DK1947172T3 - Konstruktion af metabolisk styring - Google Patents

Konstruktion af metabolisk styring

Info

Publication number
DK1947172T3
DK1947172T3 DK08000125.8T DK08000125T DK1947172T3 DK 1947172 T3 DK1947172 T3 DK 1947172T3 DK 08000125 T DK08000125 T DK 08000125T DK 1947172 T3 DK1947172 T3 DK 1947172T3
Authority
DK
Denmark
Prior art keywords
construction
metabolic control
metabolic
metabolite
metabolites
Prior art date
Application number
DK08000125.8T
Other languages
English (en)
Inventor
James C Liao
Original Assignee
Food Industry Res & Dev Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Food Industry Res & Dev Inst filed Critical Food Industry Res & Dev Inst
Application granted granted Critical
Publication of DK1947172T3 publication Critical patent/DK1947172T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Control Of Positive-Displacement Air Blowers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK08000125.8T 1999-07-27 2000-07-27 Konstruktion af metabolisk styring DK1947172T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14580199P 1999-07-27 1999-07-27
EP00950804A EP1220892B1 (en) 1999-07-27 2000-07-27 Engineering of metabolic control

Publications (1)

Publication Number Publication Date
DK1947172T3 true DK1947172T3 (da) 2013-03-25

Family

ID=22514617

Family Applications (4)

Application Number Title Priority Date Filing Date
DK10152561.6T DK2182072T3 (da) 1999-07-27 2000-07-27 Fremgangsmåde til produktion af isoprenoider
DK08000125.8T DK1947172T3 (da) 1999-07-27 2000-07-27 Konstruktion af metabolisk styring
DK10152563.2T DK2184366T3 (da) 1999-07-27 2000-07-27 Fremgangsmåde til fremstilling af lycopen
DK00950804T DK1220892T3 (da) 1999-07-27 2000-07-27 Engineering af metabolisk kontrol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10152561.6T DK2182072T3 (da) 1999-07-27 2000-07-27 Fremgangsmåde til produktion af isoprenoider

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK10152563.2T DK2184366T3 (da) 1999-07-27 2000-07-27 Fremgangsmåde til fremstilling af lycopen
DK00950804T DK1220892T3 (da) 1999-07-27 2000-07-27 Engineering af metabolisk kontrol

Country Status (8)

