DK1924600T3 - Identifikation af tumor-associerede antigener for diagnose og terapi - Google Patents

Identifikation af tumor-associerede antigener for diagnose og terapi

Info

Publication number: DK1924600T3
Authority: DK; Denmark
Prior art keywords: tumor; diagnosis; therapy; identification; associated antigens
Prior art date: 2005-09-12

Application number

DK06791878.9T

Other languages

English (en)

Inventor

Ugur Sahin

Oezlem Tuereci

Dirk Usener

Michael Koslowski

Original Assignee

Ganymed Pharmaceuticals Ag

Johannes Gutenberg Uni Mainz Vertreten Durch Den Praesidenten

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-12

Filing date

2006-09-06

Publication date

2013-11-11

2006-09-06 Application filed by Ganymed Pharmaceuticals Ag, Johannes Gutenberg Uni Mainz Vertreten Durch Den Praesidenten filed Critical Ganymed Pharmaceuticals Ag

2013-11-11 Application granted granted Critical

2013-11-11 Publication of DK1924600T3 publication Critical patent/DK1924600T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/207—Modifications characterised by siRNA, miRNA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Microbiology (AREA)
Zoology (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Wood Science & Technology (AREA)
Physics & Mathematics (AREA)
Bioinformatics & Cheminformatics (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Hospice & Palliative Care (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
General Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Food Science & Technology (AREA)
General Chemical & Material Sciences (AREA)

DK06791878.9T 2005-09-12 2006-09-06 Identifikation af tumor-associerede antigener for diagnose og terapi DK1924600T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP20050019786 EP1762575A1 (en)	2005-09-12	2005-09-12	Identification of tumor-associated antigens for diagnosis and therapy
PCT/EP2006/008695 WO2007031222A2 (en)	2005-09-12	2006-09-06	Identification of tumor-associated antigens for diagnosis and therapy

Publications (1)

Publication Number	Publication Date
DK1924600T3 true DK1924600T3 (da)	2013-11-11

Family

ID=35285406

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK06791878.9T DK1924600T3 (da)	2005-09-12	2006-09-06	Identifikation af tumor-associerede antigener for diagnose og terapi
DK11003883T DK2433954T3 (da)	2005-09-12	2006-09-06	Identifikation af tumorassocierede antigener til diagnosticering og terapi
DK15153951.7T DK2894162T3 (da)	2005-09-12	2006-09-06	Identifikation af tumorassocierede antigener til diagnose og terapi

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK11003883T DK2433954T3 (da)	2005-09-12	2006-09-06	Identifikation af tumorassocierede antigener til diagnosticering og terapi
DK15153951.7T DK2894162T3 (da)	2005-09-12	2006-09-06	Identifikation af tumorassocierede antigener til diagnose og terapi

Country Status (20)

