BE904671A - Imidazoquinoleines antithrombogenes cardiotoniques. - Google Patents

Imidazoquinoleines antithrombogenes cardiotoniques.

Info

Publication number
BE904671A
BE904671A BE0/216585A BE216585A BE904671A BE 904671 A BE904671 A BE 904671A BE 0/216585 A BE0/216585 A BE 0/216585A BE 216585 A BE216585 A BE 216585A BE 904671 A BE904671 A BE 904671A
Authority
BE
Belgium
Prior art keywords
imidazoquinoleins
antithrombogenic
cardiotonic
halogen
lower alkoxy
Prior art date
Application number
BE0/216585A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE904671A publication Critical patent/BE904671A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nouvelle série de 1,3-dihydro-2H-imidazo- (4,5-b) quinoléine -2-ones de formule où R1 est un atome d'halogène ou radical inférieur ou alcoxy inférieur, R2 est un atome d'hydrogène ou d'halogène ou radical alcoyle inférieur ou alcoxy inférieur et R3 est un atome d'hydrogène ou d'halogène ou radical alcoyle inférieur ou alcoxy inférieur. Ces composés sont inhibiteurs de l'agrétation des thrombocytes et/ou cardiotiniques.
BE0/216585A 1985-04-25 1986-04-24 Imidazoquinoleines antithrombogenes cardiotoniques. BE904671A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (1)

Publication Number Publication Date
BE904671A true BE904671A (fr) 1986-10-24

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216585A BE904671A (fr) 1985-04-25 1986-04-24 Imidazoquinoleines antithrombogenes cardiotoniques.

Country Status (32)

