DK190385A - Fremgangsmaade til fremstilling af cephalosporinforbindelser - Google Patents
Fremgangsmaade til fremstilling af cephalosporinforbindelser Download PDFInfo
- Publication number
- DK190385A DK190385A DK190385A DK190385A DK190385A DK 190385 A DK190385 A DK 190385A DK 190385 A DK190385 A DK 190385A DK 190385 A DK190385 A DK 190385A DK 190385 A DK190385 A DK 190385A
- Authority
- DK
- Denmark
- Prior art keywords
- cephalospor
- compounds
- making
- compound
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title description 3
- 238000000034 method Methods 0.000 title description 2
- 150000001450 anions Chemical class 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 description 1
- 0 C[C@](C(BC1)N2C(*)C1*1C=CC=C*1)([C@@]2(C)O)N Chemical compound C[C@](C(BC1)N2C(*)C1*1C=CC=C*1)([C@@]2(C)O)N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229960000484 ceftazidime Drugs 0.000 description 1
- NMVPEQXCMGEDNH-TZVUEUGBSA-N ceftazidime pentahydrate Chemical compound O.O.O.O.O.S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 NMVPEQXCMGEDNH-TZVUEUGBSA-N 0.000 description 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
delse med en gruppe med formlen -COOR3 i 4-stillingen (hvor R3 er en karboxylblokerende gruppe) og med en tilknyttet anion A eller salte deraf fremstilles ved omsætning af en forbindelse II
2 hvor S , B og den stiplede linie er som ovenfor defineret,
X er en fraspaltelig gruppe og bølgelinien viser at forbindelsen kan have syn- og/eller anti-konfiguration, eller et salt deraf eller en tilsvarende forbindelse med en gruppe 7COOR3 i 4-stillingen og en tilknyttet anion A , med en forbindelse III
hvor R1 er ,som ovenfor defineret. Processen er værdifuld til fremstilling af antibiotik’et ceftazidim.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8410991 | 1984-04-30 | ||
| GB848410991A GB8410991D0 (en) | 1984-04-30 | 1984-04-30 | Process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK190385D0 DK190385D0 (da) | 1985-04-29 |
| DK190385A true DK190385A (da) | 1985-10-31 |
Family
ID=10560284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK190385A DK190385A (da) | 1984-04-30 | 1985-04-29 | Fremgangsmaade til fremstilling af cephalosporinforbindelser |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0160563A3 (da) |
| JP (1) | JPH0699441B2 (da) |
| KR (1) | KR920005955B1 (da) |
| DK (1) | DK190385A (da) |
| ES (1) | ES8706156A1 (da) |
| FI (1) | FI89924C (da) |
| GB (1) | GB8410991D0 (da) |
| PT (1) | PT80367B (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01230547A (ja) * | 1988-01-14 | 1989-09-14 | Takeda Chem Ind Ltd | ３−オキソ酪酸第三ブチルの製造法及びその用途 |
| DE3809845A1 (de) * | 1988-03-24 | 1989-10-12 | Hoechst Ag | Verfahren zur herstellung von 4-halo-3-oxo-2-alkoxyiminobuttersaeureestern |
| JPH0393762A (ja) * | 1989-09-04 | 1991-04-18 | Wako Pure Chem Ind Ltd | ４‐ハロゲノ‐２‐アルコキシイミノ‐３‐オキソ脂肪酸の製造方法 |
| WO2005019227A1 (en) * | 2003-08-22 | 2005-03-03 | Orchid Chemicals & Pharmaceuticals Ltd | Process for the preparation of cephalosporin antibiotic |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
| JPS5498795A (en) * | 1978-01-13 | 1979-08-03 | Takeda Chem Ind Ltd | Cephalosporin derivative and its preparation |
| GB2025398B (en) * | 1978-05-26 | 1982-08-11 | Glaxo Group Ltd | Gephalosporin antibiotics |
| IL61458A0 (en) * | 1979-12-07 | 1980-12-31 | Erba Farmitalia | N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them |
-
1984
- 1984-04-30 GB GB848410991A patent/GB8410991D0/en active Pending
-
1985
- 1985-04-29 ES ES542674A patent/ES8706156A1/es not_active Expired
- 1985-04-29 PT PT80367A patent/PT80367B/pt not_active IP Right Cessation
- 1985-04-29 EP EP85303030A patent/EP0160563A3/en not_active Ceased
- 1985-04-29 FI FI851687A patent/FI89924C/fi not_active IP Right Cessation
- 1985-04-29 DK DK190385A patent/DK190385A/da unknown
- 1985-04-29 KR KR1019850002875A patent/KR920005955B1/ko not_active Expired
- 1985-04-30 JP JP60091305A patent/JPH0699441B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0160563A3 (en) | 1986-11-26 |
| FI851687L (fi) | 1985-10-31 |
| GB8410991D0 (en) | 1984-06-06 |
| PT80367A (en) | 1985-05-01 |
| ES542674A0 (es) | 1987-06-01 |
| PT80367B (pt) | 1987-09-30 |
| KR850007428A (ko) | 1985-12-04 |
| FI89924B (fi) | 1993-08-31 |
| ES8706156A1 (es) | 1987-06-01 |
| FI851687A0 (fi) | 1985-04-29 |
| EP0160563A2 (en) | 1985-11-06 |
| KR920005955B1 (ko) | 1992-07-25 |
| JPS6117587A (ja) | 1986-01-25 |
| JPH0699441B2 (ja) | 1994-12-07 |
| FI89924C (fi) | 1993-12-10 |
| DK190385D0 (da) | 1985-04-29 |
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