DK91782A - Fremgangsmaade til fremstilling af pyridazioner eller syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af pyridazioner eller syreadditionssalte deraf Download PDF

Info

Publication number: DK91782A
Authority: DK; Denmark
Prior art keywords: pyridazions; preparing; procedure; additional salts; acid additional
Prior art date: 1981-03-04

Application number

DK91782A

Other languages

English (en)

Other versions

DK148772C (da

DK148772B (da

Inventor

R Goeschke

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-03-04

Filing date

1982-03-03

Publication date

1982-09-05

1982-03-03 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1982-09-05 Publication of DK91782A publication Critical patent/DK91782A/da

1985-09-23 Publication of DK148772B publication Critical patent/DK148772B/da

1986-05-12 Application granted granted Critical

1986-05-12 Publication of DK148772C publication Critical patent/DK148772C/da

Links

239000002253 acid Substances 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
-1 amino, acetylamino, methyl Chemical group 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
229910052740 iodine Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Treating Waste Gases (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Chemical And Physical Treatments For Wood And The Like (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK91782A 1981-03-04 1982-03-03 Analogifremgangsmaade til fremstilling af 6-(4-morpholinophenyl)-4,5-dihydro-3(2h)-pyridazinoner eller syreadditionssalte deraf DK148772C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH144381		1981-03-04
CH144381		1981-03-04

Publications (3)

Publication Number	Publication Date
DK91782A true DK91782A (da)	1982-09-05
DK148772B DK148772B (da)	1985-09-23
DK148772C DK148772C (da)	1986-05-12

Family

ID=4210578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91782A DK148772C (da)	1981-03-04	1982-03-03	Analogifremgangsmaade til fremstilling af 6-(4-morpholinophenyl)-4,5-dihydro-3(2h)-pyridazinoner eller syreadditionssalte deraf

Country Status (24)

Country	Link
US (3)	US4613599A (da)
EP (1)	EP0059688B1 (da)
JP (1)	JPS57158762A (da)
AT (1)	ATE13294T1 (da)
AU (1)	AU558039B2 (da)
CA (1)	CA1180703A (da)
CY (1)	CY1396A (da)
DD (1)	DD209461A5 (da)
DE (1)	DE3263497D1 (da)
DK (1)	DK148772C (da)
ES (4)	ES510055A0 (da)
FI (1)	FI72718C (da)
GB (1)	GB2094302B (da)
GR (1)	GR81397B (da)
HK (1)	HK87687A (da)
HU (1)	HU191083B (da)
IE (1)	IE52672B1 (da)
IL (1)	IL65161A (da)
MY (1)	MY8700736A (da)
NO (1)	NO158135C (da)
NZ (1)	NZ199892A (da)
PT (1)	PT74520B (da)
SG (1)	SG59587G (da)
ZA (1)	ZA821397B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4734415A (en) *	1982-08-13	1988-03-29	Warner-Lambert Company	Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
GB8400863D0 (en) *	1984-01-13	1984-02-15	Smith Kline French Lab	Chemical compounds
GB8426804D0 (en) *	1984-10-23	1984-11-28	Ciba Geigy Ag	Pyridazinones preparations
JPS61158969A (ja) *	1984-12-24	1986-07-18	ワーナー‐ランバート・コンパニー	４，５‐ジヒドロ‐４，４‐ジアルキル‐６‐（置換）フエニル‐３（２ｈ）‐ピリダジノン類
IL79280A (en) *	1985-07-05	1990-07-12	Smith Kline French Lab	4-(6-oxo-dihydro or tetrahydropyridazin-3-yl)benzene derivatives,their preparation and pharmaceutical compositions containing them
US4970210A (en) *	1987-07-17	1990-11-13	Abbott Laboratories	Triazinone lipoxygenase compounds
DE3735207A1 (de) *	1987-10-17	1989-04-27	Basf Ag	Mittel auf der basis von phenylpyridazinon-derivaten zur wachstumsfoerderung und fettreduktion bei tieren
WO2014164704A2 (en) *	2013-03-11	2014-10-09	The Broad Institute, Inc.	Compounds and compositions for the treatment of cancer
JOP20200024A1 (ar)	2017-08-04	2020-02-02	Bayer Ag	مركبات ثنائي هيدروكساديازينون
EP3661917B1 (en) *	2017-08-04	2022-05-11	Bayer Aktiengesellschaft	6-((3-trifluoromethyl)phenyl)-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
AU2020215088A1 (en)	2019-02-01	2021-07-22	Bayer Aktiengesellschaft	1,2,4-triazin-3(2H)-one compounds for the treatment of hyperproliferative diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1488330A (en) *	1923-02-01	1924-03-25	Everitt James	Clothes-hanging bar formed of hinged-together members
IL37788A0 (en) *	1970-10-09	1971-12-29	American Cyanamid Co	New pyridazinone compounds,their preparation and pharmaceutical compositions containing them
US3975388A (en) *	1971-02-22	1976-08-17	Bdh Pharmaceuticals Limited	Pyridazinones
GB1383906A (en) *	1971-02-22	1974-02-12	Bdh Pharmaceuticals Ltd	Pyridazinones
GB1488330A (en) *	1973-12-19	1977-10-12	Smith Kline French Lab	Dihydropyridazinones
DE2854191A1 (de) *	1978-12-15	1980-07-03	Basf Ag	Dihydropyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel

