DK1991244T3 - Phospholipid-komplekser med forbedret biotilgængelighed - Google Patents

Phospholipid-komplekser med forbedret biotilgængelighed Download PDF

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Publication number
DK1991244T3
DK1991244T3 DK07703532T DK07703532T DK1991244T3 DK 1991244 T3 DK1991244 T3 DK 1991244T3 DK 07703532 T DK07703532 T DK 07703532T DK 07703532 T DK07703532 T DK 07703532T DK 1991244 T3 DK1991244 T3 DK 1991244T3
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Denmark
Prior art keywords
improved bioavailability
phospholipid complexes
phospholipid
complexes
bioavailability
Prior art date
Application number
DK07703532T
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English (en)
Inventor
Andrea Giori
Federico Franceschi
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36677274&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1991244(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Indena Spa filed Critical Indena Spa
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Publication of DK1991244T3 publication Critical patent/DK1991244T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
DK07703532T 2006-03-09 2007-02-21 Phospholipid-komplekser med forbedret biotilgængelighed DK1991244T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06004820A EP1837030A1 (en) 2006-03-09 2006-03-09 Phospholipid complexes of curcumin having improved bioavailability
PCT/EP2007/001487 WO2007101551A2 (en) 2006-03-09 2007-02-21 Phospholipid complexes of curcumin having improved bioavailability

Publications (1)

Publication Number Publication Date
DK1991244T3 true DK1991244T3 (da) 2019-11-18

Family

ID=36677274

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07703532T DK1991244T3 (da) 2006-03-09 2007-02-21 Phospholipid-komplekser med forbedret biotilgængelighed

Country Status (17)