Country	Link
US (5)	US20090202530A1 (da)
EP (14)	EP1762575A1 (da)
JP (5)	JP6037593B2 (da)
KR (2)	KR20130121198A (da)
CN (1)	CN101305020B (da)
AU (1)	AU2006291717B2 (da)
BR (1)	BRPI0616827A2 (da)
CA (2)	CA2620712A1 (da)
CY (3)	CY1114661T1 (da)
DK (3)	DK1924600T3 (da)
ES (4)	ES2664386T3 (da)
HR (3)	HRP20131047T1 (da)
HU (1)	HUE037307T2 (da)
LT (1)	LT2894162T (da)
PL (3)	PL2894162T3 (da)
PT (3)	PT2433954E (da)
RS (3)	RS53988B1 (da)
RU (2)	RU2485974C2 (da)
SI (3)	SI1924600T1 (da)
WO (1)	WO2007031222A2 (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10347710B4 (de)	2003-10-14	2006-03-30	Johannes-Gutenberg-Universität Mainz	Rekombinante Impfstoffe und deren Verwendung
EP1762575A1 (en)	2005-09-12	2007-03-14	Ganymed Pharmaceuticals AG	Identification of tumor-associated antigens for diagnosis and therapy
AU2013206613B2 (en) *	2005-09-12	2017-03-02	Biontech Ag	Identification of tumor-associated antigens for diagnosis and therapy
DE102005046490A1 (de)	2005-09-28	2007-03-29	Johannes-Gutenberg-Universität Mainz	Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
EP1970384A1 (en)	2007-03-14	2008-09-17	Ganymed Pharmaceuticals AG	Monoclonal antibodies for treatment of cancer
EP2060583A1 (en) *	2007-10-23	2009-05-20	Ganymed Pharmaceuticals AG	Identification of tumor-associated markers for diagnosis and therapy
AU2016201637B2 (en) *	2007-10-23	2017-05-25	Biontech Ag	Identification of tumor-associated markers for diagnosis and therapy
EP2166021A1 (en) *	2008-09-16	2010-03-24	Ganymed Pharmaceuticals AG	Monoclonal antibodies for treatment of cancer
AU2015205868B2 (en) *	2008-09-16	2017-04-27	Ganymed Pharmaceuticals Ag	Monoclonal antibodies for treatment of cancer
EP2371864A1 (en)	2010-03-23	2011-10-05	Ganymed Pharmaceuticals AG	Monoclonal antibodies for treatment of cancer
US9061066B2 (en) *	2010-06-04	2015-06-23	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Immunoadjuvant compounds and uses thereof
PL3892295T3 (pl)	2011-05-24	2023-07-24	BioNTech SE	Zindywidualizowane szczepionki przeciwnowotworowe
WO2013143555A1 (en)	2012-03-26	2013-10-03	Biontech Ag	Rna formulation for immunotherapy
EP3417874B1 (en)	2012-11-28	2024-09-11	BioNTech SE	Individualized vaccines for cancer
WO2014180490A1 (en)	2013-05-10	2014-11-13	Biontech Ag	Predicting immunogenicity of t cell epitopes
