DK1966388T3 - Tilsigte vektor-fosfolipidkonjugater - Google Patents
Tilsigte vektor-fosfolipidkonjugaterInfo
- Publication number
- DK1966388T3 DK1966388T3 DK06840164.5T DK06840164T DK1966388T3 DK 1966388 T3 DK1966388 T3 DK 1966388T3 DK 06840164 T DK06840164 T DK 06840164T DK 1966388 T3 DK1966388 T3 DK 1966388T3
- Authority
- DK
- Denmark
- Prior art keywords
- target vector
- phospholipid conjugates
- phospholipid
- conjugates
- vector
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74924005P | 2005-12-09 | 2005-12-09 | |
| US83334206P | 2006-07-25 | 2006-07-25 | |
| PCT/US2006/061793 WO2007067979A2 (en) | 2005-12-09 | 2006-12-08 | Targeting vector-phospholipid conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1966388T3 true DK1966388T3 (da) | 2013-10-28 |
Family
ID=38123651
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06840164.5T DK1966388T3 (da) | 2005-12-09 | 2006-12-08 | Tilsigte vektor-fosfolipidkonjugater |
| DK10190163.5T DK2359864T3 (da) | 2005-12-09 | 2006-12-08 | Målrettende vektor-phospholipid-konjugater |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10190163.5T DK2359864T3 (da) | 2005-12-09 | 2006-12-08 | Målrettende vektor-phospholipid-konjugater |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP2359864B1 (da) |
| JP (2) | JP5242408B2 (da) |
| KR (3) | KR101658439B1 (da) |
| CN (2) | CN103204911B (da) |
| AU (1) | AU2006321613B2 (da) |
| BR (1) | BRPI0619522B8 (da) |
| CA (3) | CA2631716C (da) |
| DK (2) | DK1966388T3 (da) |
| ES (1) | ES2428964T3 (da) |
| IL (1) | IL191850A (da) |
| MX (1) | MX2008007321A (da) |
| RU (1) | RU2433137C2 (da) |
| WO (1) | WO2007067979A2 (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7985402B2 (en) | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| ES2557286T3 (es) * | 2003-03-03 | 2016-01-25 | Dyax Corp. | Usos de péptidos que se unen específicamente al receptor del HGF (cMet) |
| ATE480561T1 (de) | 2004-10-19 | 2010-09-15 | Lonza Ag | Verfahren zur festphasen-peptidsynthese |
| ES2428964T3 (es) * | 2005-12-09 | 2013-11-12 | Bracco Suisse Sa | Conjugados de vectores específicos de una diana-fosfolípidos |
| WO2010117725A2 (en) * | 2009-04-06 | 2010-10-14 | Novetide, Ltd. | Production of peptides containing poly-gly sequences using fmoc chemistry |
| CN101637613B (zh) * | 2009-08-19 | 2011-09-14 | 王维 | 一种脂质靶向超声造影剂及其制备方法 |
| ES2673277T3 (es) | 2010-08-09 | 2018-06-21 | Bracco Suisse Sa | Microvesículas dirigidas llenas de gas |
| CN102286076B (zh) * | 2011-06-23 | 2014-03-12 | 成都圣诺科技发展有限公司 | 比伐卢定的制备方法 |
| JP6313329B2 (ja) * | 2012-12-21 | 2018-04-18 | ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ | ガス封入マイクロベシクル |
| ES2726924T3 (es) * | 2014-12-18 | 2019-10-10 | Bracco Suisse Sa | Formulación de microvesículas dirigidas rellenas de gas |
| AU2017213791B2 (en) * | 2016-02-01 | 2023-10-19 | Trust Biosonics Inc. | Lipid microbubbles and process of making thereof |
| US20190365665A1 (en) * | 2017-01-24 | 2019-12-05 | Nuvox Pharma Llc | Iso-osmotic and near iso-osmotic oxygen therapeutic formulations and methods thereof |
| EP3360884A1 (en) * | 2017-02-10 | 2018-08-15 | Neuronax | Improved process for the preparation of a dodecapeptide |
| JP7421554B2 (ja) * | 2018-12-18 | 2024-01-24 | ブラッコ・スイス・ソシエテ・アノニム | 二量体ペプチド－リン脂質コンジュゲートのための最適化された方法 |
| US11717570B2 (en) | 2019-05-15 | 2023-08-08 | Bracco Suisse Sa | Gas-filled microvesicles |
| US20200360289A1 (en) | 2019-05-15 | 2020-11-19 | Bracco Suisse Sa | Freeze-dried product and gas-filled microvesicles suspension |
| CN118786206A (zh) * | 2021-12-06 | 2024-10-15 | 西湖生物医药科技(上海)有限公司 | 经修饰的细胞及其用于递送试剂的用途 |
| CN121941488A (zh) | 2023-10-04 | 2026-04-28 | 博莱科瑞士股份有限公司 | 冷冻干燥方法 |
| CN120404964A (zh) * | 2024-02-01 | 2025-08-01 | 四川科伦药物研究院有限公司 | 磷脂及其杂质的检测方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN172208B (da) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US5338725A (en) * | 1992-06-30 | 1994-08-16 | The Research Foundation Of The State University Of New York | Anti-aggregatory agents for platelets |