Country Link
US (2) US10603329B2 (da)
EP (2) EP1837030A1 (da)
JP (1) JP5448462B2 (da)
KR (1) KR101423269B1 (da)
CN (1) CN101400360A (da)
AU (1) AU2007222667B2 (da)
CA (1) CA2644017C (da)
DK (1) DK1991244T3 (da)
ES (1) ES2757580T3 (da)
HU (1) HUE046597T2 (da)
IL (1) IL193966A (da)
NO (1) NO344242B1 (da)
PL (1) PL1991244T3 (da)
PT (1) PT1991244T (da)
RU (1) RU2450818C2 (da)
SI (1) SI1991244T1 (da)
WO (1) WO2007101551A2 (da)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1993365B1 (en) * 2006-03-06 2013-05-08 The Regents of the University of California Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders
RU2491084C2 (ru) 2007-12-21 2013-08-27 Асак Компанья Де Биотекнолохия Э Инвестигасион, С.А. Способ улучшения терапевтической эффективности куркуминоидов и их аналогов
US9700525B2 (en) 2008-08-20 2017-07-11 Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College Continuous local slow-release of therapeutics for head and neck problems and upper aerodigestive disorders
WO2010023128A1 (en) * 2008-08-29 2010-03-04 Chr. Hansen A/S Turmeric curcumin compositions with low residual solvent
IT1395086B1 (it) * 2009-03-11 2012-09-05 Velleja Res Srl Composizioni comprendenti curcumina in forma complessata con fosfolipidi e piperina ad azione chemio-sensibilizzante
AU2010224811B2 (en) 2009-03-20 2015-07-16 Bioxtract S.A. Pharmaceutical composition presenting anti-inflammatory properties
ES2548867T3 (es) 2009-03-20 2015-10-21 Bioxtract S.A. Composición farmacéutica que presenta propiedades antiinflamatorias y antihistamínicas
IT1395351B1 (it) 2009-07-09 2012-09-14 Axioma Srl Formulazioni orali ad elevata biodisponibilita' orale costituite da miscele di frazioni lipofile e idrofile ottenute a partire dalla propoli
WO2011082290A2 (en) 2009-12-31 2011-07-07 Organomed Corporation Formulations from natural products, turmeric, and aspirin
CN102068419A (zh) * 2010-12-28 2011-05-25 神威药业有限公司 一种姜黄素组合物
US8785380B2 (en) 2011-02-01 2014-07-22 M/S Akay Flavours & Aromatics Pvt Ltd. Formulation containing curcuminoids exhibiting enhanced bioavailability
KR20150064234A (ko) 2011-05-16 2015-06-10 옴니액티브 헬스 테크놀로지스 리미티드 증가된 생체이용률을 갖는 커큐민을 포함하는 수용성 조성물 및 이의 방법
ITTO20110901A1 (it) * 2011-10-10 2013-04-11 Medestea Biotech S P A Composizione sinergica per la prevenzione ed il trattamento di disturbi connessi all'invecchiamento
ITPD20120021A1 (it) 2012-01-26 2013-07-27 Fidia Farmaceutici "nuove composizioni farmaceutiche contenenti fosfatidilserina e curcumina".
EP2852395A4 (en) * 2012-05-22 2015-12-16 Harold Gordon Cave IMPROVED COMPLEXES AND COMPOSITIONS WITH CURRICULUM
US20150110866A1 (en) * 2012-05-22 2015-04-23 Harold Gordon Cave Complexes and compositions containing curcumin
CN103120798A (zh) * 2013-01-10 2013-05-29 施冬云 一种具有抗氧化应激作用的磷脂复合物制备方法及其应用
WO2014135967A1 (en) 2013-03-06 2014-09-12 Capsugel Belgium Nv Curcumin solid lipid particles and methods for their preparation and use
CA2910546C (en) * 2013-05-14 2023-03-28 Mars, Incorporated Joint care composition
DK3107555T3 (da) * 2014-02-20 2020-08-10 Indena Spa Sammensætninger indeholdende ekstrakter af curcuma longa og echinacea angustifolia, som er anvendelige til reducering af perifer inflammation og smerte
RU2571270C1 (ru) * 2014-07-17 2015-12-20 Открытое Акционерное Общество "Фаберлик" Липосомальное наносредство на основе продуктов, полученных из корневищ куркумы
AU2015330851B2 (en) 2014-10-08 2022-10-13 Boston Biopharm, Inc. Compositions and methods for increasing the bioavailability of one or more compounds
US10588866B2 (en) * 2014-11-11 2020-03-17 Verdure Sciences Stable solid lipid particle composition for improved bioavailability of lipophilic compounds for age-related diseases
EP3226845A1 (en) 2014-12-04 2017-10-11 Capsugel Belgium NV Lipid multiparticulate formulations
EP3150214A1 (en) 2015-10-01 2017-04-05 INDENA S.p.A. Compositions containing extracts of curcuma spp and zingiber officinale which are useful to reduce peripheral inflammation and pain
KR101867184B1 (ko) * 2015-11-30 2018-06-14 (의료)길의료재단 진세노사이드를 포함하는 커큐민 함유 지질나노입자 복합체 및 그의 제조방법
CN108366974A (zh) * 2015-12-16 2018-08-03 维韦克·阿南德·帕拉库尔 天然化合物的三分子复合物
CN105999290B (zh) * 2016-04-21 2019-04-09 中国人民解放军第四军医大学 一种磷脂酰丝氨酸修饰的姜黄素纳米粒
WO2018003857A1 (ja) * 2016-06-29 2018-01-04 株式会社セラバイオファーマ 非経口投与用医薬組成物
US20170172921A1 (en) * 2016-12-14 2017-06-22 Mahmoud Reza Jaafari Polyphenolic compounds encapsualated in long circulating liposomes and use thereof
KR101948407B1 (ko) 2017-01-20 2019-02-14 가천대학교 산학협력단 커큐민이 포집된 진세노사이드 및 인지질 기반 지질나노입자를 유효성분으로 함유하는 헬리코박터 파이로리 감염의 예방 또는 치료용 조성물
CN107213467A (zh) * 2017-05-22 2017-09-29 江苏大学 一种姜黄素磷脂复合物的制备方法
RU2684111C1 (ru) * 2018-02-07 2019-04-04 Федеральное государственное бюджетное образовательное учреждение высшего образования "Южно-Уральский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ЮУГМУ Минздрава России) Способ получения лекарственного средства с метионином и экстрактом куркумы в виде гранул с кишечнорастворимым покрытием системного действия
BE1026393B1 (fr) * 2018-06-18 2020-01-28 Normaphar Composition pour utilisation dans le traitement de l'ostéopénie et/ou de l'ostéoporose
FR3082425B1 (fr) * 2018-06-18 2020-09-11 Normaphar Composition pour utilisation dans le traitement de l'osteopenie et / ou de l'osteoporose
CN109846865B (zh) * 2018-12-26 2022-03-25 晨光生物科技集团股份有限公司 一种姜黄素制剂及其制备方法
CN109589410B (zh) * 2018-12-26 2022-02-01 晨光生物科技集团股份有限公司 一种姜黄素制剂及其制备方法
IT201900003907A1 (it) 2019-03-18 2020-09-18 Indena Spa Composizioni comprendenti curcumina e coenzima q10
CN111803632B (zh) * 2019-04-09 2022-04-29 北京五和博澳药业股份有限公司 黄酮多酚类药物自乳化组合物、其制备方法、药物组合物及用途
GB202011069D0 (en) 2020-07-17 2020-09-02 Univ Of Lincoln New curcumin products and uses
KR102725947B1 (ko) 2020-12-16 2024-11-06 주식회사 제이비케이랩 다당류를 이용하여 커큐민의 안정성 및 생체 이용률이 향상된 나노복합체 및 이의 제조방법
KR20220086018A (ko) 2020-12-16 2022-06-23 가톨릭대학교 산학협력단 셀룰로오스를 이용하여 커큐민의 안정성 및 생체 이용률이 향상된 나노복합체 및 이의 제조방법
EP4289287A4 (en) 2021-09-28 2025-05-28 Binotec Co., Ltd. CURCUMIN NANOPARTICLE COMPLEX HAVING MODIFIED PARTICLE SURFACE AND PREPARATION METHOD THEREOF
JP7321229B2 (ja) * 2021-10-20 2023-08-04 義美食品股▲ふん▼有限公司 ウコン根茎からクルクミノイドを分離する方法
CN114557965B (zh) * 2022-02-09 2023-06-09 汕头大学 一种提高姜黄素稳定性和生物可及性的磷脂复合物纳米粒及制备方法
IL318505A (en) * 2022-08-09 2025-03-01 Hunan Lonstar Biotech Co Ltd Metal-phospholipid complex, metal-phospholipid complex particle, drug-lipid particle, method for preparing same, and use thereof
CN117582417A (zh) * 2022-08-09 2024-02-23 湖南健瑞医药科技有限公司 药物-脂质颗粒及其制备方法和应用
IT202200025767A1 (it) 2022-12-15 2024-06-15 Prolabin & Tefarm S R L Formulazione comprendente polifenoli vanilloidi supportati su solidi lamellari per ridurre i livelli plasmatici di CGRP e sue applicazioni.
KR20250148075A (ko) 2024-04-05 2025-10-14 박형수 수용성 리포좀 커큐민의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1215291B (it) 1985-07-17 1990-01-31 Inverni Della Beffa Spa Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
IT1201149B (it) 1987-01-14 1989-01-27 Indena Spa Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
IT1203515B (it) 1987-02-26 1989-02-15 Indena Spa Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
IT1296920B1 (it) 1997-12-04 1999-08-03 Indena Spa Uso di complessi di estratti vitis vinifera con fosfolipidi come agenti anti-aterosclerotici
IT1304183B1 (it) 1998-12-18 2001-03-08 Indena Spa Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici.
WO2005020958A2 (en) * 2003-08-26 2005-03-10 Research Development Foundation Aerosol delivery of curcumin
CN1283237C (zh) * 2004-11-22 2006-11-08 山东大学 姜黄素磷脂复合物及其制备方法

