DK1896399T3 - Biphenyl- og naphthylphenyl-hydroxamsyre-derivater - Google Patents

Biphenyl- og naphthylphenyl-hydroxamsyre-derivater

Info

Publication number: DK1896399T3
Authority: DK; Denmark
Prior art keywords: naphthylphenyl; biphenyl; acid derivatives; hydroxamic acid; hydroxamic
Prior art date: 2005-06-28

Application number

DK06763427.9T

Other languages

English (en)

Inventor

Claudio Pisano

Giuseppe Giannini

Loredana Vesci

Franco Zunino

Sabrina Dallavalle

Lucio Merlini

Sergio Penco

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-28

Filing date

2006-05-31

Publication date

2011-02-21

2006-05-31 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2011-02-21 Application granted granted Critical

2011-02-21 Publication of DK1896399T3 publication Critical patent/DK1896399T3/da

Links

ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 2
NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
235000010290 biphenyl Nutrition 0.000 title 1
239000004305 biphenyl Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Diabetes (AREA)
Oncology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK06763427.9T 2005-06-28 2006-05-31 Biphenyl- og naphthylphenyl-hydroxamsyre-derivater DK1896399T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05013953		2005-06-28
PCT/EP2006/062799 WO2007000383A1 (en)	2005-06-28	2006-05-31	Biphenyl and naphthyl-phenyl hydroxamic acid derivatives

Publications (1)

Publication Number	Publication Date
DK1896399T3 true DK1896399T3 (da)	2011-02-21

Family

ID=35708385

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06763427.9T DK1896399T3 (da)	2005-06-28	2006-05-31	Biphenyl- og naphthylphenyl-hydroxamsyre-derivater

Country Status (23)

Country	Link
US (1)	US7728039B2 (da)
EP (1)	EP1896399B1 (da)
JP (1)	JP5080462B2 (da)
KR (1)	KR101288376B1 (da)
CN (2)	CN102993051A (da)
AR (1)	AR057407A1 (da)
AT (1)	ATE488493T1 (da)
AU (1)	AU2006263915B2 (da)
BR (1)	BRPI0612492A2 (da)
CA (1)	CA2607207C (da)
CY (1)	CY1111451T1 (da)
DE (1)	DE602006018298D1 (da)
DK (1)	DK1896399T3 (da)
EA (1)	EA012729B1 (da)
ES (1)	ES2356129T3 (da)
HR (1)	HRP20110106T1 (da)
MX (1)	MX2007014647A (da)
PL (1)	PL1896399T3 (da)
PT (1)	PT1896399E (da)
RS (1)	RS51576B (da)
SI (1)	SI1896399T1 (da)
TW (1)	TWI383969B (da)
WO (1)	WO2007000383A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW201031402A (en) *	2008-12-24	2010-09-01	Sigma Tau Ind Farmaceuti	New retinoid derivatives endowed with cytotoxic and/or antiangiogenic properties
WO2010106135A1 (en)	2009-03-20	2010-09-23	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Combined use for the treatment of ovarian carcinoma
WO2013101600A1 (en) *	2011-12-29	2013-07-04	Pharmacyclics, Inc.	Cinnamic acid hydroxyamides as inhibitors of histone deacetylase 8
CN105476980B (zh) *	2014-09-28	2018-07-24	复旦大学	联苯类化合物4-(3’,4’-二羟苯基)肉桂酸在制药中的用途
EP3301085A1 (en)	2016-09-29	2018-04-04	Biogem S.Ca.R.L.	Retinoid derivatives with antitumor activity
CN111566086B (zh) *	2018-01-04	2023-08-01	北京大学深圳研究生院	同时抑制lsd1和hdac靶点的化合物及其应用
CN108314630B (zh) *	2018-02-08	2020-11-06	广西民族大学	一种肟醚类衍生物及其制备方法与应用
WO2022229017A1 (en)	2021-04-27	2022-11-03	Biogem S.C.A R.L.	Adamantyl retinoid derivative with anticancer activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10182583A (ja) *	1996-12-25	1998-07-07	Mitsui Chem Inc	新規ヒドロキサム酸誘導体
JP2004359546A (ja) *	2001-03-15	2004-12-24	Ono Pharmaceut Co Ltd	ヒドロキサム酸誘導体、それらの非毒性塩およびそれらのプロドラッグ体を有効成分として含有する、固形癌の予防および／または治療剤
ITRM20010464A1 (it)	2001-07-31	2003-01-31	Sigma Tau Ind Farmaceuti	Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica.