| PL182223B1 (pl) | 1993-12-15 | 2001-11-30 | Bracco Research Sa | Biokompatybilna faza rozproszona do otrzymywania srodka kontrastowego do badan ultradzwiekowych, srodek kontrastowy do badan ultradzwiekowych, suchy preparat srodka kontrastowego oraz dwuskladnikowy zestaw do otrzymywania srodka kontrastowego do badan ultradzwiekowych PL PL PL |
| IL116328A (en) | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| CA2218541A1 (en) * | 1995-06-07 | 1996-12-19 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
| DE69721235T2 (de) | 1996-02-19 | 2004-02-05 | Amersham Health As | Verbesserungen an (oder im bezug auf) kontrastmittel |
| KR100593873B1 (ko) | 1996-08-02 | 2006-07-03 | 지이 헬스케어 에이에스 | 조영제 |
| US6071532A (en) * | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
| MXPA99003664A (es) | 1996-10-21 | 2002-06-11 | Nycomed Imaging As | Mejoras relacionadas con agentes de contraste. |
| ES2206689T3 (es) | 1996-10-28 | 2004-05-16 | Amersham Health As | Agentes de contraste. |
| EP0973552B1 (en) | 1996-10-28 | 2006-03-01 | Amersham Health AS | Improvements in or relating to diagnostic/therapeutic agents |
| ATE314097T1 (de) | 1996-10-28 | 2006-01-15 | Amersham Health As | Kontrastmittel |
| WO1998018498A2 (en) | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| EP0991427A2 (en) | 1996-10-28 | 2000-04-12 | Marsden, John Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| US6245318B1 (en) | 1997-05-27 | 2001-06-12 | Mallinckrodt Inc. | Selectively binding ultrasound contrast agents |
| GB9809084D0 (en) * | 1998-04-28 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
| JP5078212B2 (ja) * | 2000-06-02 | 2012-11-21 | ブラッコ・スイス・ソシエテ・アノニム | 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法 |
| WO2004065621A1 (en) * | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US7666979B2 (en) * | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
| US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
| SI2301587T1 (sl) * | 2002-03-01 | 2014-11-28 | Dyax Corp. | KDR in VEGF/KDR vezavni peptidi in njihova uporaba pri diagnozi |
| JP2005519980A (ja) * | 2002-03-01 | 2005-07-07 | ブラッコ インターナショナル ビー．ヴイ． | 治療および診断用途の多価構成物 |
| EP1590006B1 (en) | 2003-02-04 | 2010-09-08 | Bracco Suisse SA | Ultrasound contrast agents and process for the preparation thereof |
| FI20031528A0 (fi) * | 2003-10-17 | 2003-10-17 | Ctt Cancer Targeting Tech Oy | Terapeuttinen liposomikoostumus ja menetelmä sen valmistamiseksi |
| ES2428964T3 (es) * | 2005-12-09 | 2013-11-12 | Bracco Suisse Sa | Conjugados de vectores específicos de una diana-fosfolípidos |
-
2006
- 2006-12-08 ES ES06840164T patent/ES2428964T3/es active Active
- 2006-12-08 AU AU2006321613A patent/AU2006321613B2/en active Active
- 2006-12-08 CN CN201310052906.3A patent/CN103204911B/zh active Active
- 2006-12-08 MX MX2008007321A patent/MX2008007321A/es active IP Right Grant
- 2006-12-08 WO PCT/US2006/061793 patent/WO2007067979A2/en not_active Ceased
- 2006-12-08 CA CA2631716A patent/CA2631716C/en active Active
- 2006-12-08 EP EP10190163.5A patent/EP2359864B1/en active Active
- 2006-12-08 KR KR1020137021393A patent/KR101658439B1/ko active Active
- 2006-12-08 KR KR1020147014542A patent/KR20140083052A/ko not_active Ceased
- 2006-12-08 CA CA2947346A patent/CA2947346C/en active Active
- 2006-12-08 KR KR1020087016674A patent/KR101323849B1/ko active Active
- 2006-12-08 DK DK06840164.5T patent/DK1966388T3/da active
- 2006-12-08 CN CN2006800522791A patent/CN101374955B/zh active Active
- 2006-12-08 DK DK10190163.5T patent/DK2359864T3/da active
- 2006-12-08 RU RU2008127836/04A patent/RU2433137C2/ru active IP Right Revival
- 2006-12-08 BR BRPI0619522A patent/BRPI0619522B8/pt active IP Right Grant
- 2006-12-08 CA CA2826960A patent/CA2826960A1/en not_active Abandoned
- 2006-12-08 JP JP2008544663A patent/JP5242408B2/ja active Active
- 2006-12-08 EP EP06840164.5A patent/EP1966388B1/en active Active
-
2008
- 2008-05-29 IL IL191850A patent/IL191850A/en active IP Right Grant
-
2013
- 2013-02-13 JP JP2013025796A patent/JP5735993B2/ja active Active
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