DK1940817T3 - Cholinerge enhancere med forbedret blod-hjerne-barriere-permeabilitet til behandling af sygdomme associeret med kognitiv svækkelse - Google Patents
Cholinerge enhancere med forbedret blod-hjerne-barriere-permeabilitet til behandling af sygdomme associeret med kognitiv svækkelseInfo
- Publication number
- DK1940817T3 DK1940817T3 DK06792225.2T DK06792225T DK1940817T3 DK 1940817 T3 DK1940817 T3 DK 1940817T3 DK 06792225 T DK06792225 T DK 06792225T DK 1940817 T3 DK1940817 T3 DK 1940817T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- brain barrier
- cognitive impairment
- improved blood
- barrier permeability
- Prior art date
Links
- 208000028698 Cognitive impairment Diseases 0.000 title 1
- 230000008499 blood brain barrier function Effects 0.000 title 1
- 210000001218 blood-brain barrier Anatomy 0.000 title 1
- 230000001713 cholinergic effect Effects 0.000 title 1
- 208000010877 cognitive disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003623 enhancer Substances 0.000 title 1
- 230000035699 permeability Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05020721A EP1777222A1 (en) | 2005-09-22 | 2005-09-22 | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
| US78024306P | 2006-03-07 | 2006-03-07 | |
| PCT/EP2006/009220 WO2007039138A1 (en) | 2005-09-22 | 2006-09-22 | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1940817T3 true DK1940817T3 (da) | 2010-10-18 |
Family
ID=35717553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06792225.2T DK1940817T3 (da) | 2005-09-22 | 2006-09-22 | Cholinerge enhancere med forbedret blod-hjerne-barriere-permeabilitet til behandling af sygdomme associeret med kognitiv svækkelse |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080261954A1 (da) |
| EP (2) | EP1777222A1 (da) |
| CN (1) | CN101287719A (da) |
| CA (1) | CA2623114A1 (da) |
| DK (1) | DK1940817T3 (da) |
| ES (1) | ES2348334T3 (da) |
| PL (1) | PL1940817T3 (da) |
| PT (1) | PT1940817E (da) |
| SI (1) | SI1940817T1 (da) |
| WO (1) | WO2007039138A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090253654A1 (en) | 2005-09-22 | 2009-10-08 | Galantos Pharma Gmbh | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
| CN102007129B (zh) * | 2008-04-14 | 2014-05-07 | 神经动力生命科学公司 | 用作治疗人类脑疾病的前药的雪花胺衍生物 |
| CA2937222C (en) | 2009-06-25 | 2019-06-04 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds |
| ES3031438T3 (en) | 2009-06-25 | 2025-07-08 | Alkermes Pharma Ireland Ltd | Heterocyclic compounds for the treatment of neurological and psychological disorders |
| EP2456434A1 (en) * | 2009-07-23 | 2012-05-30 | Shire LLC | Galantamine amino acid and peptide prodrugs and uses thereof |
| WO2011163594A2 (en) | 2010-06-24 | 2011-12-29 | Alkermes, Inc. | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| US9034867B2 (en) | 2011-03-18 | 2015-05-19 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising sorbitan esters |
| WO2013088255A1 (en) | 2011-12-15 | 2013-06-20 | Alkermes Pharma Ireland Limited | Prodrugs of secondary amine compounds |
| WO2013142198A1 (en) | 2012-03-19 | 2013-09-26 | Alkermes Pharma Ireland Limited | Pharmaaceutical compositions comprising fatty acid esters |
| JP6219918B2 (ja) | 2012-03-19 | 2017-10-25 | アルカームス ファーマ アイルランド リミテッド | グリセロールエステルを含む医薬組成物 |
| WO2013142205A1 (en) | 2012-03-19 | 2013-09-26 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising benzyl alcohol |
| PT3417862T (pt) | 2012-07-27 | 2021-08-06 | Neurodyn Life Sciences Inc | Biodisponibilidade cerebral da galantamina melhorada através de formulações selecionadas e administração transmucosal de pró-fármacos lipofílicos |
| EP3718536A1 (en) | 2012-09-19 | 2020-10-07 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
