DK1910384T3 - Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser - Google Patents

Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser

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Publication number
DK1910384T3
DK1910384T3 DK06789431.1T DK06789431T DK1910384T3 DK 1910384 T3 DK1910384 T3 DK 1910384T3 DK 06789431 T DK06789431 T DK 06789431T DK 1910384 T3 DK1910384 T3 DK 1910384T3
Authority
DK
Denmark
Prior art keywords
sirtuine
imidazo
modulating compounds
thiazol derivatives
thiazol
Prior art date
Application number
DK06789431.1T
Other languages
English (en)
Inventor
Joseph J Nunes
Jill Milne
Jean Bemis
Roger Xie
Chi B Vu
Pui Yee Ng
Jeremy S Disch
Original Assignee
Sirtris Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc filed Critical Sirtris Pharmaceuticals Inc
Application granted granted Critical
Publication of DK1910384T3 publication Critical patent/DK1910384T3/da

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Diabetes (AREA)
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  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Obesity (AREA)
  • Pain & Pain Management (AREA)
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  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Ophthalmology & Optometry (AREA)
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DK06789431.1T 2005-08-04 2006-08-04 Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser DK1910384T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US70561205P 2005-08-04 2005-08-04
US74178305P 2005-12-02 2005-12-02
US77937006P 2006-03-03 2006-03-03
US79227606P 2006-04-14 2006-04-14
PCT/US2006/030510 WO2007019344A1 (en) 2005-08-04 2006-08-04 Imidazo [2,1-b] thiayole derivatives as sirtuin modulating compounds

Publications (1)

Publication Number Publication Date
DK1910384T3 true DK1910384T3 (da) 2012-12-17

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DK06789431.1T DK1910384T3 (da) 2005-08-04 2006-08-04 Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser

Country Status (11)

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US (5) US20070037865A1 (da)
EP (7) EP2468752A1 (da)
JP (7) JP5203193B2 (da)
CN (1) CN103145738A (da)
AU (5) AU2006278504B2 (da)
CA (5) CA2618360C (da)
DK (1) DK1910384T3 (da)
ES (3) ES2431050T3 (da)
PL (1) PL1910384T3 (da)
PT (1) PT1910384E (da)
WO (5) WO2007019416A1 (da)

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US20090169585A1 (en) * 2003-10-23 2009-07-02 Resveratrol Partners, Llc Resveratrol-Containing Compositions And Their Use In Modulating Gene Product Concentration Or Activity
US20050158376A1 (en) * 2003-10-23 2005-07-21 Sardi William F. Dietary supplement and method of processing same
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
CN1964627B (zh) * 2004-06-04 2011-10-19 华盛顿大学 治疗神经病变的方法和组合物
CN101124012B (zh) * 2004-12-27 2012-09-05 范因斯坦医学研究院 通过电刺激迷走神经治疗炎症性疾病的装置
US11207518B2 (en) * 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
MX2007008008A (es) 2004-12-30 2007-11-12 Astex Therapeutics Ltd Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora.
EP1850840A2 (en) * 2005-01-13 2007-11-07 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
EP1853610A1 (en) * 2005-03-03 2007-11-14 Sirtris Pharmaceuticals, Inc. N-phenyl benzamide derivatives as sirtuin modulators
EP2805719A1 (en) * 2005-03-30 2014-11-26 Glaxosmithkline LLC Nicotinamide riboside and analogues thereof
US20070014833A1 (en) * 2005-03-30 2007-01-18 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
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