DK1901736T3 - Farmaceutisk sammensætning omfattende simvastatin og ezetimib - Google Patents

Farmaceutisk sammensætning omfattende simvastatin og ezetimib

Info

Publication number: DK1901736T3
Authority: DK; Denmark
Prior art keywords: ezetimibe; simvastatin; pharmaceutical composition; oxygen; present
Prior art date: 2005-07-06

Application number

DK06762303.3T

Other languages

English (en)

Inventor

Vesna Kroselj

Rebeka Toporisic

Renata Lakse

Joze Kastelic

Original Assignee

Krka Tovarna Zdravil D D Novo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-06

Filing date

2006-06-30

Publication date

2010-08-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34937786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1901736(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-30 Application filed by Krka Tovarna Zdravil D D Novo filed Critical Krka Tovarna Zdravil D D Novo

2010-08-16 Application granted granted Critical

2010-08-16 Publication of DK1901736T3 publication Critical patent/DK1901736T3/da

Links

PNAMDJVUJCJOIX-IUNFJCKHSA-N [(1s,3r,7s,8s,8ar)-8-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate;(3r,4s)-1-(4-fluorophenyl)-3-[(3s)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1.N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 PNAMDJVUJCJOIX-IUNFJCKHSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
229940074790 simvastatin and ezetimibe Drugs 0.000 title abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000011248 coating agent Substances 0.000 abstract 1
238000000576 coating method Methods 0.000 abstract 1
239000002552 dosage form Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Dental Preparations (AREA)
Adhesives Or Adhesive Processes (AREA)

DK06762303.3T 2005-07-06 2006-06-30 Farmaceutisk sammensætning omfattende simvastatin og ezetimib DK1901736T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05014680A EP1741427A1 (en)	2005-07-06	2005-07-06	Pharmaceutical composition comprising simvastatin and ezetimibe
PCT/EP2006/006369 WO2007003365A1 (en)	2005-07-06	2006-06-30	Pharmaceutical composition comprising simvastatin and ezetimibe

Publications (1)

Publication Number	Publication Date
DK1901736T3 true DK1901736T3 (da)	2010-08-16

Family

ID=34937786

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06762303.3T DK1901736T3 (da)	2005-07-06	2006-06-30	Farmaceutisk sammensætning omfattende simvastatin og ezetimib

Country Status (17)

Country	Link
US (1)	US8921352B2 (da)
EP (2)	EP1741427A1 (da)
AT (1)	ATE464882T1 (da)
CA (1)	CA2614347A1 (da)
DE (1)	DE602006013821D1 (da)
DK (1)	DK1901736T3 (da)
EA (1)	EA013266B1 (da)
ES (1)	ES2341731T3 (da)
HR (1)	HRP20100282T1 (da)
NO (1)	NO340496B1 (da)
PL (1)	PL1901736T3 (da)
PT (1)	PT1901736E (da)
RS (1)	RS51338B (da)
SI (1)	SI1901736T1 (da)
UA (1)	UA90521C2 (da)
WO (1)	WO2007003365A1 (da)
ZA (1)	ZA200800111B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
ATE485267T1 (de)	2003-12-23	2010-11-15	Astrazeneca Ab	Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
UY29607A1 (es)	2005-06-20	2007-01-31	Astrazeneca Ab	Compuestos quimicos
SA06270191B1 (ar)	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR057072A1 (es)	2005-06-22	2007-11-14	Astrazeneca Ab	Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
TW200811098A (en)	2006-04-27	2008-03-01	Astrazeneca Ab	Chemical compounds
WO2008101723A2 (en) *	2007-02-23	2008-08-28	Krka	Pharmaceutical composition containing a cholesterol absorption inhibitor
WO2009024889A2 (en) *	2007-08-21	2009-02-26	Ranbaxy Laboratories Limited	Pharmaceutical composition comprising a hmg-coa reductase inhibitor and ezetimibe
PL2965752T3 (pl)	2007-12-10	2025-12-08	Assia Chemical Industries Ltd.	Formulacja farmaceutyczna zawierająca ezetymib
AU2008337435A1 (en) *	2007-12-17	2009-06-25	Krka, Tovarna Zdravil, D.D., Novo Mesto	Suspension comprising non-micronized ezetimibe micro-particles
TR200806302A2 (tr) *	2008-08-22	2010-03-22	Bi̇lgi̇ç Mahmut	Çözünürlük ve stabilite artırıcı farmasötik formülasyon.
TR200806300A2 (tr) *	2008-08-22	2010-03-22	B�Lg�� Mahmut	Çözünürlük artırıcı farmasötlk formulasyon
MX344885B (es) *	2008-11-10	2017-01-10	Psicofarma S A De C V	Proceso para la obtencion de una composicion de rosuvastatina calcica y producto obtenido.
EP2204170A1 (en) *	2008-12-01	2010-07-07	LEK Pharmaceuticals D.D.	Pharmaceutical composition comprising ezetimibe and simvastatin
EP2216016A1 (en) *	2009-02-06	2010-08-11	LEK Pharmaceuticals d.d.	Process for the preparation of a pharmaceutical composition comprising ezetimibe
WO2011002422A2 (en) *	2009-07-02	2011-01-06	Bilgic Mahmut	Solubility enhancing pharmaceutical formulation
WO2011019326A2 (en) *	2009-07-02	2011-02-17	Mahmut Bilgic	Solubility and stability enchancing pharmaceutical formulation
WO2011002424A2 (en)	2009-07-02	2011-01-06	Bilgic Mahmut	Solubility and stability enchancing pharmaceutical formulation
EP2368543A1 (en)	2010-03-25	2011-09-28	KRKA, tovarna zdravil, d.d., Novo mesto	Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe
EP2468258A1 (en)	2010-12-22	2012-06-27	LEK Pharmaceuticals d.d.	Process for the preparation of a pharmaceutical composition comprising a low soluble pharmaceutically active ingredient
AR086675A1 (es) *	2011-06-14	2014-01-15	Merck Sharp & Dohme	Composiciones farmaceuticas de combinaciones de inhibidores de la dipeptidil peptidasa-4 con simvastatina
CN102266323B (zh) *	2011-08-04	2013-03-27	海南锦瑞制药股份有限公司	依折麦布和辛伐他汀组合物及其制备方法
KR102578578B1 (ko) *	2016-02-03	2023-09-14	삼성전자주식회사	암모니아수 내의 불순물 검출방법
JP7115825B2 (ja) *	2017-06-28	2022-08-09	日医工株式会社	エゼチミブ含有経口製剤及びその製造方法
JP2019014700A (ja) *	2017-07-11	2019-01-31	大原薬品工業株式会社	エゼチミブ含有口腔内崩壊錠及びその製造方法
FR3069545B1 (fr) *	2017-07-27	2020-10-16	Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic	Composition d'enrobage exempte de dioxyde de titane
PL425975A1 (pl) *	2018-06-19	2020-01-02	Invest Bielany Spółka Z Ograniczoną Odpowiedzialnością	Złożona kompozycja farmaceutyczna do leczenia dyslipidemii i sposób jej wytwarzania
WO2022023206A1 (en) *	2020-07-27	2022-02-03	Krka, D.D., Novo Mesto	Bilayer tablet comprising ezetimibe and atorvastatin
CN115227659B (zh) *	2022-08-19	2023-05-02	北京百奥药业有限责任公司	一种依折麦布辛伐他汀组合物及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU548996B2 (en)	1980-02-04	1986-01-09	Merck & Co., Inc.	Tetrahydro-2h-pyran-2-one derivatives
US4820850A (en)	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4916239A (en)	1988-07-19	1990-04-10	Merck & Co., Inc.	Process for the lactonization of mevinic acids and analogs thereof
US5631365A (en) *	1993-09-21	1997-05-20	Schering Corporation	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6235311B1 (en) *	1998-03-18	2001-05-22	Bristol-Myers Squibb Company	Pharmaceutical composition containing a combination of a statin and aspirin and method
HU230253B1 (hu) *	2001-01-26	2015-11-30	Merck Sharp & Dohme Corp	Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
EP1241110A1 (en) *	2001-03-16	2002-09-18	Pfizer Products Inc.	Dispensing unit for oxygen-sensitive drugs
US6669955B2 (en) *	2001-08-28	2003-12-30	Longwood Pharmaceutical Research, Inc.	Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
AU2002353659A1 (en) *	2001-12-18	2003-07-15	Synthon B.V.	Simvastatin dosage forms
AR040588A1 (es) *	2002-07-26	2005-04-13	Schering Corp	Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
SI21400A (sl) *	2003-02-12	2004-08-31	LEK farmacevtska družba d.d.	Stabilna farmacevtska oblika z inhibitorjem HMG-CoA reduktaze
WO2005009955A1 (en)	2003-07-31	2005-02-03	Hetero Drugs Limited	Ezetimibe polymorphs
WO2005011638A2 (en) *	2003-08-05	2005-02-10	Zentiva, A. S.	Methods for the stabilization of atorvastatin
US20060223882A1 (en) *	2005-03-23	2006-10-05	Venkataraman Sundaram	Amorphous simvastatin

