DK1886112T3 - Fremgangsmåde til Måling af metabolismen af neuralt afledte biomolekyler in vivo - Google Patents

Fremgangsmåde til Måling af metabolismen af neuralt afledte biomolekyler in vivo

Info

Publication number
DK1886112T3
DK1886112T3 DK06749116.7T DK06749116T DK1886112T3 DK 1886112 T3 DK1886112 T3 DK 1886112T3 DK 06749116 T DK06749116 T DK 06749116T DK 1886112 T3 DK1886112 T3 DK 1886112T3
Authority
DK
Denmark
Prior art keywords
metabolism
vivo
procedure
measuring
derived biomolecules
Prior art date
Application number
DK06749116.7T
Other languages
English (en)
Inventor
Randall John Bateman
David Michael Holtzman
Original Assignee
Univ St Louis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ St Louis filed Critical Univ St Louis
Application granted granted Critical
Publication of DK1886112T3 publication Critical patent/DK1886112T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK06749116.7T 2005-04-06 2006-04-04 Fremgangsmåde til Måling af metabolismen af neuralt afledte biomolekyler in vivo DK1886112T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66863405P 2005-04-06 2005-04-06
PCT/US2006/012200 WO2006107814A2 (en) 2005-04-06 2006-04-04 Methods for measuring the metabolism of neurally derived biomolecules in vivo

Publications (1)

Publication Number Publication Date
DK1886112T3 true DK1886112T3 (da) 2014-09-08

Family

ID=37073989

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06749116.7T DK1886112T3 (da) 2005-04-06 2006-04-04 Fremgangsmåde til Måling af metabolismen af neuralt afledte biomolekyler in vivo

Country Status (9)

Country Link
US (5) US7892845B2 (da)
EP (1) EP1886112B1 (da)
JP (1) JP5116662B2 (da)
CN (1) CN101374555B (da)
AU (1) AU2006232338B2 (da)
CA (1) CA2604057C (da)
DK (1) DK1886112T3 (da)
ES (1) ES2498973T3 (da)
WO (1) WO2006107814A2 (da)

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US7449171B2 (en) 2002-02-12 2008-11-11 The Regents Of The University Of California Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolic products
WO2004011426A2 (en) 2002-07-30 2004-02-05 The Regents Of The University Of California Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
ATE415486T1 (de) 2002-09-13 2008-12-15 Univ California Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese
CA2504313C (en) 2002-11-04 2012-01-17 Marc K. Hellerstein Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
US7262020B2 (en) 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
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TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
JP4118918B2 (ja) 2005-02-28 2008-07-16 シャープ株式会社 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体
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US20090142766A1 (en) * 2007-11-09 2009-06-04 Washington University In St. Louis Methods for measuring the metabolism of cns derived biomolecules in vivo
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US7972868B2 (en) * 2007-11-28 2011-07-05 Quest Diagnostics Investments Incorporated Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry
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US7977117B2 (en) 2009-12-03 2011-07-12 Quest Diagnostics Investments Incorprated Vitamin D metabolite determination utilizing mass spectrometry following derivatization
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US20110203007A1 (en) * 2010-02-16 2011-08-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Assays of neurodegenerative disorders, including frontotemporal dementia and amyotrophic lateral sclerosis
DK2575596T3 (da) * 2010-05-24 2016-08-01 Univ Washington Fremgangsmåde til bestemmelse af amyloid-beta-omsætning i blod.
WO2011149461A1 (en) 2010-05-27 2011-12-01 Medtronic, Inc. Anti-amyloid beta antibodies conjugated to sialic acid-containing molecules
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WO2013036885A1 (en) 2011-09-08 2013-03-14 The Regents Of The University Of California Metabolic flux measurement, imaging and microscopy
ES2711876T3 (es) 2011-09-19 2019-05-08 C2N Diagnostics Métodos para el diagnóstico y tratamiento de las enfermedades neurológicas y neurodegenerativas, trastornos y procesos asociados
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JP6129868B2 (ja) * 2011-12-19 2017-05-17 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ アルツハイマー病を診断するための方法
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
WO2015103183A1 (en) * 2014-01-02 2015-07-09 Jasper John P Method for continuously monitoring chemical or biological processes
BR112017006419A2 (pt) * 2014-09-30 2017-12-19 Univ Washington medições cinéticas de tau
CN105021758B (zh) * 2015-07-27 2017-05-10 中国科学院生物物理研究所 一种基于化学衍生的磷脂分类检测和定量方法
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
US11313862B2 (en) * 2016-03-03 2022-04-26 Toagosei Co., Ltd. Method for diagnosing amyotrophic lateral sclerosis using signal peptide as indicator
WO2018148593A1 (en) * 2017-02-10 2018-08-16 C2N Diagnostics, Llc Methods for measuring concentrations of biomolecules in biofluids
WO2018204406A1 (en) 2017-05-01 2018-11-08 Washington University BLOOD-BASED METHODS FOR DETERMINING Aβ AMYLOIDOSIS
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Also Published As

Publication number Publication date
WO2006107814A2 (en) 2006-10-12
CN101374555A (zh) 2009-02-25
US20140199718A1 (en) 2014-07-17
CA2604057C (en) 2014-02-11
AU2006232338B2 (en) 2011-08-11
US7892845B2 (en) 2011-02-22
CA2604057A1 (en) 2006-10-12
US20160139142A1 (en) 2016-05-19
AU2006232338A1 (en) 2006-10-12
AU2006232338A2 (en) 2006-10-12
EP1886112A2 (en) 2008-02-13
EP1886112A4 (en) 2009-05-06
US8232107B2 (en) 2012-07-31
ES2498973T3 (es) 2014-09-26
WO2006107814A3 (en) 2008-10-02
US20080145941A1 (en) 2008-06-19
EP1886112B1 (en) 2014-07-09
JP5116662B2 (ja) 2013-01-09
US20120282642A1 (en) 2012-11-08
JP2008538811A (ja) 2008-11-06
CN101374555B (zh) 2013-04-17
US20110111511A1 (en) 2011-05-12

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