DK190986A - Imidazoquinolinonderivater - Google Patents

Imidazoquinolinonderivater Download PDF

Info

Publication number: DK190986A
Authority: DK; Denmark
Prior art keywords: imidazoquinoline derivatives; imidazoquinoline; derivatives
Prior art date: 1985-04-25

Application number

DK190986A

Other languages

English (en)

Other versions

DK164868C (da

DK164868B (da

DK190986D0 (da

Inventor

Nicholas A Meanwell

John J Wright

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-25

Filing date

1986-04-24

Publication date

1986-10-26

1986-04-24 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1986-04-24 Publication of DK190986D0 publication Critical patent/DK190986D0/da

1986-10-26 Publication of DK190986A publication Critical patent/DK190986A/da

1992-08-31 Publication of DK164868B publication Critical patent/DK164868B/da

1993-01-11 Application granted granted Critical

1993-01-11 Publication of DK164868C publication Critical patent/DK164868C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK190986A 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse DK164868C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US72686985A	1985-04-25	1985-04-25
US72686985		1985-04-25
US83221286		1986-02-26
US06/832,212 US4668686A (en)	1985-04-25	1986-02-26	Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (4)

Publication Number	Publication Date
DK190986D0 DK190986D0 (da)	1986-04-24
DK190986A true DK190986A (da)	1986-10-26
DK164868B DK164868B (da)	1992-08-31
DK164868C DK164868C (da)	1993-01-11

Family

ID=27111398

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK190986A DK164868C (da)	1985-04-25	1986-04-24	Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK080291A DK165248C (da)	1985-04-25	1991-04-30	1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da)	1985-04-25	1991-05-01	Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK080291A DK165248C (da)	1985-04-25	1991-04-30	1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da)	1985-04-25	1991-05-01	Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Country Status (32)

