ATE444746T1 - Eine herstellungsmethode von entacapon- enthaltenden granulaten für orale dosierformen - Google Patents

Eine herstellungsmethode von entacapon- enthaltenden granulaten für orale dosierformen

Info

Publication number
ATE444746T1
ATE444746T1 AT06755404T AT06755404T ATE444746T1 AT E444746 T1 ATE444746 T1 AT E444746T1 AT 06755404 T AT06755404 T AT 06755404T AT 06755404 T AT06755404 T AT 06755404T AT E444746 T1 ATE444746 T1 AT E444746T1
Authority
AT
Austria
Prior art keywords
entacapone
oral dosage
production
dosage forms
containing granules
Prior art date
Application number
AT06755404T
Other languages
English (en)
Inventor
Kari Vahervuo
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37400847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE444746(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orion Corp filed Critical Orion Corp
Application granted granted Critical
Publication of ATE444746T1 publication Critical patent/ATE444746T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06755404T 2005-06-08 2006-06-07 Eine herstellungsmethode von entacapon- enthaltenden granulaten für orale dosierformen ATE444746T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68833405P 2005-06-08 2005-06-08
PCT/FI2006/000182 WO2006131591A2 (en) 2005-06-08 2006-06-07 An entacapone-containing oral dosage form

Publications (1)

Publication Number Publication Date
ATE444746T1 true ATE444746T1 (de) 2009-10-15

Family

ID=37400847

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06755404T ATE444746T1 (de) 2005-06-08 2006-06-07 Eine herstellungsmethode von entacapon- enthaltenden granulaten für orale dosierformen

Country Status (19)

Country Link
US (3) US20080187590A1 (de)
EP (5) EP2335696A1 (de)
JP (2) JP5336181B2 (de)
KR (2) KR101617990B1 (de)
CN (1) CN101184483B (de)
AT (1) ATE444746T1 (de)
AU (1) AU2006256724B2 (de)
CA (1) CA2611114C (de)
CY (1) CY1109587T1 (de)
DE (1) DE602006009652D1 (de)
DK (1) DK1896006T3 (de)
EA (1) EA013161B1 (de)
ES (1) ES2311442T3 (de)
MX (1) MX2007015377A (de)
NO (1) NO345046B1 (de)
PL (1) PL1896006T3 (de)
PT (2) PT2050447T (de)
SI (1) SI1896006T1 (de)
WO (1) WO2006131591A2 (de)