2005
- 2005-07-06 EP EP05014680A patent/EP1741427A1/en not_active Withdrawn
2006
- 2006-06-30 AT AT06762303T patent/ATE464882T1/de active
- 2006-06-30 PL PL06762303T patent/PL1901736T3/pl unknown
- 2006-06-30 WO PCT/EP2006/006369 patent/WO2007003365A1/en not_active Ceased
- 2006-06-30 EP EP06762303A patent/EP1901736B1/en active Active
- 2006-06-30 HR HR20100282T patent/HRP20100282T1/hr unknown
- 2006-06-30 SI SI200630707T patent/SI1901736T1/sl unknown
- 2006-06-30 DE DE602006013821T patent/DE602006013821D1/de active Active
- 2006-06-30 PT PT06762303T patent/PT1901736E/pt unknown
- 2006-06-30 EA EA200702416A patent/EA013266B1/ru not_active IP Right Cessation
- 2006-06-30 UA UAA200714923A patent/UA90521C2/uk unknown
- 2006-06-30 RS RSP-2010/0213A patent/RS51338B/sr unknown
- 2006-06-30 DK DK06762303.3T patent/DK1901736T3/da active
- 2006-06-30 CA CA002614347A patent/CA2614347A1/en not_active Abandoned
- 2006-06-30 ES ES06762303T patent/ES2341731T3/es active Active
- 2006-06-30 US US11/994,782 patent/US8921352B2/en not_active Expired - Fee Related
2008
- 2008-01-04 ZA ZA200800111A patent/ZA200800111B/xx unknown
- 2008-02-04 NO NO20080627A patent/NO340496B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO20080627L (no)	2008-04-02
WO2007003365A1 (en)	2007-01-11
EP1901736B1 (en)	2010-04-21
EP1901736A1 (en)	2008-03-26
HRP20100282T1 (hr)	2010-07-31
EA013266B1 (ru)	2010-04-30
RS51338B (sr)	2011-02-28
UA90521C2 (uk)	2010-05-11
PL1901736T3 (pl)	2010-09-30
ZA200800111B (en)	2008-12-31
PT1901736E (pt)	2010-05-31
ES2341731T3 (es)	2010-06-25
SI1901736T1 (sl)	2010-08-31
DE602006013821D1 (en)	2010-06-02
CA2614347A1 (en)	2007-01-11
EP1741427A1 (en)	2007-01-10
ATE464882T1 (de)	2010-05-15
EA200702416A1 (ru)	2008-04-28
US8921352B2 (en)	2014-12-30
US20080300233A1 (en)	2008-12-04
NO340496B1 (no)	2017-05-02

Publication	Publication Date	Title
NO20080627L (no)	2008-04-02	Farmasoytisk sammensetning inneholdende simvastatin og ezetimibe
EA201390409A1 (ru)	2013-11-29	Составы с низкой дозой панкрелипазы и кишечно-растворимым покрытием
JP2010532765A5 (da)	2011-08-25
WO2007051811A3 (en)	2008-01-24	Pharmaceutical use of substituted amides
EA200870216A1 (ru)	2009-02-27	Амидо соединения и их применение в качестве лекарственных средств
DE602005021770D1 (de)	2010-07-22	Indol-1-yl-essigsäurederivate
EA200970081A1 (ru)	2009-06-30	Соединения, обладающие потенциирующим действием в отношении активности этионамида, и их применения
ATE486587T1 (de)	2010-11-15	Formulierungen zur oralen verabreichung von wirkstoffen
WO2010115184A3 (en)	2011-03-24	Hydroxythienoquinolones and related compounds as anti-infective agents
NO20064078L (no)	2006-09-11	Substituerte azetidinsammensetninger, deres fremstilling og anvendelse som medikamenter
EA201100430A1 (ru)	2011-10-31	Стабильная комбинированная фармацевтическая композиция
NO20045153L (no)	2005-02-04	Stabilt, fast medisinpreparat for oral administrasjon
MY147373A (en)	2012-11-30	Piperazine derivatives as antimalarial agents
PT1414467E (pt)	2006-09-29	Tratamento topico da mastalgia
EA200700130A1 (ru)	2007-06-29	Композиции, содержащие стронций и витамин d, и их применение
EP1713439B1 (en)	2009-07-01	Pharmaceutical preparation for the oral cavity
CY1120050T1 (el)	2018-12-12	Φαρμακοτεχνικες μορφες για την αποδεσμευση δραστικων ενωσεων
EA201100104A1 (ru)	2011-08-30	Фармацевтическая композиция, содержащая статин
BRPI0407529A (pt)	2006-02-14	uso de r-10-hidróxi-10,11-dihidro-carbamazepina em dor neuropática
Rathod et al.	2026	Strategies for biofilm inhibition: the role of synthetic drug-and nanotechnology-based agents
TW200736203A (en)	2007-10-01	New pleuromutilin derivative and its use
EP2801359A3 (en)	2015-05-06	The use of nicotine for the treatment of sepsis in humans caused by antibiotic
WO2007138233A3 (fr)	2008-01-24	Utilisation du zatosetron pour le traitement de la rosacee
DE602006012962D1 (de)	2010-04-29	Pharmazeutische Zubereitungen von Ciprofloxacin
CY1110814T1 (el)	2015-06-10	Νεα υποκατεστημενα αρυλοεξαδιενικα οξεα και εστερες αυτων τα οποια μπορουν να χρησιμοποιηθουν για την αγωγη και προληψη του διαβητη, δυσλιπιδαιμιας και αθηροσκληρωσης, φαρμακευτικες συνθεσεις που τα περιλαμβανουν και διεργασιες για την παρασκευη αυτων