DK1966388T3 - Tilsigte vektor-fosfolipidkonjugater - Google Patents

Tilsigte vektor-fosfolipidkonjugater

Info

Publication number
DK1966388T3
DK1966388T3 DK06840164.5T DK06840164T DK1966388T3 DK 1966388 T3 DK1966388 T3 DK 1966388T3 DK 06840164 T DK06840164 T DK 06840164T DK 1966388 T3 DK1966388 T3 DK 1966388T3
Authority
DK
Denmark
Prior art keywords
target vector
phospholipid conjugates
phospholipid
conjugates
vector
Prior art date
Application number
DK06840164.5T
Other languages
English (en)
Inventor
Philippe Bussat
Samir Cherkaoui
Hong Helen Fan
Bernard Lamy
Palaniappa Nanjappan
Radhakrishna K Pillai
Sibylle Pochon
Bo Song
Rolf E Swenson
Original Assignee
Bracco Suisse Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse Sa filed Critical Bracco Suisse Sa
Application granted granted Critical
Publication of DK1966388T3 publication Critical patent/DK1966388T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicinal Preparation (AREA)
DK06840164.5T 2005-12-09 2006-12-08 Tilsigte vektor-fosfolipidkonjugater DK1966388T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74924005P 2005-12-09 2005-12-09
US83334206P 2006-07-25 2006-07-25
PCT/US2006/061793 WO2007067979A2 (en) 2005-12-09 2006-12-08 Targeting vector-phospholipid conjugates

Publications (1)

Publication Number Publication Date
DK1966388T3 true DK1966388T3 (da) 2013-10-28

Family

ID=38123651

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06840164.5T DK1966388T3 (da) 2005-12-09 2006-12-08 Tilsigte vektor-fosfolipidkonjugater
DK10190163.5T DK2359864T3 (da) 2005-12-09 2006-12-08 Målrettende vektor-phospholipid-konjugater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10190163.5T DK2359864T3 (da) 2005-12-09 2006-12-08 Målrettende vektor-phospholipid-konjugater

Country Status (13)

Country Link
EP (2) EP1966388B1 (da)
JP (2) JP5242408B2 (da)
KR (3) KR101658439B1 (da)
CN (2) CN103204911B (da)
AU (1) AU2006321613B2 (da)
BR (1) BRPI0619522B8 (da)
CA (3) CA2631716C (da)
DK (2) DK1966388T3 (da)
ES (1) ES2428964T3 (da)
IL (1) IL191850A (da)
MX (1) MX2008007321A (da)
RU (1) RU2433137C2 (da)
WO (1) WO2007067979A2 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7985402B2 (en) 2002-03-01 2011-07-26 Bracco Suisse Sa Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
ES2396368T3 (es) * 2003-03-03 2013-02-21 Dyax Corporation Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
CA2631716C (en) * 2005-12-09 2013-11-26 Bracco International B.V. Targeting vector-phospholipid conjugates
WO2010117725A2 (en) * 2009-04-06 2010-10-14 Novetide, Ltd. Production of peptides containing poly-gly sequences using fmoc chemistry
CN101637613B (zh) * 2009-08-19 2011-09-14 王维 一种脂质靶向超声造影剂及其制备方法
WO2012020030A1 (en) 2010-08-09 2012-02-16 Bracco Suisse Sa Targeted gas-filled microvesicles
CN102286076B (zh) * 2011-06-23 2014-03-12 成都圣诺科技发展有限公司 比伐卢定的制备方法
EP2934740B1 (en) * 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
KR102190157B1 (ko) 2014-12-18 2020-12-14 브라코 스위스 에스.에이. 표적화된 기체-충전 미세소포 제형
WO2017136475A1 (en) * 2016-02-01 2017-08-10 Trust Biosonics Inc. Lipid microbubbles and process of making thereof
US20190365665A1 (en) * 2017-01-24 2019-12-05 Nuvox Pharma Llc Iso-osmotic and near iso-osmotic oxygen therapeutic formulations and methods thereof
EP3360884A1 (en) * 2017-02-10 2018-08-15 Neuronax Improved process for the preparation of a dodecapeptide
SG11202104497VA (en) 2018-12-18 2021-05-28 Bracco Suisse Sa Optimized process for dimeric peptide-phospholipid conjugate
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension
CN118786206A (zh) * 2021-12-06 2024-10-15 西湖生物医药科技(上海)有限公司 经修饰的细胞及其用于递送试剂的用途
WO2025073838A1 (en) 2023-10-04 2025-04-10 Bracco Suisse Sa Freeze-drying process
CN120404964A (zh) * 2024-02-01 2025-08-01 四川科伦药物研究院有限公司 磷脂及其杂质的检测方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (da) 1990-04-02 1993-05-01 Sint Sa
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5338725A (en) * 1992-06-30 1994-08-16 The Research Foundation Of The State University Of New York Anti-aggregatory agents for platelets
PT682530E (pt) 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
EP0831932B1 (en) * 1995-06-07 2004-05-06 Imarx Pharmaceutical Corp. Novel targeted compositions for diagnostic and therapeutic use
ES2197986T3 (es) 1996-02-19 2004-01-16 Amersham Health As Mejoras introducidas en o relacionadas con agentes de contraste.
NZ334365A (en) 1996-08-02 1999-10-28 Nycomed Imaging As Use of a contrast agent comprising microbubbles of biocompatible gas stabilised by opsonisable amphiphilic material for ultrasound imaging of the liver
US6071532A (en) 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
JP2001502349A (ja) 1996-10-21 2001-02-20 ニユコメド・イメージング・アクシエセルカペト 造影剤におけるまたはこれに関する改良
WO1998018501A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
ATE314097T1 (de) 1996-10-28 2006-01-15 Amersham Health As Kontrastmittel
WO1998018498A2 (en) 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
EP0991427A2 (en) 1996-10-28 2000-04-12 Marsden, John Christopher Improvements in or relating to diagnostic/therapeutic agents
ES2206689T3 (es) 1996-10-28 2004-05-16 Amersham Health As Agentes de contraste.
US6245318B1 (en) 1997-05-27 2001-06-12 Mallinckrodt Inc. Selectively binding ultrasound contrast agents
GB9809084D0 (en) * 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US7109167B2 (en) * 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use
ES2398393T3 (es) * 2002-03-01 2013-03-15 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia
AU2003278807A1 (en) * 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7666979B2 (en) * 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
CA2477935C (en) * 2002-03-01 2015-01-06 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US20050250700A1 (en) * 2002-03-01 2005-11-10 Sato Aaron K KDR and VEGF/KDR binding peptides
DE602004029010D1 (de) 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
FI20031528A0 (fi) * 2003-10-17 2003-10-17 Ctt Cancer Targeting Tech Oy Terapeuttinen liposomikoostumus ja menetelmä sen valmistamiseksi
CA2631716C (en) * 2005-12-09 2013-11-26 Bracco International B.V. Targeting vector-phospholipid conjugates

