DK194582A - Chromon-derivater og farmaceutisk acceptable salte deraf - Google Patents

Chromon-derivater og farmaceutisk acceptable salte deraf Download PDF

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Publication number
DK194582A
DK194582A DK194582A DK194582A DK194582A DK 194582 A DK194582 A DK 194582A DK 194582 A DK194582 A DK 194582A DK 194582 A DK194582 A DK 194582A DK 194582 A DK194582 A DK 194582A
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DK
Denmark
Prior art keywords
acceptable salts
pharmaceutical acceptable
chromon
derivatives
chromon derivatives
Prior art date
Application number
DK194582A
Other languages
English (en)
Inventor
Edwin Shen-Chou Wu
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of DK194582A publication Critical patent/DK194582A/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Figure DK194582AD00021
(2) hvori hg og Rj er som ovenfor, og OR,, or en eventuel* substitueret hydroxylgruppe, i nærværelse af et opløsningsmiddel og en base til opnåelse af en forbindelse med formlen 2, hvor OR,, er
Figure DK194582AD00022
hvorefter epoxidet omsættes med en amin R^R^NH, hvor Rj er som ovenfor, og R, er H eller benzyl, i et alkoholisk
O
opløsningsmiddel ved forhøjede temperaturer, hvorved forbindelsen 1 opnås, og dersom R^ er benzyl, fjernes gruppen ved katalytisk hydrogenering til opnåelse af den sekundære amin.
Forbindelserne er lægemidler med antihypertensiv virkning.
DK194582A 1981-12-14 1982-04-30 Chromon-derivater og farmaceutisk acceptable salte deraf DK194582A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33012281A 1981-12-14 1981-12-14
US33012281 1981-12-14

Publications (1)

Publication Number Publication Date
DK194582A true DK194582A (da) 1983-06-15

Family

ID=23288410

Family Applications (1)

Application Number Title Priority Date Filing Date
DK194582A DK194582A (da) 1981-12-14 1982-04-30 Chromon-derivater og farmaceutisk acceptable salte deraf

Country Status (7)

Country Link
EP (1) EP0081621A1 (da)
JP (1) JPS58105982A (da)
KR (1) KR830010094A (da)
AU (1) AU8045382A (da)
DK (1) DK194582A (da)
FI (1) FI821515L (da)
NO (1) NO821421L (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889941A (en) * 1987-04-23 1989-12-26 Fisons Corporation Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase
US5474994A (en) * 1992-05-26 1995-12-12 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
US5605896A (en) * 1992-02-25 1997-02-25 Recordati S.A., Chemical And Pharmaceutical Company Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
IT1254469B (it) * 1992-02-25 1995-09-25 Recordati Chem Pharm Derivati benzopiranici e benzotiopiranici
IT1258315B (it) * 1992-04-10 1996-02-22 Recordati Chem Pharm Derivati del flavone

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046275A (en) * 1958-05-30 1962-07-24 Chemiewerk Homburg Zweignieder N-substituted 2-phenyl-7-aminoalkoxy chromones
BE767309A (fr) * 1971-02-19 1971-10-18 Recordati Chem Pharm Procede de preparation des flavone-7-oxyacetates d'alcoyle inferieur
BE790074A (fr) * 1971-10-21 1973-02-01 Blaise Rolland Nouveaux composes derives de la tetrahydroisoquinoleine et la gamma-benzopyrone et leurs procedes de preparation
DE2740950A1 (de) * 1977-09-10 1979-03-22 Merck Patent Gmbh Verfahren zur herstellung von flavonen
DE2950135A1 (de) * 1979-12-13 1981-06-19 Merck Patent Gmbh, 6100 Darmstadt Basischer aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI821515A0 (fi) 1982-04-29
EP0081621A1 (en) 1983-06-22
FI821515A7 (fi) 1983-06-15
AU8045382A (en) 1983-06-23
NO821421L (no) 1983-06-15
FI821515L (fi) 1983-06-15
KR830010094A (ko) 1983-12-26
JPS58105982A (ja) 1983-06-24

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