| CN103193787B (zh) * | 2013-03-11 | 2015-10-28 | 华中科技大学 | 具有神经保护作用的石蒜伦碱类化合物及其制备方法 |
| CN103204860B (zh) * | 2013-03-11 | 2015-10-28 | 华中科技大学 | 具有神经保护作用的石蒜科生物碱类化合物 |
| EP3119399A4 (en) | 2014-03-20 | 2017-09-27 | Alkermes Pharma Ireland Limited | Aripiprazole formulations having increased injection speeds |
| US11219627B2 (en) * | 2014-05-16 | 2022-01-11 | Synaptec Development Llc | Clearance of amyloid beta |
| CA3092335A1 (en) | 2018-03-05 | 2019-09-12 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| CN114621242A (zh) * | 2020-12-11 | 2022-06-14 | 哈药(北京)生物科技有限公司 | 加兰他敏的衍生物及制剂 |
| EP4029867A1 (en) | 2021-01-13 | 2022-07-20 | Alpha Cognition Inc. | Solid forms of galantamine benzoate gluconate |
| EP4186509A1 (en) | 2021-11-26 | 2023-05-31 | Alpha Cognition Inc. | Alpha-1062 for treating traumatic brain injury |
| CN116217641A (zh) * | 2023-03-01 | 2023-06-06 | 上海原思标物科技有限公司 | 吗啡-D3-6-β-D-葡萄糖醛酸苷的合成方法及其中间体化合物 |
| US12208167B1 (en) | 2024-02-06 | 2025-01-28 | Alpha Cognition Inc. | Coated tablets for pH-dependent release of benzgalantamine |
| US12551491B1 (en) | 2025-07-23 | 2026-02-17 | Alpha Cognition Inc. | Dosage regimens for benzgalantamine |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150354A (en) * | 1987-01-15 | 2000-11-21 | Bonnie Davis | Compounds for the treatment of Alzheimer's disease |
| JP2755403B2 (ja) * | 1987-05-04 | 1998-05-20 | デイービス、ボニー | アルツハイマー病の治療のための化合物 |
| US4981849A (en) * | 1989-02-23 | 1991-01-01 | Smithkline Beecham Corporation | Alpha-adrenergic receptor antagonists |
| EP0584185B1 (en) * | 1991-05-14 | 1999-08-11 | Ernir Snorrason | Treatment of fatigue syndrome with cholinesterase inhibitors |
| US6323195B1 (en) * | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| US6323196B1 (en) * | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| AU8742198A (en) * | 1997-08-15 | 1999-03-08 | Shire International Licensing B.V. | Use of cholinesterase inhibitor for treating diseases associated with pro teolytic enzyme activity |
| ATE306264T1 (de) * | 1998-12-11 | 2005-10-15 | Bonnie M Davis | Verwendung von acetylcholinesterase inhibitoren zur modulierung der hypothalamus-hypophysen- gonadenachse |
| JP4721386B2 (ja) * | 2001-07-10 | 2011-07-13 | 第一三共株式会社 | 新規ガランタミン類縁体 |
| US20030162770A1 (en) * | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
| US20040266659A1 (en) * | 2003-06-27 | 2004-12-30 | Stephen LaBerge | Substances that enhance recall and lucidity during dreaming |
-
2005
- 2005-09-22 EP EP05020721A patent/EP1777222A1/en not_active Withdrawn
-
2006
- 2006-09-22 PT PT06792225T patent/PT1940817E/pt unknown
- 2006-09-22 CA CA002623114A patent/CA2623114A1/en not_active Abandoned
- 2006-09-22 ES ES06792225T patent/ES2348334T3/es active Active
- 2006-09-22 US US12/067,799 patent/US20080261954A1/en not_active Abandoned
- 2006-09-22 SI SI200630770T patent/SI1940817T1/sl unknown
- 2006-09-22 PL PL06792225T patent/PL1940817T3/pl unknown
- 2006-09-22 CN CNA2006800351514A patent/CN101287719A/zh active Pending
- 2006-09-22 DK DK06792225.2T patent/DK1940817T3/da active
- 2006-09-22 EP EP06792225A patent/EP1940817B1/en not_active Revoked
- 2006-09-22 WO PCT/EP2006/009220 patent/WO2007039138A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN101287719A (zh) | 2008-10-15 |
| WO2007039138A1 (en) | 2007-04-12 |
| PT1940817E (pt) | 2010-10-11 |
| CA2623114A1 (en) | 2007-04-12 |
| EP1940817A1 (en) | 2008-07-09 |
| SI1940817T1 (sl) | 2010-10-29 |
| ES2348334T3 (es) | 2010-12-02 |
| US20080261954A1 (en) | 2008-10-23 |
| PL1940817T3 (pl) | 2011-03-31 |
| EP1777222A1 (en) | 2007-04-25 |
| EP1940817B1 (en) | 2010-07-07 |
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