SG11201606439VA (en)	2014-02-07	2016-09-29	Dong Wha Pharm Co Ltd	Anticancer adjuvant composition containing rip3 expression promoter as active ingredient, method for screening for anticancer adjuvant enhancing sensitivity of anticancer drug by promoting rip3 expression, and method for monitoring sensitivity of anticancer drug
CN113791220A (zh)	2014-09-10	2021-12-14	豪夫迈·罗氏有限公司	免疫原性突变体肽筛选平台
WO2016045732A1 (en)	2014-09-25	2016-03-31	Biontech Rna Pharmaceuticals Gmbh	Stable formulations of lipids and liposomes
RU2620306C2 (ru) *	2015-01-15	2017-05-24	Олег Викторович Бухтояров	Способ прогнозирования рецидива злокачественного опухолевого заболевания
WO2016128060A1 (en)	2015-02-12	2016-08-18	Biontech Ag	Predicting t cell epitopes useful for vaccination
DK3271382T3 (da) *	2015-03-16	2020-05-04	Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft	Fremgangsmåde til detektion af nye immunogene T-celleepitoper og isolering af nye antigenspecifikke T-cellereceptorer ved hjælp af et MHC-cellebibliotek
BR112017025728A2 (pt) *	2015-06-16	2018-08-07	Targovax Asa	fragmentos mutantes da proteína ras
GB201516047D0 (en)	2015-09-10	2015-10-28	Cancer Rec Tech Ltd	Method
WO2017059902A1 (en)	2015-10-07	2017-04-13	Biontech Rna Pharmaceuticals Gmbh	3' utr sequences for stabilization of rna
ES2970865T3 (es)	2015-12-16	2024-05-31	Gritstone Bio Inc	Identificación, fabricación y uso de neoantígenos
IL260030B2 (en)	2016-01-08	2025-12-01	Nykode Therapeutics ASA	Therapeutic anticancer neoepitope vaccine
US10712310B2 (en)	2016-01-22	2020-07-14	Temple University—Of the Commonwealth System of Higher Education	Protein quantification by near infrared spectral imaging
CN107266552B (zh) *	2016-03-30	2022-02-08	香雪生命科学技术（广东）有限公司	源自于prame的肿瘤抗原短肽
JP6717982B2 (ja)	2016-05-20	2020-07-08	アランセオ・ネザーランズ・ベー・フェー	ゴム組成物
DE102016115246C5 (de) *	2016-08-17	2018-12-20	Immatics Biotechnologies Gmbh	Neue t-zellrezeptoren und deren verwendung in immuntherapie
CN108250289B (zh) *	2016-12-28	2021-10-08	香雪生命科学技术（广东）有限公司	源自于mage b6的肿瘤抗原短肽
WO2018224166A1 (en)	2017-06-09	2018-12-13	Biontech Rna Pharmaceuticals Gmbh	Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy
TWI676483B (zh) *	2017-08-06	2019-11-11	強普生技股份有限公司	醫藥套組及其用途
EP4576103A3 (en)	2017-10-10	2025-08-27	Gritstone bio, Inc.	Neoantigen identification using hotspots
CN111630602A (zh)	2017-11-22	2020-09-04	磨石肿瘤生物技术公司	减少新抗原的接合表位呈递