Country	Link
US (1)	US4668686A (da)
KR (1)	KR940000828B1 (da)
CN (1)	CN1016175B (da)
AT (1)	AT390257B (da)
AU (1)	AU592983B2 (da)
BE (1)	BE904671A (da)
CA (1)	CA1298836C (da)
CH (1)	CH675722A5 (da)
CY (1)	CY1641A (da)
DE (1)	DE3614132A1 (da)
DK (3)	DK164868C (da)
EG (1)	EG18104A (da)
ES (3)	ES8708229A1 (da)
FI (1)	FI83316C (da)
FR (1)	FR2581065B1 (da)
GB (1)	GB2174987B (da)
GR (1)	GR861086B (da)
HK (1)	HK64492A (da)
HU (1)	HU195813B (da)
IL (1)	IL78581A0 (da)
IT (1)	IT1215651B (da)
LU (1)	LU86406A1 (da)
MY (1)	MY102086A (da)
NL (1)	NL8601053A (da)
NO (1)	NO163406C (da)
NZ (1)	NZ215885A (da)
OA (1)	OA08242A (da)
PT (1)	PT82460B (da)
SE (1)	SE461468B (da)
SG (1)	SG29092G (da)
SU (3)	SU1450746A3 (da)
YU (1)	YU46054B (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4775674A (en) *	1986-05-23	1988-10-04	Bristol-Myers Company	Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) *	1986-07-08	1987-10-20	Bristol-Myers Company	7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) *	1987-05-29	1988-05-10	Merrell Dow Pharmaceuticals Inc.	Cardiotonic tricyclic imidazolones
US4803210A (en) *	1987-05-29	1989-02-07	Merrell Dow Pharmaceuticals Inc.	Cardiotonic tricyclic oxazolones
US4943573A (en) *	1989-11-01	1990-07-24	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) *	1990-11-10	1996-10-02	Daimler Benz Ag	Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) *	1991-10-30	1998-06-18	Janssen Pharmaceutica Nv	1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5196428A (en) *	1992-04-03	1993-03-23	Bristol-Myers Squibb Company	Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5208237A (en) *	1992-04-03	1993-05-04	Bristol-Meyers Squibb Company	7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5552267A (en) *	1992-04-03	1996-09-03	The Trustees Of Columbia University In The City Of New York	Solution for prolonged organ preservation
US5158958A (en) *	1992-04-03	1992-10-27	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5348960A (en) *	1992-04-03	1994-09-20	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
TW593317B (en) *	1993-06-21	2004-06-21	Janssen Pharmaceutica Nv	Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
CN1048015C (zh) *	1993-07-06	2000-01-05	美国辉瑞有限公司	双环四氢吡唑并吡啶类化合物
TW574214B (en) *	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
US6664264B2 (en) *	2000-12-08	2003-12-16	3M Innovative Properties Company	Thioether substituted imidazoquinolines
WO2005018556A2 (en)	2003-08-12	2005-03-03	3M Innovative Properties Company	Hydroxylamine substituted imidazo-containing compounds
RU2006105101A (ru)	2003-08-27	2007-10-10	3М Инновейтив Пропертиз Компани (US)	Арилокси и арилалкиленокси замещенные имидазохинолины
WO2005023190A2 (en)	2003-09-05	2005-03-17	3M Innovative Properties Company	Treatment for cd5+ b cell lymphoma
US8871782B2 (en) *	2003-10-03	2014-10-28	3M Innovative Properties Company	Alkoxy substituted imidazoquinolines
US7544697B2 (en)	2003-10-03	2009-06-09	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and analogs thereof
US8598192B2 (en) *	2003-11-14	2013-12-03	3M Innovative Properties Company	Hydroxylamine substituted imidazoquinolines
CA2545774A1 (en)	2003-11-14	2005-06-02	3M Innovative Properties Company	Oxime substituted imidazo ring compounds
AR046781A1 (es)	2003-11-25	2005-12-21	3M Innovative Properties Co	Derivados de imidazoquinolinas. composiciones farmaceuticas.
WO2005066170A1 (en)	2003-12-29	2005-07-21	3M Innovative Properties Company	Arylalkenyl and arylalkynyl substituted imidazoquinolines
CA2551399A1 (en)	2003-12-30	2005-07-21	3M Innovative Properties Company	Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
AU2005228150A1 (en)	2004-03-24	2005-10-13	3M Innovative Properties Company	Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en)	2004-06-15	2005-12-29	3M Innovative Properties Company	Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006038923A2 (en)	2004-06-18	2006-04-13	3M Innovative Properties Company	Aryl substituted imidazonaphthyridines
WO2006065280A2 (en)	2004-06-18	2006-06-22	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US8026366B2 (en)	2004-06-18	2011-09-27	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
AU2005284835A1 (en) *	2004-09-14	2006-03-23	Novartis Vaccines And Diagnostics Inc.	Imidazoquinoline compounds
EP1831226B1 (en)	2004-12-30	2012-08-08	3M Innovative Properties Company	Chiral tetracyclic compounds inducing interferon biosynthesis
AU2005326708C1 (en)	2004-12-30	2012-08-30	3M Innovative Properties Company	Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
AU2006210392A1 (en)	2005-02-04	2006-08-10	Coley Pharmaceutical Group, Inc.	Aqueous gel formulations containing immune response modifiers
CA2597587A1 (en)	2005-02-11	2006-08-17	Coley Pharmaceutical Group, Inc.	Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943636B2 (en)	2005-04-01	2011-05-17	3M Innovative Properties Company	1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (en)	2005-04-01	2006-10-12	Coley Pharmaceutical Group, Inc.	Pyrazolopyridine-1,4-diamines and analogs thereof
US7906506B2 (en)	2006-07-12	2011-03-15	3M Innovative Properties Company	Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en)	2006-08-01	2012-07-24	Cytokinetics, Inc.	Modulating skeletal muscle
BRPI0714725B1 (pt)	2006-08-02	2021-05-25	Cytokinetics, Inc	Entidade química, composição farmaceuticamente aceitável, e, uso de uma entidade química
US8299248B2 (en)	2006-08-02	2012-10-30	Cytokinetics, Incorporated	Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
US7851484B2 (en)	2007-03-30	2010-12-14	Cytokinetics, Inc.	Certain chemical entities, compositions, and methods
CN109316480A (zh)	2011-07-13	2019-02-12	赛特凯恩蒂克公司	组合als疗法
EP4678641A1 (en) *	2023-01-13	2026-01-14	Shanghai Helioson Pharmaceutical Co., Ltd.	Quinolinone compound and naphthyridinone compound and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3932407A (en) *	1973-11-19	1976-01-13	Bristol-Myers Company	Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