Country Link
US (1) US4668686A (fr)
KR (1) KR940000828B1 (fr)
CN (1) CN1016175B (fr)
AT (1) AT390257B (fr)
AU (1) AU592983B2 (fr)
BE (1) BE904671A (fr)
CA (1) CA1298836C (fr)
CH (1) CH675722A5 (fr)
CY (1) CY1641A (fr)
DE (1) DE3614132A1 (fr)
DK (3) DK164868C (fr)
EG (1) EG18104A (fr)
ES (3) ES8708229A1 (fr)
FI (1) FI83316C (fr)
FR (1) FR2581065B1 (fr)
GB (1) GB2174987B (fr)
GR (1) GR861086B (fr)
HK (1) HK64492A (fr)
HU (1) HU195813B (fr)
IL (1) IL78581A0 (fr)
IT (1) IT1215651B (fr)
LU (1) LU86406A1 (fr)
MY (1) MY102086A (fr)
NL (1) NL8601053A (fr)
NO (1) NO163406C (fr)
NZ (1) NZ215885A (fr)
OA (1) OA08242A (fr)
PT (1) PT82460B (fr)
SE (1) SE461468B (fr)
SG (1) SG29092G (fr)
SU (3) SU1450746A3 (fr)
YU (1) YU46054B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
HUT74170A (en) * 1993-07-06 1996-11-28 Pfizer Bicyclic tetrahydro pyrazolopyridines
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
AR045261A1 (es) 2003-08-12 2005-10-19 3M Innovative Properties Co Compuestos que contienen imidazo quinolina o imidazo piridina sustituidos; composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos inmunomoduladores
ES2406730T3 (es) 2003-08-27 2013-06-07 3M Innovative Properties Company Imidazoquinolinas sustituidas con ariloxi y arilalquilenoxi
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
AR046046A1 (es) 2003-10-03 2005-11-23 3M Innovative Properties Co Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
US7897767B2 (en) 2003-11-14 2011-03-01 3M Innovative Properties Company Oxime substituted imidazoquinolines
CA2545825A1 (fr) * 2003-11-14 2005-06-02 3M Innovative Properties Company Composes d'un anneau d'imidazo substitue par hydroxylamine
MXPA06005910A (es) 2003-11-25 2006-08-23 3M Innovative Properties Co Sistemas de anillo imidazo sustituido y metodos.
EP1701955A1 (fr) 2003-12-29 2006-09-20 3M Innovative Properties Company Imidazoquinolines a substitution arylalcenyle et arylalkynyle
WO2005066169A2 (fr) 2003-12-30 2005-07-21 3M Innovative Properties Company Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle
CA2559863A1 (fr) 2004-03-24 2005-10-13 3M Innovative Properties Company Imidazopyridines, imidazoquinolines, et imidazonaphthyridines a substitution amide
WO2005123080A2 (fr) 2004-06-15 2005-12-29 3M Innovative Properties Company Imidazoquinolines et imidazonaphthyridines substituees par un heterocyclyle contenant un azote
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (fr) 2004-06-18 2006-06-22 3M Innovative Properties Company Composes a noyau imidazo a substitutif d'isoxazole, de dihydroisoxazole et d'oxadiazole
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
EP1797091A2 (fr) * 2004-09-14 2007-06-20 Novartis Vaccines and Diagnostics, Inc. Compos s à base d'imidazoquinoline
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
ES2392648T3 (es) 2004-12-30 2012-12-12 3M Innovative Properties Company Compuestos quirales sustituidos que contienen un núcleo 1,2-imidazo-4,5-c condensado
CA2597092A1 (fr) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Formulations des gel aqueux contenant des modificateurs de reponse immunitaire
CA2597587A1 (fr) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Composes cycliques imidazo[4,5-c] substitues par oxime et hydroxylamine et procedes associes
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
JP2008538550A (ja) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ，インコーポレイテッド ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
WO2008008432A2 (fr) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
EP2666777A1 (fr) 2006-08-02 2013-11-27 Cytokinetics, Inc. Certaines entités chimiques avec un noyeau imidazo<4,5-b>pyrazin-2(3H)-one, compositions et procédés
EP2139478A4 (fr) * 2007-03-30 2010-05-05 Cytokinetics Inc Entités chimiques, compositions et procédés
WO2013010015A2 (fr) 2011-07-13 2013-01-17 Cytokinetics, Inc. Polythérapie pour als
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
SU1470192A3 (ru) 1989-03-30
SU1450746A3 (ru) 1989-01-07
SE461468B (sv) 1990-02-19
AU5641386A (en) 1986-10-30
ES8802521A1 (es) 1988-07-16
HU195813B (en) 1988-07-28
EG18104A (en) 1992-09-30
ES554336A0 (es) 1987-10-01
ATA112186A (de) 1989-09-15
ES557551A0 (es) 1988-02-16
FI861684A0 (fi) 1986-04-22
DK164868C (da) 1993-01-11
CA1298836C (fr) 1992-04-14
HK64492A (en) 1992-09-04
NL8601053A (nl) 1986-11-17
DK81091D0 (da) 1991-05-01
LU86406A1 (fr) 1986-11-05
DK165248B (da) 1992-10-26
SG29092G (en) 1992-05-15
GB2174987B (en) 1989-08-02
CN86102747A (zh) 1987-02-04
DK190986D0 (da) 1986-04-24
DK80291A (da) 1991-04-30
ES557552A0 (es) 1988-07-16
NO861617L (no) 1986-10-27
MY102086A (en) 1992-03-31
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
FI861684L (fi) 1986-10-26
NO163406C (no) 1990-05-23
ES8708229A1 (es) 1987-10-01
CY1641A (en) 1992-11-06
NO163406B (no) 1990-02-12
IT1215651B (it) 1990-02-22
DK190986A (da) 1986-10-26
SE8601907L (sv) 1986-10-26
AU592983B2 (en) 1990-02-01
DK164868B (da) 1992-08-31
YU46054B (sh) 1992-12-21
IL78581A0 (en) 1986-08-31
PT82460B (pt) 1988-11-30
FR2581065A1 (fr) 1986-10-31
DK165249B (da) 1992-10-26
SE8601907D0 (sv) 1986-04-24
AT390257B (de) 1990-04-10
DE3614132A1 (de) 1986-11-27
YU116787A (en) 1988-04-30
HUT42089A (en) 1987-06-29
KR860008177A (ko) 1986-11-12
SU1560056A3 (ru) 1990-04-23
FI83316B (fi) 1991-03-15
CH675722A5 (fr) 1990-10-31
US4668686A (en) 1987-05-26
CN1016175B (zh) 1992-04-08
FR2581065B1 (fr) 1990-02-02
NZ215885A (en) 1989-04-26
FI83316C (fi) 1991-06-25
GB8610037D0 (en) 1986-05-29
KR940000828B1 (ko) 1994-02-02
IT8620206A0 (it) 1986-04-24
GR861086B (en) 1986-09-01
PT82460A (en) 1986-05-01
DK165249C (da) 1993-03-22
ES8801829A1 (es) 1988-02-16
DK80291D0 (da) 1991-04-30
GB2174987A (en) 1986-11-19
OA08242A (en) 1987-10-30

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19940430