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4475196A (en)	1981-03-06	1984-10-02	Zor Clair G	Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en)	1981-04-10	1984-05-08	Parker-Hannifin Corporation	Medication infusion pump
US4474893A (en)	1981-07-01	1984-10-02	The University of Texas System Cancer Center	Recombinant monoclonal antibodies
US4439196A (en)	1982-03-18	1984-03-27	Merck & Co., Inc.	Osmotic drug delivery system
US4522811A (en)	1982-07-08	1985-06-11	Syntex (U.S.A.) Inc.	Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4447224A (en)	1982-09-20	1984-05-08	Infusaid Corporation	Variable flow implantable infusion apparatus
US4487603A (en)	1982-11-26	1984-12-11	Cordis Corporation	Implantable microinfusion pump system
US4486194A (en)	1983-06-08	1984-12-04	James Ferrara	Therapeutic device for administering medicaments through the skin
US4596556A (en)	1985-03-25	1986-06-24	Bioject, Inc.	Hypodermic injection apparatus
US5374548A (en)	1986-05-02	1994-12-20	Genentech, Inc.	Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
MX9203291A (es)	1985-06-26	1992-08-01	Liposome Co Inc	Metodo para acoplamiento de liposomas.
GB8601597D0 (en)	1986-01-23	1986-02-26	Wilson R H	Nucleotide sequences
US4954617A (en)	1986-07-07	1990-09-04	Trustees Of Dartmouth College	Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
US4881175A (en)	1986-09-02	1989-11-14	Genex Corporation	Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US4946778A (en)	1987-09-21	1990-08-07	Genex Corporation	Single polypeptide chain binding molecules
US5260203A (en)	1986-09-02	1993-11-09	Enzon, Inc.	Single polypeptide chain binding molecules
JP3101690B2 (ja)	1987-03-18	2000-10-23	エス・ビィ・２・インコーポレイテッド	変性抗体の、または変性抗体に関する改良
US5013653A (en)	1987-03-20	1991-05-07	Creative Biomolecules, Inc.	Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5091513A (en)	1987-05-21	1992-02-25	Creative Biomolecules, Inc.	Biosynthetic antibody binding sites
US5132405A (en)	1987-05-21	1992-07-21	Creative Biomolecules, Inc.	Biosynthetic antibody binding sites
US5258498A (en)	1987-05-21	1993-11-02	Creative Biomolecules, Inc.	Polypeptide linkers for production of biosynthetic proteins
ATE243754T1 (de)	1987-05-21	2003-07-15	Micromet Ag	Multifunktionelle proteine mit vorbestimmter zielsetzung
US4941880A (en)	1987-06-19	1990-07-17	Bioject, Inc.	Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en)	1987-06-19	1988-12-13	Bioject, Inc.	Non-invasive hypodermic injection device
GB8717430D0 (en)	1987-07-23	1987-08-26	Celltech Ltd	Recombinant dna product
GB8809129D0 (en)	1988-04-18	1988-05-18	Celltech Ltd	Recombinant dna methods vectors and host cells
US5108921A (en)	1989-04-03	1992-04-28	Purdue Research Foundation	Method for enhanced transmembrane transport of exogenous molecules
US5064413A (en)	1989-11-09	1991-11-12	Bioject, Inc.	Needleless hypodermic injection device
US5312335A (en)	1989-11-09	1994-05-17	Bioject Inc.	Needleless hypodermic injection device
US6255458B1 (en)	1990-08-29	2001-07-03	Genpharm International	High affinity human antibodies and human antibodies against digoxin
GB9019812D0 (en)	1990-09-11	1990-10-24	Scotgen Ltd	Novel antibodies for treatment and prevention of infection in animals and man
US5383851A (en)	1992-07-24	1995-01-24	Bioject Inc.	Needleless hypodermic injection device
GB9223377D0 (en)	1992-11-04	1992-12-23	Medarex Inc	Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
DK0752248T3 (da) *	1992-11-13	2000-11-13	Idec Pharma Corp	Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
US5744585A (en) *	1995-03-16	1998-04-28	Medenica; Rajko D.	Human monoclonal antibody against lung carcinoma
US6121022A (en)	1995-04-14	2000-09-19	Genentech, Inc.	Altered polypeptides with increased half-life
US5677139A (en)	1995-04-21	1997-10-14	President And Fellows Of Harvard College	In vitro differentiation of CD34+ progenitor cells into T lymphocytes
UA56132C2 (uk)	1995-04-25	2003-05-15	Смітклайн Бічем Байолоджікалс С.А.	Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
US6277375B1 (en)	1997-03-03	2001-08-21	Board Of Regents, The University Of Texas System	Immunoglobulin-like domains with increased half-lives