1986
- 1986-02-26 US US06/832,212 patent/US4668686A/en not_active Expired - Fee Related
- 1986-03-26 CA CA000505136A patent/CA1298836C/en not_active Expired - Fee Related
- 1986-04-18 NZ NZ215885A patent/NZ215885A/xx unknown
- 1986-04-21 AU AU56413/86A patent/AU592983B2/en not_active Ceased
- 1986-04-22 IL IL78581A patent/IL78581A0/xx not_active IP Right Cessation
- 1986-04-22 FI FI861684A patent/FI83316C/fi not_active IP Right Cessation
- 1986-04-23 EG EG237/86A patent/EG18104A/xx active
- 1986-04-23 CN CN86102747A patent/CN1016175B/zh not_active Expired
- 1986-04-24 BE BE0/216585A patent/BE904671A/fr not_active IP Right Cessation
- 1986-04-24 DK DK190986A patent/DK164868C/da not_active IP Right Cessation
- 1986-04-24 PT PT82460A patent/PT82460B/pt not_active IP Right Cessation
- 1986-04-24 GR GR861086A patent/GR861086B/el unknown
- 1986-04-24 SU SU864027355A patent/SU1450746A3/ru active
- 1986-04-24 LU LU86406A patent/LU86406A1/fr unknown
- 1986-04-24 SE SE8601907A patent/SE461468B/sv not_active IP Right Cessation
- 1986-04-24 IT IT8620206A patent/IT1215651B/it active
- 1986-04-24 FR FR868605966A patent/FR2581065B1/fr not_active Expired - Fee Related
- 1986-04-24 NO NO861617A patent/NO163406C/no unknown
- 1986-04-24 ES ES554336A patent/ES8708229A1/es not_active Expired
- 1986-04-24 CH CH1679/86A patent/CH675722A5/de not_active IP Right Cessation
- 1986-04-24 NL NL8601053A patent/NL8601053A/xx not_active Application Discontinuation
- 1986-04-24 GB GB8610037A patent/GB2174987B/en not_active Expired
- 1986-04-25 DE DE19863614132 patent/DE3614132A1/de not_active Ceased
- 1986-04-25 KR KR1019860003204A patent/KR940000828B1/ko not_active Expired - Lifetime
- 1986-04-25 AT AT0112186A patent/AT390257B/de not_active IP Right Cessation
- 1986-04-25 OA OA58845A patent/OA08242A/xx unknown
- 1986-04-25 HU HU861723A patent/HU195813B/hu not_active IP Right Cessation
1987
- 1987-02-27 SU SU874202071A patent/SU1470192A3/ru active
- 1987-05-14 ES ES557552A patent/ES8802521A1/es not_active Expired
- 1987-05-14 ES ES557551A patent/ES8801829A1/es not_active Expired
- 1987-06-23 YU YU116787A patent/YU46054B/sh unknown
- 1987-09-25 SU SU874203391A patent/SU1560056A3/ru active
- 1987-09-29 MY MYPI87002266A patent/MY102086A/en unknown
1991
- 1991-04-30 DK DK080291A patent/DK165248C/da not_active IP Right Cessation
- 1991-05-01 DK DK081091A patent/DK165249C/da not_active IP Right Cessation
1992
- 1992-03-10 SG SG290/92A patent/SG29092G/en unknown
- 1992-08-27 HK HK644/92A patent/HK64492A/xx unknown
- 1992-11-06 CY CY1641A patent/CY1641A/en unknown