Country Link
US (1) US7122341B1 (da)
EP (4) EP1947172B1 (da)
JP (2) JP4685308B2 (da)
CN (4) CN1900304A (da)
AT (1) ATE386103T1 (da)
DE (1) DE60038032T2 (da)
DK (4) DK2182072T3 (da)
WO (1) WO2001007567A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200934872A (en) 2008-02-05 2009-08-16 Echem Hightech Co Ltd A strain of genetically reengineered escherichia coli for biosynthesis of high yield carotenoids after mutation screening
CN102482648B (zh) 2009-06-22 2014-12-10 科德克希思公司 酮还原酶介导的产生α氯代醇的立体选择性途径
WO2011100265A2 (en) 2010-02-10 2011-08-18 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
CN101979587B (zh) * 2010-10-14 2013-05-01 浙江大学 少动鞘氨醇单胞菌的八氢番茄红素脱氢酶基因及其应用
HUE046506T2 (hu) 2011-06-16 2020-03-30 Univ California Szintetikus génklaszterek
WO2014071182A1 (en) 2012-11-01 2014-05-08 Massachusetts Institute Of Technology Directed evolution of synthetic gene cluster
CN103232986B (zh) * 2013-05-27 2014-06-18 青岛蔚蓝生物集团有限公司 一种异戊二烯生产方法
EP3155103A1 (en) * 2014-06-13 2017-04-19 Deinove Method of producing terpenes or terpenoids
CN108602729B (zh) 2015-07-13 2022-07-05 皮沃特生物公司 改良植物性状的方法及组合物
WO2017062412A1 (en) 2015-10-05 2017-04-13 Massachusetts Institute Of Technology Nitrogen fixation using refactored nif clusters
JP7234116B2 (ja) 2017-01-12 2023-03-07 ピボット バイオ， インコーポレイテッド 植物形質を改善するための方法および組成物
JP2021500907A (ja) 2017-10-25 2021-01-14 ピボット バイオ， インコーポレイテッド 植物の形質の改良を目的とした窒素固定のための遺伝子標的
AU2018354221B2 (en) 2017-10-25 2025-04-17 Pivot Bio, Inc. Methods and compositions for improving engineered microbes that fix nitrogen
WO2019113387A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
JP2021506316A (ja) 2017-12-21 2021-02-22 ザイマージェン インコーポレイテッド ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物
CN108441510B (zh) * 2018-03-26 2020-12-22 武汉天问生物科技有限公司 转基因水稻grh和黑金米的培育及grh目的基因的检测方法
CN108624600B (zh) * 2018-05-22 2021-06-18 昆明理工大学 锌指转录因子基因RkMsn4的用途
CN112739668A (zh) 2018-06-27 2021-04-30 皮沃特生物股份有限公司 包括重构固氮微生物的农业组合物
KR20210060434A (ko) 2018-07-11 2021-05-26 피벗 바이오, 인크. 리모델링된 미생물에 의한 시간적 및 공간적 표적화 동적 질소 전달
WO2020146372A1 (en) 2019-01-07 2020-07-16 Pivot Bio, Inc. Plant colonization assays using natural microbial barcodes
WO2020190363A1 (en) 2019-03-19 2020-09-24 Massachusetts Institute Of Technology Control of nitrogen fixation in rhizobia that associate with cereals
KR102229379B1 (ko) * 2019-06-11 2021-03-19 주식회사 제노포커스 파이토플루엔 고생산성 재조합 미생물 및 이를 이용한 파이토플루엔의 제조방법
PY2134250A (es) 2020-05-01 2022-01-28 Pivot Bio Inc Formulaciones líquidas estables para microorganismos fijadores de nitrógeno
AU2020445067A1 (en) 2020-05-01 2022-12-01 Pivot Bio, Inc. Measurement of nitrogen fixation and incorporation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5429939A (en) * 1989-04-21 1995-07-04 Kirin Beer Kabushiki Kaisha DNA sequences useful for the synthesis of carotenoids
JP2950888B2 (ja) * 1989-04-21 1999-09-20 麒麟麦酒株式会社 カロチノイドの合成に有用なｄｎａ鎖
US5530189A (en) 1990-03-02 1996-06-25 Amoco Corporation Lycopene biosynthesis in genetically engineered hosts
WO1996006172A1 (en) * 1994-08-23 1996-02-29 Kirin Beer Kabushiki Kaisha Keto group introducing enzyme, dna coding for the same, and process for producing ketocarotenoid
DK0782621T3 (da) 1994-09-16 2006-07-03 Texas A & M Univ Sys Mikroorganismer samt fremgangsmåde til overproduktion af DAHP ved hjælp af klonet PPS-gen
US5830692A (en) * 1995-03-24 1998-11-03 Consortium Fur Elektrochemische Industrie Gmbh Expression system which can be regulated
US5744341A (en) 1996-03-29 1998-04-28 University Of Maryland College Park Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes
DE69722766T2 (de) * 1996-12-02 2004-04-22 Dsm Ip Assets B.V. Verbesserte fermentative Herstellung von Carotenoide
JPH10327865A (ja) * 1997-05-29 1998-12-15 Kirin Brewery Co Ltd カロテノイド配糖体およびその製造法
US20020045220A1 (en) * 1999-10-13 2002-04-18 Chaitan Khosla Biosynthesis of polyketide synthase substrates

Also Published As

Publication number Publication date
CN1896246B (zh) 2013-01-16
EP2184366A2 (en) 2010-05-12
CN1224698C (zh) 2005-10-26
DK2184366T3 (da) 2014-06-02
EP2182072A2 (en) 2010-05-05
CN1900304A (zh) 2007-01-24
HK1142367A1 (en) 2010-12-03
EP2184366A3 (en) 2010-06-02
JP2010284173A (ja) 2010-12-24
JP4685308B2 (ja) 2011-05-18
DE60038032T2 (de) 2009-02-05
EP1947172A3 (en) 2008-10-15
EP1220892A4 (en) 2004-04-14
CN1365386A (zh) 2002-08-21
ATE386103T1 (de) 2008-03-15
EP2182072B1 (en) 2012-12-26
CN1896246A (zh) 2007-01-17
EP2184366B1 (en) 2014-03-12
JP5419829B2 (ja) 2014-02-19
CN1670189A (zh) 2005-09-21
WO2001007567A1 (en) 2001-02-01
EP2182072A3 (en) 2010-06-09
HK1119742A1 (en) 2009-03-13
DE60038032D1 (de) 2008-03-27
DK2182072T3 (da) 2013-04-02
EP1220892A1 (en) 2002-07-10
EP1220892B1 (en) 2008-02-13
EP1947172A2 (en) 2008-07-23
US7122341B1 (en) 2006-10-17
CN100432216C (zh) 2008-11-12
JP2003508085A (ja) 2003-03-04
HK1142368A1 (en) 2010-12-03
EP1947172B1 (en) 2012-12-19
DK1220892T3 (da) 2008-06-09

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