US20020065394A1 (en) *	1998-03-18	2002-05-30	Kenneth Jacobs	Secreted proteins and polynucleotides encoding them
US6194551B1 (en)	1998-04-02	2001-02-27	Genentech, Inc.	Polypeptide variants
GB9826143D0 (en)	1998-11-27	1999-01-20	Ludwig Inst Cancer Res	Tumour rejection antigens
HU226150B1 (en) *	1999-01-13	2008-05-28	Igeneon Krebs Immuntherapie	Use of antibodies for anticancer vaccination
US6943235B1 (en) *	1999-04-12	2005-09-13	Agensys, Inc.	Transmembrane protein expressed in prostate cancer
ES2336887T5 (es)	2000-03-30	2019-03-06	Whitehead Inst Biomedical Res	Mediadores de interferencia por ARN específicos de secuencias de ARN
US6974667B2 (en) *	2000-06-14	2005-12-13	Gene Logic, Inc.	Gene expression profiles in liver cancer
AU2001280608A1 (en) *	2000-07-18	2002-01-30	Curagen Corporation	Human polynucleotides and polypeptides encoded thereby
EA013564B1 (ru)	2000-08-03	2010-06-30	Терапеутик Хьюман Поликлоналз Инк.	Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
US6812339B1 (en) *	2000-09-08	2004-11-02	Applera Corporation	Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
CA2430013C (en)	2000-11-30	2011-11-22	Medarex, Inc.	Transgenic transchromosomal rodents for making human antibodies
US20020177547A1 (en) *	2001-01-16	2002-11-28	Karin Molling	Pharmaceutical compositions for treating or preventing cancer
US20030133939A1 (en)	2001-01-17	2003-07-17	Genecraft, Inc.	Binding domain-immunoglobulin fusion proteins
US7754208B2 (en)	2001-01-17	2010-07-13	Trubion Pharmaceuticals, Inc.	Binding domain-immunoglobulin fusion proteins
EP1578899A2 (en) *	2001-05-25	2005-09-28	Incyte Genomics, Inc.	Secreted proteins
AU2002324700A1 (en) *	2001-08-14	2003-03-03	Bayer Ag	Nucleic acid and amino acid sequences involved in pain
WO2003075014A2 (en)	2002-03-06	2003-09-12	Oxford Glycosciences (Uk) Ltd	Protein-protein interactions in human tumours involving bcmp-7 and bcmp-11
WO2003102159A2 (en) *	2002-06-04	2003-12-11	Curagen Corporation	Novel proteins and nucleic acids encoding same
US7053201B2 (en) *	2002-08-30	2006-05-30	National Defense Medical Center	Nucleic acid molecules and polypeptides related to h-ADAM7
TW200413539A (en) *	2002-09-30	2004-08-01	Oncotherapy Science Inc	Genes and polypeptides relating to prostate cancers
BRPI0315295C1 (pt)	2002-10-17	2021-05-25	Genmab As	anticorpo monoclonal humano isolado, célula hospedeira procariótica, composição farmacêutica, molécula biespecífica, usos de um anticorpo, métodos in vitro de detectar a presença de antígeno de cd20 ou uma célula que expressa cd20 em uma amostra, kit, e, vetor de expressão
WO2004044163A2 (en) *	2002-11-06	2004-05-27	Sequenom, Inc.	Methods for identifying risk of melanoma and treatments thereof
WO2004065629A1 (en) *	2003-01-17	2004-08-05	The Chinese University Of Hong Kong	Circulating mrna as diagnostic markers for pregnancy-related disorders
AU2004210986A1 (en) *	2003-02-11	2004-08-26	Wyeth	Methods for monitoring drug activities in vivo
WO2005049806A2 (en) *	2003-03-14	2005-06-02	Nuvelo, Inc.	Novel nucleic acids and polypeptides
US20050255114A1 (en) *	2003-04-07	2005-11-17	Nuvelo, Inc.	Methods and diagnosis for the treatment of preeclampsia
RU2256924C2 (ru) *	2003-09-03	2005-07-20	Торопова Надежда Ефимовна	Способ дифференциальной диагностики злокачественных опухолей простаты
WO2005079490A2 (en) *	2004-02-13	2005-09-01	Nuvelo, Inc.	Methods of therapy and diagnosis using targeting of cells that express steap2 polypeptides
CN1663603A (zh) *	2004-03-02	2005-09-07	北京大学	一种肿瘤－胎盘抗原蛋白及其dna在肿瘤治疗中的应用
EP1762575A1 (en)	2005-09-12	2007-03-14	Ganymed Pharmaceuticals AG	Identification of tumor-associated antigens for diagnosis and therapy
EP1970384A1 (en)	2007-03-14	2008-09-17	Ganymed Pharmaceuticals AG	Monoclonal antibodies for treatment of cancer
EP2166021A1 (en)	2008-09-16	2010-03-24	Ganymed Pharmaceuticals AG	Monoclonal antibodies for treatment of cancer
EP2221063A1 (en)	2009-02-20	2010-08-25	Ganymed Pharmaceuticals AG	Methods and compositions for diagnosis and treatment of cancer
SMT202300421T1 (it)	2009-02-20	2024-01-10	Astellas Pharma Inc	Metodi e composizioni per la diagnosi e il trattamento del cancro
EP2371864A1 (en)	2010-03-23	2011-10-05	Ganymed Pharmaceuticals AG	Monoclonal antibodies for treatment of cancer

