DK2184366T3 - Fremgangsmåde til fremstilling af lycopen - Google Patents
Fremgangsmåde til fremstilling af lycopenInfo
- Publication number
- DK2184366T3 DK2184366T3 DK10152563.2T DK10152563T DK2184366T3 DK 2184366 T3 DK2184366 T3 DK 2184366T3 DK 10152563 T DK10152563 T DK 10152563T DK 2184366 T3 DK2184366 T3 DK 2184366T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparing lycopene
- lycopene
- preparing
- metabolite
- metabolites
- Prior art date
Links
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 title 1
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 title 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 title 1
- 229960004999 lycopene Drugs 0.000 title 1
- 235000012661 lycopene Nutrition 0.000 title 1
- 239000001751 lycopene Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 title 1
- 239000002207 metabolite Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000004907 flux Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Control Of Positive-Displacement Air Blowers (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14580199P | 1999-07-27 | 1999-07-27 | |
| EP08000125A EP1947172B1 (en) | 1999-07-27 | 2000-07-27 | Engineering of metabolic control |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2184366T3 true DK2184366T3 (da) | 2014-06-02 |
Family
ID=22514617
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10152561.6T DK2182072T3 (da) | 1999-07-27 | 2000-07-27 | Fremgangsmåde til produktion af isoprenoider |
| DK08000125.8T DK1947172T3 (da) | 1999-07-27 | 2000-07-27 | Konstruktion af metabolisk styring |
| DK10152563.2T DK2184366T3 (da) | 1999-07-27 | 2000-07-27 | Fremgangsmåde til fremstilling af lycopen |
| DK00950804T DK1220892T3 (da) | 1999-07-27 | 2000-07-27 | Engineering af metabolisk kontrol |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10152561.6T DK2182072T3 (da) | 1999-07-27 | 2000-07-27 | Fremgangsmåde til produktion af isoprenoider |
| DK08000125.8T DK1947172T3 (da) | 1999-07-27 | 2000-07-27 | Konstruktion af metabolisk styring |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00950804T DK1220892T3 (da) | 1999-07-27 | 2000-07-27 | Engineering af metabolisk kontrol |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7122341B1 (da) |
| EP (4) | EP1947172B1 (da) |
| JP (2) | JP4685308B2 (da) |
| CN (4) | CN1900304A (da) |
| AT (1) | ATE386103T1 (da) |
| DE (1) | DE60038032T2 (da) |
| DK (4) | DK2182072T3 (da) |
| WO (1) | WO2001007567A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200934872A (en) | 2008-02-05 | 2009-08-16 | Echem Hightech Co Ltd | A strain of genetically reengineered escherichia coli for biosynthesis of high yield carotenoids after mutation screening |
| CN102482648B (zh) | 2009-06-22 | 2014-12-10 | 科德克希思公司 | 酮还原酶介导的产生α氯代醇的立体选择性途径 |
| WO2011100265A2 (en) | 2010-02-10 | 2011-08-18 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| CN101979587B (zh) * | 2010-10-14 | 2013-05-01 | 浙江大学 | 少动鞘氨醇单胞菌的八氢番茄红素脱氢酶基因及其应用 |
| HUE046506T2 (hu) | 2011-06-16 | 2020-03-30 | Univ California | Szintetikus génklaszterek |
