BE904671A - Imidazoquinoleines antithrombogenes cardiotoniques. - Google Patents

Imidazoquinoleines antithrombogenes cardiotoniques.

Info

Publication number
BE904671A
BE904671A BE0/216585A BE216585A BE904671A BE 904671 A BE904671 A BE 904671A BE 0/216585 A BE0/216585 A BE 0/216585A BE 216585 A BE216585 A BE 216585A BE 904671 A BE904671 A BE 904671A
Authority
BE
Belgium
Prior art keywords
imidazoquinoleins
antithrombogenic
cardiotonic
halogen
lower alkoxy
Prior art date
Application number
BE0/216585A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE904671A publication Critical patent/BE904671A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nouvelle série de 1,3-dihydro-2H-imidazo- (4,5-b) quinoléine -2-ones de formule où R1 est un atome d'halogène ou radical inférieur ou alcoxy inférieur, R2 est un atome d'hydrogène ou d'halogène ou radical alcoyle inférieur ou alcoxy inférieur et R3 est un atome d'hydrogène ou d'halogène ou radical alcoyle inférieur ou alcoxy inférieur. Ces composés sont inhibiteurs de l'agrétation des thrombocytes et/ou cardiotiniques.
BE0/216585A 1985-04-25 1986-04-24 Imidazoquinoleines antithrombogenes cardiotoniques. BE904671A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (1)

Publication Number Publication Date
BE904671A true BE904671A (fr) 1986-10-24

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216585A BE904671A (fr) 1985-04-25 1986-04-24 Imidazoquinoleines antithrombogenes cardiotoniques.

Country Status (32)

Country Link
US (1) US4668686A (fr)
KR (1) KR940000828B1 (fr)
CN (1) CN1016175B (fr)
AT (1) AT390257B (fr)
AU (1) AU592983B2 (fr)
BE (1) BE904671A (fr)
CA (1) CA1298836C (fr)
CH (1) CH675722A5 (fr)
CY (1) CY1641A (fr)
DE (1) DE3614132A1 (fr)
DK (3) DK164868C (fr)
EG (1) EG18104A (fr)
ES (3) ES8708229A1 (fr)
FI (1) FI83316C (fr)
FR (1) FR2581065B1 (fr)
GB (1) GB2174987B (fr)
GR (1) GR861086B (fr)
HK (1) HK64492A (fr)
HU (1) HU195813B (fr)
IL (1) IL78581A0 (fr)
IT (1) IT1215651B (fr)
LU (1) LU86406A1 (fr)
MY (1) MY102086A (fr)
NL (1) NL8601053A (fr)
NO (1) NO163406C (fr)
NZ (1) NZ215885A (fr)
OA (1) OA08242A (fr)
PT (1) PT82460B (fr)
SE (1) SE461468B (fr)
SG (1) SG29092G (fr)
SU (3) SU1450746A3 (fr)
YU (1) YU46054B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
AU695301B2 (en) * 1993-07-06 1998-08-13 Pfizer Inc. Bicyclic tetrahydro pyrazolopyridines
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
MXPA06001669A (es) 2003-08-12 2006-04-28 3M Innovative Properties Co Compuestos que contienen imidazo-oxima sustituidos.
NZ545412A (en) 2003-08-27 2008-12-24 Coley Pharm Group Inc Aryloxy and arylalkyleneoxy substituted imidazoquinolines
JP2007504269A (ja) 2003-09-05 2007-03-01 スリーエム イノベイティブ プロパティズ カンパニー Ｃｄ５＋ｂ細胞リンパ腫の治療方法
EP1673087B1 (fr) * 2003-10-03 2015-05-13 3M Innovative Properties Company Imidazoquinolines a substitution alcoxy
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
CN1906192A (zh) * 2003-11-14 2007-01-31 3M创新有限公司 羟胺取代的咪唑环化合物
WO2005048933A2 (fr) 2003-11-14 2005-06-02 3M Innovative Properties Company Composes d'un anneau d'imidazo substitues par oxime
AU2004293078B2 (en) 2003-11-25 2012-01-19 3M Innovative Properties Company Substituted imidazo ring systems and methods
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
EP1699788A2 (fr) 2003-12-30 2006-09-13 3M Innovative Properties Company Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006009826A1 (fr) 2004-06-18 2006-01-26 3M Innovative Properties Company Thiazoloquinolines et thiazolonaphtyridines substitues par aryloxy et arylalkyleneoxy
WO2006038923A2 (fr) 2004-06-18 2006-04-13 3M Innovative Properties Company Imidazonaphthyridines substituees par aryle
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
CN101056877B (zh) * 2004-09-14 2010-06-09 诺华疫苗和诊断公司 咪唑并喹啉化合物
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
CA2592904C (fr) 2004-12-30 2015-04-07 3M Innovative Properties Company Composes chiraux a cycle [1,2]imidazo[4,5] fusionne
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
EP1846405A2 (fr) 2005-02-11 2007-10-24 3M Innovative Properties Company Composes cycliques imidazo 4,5-c substitues par oxime et hydroxylamine et procedes associes
CA2602683A1 (fr) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines et analogues associes
CA2602590A1 (fr) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Composes cycliques 1-pyrazolo[3,4-c] substitues comme modulateurs de la biosynthese de cytokine destines au traitement d'infections virales et de maladies neoplastiques
WO2008008432A2 (fr) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
DK2069352T5 (en) 2006-08-02 2017-04-03 Cytokinetics Inc SPECIFIC CHEMICAL UNITS, COMPOSITIONS AND PROCEDURES
EP2139478A4 (fr) * 2007-03-30 2010-05-05 Cytokinetics Inc Entités chimiques, compositions et procédés
US10272082B2 (en) 2011-07-13 2019-04-30 Cytokinetics, Inc. Combination ALS therapy
WO2024149378A1 (fr) * 2023-01-13 2024-07-18 上海超阳药业有限公司 Composé quinolinone et composé naphtyridinone et leur utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
FI861684A0 (fi) 1986-04-22
FI83316B (fi) 1991-03-15
DK80291A (da) 1991-04-30
PT82460B (pt) 1988-11-30
ES554336A0 (es) 1987-10-01
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
DK165248B (da) 1992-10-26
YU116787A (en) 1988-04-30
FI83316C (fi) 1991-06-25
AU592983B2 (en) 1990-02-01
EG18104A (en) 1992-09-30
DK190986A (da) 1986-10-26
ES8801829A1 (es) 1988-02-16
NZ215885A (en) 1989-04-26
AU5641386A (en) 1986-10-30
KR860008177A (ko) 1986-11-12
CN1016175B (zh) 1992-04-08
SG29092G (en) 1992-05-15
GR861086B (en) 1986-09-01
MY102086A (en) 1992-03-31
ES8802521A1 (es) 1988-07-16
IT1215651B (it) 1990-02-22
SE461468B (sv) 1990-02-19
SU1450746A3 (ru) 1989-01-07
FR2581065A1 (fr) 1986-10-31
OA08242A (en) 1987-10-30
DK80291D0 (da) 1991-04-30
NL8601053A (nl) 1986-11-17
FR2581065B1 (fr) 1990-02-02
IL78581A0 (en) 1986-08-31
AT390257B (de) 1990-04-10
CN86102747A (zh) 1987-02-04
SE8601907L (sv) 1986-10-26
YU46054B (sh) 1992-12-21
DK190986D0 (da) 1986-04-24
CY1641A (en) 1992-11-06
ES557552A0 (es) 1988-07-16
DK165249C (da) 1993-03-22
GB8610037D0 (en) 1986-05-29
PT82460A (en) 1986-05-01
HK64492A (en) 1992-09-04
HU195813B (en) 1988-07-28
LU86406A1 (fr) 1986-11-05
DK164868B (da) 1992-08-31
FI861684L (fi) 1986-10-26
US4668686A (en) 1987-05-26
ATA112186A (de) 1989-09-15
ES8708229A1 (es) 1987-10-01
SE8601907D0 (sv) 1986-04-24
SU1560056A3 (ru) 1990-04-23
IT8620206A0 (it) 1986-04-24
CA1298836C (fr) 1992-04-14
CH675722A5 (fr) 1990-10-31
NO163406C (no) 1990-05-23
NO861617L (no) 1986-10-27
HUT42089A (en) 1987-06-29
DE3614132A1 (de) 1986-11-27
DK81091D0 (da) 1991-05-01
DK164868C (da) 1993-01-11
ES557551A0 (es) 1988-02-16
KR940000828B1 (ko) 1994-02-02
NO163406B (no) 1990-02-12
SU1470192A3 (ru) 1989-03-30
DK165249B (da) 1992-10-26
GB2174987A (en) 1986-11-19
GB2174987B (en) 1989-08-02

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19940430