2005
- 2005-09-12 EP EP20050019786 patent/EP1762575A1/en not_active Withdrawn
2006
- 2006-09-06 CA CA002620712A patent/CA2620712A1/en not_active Abandoned
- 2006-09-06 EP EP15156794.8A patent/EP2902412B1/en active Active
- 2006-09-06 ES ES15153951.7T patent/ES2664386T3/es active Active
- 2006-09-06 PL PL15153951T patent/PL2894162T3/pl unknown
- 2006-09-06 SI SI200631679T patent/SI1924600T1/sl unknown
- 2006-09-06 PL PL06791878T patent/PL1924600T3/pl unknown
- 2006-09-06 EP EP20110003888 patent/EP2433959A3/en not_active Withdrawn
- 2006-09-06 EP EP20110003883 patent/EP2433954B8/en active Active
- 2006-09-06 PT PT110038833T patent/PT2433954E/pt unknown
- 2006-09-06 ES ES11003887.4T patent/ES2532410T3/es active Active
- 2006-09-06 EP EP15153951.7A patent/EP2894162B1/en active Active
- 2006-09-06 ES ES06791878T patent/ES2434945T3/es active Active
- 2006-09-06 SI SI200631922T patent/SI2433954T1/sl unknown
- 2006-09-06 EP EP20110003887 patent/EP2433958B1/en active Active
- 2006-09-06 SI SI200632252T patent/SI2894162T1/en unknown
- 2006-09-06 EP EP20110003885 patent/EP2433956A3/en not_active Withdrawn
- 2006-09-06 US US12/066,399 patent/US20090202530A1/en not_active Abandoned
- 2006-09-06 EP EP06791878.9A patent/EP1924600B1/en active Active
- 2006-09-06 HU HUE15153951A patent/HUE037307T2/hu unknown
- 2006-09-06 RS RS20150290A patent/RS53988B1/sr unknown
- 2006-09-06 EP EP20110003886 patent/EP2433957A3/en not_active Withdrawn
- 2006-09-06 PT PT67918789T patent/PT1924600E/pt unknown
- 2006-09-06 EP EP20110003889 patent/EP2433960B1/en active Active
- 2006-09-06 EP EP20110003884 patent/EP2433955A3/en not_active Withdrawn
- 2006-09-06 CN CN200680041875.XA patent/CN101305020B/zh not_active Expired - Fee Related
- 2006-09-06 BR BRPI0616827-2A patent/BRPI0616827A2/pt not_active Application Discontinuation
- 2006-09-06 RS RS20180353A patent/RS57080B1/sr unknown
- 2006-09-06 ES ES11003883.3T patent/ES2535500T3/es active Active
- 2006-09-06 DK DK06791878.9T patent/DK1924600T3/da active
- 2006-09-06 JP JP2008530387A patent/JP6037593B2/ja not_active Expired - Fee Related
- 2006-09-06 CA CA2820201A patent/CA2820201C/en active Active
- 2006-09-06 EP EP20110003890 patent/EP2433961A3/en not_active Withdrawn
- 2006-09-06 PL PL11003883T patent/PL2433954T3/pl unknown
- 2006-09-06 RS RS20130469A patent/RS53009B/sr unknown
- 2006-09-06 HR HRP20131047TT patent/HRP20131047T1/hr unknown
- 2006-09-06 EP EP20110003891 patent/EP2433962B1/en active Active
- 2006-09-06 EP EP15160484.0A patent/EP2966082B1/en active Active
- 2006-09-06 DK DK11003883T patent/DK2433954T3/da active
- 2006-09-06 RU RU2008114318/10A patent/RU2485974C2/ru not_active IP Right Cessation
- 2006-09-06 KR KR1020137026645A patent/KR20130121198A/ko not_active Ceased
- 2006-09-06 PT PT151539517T patent/PT2894162T/pt unknown
- 2006-09-06 LT LTEP15153951.7T patent/LT2894162T/lt unknown
- 2006-09-06 KR KR1020087008926A patent/KR101359697B1/ko not_active Expired - Fee Related
- 2006-09-06 AU AU2006291717A patent/AU2006291717B2/en not_active Ceased
- 2006-09-06 WO PCT/EP2006/008695 patent/WO2007031222A2/en not_active Ceased
- 2006-09-06 DK DK15153951.7T patent/DK2894162T3/da active
2011
- 2011-04-13 US US13/086,176 patent/US8975375B2/en not_active Expired - Fee Related
2012
- 2012-12-28 JP JP2012288124A patent/JP5750433B2/ja active Active
2013
- 2013-03-26 RU RU2013113439A patent/RU2644686C2/ru not_active IP Right Cessation
- 2013-07-19 US US13/946,302 patent/US20140017254A1/en not_active Abandoned
- 2013-11-13 CY CY20131101005T patent/CY1114661T1/el unknown
2014
- 2014-12-17 JP JP2014254806A patent/JP5913547B2/ja active Active
2015
- 2015-01-27 US US14/606,729 patent/US9919036B2/en not_active Expired - Fee Related
- 2015-04-21 HR HRP20150432TT patent/HRP20150432T1/hr unknown
- 2015-04-30 CY CY20151100395T patent/CY1116951T1/el unknown
- 2015-11-24 JP JP2015228705A patent/JP2016102116A/ja active Pending
2016
- 2016-02-15 JP JP2016025541A patent/JP6196338B2/ja active Active
- 2016-07-27 US US15/220,973 patent/US20170080068A1/en not_active Abandoned
2018
- 2018-03-27 CY CY20181100344T patent/CY1120096T1/el unknown
- 2018-03-27 HR HRP20180507TT patent/HRP20180507T1/hr unknown

