DK196885A - Farmaceutiske praeparater indeholdende isoquinolinderivater og isoquinolinderivater indeholdende saadanne derivater - Google Patents

Farmaceutiske praeparater indeholdende isoquinolinderivater og isoquinolinderivater indeholdende saadanne derivater Download PDF

Info

Publication number: DK196885A
Authority: DK; Denmark
Prior art keywords: derivatives; isoquinolin; pharmaceutical preparations; preparations containing; isoquinolin derivatives
Prior art date: 1984-05-03

Application number

DK196885A

Other languages

English (en)

Other versions

DK196885D0 (da

DK160991C (da

DK160991B (da

Inventor

Gordon Hanley Phillipps

Stanley Frederick Dyke

Esme Joan Bailey

Peter David Howes

David Ian Carter Scopes

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-03

Filing date

1985-05-02

Publication date

1985-11-04

1984-05-03 Priority claimed from GB848411407A external-priority patent/GB8411407D0/en

1984-05-03 Priority claimed from GB848411408A external-priority patent/GB8411408D0/en

1985-05-02 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1985-05-02 Publication of DK196885D0 publication Critical patent/DK196885D0/da

1985-11-04 Publication of DK196885A publication Critical patent/DK196885A/da

1991-05-13 Publication of DK160991B publication Critical patent/DK160991B/da

1991-11-11 Application granted granted Critical

1991-11-11 Publication of DK160991C publication Critical patent/DK160991C/da

Links

AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 description 4
239000001257 hydrogen Substances 0.000 description 4
150000002431 hydrogen Chemical group 0.000 description 3
125000004423 acyloxy group Chemical group 0.000 description 2
125000003545 alkoxy group Chemical group 0.000 description 2
229910052736 halogen Inorganic materials 0.000 description 2
150000002367 halogens Chemical group 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

Description

4 R hydrogen, halogen, C1-3 alkyl eller fenyl eventuelt substitueret med halogen, hydroxy, alkyl, alkoxy eller alkanoyloxy, og ringen A er en gruppe med formlen

hvor R^ og R^ hver er hydrogen, hydroxyl. C, » alkoxy eller 7 8 ι.~** C. . alkanoyloxy, R og R hver hydrogen eller metyl og 12 3 ét af X, X , X og X er nitrogen og de øvrige -CH-, dog således at når A er en gruppe (i) så er mindst ét af R^-R® forskellig fra hydrogen, sammen med mir farmaceutisk acceptabel bærer eller excipient.

Opfindelsen angår også selve forbindelserne, der kan fremstilles ved forskellige analogifremgangsmåder.

DK196885A 1984-05-03 1985-05-02 5,14-dihydrobenzoe5,6aaisoindolooe2,1-baaisoquinolin-8,13-dionderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse DK160991C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB8411407		1984-05-03
GB8411408		1984-05-03
GB848411407A GB8411407D0 (en)	1984-05-03	1984-05-03	Chemical compounds
GB848411408A GB8411408D0 (en)	1984-05-03	1984-05-03	Chemical compounds

Publications (4)

Publication Number	Publication Date
DK196885D0 DK196885D0 (da)	1985-05-02
DK196885A true DK196885A (da)	1985-11-04
DK160991B DK160991B (da)	1991-05-13
DK160991C DK160991C (da)	1991-11-11

Family

ID=26287697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK196885A DK160991C (da)	1984-05-03	1985-05-02	5,14-dihydrobenzoe5,6aaisoindolooe2,1-baaisoquinolin-8,13-dionderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse

Country Status (9)