Also Published As

Publication number Publication date
EP1837030A1 (en) 2007-09-26
NO20083850L (no) 2008-12-03
JP5448462B2 (ja) 2014-03-19
US20090131373A1 (en) 2009-05-21
IL193966A (en) 2015-01-29
PT1991244T (pt) 2019-11-29
JP2009529506A (ja) 2009-08-20
AU2007222667A1 (en) 2007-09-13
US20190175628A1 (en) 2019-06-13
ES2757580T3 (es) 2020-04-29
KR101423269B1 (ko) 2014-07-25
SI1991244T1 (sl) 2019-11-29
EP1991244B1 (en) 2019-10-02
RU2450818C2 (ru) 2012-05-20
CA2644017A1 (en) 2007-09-13
NO344242B1 (no) 2019-10-14
RU2008136189A (ru) 2010-03-20
IL193966A0 (en) 2011-08-01
KR20080112224A (ko) 2008-12-24
CA2644017C (en) 2019-07-30
PL1991244T3 (pl) 2020-03-31
US10603329B2 (en) 2020-03-31
WO2007101551A2 (en) 2007-09-13
HUE046597T2 (hu) 2020-03-30
WO2007101551A3 (en) 2007-10-25
CN101400360A (zh) 2009-04-01
EP1991244A2 (en) 2008-11-19
AU2007222667B2 (en) 2012-11-08

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