Also Published As

Publication number	Publication date
US20110189179A1 (en)	2011-08-04
RU2008114318A (ru)	2009-10-20
US8975375B2 (en)	2015-03-10
US20150197576A1 (en)	2015-07-16
CA2820201A1 (en)	2007-03-22
CA2620712A1 (en)	2007-03-22
US9919036B2 (en)	2018-03-20
HRP20180507T1 (hr)	2018-05-04
JP5913547B2 (ja)	2016-04-27
EP1762575A1 (en)	2007-03-14
HK1168608A1 (en)	2013-01-04
RU2485974C2 (ru)	2013-06-27
EP2433955A2 (en)	2012-03-28
HK1118840A1 (en)	2009-02-20
AU2006291717B2 (en)	2013-06-06
LT2894162T (lt)	2018-04-10
EP2433960B1 (en)	2015-03-04
EP2433960A2 (en)	2012-03-28
EP2966082A1 (en)	2016-01-13
JP5750433B2 (ja)	2015-07-22
PL2433954T3 (pl)	2015-07-31
RS53009B (sr)	2014-04-30
ES2664386T3 (es)	2018-04-19
RU2013113439A (ru)	2014-10-10
DK2433954T3 (da)	2015-05-04
US20090202530A1 (en)	2009-08-13
HRP20131047T1 (hr)	2013-12-06
EP2433956A3 (en)	2012-07-04
CA2820201C (en)	2018-07-17
HK1211606A1 (en)	2016-05-27
KR20130121198A (ko)	2013-11-05
JP6037593B2 (ja)	2016-12-07
EP2894162B1 (en)	2018-01-03
BRPI0616827A2 (pt)	2011-07-05
EP2433957A2 (en)	2012-03-28
EP2433958A3 (en)	2012-07-04
PT2894162T (pt)	2018-04-02
EP1924600A2 (en)	2008-05-28
EP2433958A2 (en)	2012-03-28
EP2433960A3 (en)	2012-07-04
SI1924600T1 (sl)	2013-12-31
CY1114661T1 (el)	2016-10-05
HRP20150432T1 (hr)	2015-09-25
AU2006291717A1 (en)	2007-03-22
KR20080052664A (ko)	2008-06-11
EP2433954A3 (en)	2012-07-04
JP2015120691A (ja)	2015-07-02
JP2013136579A (ja)	2013-07-11
DK2894162T3 (da)	2018-04-16
JP2016102116A (ja)	2016-06-02
RS57080B1 (sr)	2018-06-29
EP2433961A3 (en)	2012-06-27
EP2433954B8 (en)	2015-05-13
EP2433954B1 (en)	2015-02-25
ES2532410T3 (es)	2015-03-26
EP2433955A3 (en)	2012-07-04
PL2894162T3 (pl)	2018-06-29
EP2902412B1 (en)	2018-02-21
EP1924600B1 (en)	2013-08-28
EP2433961A2 (en)	2012-03-28
EP2433962B1 (en)	2015-03-25
ES2434945T3 (es)	2013-12-18
RS53988B1 (sr)	2015-10-30
WO2007031222A2 (en)	2007-03-22
EP2433962A3 (en)	2012-07-04
EP2433954A2 (en)	2012-03-28
PL1924600T3 (pl)	2014-01-31
US20170080068A1 (en)	2017-03-23
PT1924600E (pt)	2013-11-18
JP2009507868A (ja)	2009-02-26
ES2535500T3 (es)	2015-05-12
EP2894162A1 (en)	2015-07-15
US20140017254A1 (en)	2014-01-16
SI2433954T1 (sl)	2015-06-30
EP2433959A3 (en)	2012-06-27
EP2433956A2 (en)	2012-03-28
CN101305020A (zh)	2008-11-12
JP2016166175A (ja)	2016-09-15
WO2007031222A3 (en)	2007-07-26
JP6196338B2 (ja)	2017-09-13
EP2433958B1 (en)	2015-02-25
RU2644686C2 (ru)	2018-02-13
EP2902412A1 (en)	2015-08-05
EP2433959A2 (en)	2012-03-28
SI2894162T1 (en)	2018-05-31
CN101305020B (zh)	2015-09-02
CY1120096T1 (el)	2018-12-12
EP2433962A2 (en)	2012-03-28
EP2966082B1 (en)	2017-08-30
PT2433954E (pt)	2015-06-02
EP2433957A3 (en)	2012-07-04
KR101359697B1 (ko)	2014-02-07
CY1116951T1 (el)	2017-04-05
HUE037307T2 (hu)	2018-08-28