| WO2014071182A1 (en) | 2012-11-01 | 2014-05-08 | Massachusetts Institute Of Technology | Directed evolution of synthetic gene cluster |
| CN103232986B (zh) * | 2013-05-27 | 2014-06-18 | 青岛蔚蓝生物集团有限公司 | 一种异戊二烯生产方法 |
| EP3155103A1 (en) * | 2014-06-13 | 2017-04-19 | Deinove | Method of producing terpenes or terpenoids |
| CN108602729B (zh) | 2015-07-13 | 2022-07-05 | 皮沃特生物公司 | 改良植物性状的方法及组合物 |
| WO2017062412A1 (en) | 2015-10-05 | 2017-04-13 | Massachusetts Institute Of Technology | Nitrogen fixation using refactored nif clusters |
| JP7234116B2 (ja) | 2017-01-12 | 2023-03-07 | ピボット バイオ, インコーポレイテッド | 植物形質を改善するための方法および組成物 |
| JP2021500907A (ja) | 2017-10-25 | 2021-01-14 | ピボット バイオ, インコーポレイテッド | 植物の形質の改良を目的とした窒素固定のための遺伝子標的 |
| AU2018354221B2 (en) | 2017-10-25 | 2025-04-17 | Pivot Bio, Inc. | Methods and compositions for improving engineered microbes that fix nitrogen |
| WO2019113387A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| JP2021506316A (ja) | 2017-12-21 | 2021-02-22 | ザイマージェン インコーポレイテッド | ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物 |
| CN108441510B (zh) * | 2018-03-26 | 2020-12-22 | 武汉天问生物科技有限公司 | 转基因水稻grh和黑金米的培育及grh目的基因的检测方法 |
| CN108624600B (zh) * | 2018-05-22 | 2021-06-18 | 昆明理工大学 | 锌指转录因子基因RkMsn4的用途 |
| CN112739668A (zh) | 2018-06-27 | 2021-04-30 | 皮沃特生物股份有限公司 | 包括重构固氮微生物的农业组合物 |
| KR20210060434A (ko) | 2018-07-11 | 2021-05-26 | 피벗 바이오, 인크. | 리모델링된 미생물에 의한 시간적 및 공간적 표적화 동적 질소 전달 |
| WO2020146372A1 (en) | 2019-01-07 | 2020-07-16 | Pivot Bio, Inc. | Plant colonization assays using natural microbial barcodes |
| WO2020190363A1 (en) | 2019-03-19 | 2020-09-24 | Massachusetts Institute Of Technology | Control of nitrogen fixation in rhizobia that associate with cereals |
| KR102229379B1 (ko) * | 2019-06-11 | 2021-03-19 | 주식회사 제노포커스 | 파이토플루엔 고생산성 재조합 미생물 및 이를 이용한 파이토플루엔의 제조방법 |
| PY2134250A (es) | 2020-05-01 | 2022-01-28 | Pivot Bio Inc | Formulaciones líquidas estables para microorganismos fijadores de nitrógeno |
| AU2020445067A1 (en) | 2020-05-01 | 2022-12-01 | Pivot Bio, Inc. | Measurement of nitrogen fixation and incorporation |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5429939A (en) * | 1989-04-21 | 1995-07-04 | Kirin Beer Kabushiki Kaisha | DNA sequences useful for the synthesis of carotenoids |
| JP2950888B2 (ja) * | 1989-04-21 | 1999-09-20 | 麒麟麦酒株式会社 | カロチノイドの合成に有用なdna鎖 |
| US5530189A (en) | 1990-03-02 | 1996-06-25 | Amoco Corporation | Lycopene biosynthesis in genetically engineered hosts |
| WO1996006172A1 (en) * | 1994-08-23 | 1996-02-29 | Kirin Beer Kabushiki Kaisha | Keto group introducing enzyme, dna coding for the same, and process for producing ketocarotenoid |
| DK0782621T3 (da) | 1994-09-16 | 2006-07-03 | Texas A & M Univ Sys | Mikroorganismer samt fremgangsmåde til overproduktion af DAHP ved hjælp af klonet PPS-gen |
| US5830692A (en) * | 1995-03-24 | 1998-11-03 | Consortium Fur Elektrochemische Industrie Gmbh | Expression system which can be regulated |