1982
- 1982-02-26 DE DE8282810090T patent/DE3263497D1/de not_active Expired
- 1982-02-26 FI FI820699A patent/FI72718C/fi not_active IP Right Cessation
- 1982-02-26 AT AT82810090T patent/ATE13294T1/de active
- 1982-02-26 EP EP82810090A patent/EP0059688B1/de not_active Expired
- 1982-03-02 CA CA000397433A patent/CA1180703A/en not_active Expired
- 1982-03-02 GB GB8205989A patent/GB2094302B/en not_active Expired
- 1982-03-02 ES ES510055A patent/ES510055A0/es active Granted
- 1982-03-02 CY CY139682A patent/CY1396A/en unknown
- 1982-03-02 GR GR67459A patent/GR81397B/el unknown
- 1982-03-03 DD DD82237856A patent/DD209461A5/de unknown
- 1982-03-03 AU AU81065/82A patent/AU558039B2/en not_active Ceased
- 1982-03-03 ZA ZA821397A patent/ZA821397B/xx unknown
- 1982-03-03 IL IL65161A patent/IL65161A/xx unknown
- 1982-03-03 NO NO820670A patent/NO158135C/no unknown
- 1982-03-03 PT PT74520A patent/PT74520B/pt unknown
- 1982-03-03 NZ NZ199892A patent/NZ199892A/en unknown
- 1982-03-03 DK DK91782A patent/DK148772C/da not_active IP Right Cessation
- 1982-03-03 IE IE478/82A patent/IE52672B1/en unknown
- 1982-03-03 HU HU82652A patent/HU191083B/hu unknown
- 1982-03-04 JP JP57033169A patent/JPS57158762A/ja active Pending
1983
- 1983-02-23 ES ES520022A patent/ES8403892A1/es not_active Expired
- 1983-02-23 ES ES520023A patent/ES520023A0/es active Granted
- 1983-02-23 ES ES520024A patent/ES520024A0/es active Granted
1985
- 1985-07-24 US US06/758,833 patent/US4613599A/en not_active Expired - Fee Related
1986
- 1986-05-05 US US06/859,684 patent/US4654340A/en not_active Expired - Fee Related
- 1986-11-28 US US06/935,901 patent/US4704391A/en not_active Expired - Fee Related
1987
- 1987-07-22 SG SG595/87A patent/SG59587G/en unknown
- 1987-11-26 HK HK876/87A patent/HK87687A/xx unknown
- 1987-12-30 MY MY736/87A patent/MY8700736A/xx unknown