Publication	Publication Date	Title
DK1924600T3 (da)	2013-11-11	Identifikation af tumor-associerede antigener for diagnose og terapi
HUS2000026I1 (hu)	2020-07-15	Anti-CD79b antitestek és immunkonjugátumok és alkalmazási eljárások
NO20080692L (no)	2008-04-03	SP35 antistoffer og anvendelse derav
DK1871418T3 (da)	2014-06-10	Humaniserede anti-cd70-bindende midler og anvendelser deraf
DK2118140T3 (da)	2013-07-01	Humancytomegalovirus-neutraliserende antistoffer og anvendelse deraf
BRPI0719202A2 (pt)	2015-06-16	Diagnóstico e tratamento de câncer usando anticorpo antiereg
DK1899484T3 (da)	2015-11-23	Identifikation af tumorer og væv
HUE058876T2 (hu)	2022-09-28	Anti-GM-CSF antitestek és felhasználásuk
HUE048404T2 (hu)	2020-07-28	Claudin-18 elleni monoklonális antitestek rák kezelésére
DK1740207T3 (da)	2013-01-21	Antigenafgivelsesvektorer og konstrukter
DK2061814T3 (da)	2012-08-27	Antistoffer og immunokonjugater og anvendelse deraf.
PT1920065T (pt)	2018-12-04	Anticorpos anti-alfavbeta6 e suas utilizações
DK2107373T3 (da)	2012-08-20	Analysechip og analysefremgangsmåde
PT1814580T (pt)	2016-11-11	Métodos de utilização de il-21 para imunoterapia adotiva e identificação de antigénios tumorais
DE602006021274D1 (de)	2011-05-26	Ultraschallvorrichtung und ultraschallverfahren
DK1844074T3 (da)	2013-07-15	Humane antistoffer og proteiner
FI20060449A0 (fi)	2006-05-09	Mammografiamenetelmä ja mammografialaite
DK1587837T3 (da)	2012-09-24	Epitopsekvenser til diagnose og behandling af prostatacancer
EP1853428A4 (en)	2010-04-28	IMAGING DEVICE
DK2118128T3 (da)	2013-02-18	Fusionsproteiner omfattende tumorrejektionantigenerne NY-ESO-1 og LAGE-1
DE602006008682D1 (de)	2009-10-08	Bildgebungsanordnung und Prüfverfahren
DE602005023094D1 (de)	2010-10-07	Entwickler und Bilderzeugungsmethode
DE602005002895D1 (de)	2007-11-29	Ultraschall-Endoskop
EP1881898A4 (en)	2010-07-07	IMAGING DEVICE
DE602006006244D1 (de)	2009-05-28	Bildaufzeichnungsgerät und Verfahren