DK198182A - 1,5-substituerede isoquinolinderivater og fremgangsmaade til fremstilling deraf - Google Patents

1,5-substituerede isoquinolinderivater og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number: DK198182A
Authority: DK; Denmark
Prior art keywords: procedures; preparing; isoquinoline derivatives; substituted isoquinoline; substituted
Prior art date: 1981-05-04

Application number

DK198182A

Other languages

English (en)

Inventor

H S Lowrie

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-05-04

Filing date

1982-05-03

Publication date

1982-11-05

1982-05-03 Application filed by Searle & Co filed Critical Searle & Co

1982-11-05 Publication of DK198182A publication Critical patent/DK198182A/da

Links

238000000034 method Methods 0.000 title description 2
AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 description 3
150000003839 salts Chemical class 0.000 description 2
-1 (p-toluenesulfonyloxymethyl) -3-substituted-2-oxazolidinone Chemical class 0.000 description 1
0 CC(CN1*)O*1=O Chemical compound CC(CN1*)O*1=O 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

R7 er H eller alkyl, Rg, og R^q er H, alkyl eller dialk-oxyphenylalkyl, R^ er halogen, H, alkyl eller alkoxy, R11 er H eller

III

idet dog R^ kun er til stede, når bindingen mellem carbon-atomerne 1 og 2 er mættet, eller salte deraf fremstilles ved omsætning af 5(p-toluensulfonyloxymethyl)-3-substitueret--2-oxazolidinon med formlen

XIV

ved to forskellige metoder til et produkt méd formlen

XXIV

som derefter om ønsket solvolyseres og/eller omdannes til et salt.

Forbindelserne med formel I er pharmakologisk aktive til behandling af hypertension.

DK198182A 1981-05-04 1982-05-03 1,5-substituerede isoquinolinderivater og fremgangsmaade til fremstilling deraf DK198182A (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US26054781A	1981-05-04	1981-05-04
US26054781		1981-05-04
US06/329,789 US4473501A (en)	1981-05-04	1981-12-11	Dihydro azino isoquinolines
US32978981		1981-12-11

Publications (1)

Publication Number	Publication Date
DK198182A true DK198182A (da)	1982-11-05

Family

ID=26948062

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198182A DK198182A (da)	1981-05-04	1982-05-03	1,5-substituerede isoquinolinderivater og fremgangsmaade til fremstilling deraf

Country Status (7)

Country	Link
US (1)	US4473501A (da)
EP (1)	EP0064294A1 (da)
AU (1)	AU8321782A (da)
DK (1)	DK198182A (da)
ES (1)	ES8401066A1 (da)
NO (1)	NO821458L (da)
PT (1)	PT74838B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60237070A (ja) *	1984-05-08	1985-11-25	Nisshin Flour Milling Co Ltd	光学活性イソカルボスチリル誘導体の製法
SE8801518D0 (sv) *	1988-04-22	1988-04-22	Astra Pharma Prod	A novel process
TW575567B (en) *	1998-10-23	2004-02-11	Akzo Nobel Nv	Serine protease inhibitor
WO2003106413A2 (en)	2001-10-18	2003-12-24	Michigan State University	Process for the preparation of oxazolidinones and method of use thereof
US7094789B2 (en) *	2002-07-22	2006-08-22	Asahi Kasei Pharma Corporation	5-substituted isoquinoline derivatives
JPWO2008120655A1 (ja)	2007-03-30	2010-07-15	株式会社医薬分子設計研究所	Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有するオキサゾリジノン誘導体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA536744A (en) *		1957-02-05	Druey Jean	Isoquinoline compounds and process of making same
CH307873A (de) *	1952-05-30	1955-06-15	Ciba Geigy	Verfahren zur Herstellung einer neuen Isochinolinverbindung.
GB1058822A (en) *	1963-07-30	1967-02-15	Ici Ltd	3-amino-2-hydroxypropoxy heterocyclic derivatives
US3753994A (en) *	1970-08-10	1973-08-21	Sterling Drug Inc	1,1'-azinobis(1,2,3,4-tetrahydroisoquinolines)
US4009170A (en) *	1970-08-10	1977-02-22	Sterling Drug Inc.	1-Ethoxy-3,4-dihydroisoquindines
US3946009A (en) *	1972-05-05	1976-03-23	Merck Sharp & Dohme (I.A.) Corporation	2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
US4115575A (en) *	1973-02-20	1978-09-19	Ciba-Geigy Corporation	2-(3-Amino-2-hydroxy-propoxy)-pyrazines
US4073909A (en) *	1973-10-08	1978-02-14	Sandoz Ltd.	Isoquinoline compounds
NL179275C (nl) *	1973-10-24	1986-08-18	Otsuka Pharma Co Ltd	Werkwijze voor de bereiding van farmacologisch werkzame glycerol-derivaten en werkwijze voor de bereiding van preparaten die ze bevatten.
JPS538707B2 (da) *	1974-02-05	1978-03-31
JPS5318032B2 (da) *	1974-03-04	1978-06-13
DE2639718C2 (de) *	1976-09-03	1987-03-05	Dr. Karl Thomae Gmbh, 7950 Biberach	1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel
DE2644833A1 (de) *	1976-10-05	1978-04-20	Boehringer Sohn Ingelheim	Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung

1981
- 1981-12-11 US US06/329,789 patent/US4473501A/en not_active Expired - Lifetime
1982
- 1982-05-03 DK DK198182A patent/DK198182A/da not_active Application Discontinuation
- 1982-05-03 AU AU83217/82A patent/AU8321782A/en not_active Abandoned
- 1982-05-03 PT PT74838A patent/PT74838B/pt unknown
- 1982-05-03 NO NO821458A patent/NO821458L/no unknown
- 1982-05-04 ES ES82511914A patent/ES8401066A1/es not_active Expired
- 1982-05-04 EP EP82103812A patent/EP0064294A1/en not_active Withdrawn

Also Published As

Publication number	Publication date
PT74838B (en)	1983-12-07
ES511914A0 (es)	1983-12-01
NO821458L (no)	1982-11-05
US4473501A (en)	1984-09-25
EP0064294A1 (en)	1982-11-10
PT74838A (en)	1982-06-01
ES8401066A1 (es)	1983-12-01
AU8321782A (en)	1982-11-11

Similar Documents

Publication	Publication Date	Title
ES520441A0 (es)	1983-12-16	Procedimiento para la obtencion de derivados de piridina.
EA200101194A1 (ru)	2002-06-27	Производные 4,5,6,7-тетрагидроиндазола в качестве противоопухолевых средств
EP0355049A3 (en)	1990-06-13	Heterocyclic compounds
DK129282A (da)	1982-09-24	Fremgangsmaade til fremstilling af indolylethylderivater
DK148805C (da)	1986-04-01	Fremgangsmaade til fremstilling af 4-aminochlorquinoliner
EP0077938A3 (en)	1983-08-24	N-(3-substituted aminophenyl) tetrahydrophthalimides and herbicidal composition
NO159167C (no)	1988-12-07	Nye 1-substituerte-5-hydroksymetyl-2-merkapto-imidazol-derivater og fremgangsmaate for fremstilling derav.
MA22096A1 (fr)	1991-12-31	Procede de preparation d'un derive substitue de n - (imidazolyl alkyl) alanine .
ES521124A0 (es)	1984-06-01	Procedimiento para preparar espino (piperidino-oxobenzo-xazinas) substituidas en posicion 1 anti-hipertensivas.
DK198182A (da)	1982-11-05	1,5-substituerede isoquinolinderivater og fremgangsmaade til fremstilling deraf
KR840000533A (ko)	1984-02-25	화합물의 제조방법
ES525256A0 (es)	1984-05-16	Procedimiento para la obtencion de 2-nitro-1,1-etendiaminas
DE3166615D1 (en)	1984-11-15	Indole derivatives and process for their production
PT76123A (fr)	1983-02-01	Procede de preparation de nouveaux derives de benzadioxine
DK188183A (da)	1983-11-06	Thiomethylpyridinderivater, fremgangsmaade til deres fremstilling og laegemidler indeholdende disse forbindelser
MX10721A (es)	1993-09-01	Procedimiento para la preparacion de derivados de imidazol y producto obtenido.
DK186880A (da)	1980-12-13	Fremgangsmaade til fremstilling af indolderivater
DE69906243T2 (de)	2004-01-29	2-Indanmethanolderivate und ihre Verwendung als Riechstoffe
ES473547A1 (es)	1979-04-16	Un metodo para la preparacion de compuestos derivados de 2- oxazolidona.
EP0031388A4 (en)	1981-11-24	METHOD FOR PRODUCING IMIDAZOLE DERIVATIVES.
BG51043A3 (bg)	1993-01-15	Метод за получаване на триазолови производни
DK17982A (da)	1982-07-17	Fremgangsmaade til fremstilling af cycloheptenderivater
ES511869A0 (es)	1983-10-01	Procedimiento para preparar derivados de acido 5-aminometil-2,3-dihidro-2-oxo-1h-imidazol-4-carboxilico.
IL65666A (en)	1985-12-31	Derivatives of 4-aminomethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones and process for their preparation
JPS5371080A (en)	1978-06-24	Novel benzimidazole cpds. and process for preparing them

Legal Events

Date	Code	Title	Description
1984-11-17	AHS	Application shelved for other reasons than non-payment