Also Published As

Publication number	Publication date
CH675722A5 (da)	1990-10-31
NO861617L (no)	1986-10-27
SE461468B (sv)	1990-02-19
PT82460A (en)	1986-05-01
SU1470192A3 (ru)	1989-03-30
HK64492A (en)	1992-09-04
FI83316B (fi)	1991-03-15
IT8620206A0 (it)	1986-04-24
NZ215885A (en)	1989-04-26
NL8601053A (nl)	1986-11-17
YU116787A (en)	1988-04-30
DK80291A (da)	1991-04-30
DK165248B (da)	1992-10-26
ES557551A0 (es)	1988-02-16
ES8708229A1 (es)	1987-10-01
DK164868C (da)	1993-01-11
ES554336A0 (es)	1987-10-01
DK80291D0 (da)	1991-04-30
AT390257B (de)	1990-04-10
IL78581A0 (en)	1986-08-31
AU592983B2 (en)	1990-02-01
ES557552A0 (es)	1988-07-16
US4668686A (en)	1987-05-26
ES8801829A1 (es)	1988-02-16
MY102086A (en)	1992-03-31
DE3614132A1 (de)	1986-11-27
AU5641386A (en)	1986-10-30
GR861086B (en)	1986-09-01
DK164868B (da)	1992-08-31
YU46054B (sh)	1992-12-21
GB2174987A (en)	1986-11-19
IT1215651B (it)	1990-02-22
NO163406B (no)	1990-02-12
CY1641A (en)	1992-11-06
DK165248C (da)	1993-03-22
DK81091A (da)	1991-05-01
SG29092G (en)	1992-05-15
FI861684A0 (fi)	1986-04-22
DK165249C (da)	1993-03-22
NO163406C (no)	1990-05-23
PT82460B (pt)	1988-11-30
EG18104A (en)	1992-09-30
CN1016175B (zh)	1992-04-08
CA1298836C (en)	1992-04-14
SU1450746A3 (ru)	1989-01-07
GB8610037D0 (en)	1986-05-29
HUT42089A (en)	1987-06-29
SE8601907D0 (sv)	1986-04-24
KR860008177A (ko)	1986-11-12
ATA112186A (de)	1989-09-15
OA08242A (en)	1987-10-30
DK165249B (da)	1992-10-26
LU86406A1 (fr)	1986-11-05
FI861684L (fi)	1986-10-26
FR2581065A1 (fr)	1986-10-31
FI83316C (fi)	1991-06-25
ES8802521A1 (es)	1988-07-16
SE8601907L (sv)	1986-10-26
KR940000828B1 (ko)	1994-02-02
BE904671A (fr)	1986-10-24
SU1560056A3 (ru)	1990-04-23
DK190986D0 (da)	1986-04-24
HU195813B (en)	1988-07-28
CN86102747A (zh)	1987-02-04
GB2174987B (en)	1989-08-02
DK81091D0 (da)	1991-05-01
FR2581065B1 (fr)	1990-02-02

Legal Events

Date	Code	Title	Description
1994-12-27	PBP	Patent lapsed

Publication	Publication Date	Title
DK190986D0 (da)	1986-04-24	Imidazoquinolinonderivater
DK394586D0 (da)	1986-08-19	Fungicidt aktive propenoatderivater
DE3571437D1 (de)	1989-08-17	Pyrazolopyridine derivatives
DK572186D0 (da)	1986-11-27	Thioxanthonderivater
BR8606663A (pt)	1987-08-11	Derivados de triazolil-quinolina
DK109186D0 (da)	1986-03-10	Dihydropyridazinonderivater
DK163486A (da)	1986-10-17	Phenylethanolaminderivater
DK15686A (da)	1986-07-16	Dihydropyridinderivater
DK281886A (da)	1986-12-19	Glycerinderivater
DK17386D0 (da)	1986-01-14	Aminderivater
DK64286A (da)	1986-08-12	Dihydropyridinderivater
DK491786D0 (da)	1986-10-14	Dichloranilinderivater
DK556386D0 (da)	1986-11-20	Quinilinderivater
DK303886A (da)	1986-12-29	Secocanthinderivater
DK224786D0 (da)	1986-05-14	Dihydropyridinderivater
DK66186A (da)	1986-08-12	Alkanolaminderivater
FI864092A7 (fi)	1987-04-26	Bruksvagn foersedd med frigoerningsanordning
DE3662889D1 (de)	1989-05-24	Tetrahydrofurancarboxylic-acid derivatives
KR880700821A (ko)	1988-04-12	데--데옥시테이코플라닌 유도체
DK246986D0 (da)	1986-05-27	Substituerede benzisoindolo-isoquinolinderivater
DE3474664D1 (de)	1988-11-24	Imidazoquinoline derivatives
DK625186D0 (da)	1986-12-22	Sulfonamidderivater
DK109086D0 (da)	1986-03-10	2-aminopyrimidinonderivater
DE3662890D1 (de)	1989-05-24	Furobenzisoxazole derivatives
DE3666818D1 (de)	1989-12-14	Anisole derivatives