DK1887359T3 - Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K - Google Patents

Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K

Info

Publication number
DK1887359T3
DK1887359T3 DK06016205T DK06016205T DK1887359T3 DK 1887359 T3 DK1887359 T3 DK 1887359T3 DK 06016205 T DK06016205 T DK 06016205T DK 06016205 T DK06016205 T DK 06016205T DK 1887359 T3 DK1887359 T3 DK 1887359T3
Authority
DK
Denmark
Prior art keywords
pi3k
phenylthiazole ligand
immobilized
phenylthiazole
ligand
Prior art date
Application number
DK06016205T
Other languages
English (en)
Inventor
Moore Giovanna Bergamini
Andrew Cansfield
Nigel Ramsden
Gitte Neubauer
Original Assignee
Cellzome Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ag filed Critical Cellzome Ag
Application granted granted Critical
Publication of DK1887359T3 publication Critical patent/DK1887359T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Networks Using Active Elements (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK06016205T 2006-08-03 2006-08-03 Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K DK1887359T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06016205A EP1887359B1 (en) 2006-08-03 2006-08-03 Methods for the identification of PI3K interacting molecules and for the purification of PI3K

Publications (1)

Publication Number Publication Date
DK1887359T3 true DK1887359T3 (da) 2009-03-02

Family

ID=37635850

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06016205T DK1887359T3 (da) 2006-08-03 2006-08-03 Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K

Country Status (11)

Country Link
US (1) US8153389B2 (da)
EP (1) EP1887359B1 (da)
JP (1) JP5234668B2 (da)
CN (1) CN101563612B (da)
AT (1) ATE414281T1 (da)
AU (1) AU2007280631B2 (da)
CA (1) CA2658904A1 (da)
DE (1) DE602006003651D1 (da)
DK (1) DK1887359T3 (da)
ES (1) ES2317382T3 (da)
WO (1) WO2008015013A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2549862T3 (es) 2006-08-30 2015-11-02 Cellzome Limited Derivados de triazol como inhibidores de quinasa
EP2222674B8 (en) 2007-11-27 2016-01-06 Cellzome Limited Amino triazoles as pi3k inhibitors
WO2009098021A1 (en) 2008-02-04 2009-08-13 Cellzome Ag Selectivity profiling of pi3k interacting molecules against multiple targets
CA2723852A1 (en) * 2008-05-16 2009-11-19 Cellzome Ag Methods for the identification of parp interacting molecules and for the purification of parp proteins
WO2010092015A1 (en) 2009-02-10 2010-08-19 Cellzome Limited Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors
EP2406258B1 (en) 2009-03-13 2014-12-03 Cellzome Limited PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2414337B1 (en) 2009-04-03 2013-05-01 Cellzome GmbH Methods for the identification of kinase interacting molecules and for the purification of kinase proteins
US8367830B2 (en) 2009-05-20 2013-02-05 Cellzome Ag Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins
EP2542536B1 (en) 2010-03-04 2015-01-21 Cellzome Limited Morpholino substituted urea derivatives as mtor inhibitors
WO2012136622A1 (en) 2011-04-04 2012-10-11 Cellzome Limited Dihydropyrrolo pyrimidine derivatives as mtor inhibitors
CA2849189A1 (en) 2011-09-21 2013-03-28 Cellzome Limited Morpholino substituted urea or carbamate derivatives as mtor inhibitors
JP5995977B2 (ja) 2011-10-07 2016-09-21 セルゾーム リミテッド Ｍｔｏｒ阻害剤としてのモルホリノ置換二環式ピリミジン尿素またはカルバメート誘導体
WO2014144858A1 (en) * 2013-03-15 2014-09-18 Icahn School Of Medicine At Mount Sinai Therapeutic methods for treating solid tumors and related diagnostic methods
CN115754306A (zh) * 2022-12-02 2023-03-07 中国科学院生态环境研究中心 化合物下拉靶点蛋白的方法
CN116773823A (zh) * 2023-06-25 2023-09-19 济宁医学院附属医院 一种快速鉴定与蛋白相互作用的小分子代谢物配体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952512A (en) * 1984-06-22 1990-08-28 Loskutoff David J Gene encoding an inhibitor of tissue-type and urokinase-type plasminogen activators
US5994082A (en) * 1994-08-26 1999-11-30 Mach; Bernard Methods for the identification of inhibitors which suppress the activity of proteins displaying CIITA activity
WO1998020126A1 (en) * 1996-11-01 1998-05-14 Onyx Pharmaceuticals, Inc. Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof
AR038703A1 (es) 2002-02-28 2005-01-26 Novartis Ag Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3
NZ546611A (en) * 2003-09-18 2010-02-26 Conforma Therapeutics Corp Novel heterocyclic compounds as HSP90-inhibitors
SE0402735D0 (sv) * 2004-11-09 2004-11-09 Astrazeneca Ab Novel compounds
WO2006134056A1 (en) 2005-06-14 2006-12-21 Cellzome Ag Process for the identification of novel enzyme interacting compounds
WO2009098021A1 (en) 2008-02-04 2009-08-13 Cellzome Ag Selectivity profiling of pi3k interacting molecules against multiple targets

Also Published As

Publication number Publication date
DE602006003651D1 (de) 2008-12-24
CA2658904A1 (en) 2008-02-07
HK1111218A1 (en) 2008-08-01
ATE414281T1 (de) 2008-11-15
EP1887359B1 (en) 2008-11-12
WO2008015013A1 (en) 2008-02-07
CN101563612B (zh) 2013-05-29
JP5234668B2 (ja) 2013-07-10
ES2317382T3 (es) 2009-04-16
CN101563612A (zh) 2009-10-21
AU2007280631A1 (en) 2008-02-07
JP2010500870A (ja) 2010-01-14
US20100055711A1 (en) 2010-03-04
US8153389B2 (en) 2012-04-10
EP1887359A1 (en) 2008-02-13
AU2007280631B2 (en) 2013-02-21

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