2006
- 2006-05-31 AT AT06763427T patent/ATE488493T1/de active
- 2006-05-31 KR KR1020077029094A patent/KR101288376B1/ko not_active Expired - Fee Related
- 2006-05-31 BR BRPI0612492-5A patent/BRPI0612492A2/pt not_active IP Right Cessation
- 2006-05-31 CA CA2607207A patent/CA2607207C/en not_active Expired - Fee Related
- 2006-05-31 RS RS20110074A patent/RS51576B/sr unknown
- 2006-05-31 DE DE602006018298T patent/DE602006018298D1/de not_active Expired - Lifetime
- 2006-05-31 ES ES06763427T patent/ES2356129T3/es not_active Expired - Lifetime
- 2006-05-31 CN CN2012102945853A patent/CN102993051A/zh active Pending
- 2006-05-31 JP JP2008518775A patent/JP5080462B2/ja not_active Expired - Fee Related
- 2006-05-31 WO PCT/EP2006/062799 patent/WO2007000383A1/en not_active Ceased
- 2006-05-31 US US11/993,184 patent/US7728039B2/en not_active Expired - Fee Related
- 2006-05-31 DK DK06763427.9T patent/DK1896399T3/da active
- 2006-05-31 EA EA200800156A patent/EA012729B1/ru not_active IP Right Cessation
- 2006-05-31 EP EP06763427A patent/EP1896399B1/en not_active Expired - Lifetime
- 2006-05-31 CN CNA200680021008XA patent/CN101198586A/zh active Pending
- 2006-05-31 PL PL06763427T patent/PL1896399T3/pl unknown
- 2006-05-31 MX MX2007014647A patent/MX2007014647A/es active IP Right Grant
- 2006-05-31 SI SI200630925T patent/SI1896399T1/sl unknown
- 2006-05-31 HR HR20110106T patent/HRP20110106T1/hr unknown
- 2006-05-31 AU AU2006263915A patent/AU2006263915B2/en not_active Ceased
- 2006-05-31 PT PT06763427T patent/PT1896399E/pt unknown
- 2006-06-12 TW TW095120842A patent/TWI383969B/zh not_active IP Right Cessation
- 2006-06-26 AR ARP060102734A patent/AR057407A1/es unknown
2011
- 2011-02-16 CY CY20111100190T patent/CY1111451T1/el unknown

Also Published As

Publication number	Publication date
TWI383969B (zh)	2013-02-01
SI1896399T1 (sl)	2011-08-31
AR057407A1 (es)	2007-12-05
MX2007014647A (es)	2008-02-11
KR101288376B1 (ko)	2013-07-22
EA200800156A1 (ru)	2008-04-28
AU2006263915A1 (en)	2007-01-04
PT1896399E (pt)	2011-02-16
US20080319082A1 (en)	2008-12-25
AU2006263915B2 (en)	2011-12-01
CA2607207C (en)	2015-01-20
CN101198586A (zh)	2008-06-11
WO2007000383A1 (en)	2007-01-04
ATE488493T1 (de)	2010-12-15
CA2607207A1 (en)	2007-01-04
JP5080462B2 (ja)	2012-11-21
ES2356129T3 (es)	2011-04-05
KR20080017028A (ko)	2008-02-25
EA012729B1 (ru)	2009-12-30
EP1896399B1 (en)	2010-11-17
CN102993051A (zh)	2013-03-27
HRP20110106T1 (hr)	2011-03-31
CY1111451T1 (el)	2015-08-05
JP2008546822A (ja)	2008-12-25
RS51576B (sr)	2011-08-31
US7728039B2 (en)	2010-06-01
PL1896399T3 (pl)	2011-04-29
TW200740728A (en)	2007-11-01
BRPI0612492A2 (pt)	2010-11-23
DE602006018298D1 (da)	2010-12-30
EP1896399A1 (en)	2008-03-12

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DK1871738T3 (da)	2009-09-21	N-alkylcarbonylaminosyreester- og N-alkylcarbonylaminolactonforbindelser og deres anvendelse
DK2079485T3 (da)	2012-08-06	Phenylpropionamidforbindelser og anvendelsen deraf
ATE538092T1 (de)	2012-01-15	Asparaginsäureproteaseinhibitoren
PL1926477T3 (pl)	2017-09-29	Kompozycja zawierająca NLPZ oraz paracetamol
FI20050284A0 (fi)	2005-03-17	Sekoitin
EP1852499A4 (en)	2009-05-06	NEUROTISATIONSFÖRDERNDES AGENS
ATE488493T1 (de)	2010-12-15	Biphenyl- und naphthylphenylhydroxamsäurederivate
DK1877102T3 (da)	2014-07-21	Tab-molekyler
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