Also Published As

Publication number	Publication date
SG59587G (en)	1987-10-23
CA1180703A (en)	1985-01-08
NO158135B (no)	1988-04-11
IE820478L (en)	1982-09-04
ATE13294T1 (de)	1985-06-15
DK148772C (da)	1986-05-12
PT74520A (de)	1982-04-01
ES8308561A1 (es)	1983-09-16
ES520022A0 (es)	1984-04-01
FI72718C (fi)	1987-07-10
ES8403894A1 (es)	1984-04-01
IL65161A0 (en)	1982-05-31
MY8700736A (en)	1987-12-31
AU558039B2 (en)	1987-01-15
NO158135C (no)	1988-07-20
FI72718B (fi)	1987-03-31
EP0059688A1 (de)	1982-09-08
ES8403892A1 (es)	1984-04-01
PT74520B (de)	1984-11-19
ZA821397B (en)	1983-01-26
NZ199892A (en)	1985-05-31
ES8403893A1 (es)	1984-04-01
IL65161A (en)	1985-05-31
US4613599A (en)	1986-09-23
DK148772B (da)	1985-09-23
FI820699L (fi)	1982-09-05
HK87687A (en)	1987-12-04
CY1396A (en)	1987-12-18
IE52672B1 (en)	1988-01-20
GR81397B (da)	1984-12-11
GB2094302B (en)	1984-10-10
ES520024A0 (es)	1984-04-01
AU8106582A (en)	1982-09-09
ES510055A0 (es)	1983-09-16
GB2094302A (en)	1982-09-15
US4704391A (en)	1987-11-03
JPS57158762A (en)	1982-09-30
DE3263497D1 (en)	1985-06-20
ES520023A0 (es)	1984-04-01
HU191083B (en)	1987-01-28
US4654340A (en)	1987-03-31
EP0059688B1 (de)	1985-05-15
DD209461A5 (de)	1984-05-09
NO820670L (no)	1982-09-06

Legal Events

Date	Code	Title	Description
1987-11-30	AHB	Application shelved due to non-payment
1989-11-13	PBP	Patent lapsed

Publication	Publication Date	Title
DK154978C (da)	1989-06-12	Analogifremgangsmaade til fremstilling af 1-carboxy-(alkanoyl eller aralkanoyl)-indolin-2-carboxylsyrederivater eller stereoisomere salte deraf
DK154417C (da)	1989-04-10	Fremgangsmaade til fremstilling af di-n-propyleddikesyre eller dens ikke-toksiske akalimetal- eller jordalkalimetalsalte
DK45081A (da)	1981-08-05	Fremgangsmaade til fremstilling af 2-(2-(1,4-benzodioxanyl) )--imidazolin eller ikke-toxiske syreadditionssalte deraf
AU558039B2 (en)	1987-01-15	Pyridazinones
ATE9794T1 (de)	1984-10-15	Indolderivate und verfahren zu ihrer herstellung.
DK321482A (da)	1983-01-19	Fremgangsmaade til fremstilling af 1-imidazolyl-2-phenyl-8-piperazinylphenoxy-octan-2-ol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
ES543368A0 (es)	1986-08-01	Procedimiento para la obtencion de derivados de 1-fluoro-1- -azolil-2,2-diaril-etano
DK438482A (da)	1983-04-06	Fremgangsmaade til fremstilling af indanderivater eller syreadditionssalte deraf
DK154979C (da)	1989-07-10	Analogifremgangsmaade til fremstilling af phenethanolaminderivater eller farmaceutisk acceptable syreadditionssalte deraf
SE8200309L (sv)	1982-07-23	Guanidinocyklohexankarboxylsyraderivat
DK553982A (da)	1983-06-15	Fremgangsmaade til fremstilling af omt-esterderivater eller syreadditionssalte deraf
DE3566666D1 (en)	1989-01-12	Substituted pyridazinones, method for their preparation, pharmaceutical preparation containing these compounds and their use
DK148036C (da)	1985-07-15	Analogifremgangsmaade til fremstilling af epimere 4''-amino-erythromycin-forbindelser eller syreadditionssalte deraf
DK488282A (da)	1983-05-05	Fremgangsmaade til fremstilling af imidazolcarboxylsyrederivater
DK148709C (da)	1986-04-28	Analogifremgangsmaade til fremstilling af n',n'-disubstituerede n-amino-alkanoyl-4,6-dimethyl-o-anisidiner eller ikke-toxiske syreadditionssalte heraf
DK295782A (da)	1983-01-08	Fremgangsmaade til fremstilling af cystinderivater eller syreadditionssalte deraf
DK101082A (da)	1982-12-30	Fremgangsmaade til fremstilling af 1-fenyltio-2-aminopropanderivater eller syreadditionssalte deraf
DK333081A (da)	1983-01-25	Fremgangsmaade til fremstilling af 2-(4-hydroxyalkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-onderivater eller terapeutisk aacceptable syreadditionssalte deraf
DK24082A (da)	1982-09-07	Fremgangsmaade til fremstilling af syreadditionssalte af 3,4-diacyloxy-alfa-( (methylamino)-methyl)-benzylalkohol
DK194781A (da)	1982-11-02	Fremgangsmaade til fremstilling af 16-aminoprostaglandinderivater eller syreadditionssalte deraf