ES531975A patent/ES8506584A1/es not_active Expired

Also Published As

Publication number	Publication date
DK188384D0 (da)	1984-04-11
GR81490B (da)	1984-12-11
ES531975A0 (es)	1985-08-01
US4540819A (en)	1985-09-10
DE3460757D1 (en)	1986-10-23
AU573209B2 (en)	1988-06-02
PT78470A (en)	1984-05-01
AU2668084A (en)	1984-11-01
ATE22285T1 (de)	1986-10-15
DK162980B (da)	1992-01-06
IE841022L (en)	1984-10-28
IE57250B1 (en)	1992-06-17
JPH0472818B2 (da)	1992-11-19
EP0125053B1 (en)	1986-09-17
JPS59206339A (ja)	1984-11-22
ES8506584A1 (es)	1985-08-01
EP0125053A1 (en)	1984-11-14
DK162980C (da)	1992-06-01
CA1210780A (en)	1986-09-02
ZA842474B (en)	1985-04-24
PT78470B (en)	1986-08-28

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