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GB2429645A (en) * 2006-03-10 2007-03-07 Sekhsaria Chemicals Ltd Solid pharmaceutical composition comprising a COMT inhibitor, a starch and a wetting agent
EP2114374A4 (de) * 2006-12-27 2011-03-23 Wockhardt Research Center Pharmazeutische zusammensetzungen von entacapon
EP1946756A1 (de) * 2007-01-17 2008-07-23 Revotar Biopharmaceuticals AG Verwendung von Entacapon für kosmetische, dermatologische und pharmazeutische Zusammensetzungen
EP2252284B1 (de) * 2008-02-06 2011-05-25 Wockhardt Research Centre Pharmazeutische zusammensetzungen von entacapon, levodopa und carbidopa mit verbesserter bioverfügbarkeit
MX2010008707A (es) * 2008-02-06 2011-03-25 Wockhardt Ltd Composiciones farmaceuticas de entacapona comicronizada con alcoholes de azucar.
CA2734972C (en) * 2008-08-22 2017-03-28 Wockhardt Research Centre An extended release pharmaceutical composition of entacapone or salts thereof
TR200806646A2 (tr) * 2008-09-03 2009-06-22 Dr. F. Fri̇k İlaç San. Ve Ti̇c. A.Ş. Entakapon, levodopa ve karbidoba içeren farmasötik kombinasyonlar
EA026419B1 (ru) 2010-03-04 2017-04-28 Орион Корпорейшн Применение леводопы, карбидопы и энтакапона для лечения болезни паркинсона
DE102010023828A1 (de) * 2010-06-15 2011-12-15 IIP - Institut für industrielle Pharmazie, Forschungs- und Entwicklungsgesellschaft mbH Pharmazeutisches Präparat, welches Entacapon, Levodopa und Carbidopa enthält
US8263119B2 (en) * 2010-12-01 2012-09-11 Shire Llc Capsule formulations containing lanthanum compounds
CA2833443C (en) * 2011-04-26 2017-11-07 Innopharmax, Inc. A composition of entacapone
CN103845318A (zh) * 2012-12-07 2014-06-11 天津市汉康医药生物技术有限公司 恩他卡朋分散片
AU2014229127B2 (en) * 2013-03-13 2018-04-05 Neuroderm Ltd Method for treatment of parkinson's disease
CN113413393B (zh) * 2013-08-19 2025-03-04 塔里斯生物医药公司 多单元药物递送装置和方法
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
DK3116475T3 (da) 2014-03-13 2020-12-07 Neuroderm Ltd Dopa-decarboxylasehæmmersammensætninger
RU2017120184A (ru) 2014-11-28 2018-12-28 БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. Лекарства для замедления течения болезни паркинсона
JP6411265B2 (ja) * 2015-03-30 2018-10-24 共和薬品工業株式会社 エンタカポン含有医薬組成物
AU2016259897A1 (en) * 2015-05-08 2017-08-17 Wockhardt Limited Stable pharmaceutical compositions comprising antibacterial agent
TW201717947A (zh) * 2015-08-20 2017-06-01 漢達生技醫藥股份有限公司 包含氨氯地平和右美沙芬的藥物組合物
EP3275433A1 (de) * 2016-07-29 2018-01-31 Som Innovation Biotech S.L. Zusammensetzung mit verzögerter freisetzung mit mikronisiertem tolcapon
EP3500246B1 (de) * 2016-08-18 2021-08-04 Ilko Ilaç Sanayi Ve Ticaret Anonim Sirketi Tablettenformulierung gegen parkinson mit verbessertem auflösungsprofil
CN106236720A (zh) * 2016-08-29 2016-12-21 海南通用康力制药有限公司 一种恩他卡朋的药物组合物及其制备方法
TWI595871B (zh) * 2016-09-22 2017-08-21 生達化學製藥股份有限公司 含有兒茶酚－ｏ－甲基轉移酶抑制劑之口服醫藥組成物及其製造方法
JP6735007B2 (ja) * 2018-09-26 2020-08-05 共和薬品工業株式会社 エンタカポン含有医薬組成物
WO2021182981A1 (en) * 2020-03-13 2021-09-16 BIAL - PORTELA & Cª, S.A. Micronised opicapone
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US20240300930A1 (en) * 2021-02-26 2024-09-12 Msn Laboratories Private Limited, R&D Center Novel process for the preparation of 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine-1-oxide
CN113274362A (zh) * 2021-03-31 2021-08-20 海南通用康力制药有限公司 恩他卡朋片的生产方法
US12161612B2 (en) 2023-04-14 2024-12-10 Neuroderm, Ltd. Methods and compositions for reducing symptoms of Parkinson's disease

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Also Published As

Publication number Publication date
NO20076687L (no) 2007-12-28
EP2050447A1 (de) 2009-04-22
EA200702616A1 (ru) 2008-04-28
WO2006131591A2 (en) 2006-12-14
CN101184483A (zh) 2008-05-21
EP1896006B1 (de) 2009-10-07
PL1896006T3 (pl) 2010-03-31
KR101468738B1 (ko) 2014-12-03
CA2611114C (en) 2014-09-23
KR20080012945A (ko) 2008-02-12
JP2013173760A (ja) 2013-09-05
US20130274330A1 (en) 2013-10-17
EP2050447B1 (de) 2017-10-11
CY1109587T1 (el) 2014-08-13
CA2611114A1 (en) 2006-12-14
EP2308487A1 (de) 2011-04-13
EP2335696A1 (de) 2011-06-22
DK1896006T3 (da) 2009-12-07
KR20150001843A (ko) 2015-01-06
AU2006256724A1 (en) 2006-12-14
WO2006131591A3 (en) 2007-03-01
EP1896006A2 (de) 2008-03-12
NO345046B1 (no) 2020-09-07
EP2316448A1 (de) 2011-05-04
ES2311442T3 (es) 2010-01-07
EA013161B1 (ru) 2010-02-26
ES2311442T1 (es) 2009-02-16
CN101184483B (zh) 2011-08-10
PT1896006E (pt) 2009-10-19
SI1896006T1 (sl) 2010-02-26
KR101617990B1 (ko) 2016-05-03
DE602006009652D1 (de) 2009-11-19
JP2008542434A (ja) 2008-11-27
PT2050447T (pt) 2018-01-17
MX2007015377A (es) 2008-02-14
JP5336181B2 (ja) 2013-11-06
US20120289594A1 (en) 2012-11-15
AU2006256724B2 (en) 2012-06-07
US20080187590A1 (en) 2008-08-07

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