| US5744341A (en) | 1996-03-29 | 1998-04-28 | University Of Maryland College Park | Genes of carotenoid biosynthesis and metabolism and a system for screening for such genes |
| DE69722766T2 (de) * | 1996-12-02 | 2004-04-22 | Dsm Ip Assets B.V. | Verbesserte fermentative Herstellung von Carotenoide |
| JPH10327865A (ja) * | 1997-05-29 | 1998-12-15 | Kirin Brewery Co Ltd | カロテノイド配糖体およびその製造法 |
| US20020045220A1 (en) * | 1999-10-13 | 2002-04-18 | Chaitan Khosla | Biosynthesis of polyketide synthase substrates |
-
2000
- 2000-07-27 EP EP08000125A patent/EP1947172B1/en not_active Expired - Lifetime
- 2000-07-27 CN CNA2006101007709A patent/CN1900304A/zh active Pending
- 2000-07-27 CN CNB008108781A patent/CN1224698C/zh not_active Expired - Lifetime
- 2000-07-27 CN CNB2005100659541A patent/CN100432216C/zh not_active Expired - Lifetime
- 2000-07-27 WO PCT/US2000/020519 patent/WO2001007567A1/en not_active Ceased
- 2000-07-27 EP EP10152563.2A patent/EP2184366B1/en not_active Expired - Lifetime
- 2000-07-27 CN CN2006101007696A patent/CN1896246B/zh not_active Expired - Lifetime
- 2000-07-27 DE DE60038032T patent/DE60038032T2/de not_active Expired - Lifetime
- 2000-07-27 AT AT00950804T patent/ATE386103T1/de not_active IP Right Cessation
- 2000-07-27 DK DK10152561.6T patent/DK2182072T3/da active
- 2000-07-27 EP EP10152561A patent/EP2182072B1/en not_active Expired - Lifetime
- 2000-07-27 EP EP00950804A patent/EP1220892B1/en not_active Expired - Lifetime
- 2000-07-27 DK DK08000125.8T patent/DK1947172T3/da active
- 2000-07-27 JP JP2001521952A patent/JP4685308B2/ja not_active Expired - Lifetime
- 2000-07-27 DK DK10152563.2T patent/DK2184366T3/da active
- 2000-07-27 DK DK00950804T patent/DK1220892T3/da active
- 2000-07-27 US US10/048,186 patent/US7122341B1/en not_active Expired - Lifetime
-
2010
- 2010-08-25 JP JP2010188609A patent/JP5419829B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1896246B (zh) | 2013-01-16 |
| DK1947172T3 (da) | 2013-03-25 |
| EP2184366A2 (en) | 2010-05-12 |
| CN1224698C (zh) | 2005-10-26 |
| EP2182072A2 (en) | 2010-05-05 |
| CN1900304A (zh) | 2007-01-24 |
| HK1142367A1 (en) | 2010-12-03 |
| EP2184366A3 (en) | 2010-06-02 |
| JP2010284173A (ja) | 2010-12-24 |
| JP4685308B2 (ja) | 2011-05-18 |
| DE60038032T2 (de) | 2009-02-05 |
| EP1947172A3 (en) | 2008-10-15 |
| EP1220892A4 (en) | 2004-04-14 |
| CN1365386A (zh) | 2002-08-21 |
| ATE386103T1 (de) | 2008-03-15 |
| EP2182072B1 (en) | 2012-12-26 |
| CN1896246A (zh) | 2007-01-17 |
| EP2184366B1 (en) | 2014-03-12 |
| JP5419829B2 (ja) | 2014-02-19 |
| CN1670189A (zh) | 2005-09-21 |
| WO2001007567A1 (en) | 2001-02-01 |
| EP2182072A3 (en) | 2010-06-09 |
| HK1119742A1 (en) | 2009-03-13 |
| DE60038032D1 (de) | 2008-03-27 |
| DK2182072T3 (da) | 2013-04-02 |
| EP1220892A1 (en) | 2002-07-10 |
| EP1220892B1 (en) | 2008-02-13 |
| EP1947172A2 (en) | 2008-07-23 |
| US7122341B1 (en) | 2006-10-17 |
| CN100432216C (zh) | 2008-11-12 |
| JP2003508085A (ja) | 2003-03-04 |
| HK1142368A1 (en) | 2010-12-03 |
| EP1947172B1 (en) | 2012-12-19 |
| DK1220892T3 (da) | 2008-06-09 |
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