Country	Link
US (1)	US4835158A (da)
EP (1)	EP0161102B1 (da)
AU (1)	AU587184B2 (da)
CA (1)	CA1268178A (da)
DE (1)	DE3576066D1 (da)
DK (1)	DK160991C (da)
IL (1)	IL75083A (da)
NO (1)	NO163330C (da)
NZ (1)	NZ211960A (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN109678798A (zh) *	2019-01-20	2019-04-26	湖南科技大学	一种异喹啉化合物的合成方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK158666C (da) *	1982-11-04	1990-11-19	Glaxo Group Ltd	Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
CA1268178A (en) *	1984-05-03	1990-04-24	Gordon H. Phillipps	Isoquinoline derivatives
GB8513460D0 (en) *	1985-05-29	1985-07-03	Glaxo Group Ltd	Chemical compounds
NO872963L (no) *	1986-07-29	1988-02-01	Glaxo Group Ltd	Isokinolinderivater.
DK616087A (da) *	1986-11-27	1988-05-28	Glaxo Group Ltd	Isoquinolinderivater og farmaceutiske praeparater indeholdende dem
GB8800312D0 (en) *	1988-01-07	1988-02-10	Glaxo Group Ltd	Process
GB9708119D0 (en) *	1997-04-22	1997-06-11	Glaxo Group Ltd	Chemical compounds
IT1318986B1 (it) *	2000-10-09	2003-09-19	Archimica S P A Ora Clariant L	Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
CN114805204B (zh) *	2022-04-01	2023-09-15	云南师范大学	一种制备4-碘异喹啉-1(2h)-酮类化合物的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1087222A (en) *	1963-03-16	1967-10-18	Geigy Uk Ltd	12-nitronaphthindolizinediones and processes for their manufacture
US4042591A (en) *	1973-05-30	1977-08-16	Sandoz Ltd.	Naphthoquinone compounds
US4033966A (en) *	1975-06-24	1977-07-05	Kanebo, Ltd.	Novel berbine derivatives
US4087426A (en) *	1976-08-16	1978-05-02	Research Corporation	Oxybisberberine and a process for its production
FR2387229A1 (fr) *	1977-04-13	1978-11-10	Anvar	Dipyrido (4,3-b) (3,4-f) indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant
FR2436786A1 (fr) *	1978-09-21	1980-04-18	Anvar	Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments
US4399282A (en) *	1979-07-10	1983-08-16	Kabushiki Kaisha Yakult Honsha	Camptothecin derivatives
DK158666C (da) *	1982-11-04	1990-11-19	Glaxo Group Ltd	Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
CA1268178A (en) *	1984-05-03	1990-04-24	Gordon H. Phillipps	Isoquinoline derivatives

1985
- 1985-05-02 CA CA000480589A patent/CA1268178A/en not_active Expired - Fee Related
- 1985-05-02 NZ NZ211960A patent/NZ211960A/xx unknown
- 1985-05-02 EP EP85303139A patent/EP0161102B1/en not_active Expired - Lifetime
- 1985-05-02 DK DK196885A patent/DK160991C/da active
- 1985-05-02 NO NO851758A patent/NO163330C/no unknown
- 1985-05-02 DE DE8585303139T patent/DE3576066D1/de not_active Expired - Fee Related
- 1985-05-03 IL IL75083A patent/IL75083A/xx unknown
- 1985-05-03 AU AU41965/85A patent/AU587184B2/en not_active Ceased
1987
- 1987-11-16 US US07/120,654 patent/US4835158A/en not_active Expired - Fee Related

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN109678798A (zh) *	2019-01-20	2019-04-26	湖南科技大学	一种异喹啉化合物的合成方法
CN109678798B (zh) *	2019-01-20	2023-01-17	湖南科技大学	一种异喹啉化合物的合成方法

Also Published As

Publication number	Publication date
IL75083A (en)	1990-07-12
AU587184B2 (en)	1989-08-10
DE3576066D1 (de)	1990-03-29
DK196885D0 (da)	1985-05-02
NO163330B (no)	1990-01-29
DK160991C (da)	1991-11-11
EP0161102B1 (en)	1990-02-21
NO163330C (no)	1990-05-09
CA1268178A (en)	1990-04-24
US4835158A (en)	1989-05-30
NO851758L (no)	1985-11-04
EP0161102A2 (en)	1985-11-13
IL75083A0 (en)	1985-09-29
AU4196585A (en)	1985-11-07
NZ211960A (en)	1989-05-29
DK160991B (da)	1991-05-13
EP0161102A3 (en)	1987-03-04

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