Also Published As

Publication number Publication date
AU2006321613B2 (en) 2012-01-12
CN101374955A (zh) 2009-02-25
WO2007067979A2 (en) 2007-06-14
CN103204911A (zh) 2013-07-17
CA2947346C (en) 2018-07-24
CN101374955B (zh) 2013-03-27
JP2009518448A (ja) 2009-05-07
CA2947346A1 (en) 2007-06-14
EP1966388A4 (en) 2009-11-25
IL191850A (en) 2014-06-30
EP1966388A2 (en) 2008-09-10
BRPI0619522A2 (pt) 2011-10-04
KR20130099251A (ko) 2013-09-05
MX2008007321A (es) 2008-09-30
DK2359864T3 (da) 2019-07-08
EP1966388B1 (en) 2013-08-07
CA2631716A1 (en) 2007-06-14
IL191850A0 (en) 2008-12-29
JP5242408B2 (ja) 2013-07-24
RU2433137C2 (ru) 2011-11-10
CN103204911B (zh) 2015-04-01
AU2006321613A1 (en) 2007-06-14
JP5735993B2 (ja) 2015-06-17
CA2826960A1 (en) 2007-06-14
EP2359864B1 (en) 2019-04-17
KR20140083052A (ko) 2014-07-03
EP2359864A3 (en) 2012-08-01
WO2007067979A3 (en) 2008-07-31
JP2013136608A (ja) 2013-07-11
BRPI0619522B8 (pt) 2021-07-27
KR101323849B1 (ko) 2013-11-07
EP2359864A2 (en) 2011-08-24
CA2631716C (en) 2013-11-26
RU2008127836A (ru) 2010-01-20
ES2428964T3 (es) 2013-11-12
KR101658439B1 (ko) 2016-09-21
BRPI0619522B1 (pt) 2020-11-24
KR20090009187A (ko) 2009-01-22

Similar Documents

Publication Publication Date Title
DK3248613T3 (da) Beta-glucuronid-lægemiddel-linkerkonjugater
PL1937866T3 (pl) Rurowy target
ATE408603T1 (de) Pyrazolylcarboxanilide
CR9974A (es) Gavión
DK1966388T3 (da) Tilsigte vektor-fosfolipidkonjugater
DE502006003394D1 (de) Lehnenklappung
DE602006012066D1 (de) Daraus
DE502006005667D1 (de) Gelenklager
DE502006008475D1 (de) Wasserpumpenflügelrad
ATE549324T1 (de) Tetrahydrobenzoxazine
DE502006006857D1 (de) Wingungserregern
DE502006005768D1 (de) Hydrolysestabilisatorformulierungen
DE112006002964A5 (de) Zweirichtungsreflektanzverteilungsmessgerät
DE502006004302D1 (de) Verschlusskappe
EP1867636A4 (en) PYRIDYLMETHYLSULFONDERIVAT
DE502006001397D1 (de) Lagerbuchse
DE602005003547D1 (de) Fahrradantriebsnabe
DE102005052834B8 (de) Punktschweißklebverbindung
DE502006001004D1 (de) Hydrolager
DE502006006589D1 (de) Teils
ATE485368T1 (de) Hiv - impfung
AT501523A3 (de) Estrich
DE502006003147D1 (de) Verbundgußplatte
PT1889059E (pt) Métodos de imunoensaio melhorados
DE502006003210D1 (de) Nohydrogenpolysiloxanen