ES8706156A1 - Un procedimiento para la preparacion de compuestos de cefa- losporina - Google Patents
Un procedimiento para la preparacion de compuestos de cefa- losporinaInfo
- Publication number
- ES8706156A1 ES8706156A1 ES542674A ES542674A ES8706156A1 ES 8706156 A1 ES8706156 A1 ES 8706156A1 ES 542674 A ES542674 A ES 542674A ES 542674 A ES542674 A ES 542674A ES 8706156 A1 ES8706156 A1 ES 8706156A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- group
- cephalosporin compounds
- ceph
- preparing cephalosporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 cephalosporin compounds Chemical class 0.000 title abstract 2
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000000903 blocking effect Effects 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- SXBDXXFTJVHSAF-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-3-en-8-one Chemical compound S1C=CCN2C(=O)C[C@H]21 SXBDXXFTJVHSAF-ZCFIWIBFSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE CEFALOSPORINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN UN ALCOHOL, ETER O AMIDA, EN PRESENCIA DE AGUA Y CON UN AGENTE DE FIJACION, PARA OBTENER COMPUESTOS DE CEFALOSPORINA DE FORMULA (I) EN LA QUE R1 ES UN GRUPO AMINO O AMINO PROTEGIDO; R2 ES H O UN GRUPO DE BLOQUEO DE CARBOXILO; B ES FS O FSO; Y LA LINEA DE TRAZOS QUE FORMA PUENTE EN LAS POSICIONES 2, 3 Y 4 INDICA QUE EL COMPUESTO ES UN COMPUESTO CEF-2-EM O CEF-3-EM. TIENE APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD ANTIBIOTICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848410991A GB8410991D0 (en) | 1984-04-30 | 1984-04-30 | Process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8706156A1 true ES8706156A1 (es) | 1987-06-01 |
| ES542674A0 ES542674A0 (es) | 1987-06-01 |
Family
ID=10560284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES542674A Expired ES8706156A1 (es) | 1984-04-30 | 1985-04-29 | Un procedimiento para la preparacion de compuestos de cefa- losporina |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0160563A3 (es) |
| JP (1) | JPH0699441B2 (es) |
| KR (1) | KR920005955B1 (es) |
| DK (1) | DK190385A (es) |
| ES (1) | ES8706156A1 (es) |
| FI (1) | FI89924C (es) |
| GB (1) | GB8410991D0 (es) |
| PT (1) | PT80367B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01230547A (ja) * | 1988-01-14 | 1989-09-14 | Takeda Chem Ind Ltd | ３−オキソ酪酸第三ブチルの製造法及びその用途 |
| DE3809845A1 (de) * | 1988-03-24 | 1989-10-12 | Hoechst Ag | Verfahren zur herstellung von 4-halo-3-oxo-2-alkoxyiminobuttersaeureestern |
| JPH0393762A (ja) * | 1989-09-04 | 1991-04-18 | Wako Pure Chem Ind Ltd | ４‐ハロゲノ‐２‐アルコキシイミノ‐３‐オキソ脂肪酸の製造方法 |
| WO2005019227A1 (en) * | 2003-08-22 | 2005-03-03 | Orchid Chemicals & Pharmaceuticals Ltd | Process for the preparation of cephalosporin antibiotic |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
| JPS5498795A (en) * | 1978-01-13 | 1979-08-03 | Takeda Chem Ind Ltd | Cephalosporin derivative and its preparation |
| ZA792581B (en) * | 1978-05-26 | 1981-01-28 | Glaxo Group Ltd | Cephalosporin antibiotics |
| IL61458A0 (en) * | 1979-12-07 | 1980-12-31 | Erba Farmitalia | N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them |
-
1984
- 1984-04-30 GB GB848410991A patent/GB8410991D0/en active Pending
-
1985
- 1985-04-29 FI FI851687A patent/FI89924C/fi not_active IP Right Cessation
- 1985-04-29 DK DK190385A patent/DK190385A/da unknown
- 1985-04-29 EP EP85303030A patent/EP0160563A3/en not_active Ceased
- 1985-04-29 ES ES542674A patent/ES8706156A1/es not_active Expired
- 1985-04-29 KR KR1019850002875A patent/KR920005955B1/ko not_active Expired
- 1985-04-29 PT PT80367A patent/PT80367B/pt not_active IP Right Cessation
- 1985-04-30 JP JP60091305A patent/JPH0699441B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6117587A (ja) | 1986-01-25 |
| FI851687L (fi) | 1985-10-31 |
| GB8410991D0 (en) | 1984-06-06 |
| DK190385A (da) | 1985-10-31 |
| KR920005955B1 (ko) | 1992-07-25 |
| DK190385D0 (da) | 1985-04-29 |
| KR850007428A (ko) | 1985-12-04 |
| PT80367B (pt) | 1987-09-30 |
| JPH0699441B2 (ja) | 1994-12-07 |
| FI89924C (fi) | 1993-12-10 |
| FI851687A0 (fi) | 1985-04-29 |
| PT80367A (en) | 1985-05-01 |
| EP0160563A2 (en) | 1985-11-06 |
| FI89924B (fi) | 1993-08-31 |
| ES542674A0 (es) | 1987-06-01 |
| EP0160563A3 (en) | 1986-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20041102 |