DK194582A - Chromon-derivater og farmaceutisk acceptable salte deraf - Google Patents
Chromon-derivater og farmaceutisk acceptable salte deraf Download PDFInfo
- Publication number
- DK194582A DK194582A DK194582A DK194582A DK194582A DK 194582 A DK194582 A DK 194582A DK 194582 A DK194582 A DK 194582A DK 194582 A DK194582 A DK 194582A DK 194582 A DK194582 A DK 194582A
- Authority
- DK
- Denmark
- Prior art keywords
- acceptable salts
- pharmaceutical acceptable
- chromon
- derivatives
- chromon derivatives
- Prior art date
Links
- 0 CC1(CCCCC1)C(CCC12)(CC1OC(*1ccccc1)=C(*)C2O)O Chemical compound CC1(CCCCC1)C(CCC12)(CC1OC(*1ccccc1)=C(*)C2O)O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Description
(2) hvori hg og Rj er som ovenfor, og OR,, or en eventuel* substitueret hydroxylgruppe, i nærværelse af et opløsningsmiddel og en base til opnåelse af en forbindelse med formlen 2, hvor OR,, er
hvorefter epoxidet omsættes med en amin R^R^NH, hvor Rj er som ovenfor, og R, er H eller benzyl, i et alkoholisk
O
opløsningsmiddel ved forhøjede temperaturer, hvorved forbindelsen 1 opnås, og dersom R^ er benzyl, fjernes gruppen ved katalytisk hydrogenering til opnåelse af den sekundære amin.
Forbindelserne er lægemidler med antihypertensiv virkning.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33012281A | 1981-12-14 | 1981-12-14 | |
| US33012281 | 1981-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK194582A true DK194582A (da) | 1983-06-15 |
Family
ID=23288410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK194582A DK194582A (da) | 1981-12-14 | 1982-04-30 | Chromon-derivater og farmaceutisk acceptable salte deraf |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0081621A1 (da) |
| JP (1) | JPS58105982A (da) |
| KR (1) | KR830010094A (da) |
| AU (1) | AU8045382A (da) |
| DK (1) | DK194582A (da) |
| FI (1) | FI821515A7 (da) |
| NO (1) | NO821421L (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889941A (en) * | 1987-04-23 | 1989-12-26 | Fisons Corporation | Synthetic flavonoids as inhibitors of leukotrienes and 5-lipoxygenase |
| US5474994A (en) * | 1992-05-26 | 1995-12-12 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A |
| US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| IT1254469B (it) * | 1992-02-25 | 1995-09-25 | Recordati Chem Pharm | Derivati benzopiranici e benzotiopiranici |
| IT1258315B (it) * | 1992-04-10 | 1996-02-22 | Recordati Chem Pharm | Derivati del flavone |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3046275A (en) * | 1958-05-30 | 1962-07-24 | Chemiewerk Homburg Zweignieder | N-substituted 2-phenyl-7-aminoalkoxy chromones |
| BE767309A (fr) * | 1971-02-19 | 1971-10-18 | Recordati Chem Pharm | Procede de preparation des flavone-7-oxyacetates d'alcoyle inferieur |
| BE790074A (fr) * | 1971-10-21 | 1973-02-01 | Blaise Rolland | Nouveaux composes derives de la tetrahydroisoquinoleine et la gamma-benzopyrone et leurs procedes de preparation |
| DE2740950A1 (de) * | 1977-09-10 | 1979-03-22 | Merck Patent Gmbh | Verfahren zur herstellung von flavonen |
| DE2950135A1 (de) * | 1979-12-13 | 1981-06-19 | Merck Patent Gmbh, 6100 Darmstadt | Basischer aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
-
1982
- 1982-02-12 AU AU80453/82A patent/AU8045382A/en not_active Abandoned
- 1982-03-02 EP EP82101592A patent/EP0081621A1/en not_active Withdrawn
- 1982-04-26 JP JP57068885A patent/JPS58105982A/ja active Pending
- 1982-04-29 NO NO821421A patent/NO821421L/no unknown
- 1982-04-29 FI FI821515A patent/FI821515A7/fi not_active Application Discontinuation
- 1982-04-30 KR KR1019820001906A patent/KR830010094A/ko not_active Withdrawn
- 1982-04-30 DK DK194582A patent/DK194582A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU8045382A (en) | 1983-06-23 |
| JPS58105982A (ja) | 1983-06-24 |
| NO821421L (no) | 1983-06-15 |
| EP0081621A1 (en) | 1983-06-22 |
| FI821515L (fi) | 1983-06-15 |
| KR830010094A (ko) | 1983-12-26 |
| FI821515A0 (fi) | 1982-04-29 |
| FI821515A7 (fi) | 1983-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |