DK1997510T3 - Ikke-neurotoksiske plasminogen-aktiverende faktorer til behandling af et slagtilfælde - Google Patents

Ikke-neurotoksiske plasminogen-aktiverende faktorer til behandling af et slagtilfælde

Info

Publication number: DK1997510T3
Authority: DK; Denmark
Prior art keywords: stroke; treatment; plasminogen activating; activating factors; activity
Prior art date: 2001-11-02

Application number

DK08012976.0T

Other languages

English (en)

Inventor

Mariola Soehngen

Wolfgang Soehngen

Wolf-Dieter Schleuning

Robert Medcalf

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-02

Filing date

2002-10-31

Publication date

2012-05-21

2002-10-31 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2012-05-21 Application granted granted Critical

2012-05-21 Publication of DK1997510T3 publication Critical patent/DK1997510T3/da

Links

102000013566 Plasminogen Human genes 0.000 title abstract 2
108010051456 Plasminogen Proteins 0.000 title abstract 2
230000003213 activating effect Effects 0.000 title abstract 2
231100000501 nonneurotoxic Toxicity 0.000 title 1
208000035404 Autolysis Diseases 0.000 abstract 2
206010057248 Cell death Diseases 0.000 abstract 2
102000003978 Tissue Plasminogen Activator Human genes 0.000 abstract 2
108090000373 Tissue Plasminogen Activator Proteins 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
230000028043 self proteolysis Effects 0.000 abstract 2
229960000187 tissue plasminogen activator Drugs 0.000 abstract 2
102000009123 Fibrin Human genes 0.000 abstract 1
108010073385 Fibrin Proteins 0.000 abstract 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
102000003990 Urokinase-type plasminogen activator Human genes 0.000 abstract 1
108090000435 Urokinase-type plasminogen activator Proteins 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
230000001966 cerebroprotective effect Effects 0.000 abstract 1
229950003499 fibrin Drugs 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229960005356 urokinase Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)

DK08012976.0T 2001-11-02 2002-10-31 Ikke-neurotoksiske plasminogen-aktiverende faktorer til behandling af et slagtilfælde DK1997510T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10153601A DE10153601A1 (de)	2001-11-02	2001-11-02	DSPA zur Behandlung von Schlaganfall
EP01130006A EP1308166B1 (de)	2001-11-02	2001-12-17	Nicht-neurotoxische Plasminogen Aktivierende Faktoren zur Behandlung von Schlaganfällen
EP02785348A EP1441757B1 (de)	2001-11-02	2002-10-31	Nicht-neurotoxische plasminogen aktivierende faktoren zur behandlung von schlaganfall

Publications (1)

Publication Number	Publication Date
DK1997510T3 true DK1997510T3 (da)	2012-05-21

Family

ID=7704253

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK01130006T DK1308166T3 (da)	2001-11-02	2001-12-17	Ikke-neurotoksisk plasminogenaktiverende faktorer til behandling af slagtilfælde
DK02785348T DK1441757T3 (da)	2001-11-02	2002-10-31	Ikke-neurotoksiske plasminogenaaktiverende faktorer til behandling af slagtilfælde
DK08012976.0T DK1997510T3 (da)	2001-11-02	2002-10-31	Ikke-neurotoksiske plasminogen-aktiverende faktorer til behandling af et slagtilfælde

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK01130006T DK1308166T3 (da)	2001-11-02	2001-12-17	Ikke-neurotoksisk plasminogenaktiverende faktorer til behandling af slagtilfælde
DK02785348T DK1441757T3 (da)	2001-11-02	2002-10-31	Ikke-neurotoksiske plasminogenaaktiverende faktorer til behandling af slagtilfælde

Country Status (26)

Country	Link
US (7)	US20050048027A1 (da)
EP (4)	EP1308166B1 (da)
JP (2)	JP5004407B2 (da)
KR (3)	KR20070087248A (da)
CN (2)	CN100446810C (da)
AT (3)	ATE440614T1 (da)
AU (1)	AU2002350660C1 (da)
BR (1)	BR0213856A (da)
CA (1)	CA2465792C (da)
CY (3)	CY1108446T1 (da)
DE (3)	DE10153601A1 (da)
DK (3)	DK1308166T3 (da)
EA (3)	EA013707B1 (da)
ES (3)	ES2332576T3 (da)
HR (1)	HRP20040383B1 (da)
HU (1)	HU230163B1 (da)
IL (1)	IL205695A0 (da)
MX (1)	MXPA04004155A (da)
NO (1)	NO329789B1 (da)
NZ (2)	NZ532903A (da)
PL (1)	PL208343B1 (da)
PT (3)	PT1308166E (da)
SG (1)	SG148034A1 (da)
SI (2)	SI1441757T1 (da)
WO (1)	WO2003037363A2 (da)
ZA (1)	ZA200403285B (da)

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DE10153601A1 (de) *	2001-11-02	2003-05-22	Paion Gmbh	DSPA zur Behandlung von Schlaganfall
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AU2003227721A1 (en) *	2003-05-02	2004-11-23	Paion Gmbh	Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke
US20060135425A1 (en) *	2003-05-02	2006-06-22	Paion Deutschland Gmbh	Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
BRPI0409865A (pt) *	2003-05-02	2006-05-16	Paion Deutschland Gmbh	injeção intravenosa de ativadores de plasminogênio não neurotóxicos para o tratamento do ataque de apoplexia
BRPI0410055A (pt) *	2003-05-05	2006-04-25	Paion Deutschland Gmbh	antagonistas de receptor de glutamato como neuroprotetores
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JP2006241109A (ja) *	2005-03-04	2006-09-14	Paion Deutschland Gmbh	ヒトＰセレクチンおよびＤＳＰＡα１に対する抗体を含む融合タンパク質
AR068914A1 (es) *	2007-10-18	2009-12-16	Paion Deutschland Gmbh	Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
WO2011107299A2 (en)	2010-04-16	2011-09-09	Paion Deutschland Gmbh	Method for the manufacture of recombinant dspa alpha1
RU2604807C2 (ru) *	2011-01-05	2016-12-10	ТромбоДженикс НВ	Варианты плазминогена и плазмина
JP6000353B2 (ja)	2011-08-12	2016-09-28	スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓＮＶ	プラスミノーゲンおよびプラスミンの変異体
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WO2020140101A1 (en) *	2018-12-28	2020-07-02	Catalyst Biosciences, Inc.	Modified urokinase-type plasminogen activator polypeptides and methods of use

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BRPI0409865A (pt)	2003-05-02	2006-05-16	Paion Deutschland Gmbh	injeção intravenosa de ativadores de plasminogênio não neurotóxicos para o tratamento do ataque de apoplexia
BRPI0410055A (pt)	2003-05-05	2006-04-25	Paion Deutschland Gmbh	antagonistas de receptor de glutamato como neuroprotetores
WO2005018564A2 (en)	2003-08-22	2005-03-03	Pharmacia Corporation	Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage
DE10342518A1 (de)	2003-09-12	2005-05-12	Paion Gmbh	Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
AR068914A1 (es)	2007-10-18	2009-12-16	Paion Deutschland Gmbh	Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia

2001
- 2001-11-02 DE DE10153601A patent/DE10153601A1/de not_active Ceased
- 2001-12-17 AT AT01130006T patent/ATE440614T1/de active
- 2001-12-17 ES ES01130006T patent/ES2332576T3/es not_active Expired - Lifetime
- 2001-12-17 DK DK01130006T patent/DK1308166T3/da active
- 2001-12-17 EP EP01130006A patent/EP1308166B1/de not_active Expired - Lifetime
- 2001-12-17 PT PT01130006T patent/PT1308166E/pt unknown
- 2001-12-17 DE DE50115077T patent/DE50115077D1/de not_active Expired - Lifetime
2002
- 2002-10-31 AT AT02785348T patent/ATE401910T1/de active
- 2002-10-31 EP EP10011603A patent/EP2368567A1/de not_active Withdrawn
- 2002-10-31 SG SG200604427-5A patent/SG148034A1/en unknown
- 2002-10-31 KR KR1020077017712A patent/KR20070087248A/ko not_active Ceased
- 2002-10-31 EP EP02785348A patent/EP1441757B1/de not_active Expired - Lifetime
- 2002-10-31 HU HU0402165A patent/HU230163B1/hu not_active IP Right Cessation
- 2002-10-31 DK DK02785348T patent/DK1441757T3/da active
- 2002-10-31 SI SI200230745T patent/SI1441757T1/sl unknown
- 2002-10-31 AU AU2002350660A patent/AU2002350660C1/en not_active Ceased
- 2002-10-31 ES ES08012976T patent/ES2382224T3/es not_active Expired - Lifetime
- 2002-10-31 EA EA200801714A patent/EA013707B1/ru not_active IP Right Cessation
- 2002-10-31 EP EP08012976A patent/EP1997510B1/de not_active Expired - Lifetime
- 2002-10-31 KR KR1020047006691A patent/KR100816221B1/ko not_active Expired - Fee Related
- 2002-10-31 NZ NZ532903A patent/NZ532903A/en not_active IP Right Cessation
- 2002-10-31 AT AT08012976T patent/ATE547115T1/de active
- 2002-10-31 DE DE50212548T patent/DE50212548D1/de not_active Expired - Lifetime
- 2002-10-31 MX MXPA04004155A patent/MXPA04004155A/es active IP Right Grant
- 2002-10-31 DK DK08012976.0T patent/DK1997510T3/da active
- 2002-10-31 JP JP2003539706A patent/JP5004407B2/ja not_active Expired - Fee Related
- 2002-10-31 CA CA2465792A patent/CA2465792C/en not_active Expired - Fee Related
- 2002-10-31 CN CNB028234782A patent/CN100446810C/zh not_active Expired - Fee Related
- 2002-10-31 PT PT08012976T patent/PT1997510E/pt unknown
- 2002-10-31 PL PL369872A patent/PL208343B1/pl unknown
- 2002-10-31 ES ES02785348T patent/ES2311070T3/es not_active Expired - Lifetime
- 2002-10-31 SI SI200230980T patent/SI1997510T1/sl unknown
- 2002-10-31 EA EA200400624A patent/EA010858B1/ru not_active IP Right Cessation
- 2002-10-31 HR HRP20040383AA patent/HRP20040383B1/xx not_active IP Right Cessation
- 2002-10-31 PT PT02785348T patent/PT1441757E/pt unknown
- 2002-10-31 KR KR1020097025518A patent/KR20090128583A/ko not_active Ceased
- 2002-10-31 NZ NZ545414A patent/NZ545414A/en not_active IP Right Cessation
- 2002-10-31 BR BR0213856-5A patent/BR0213856A/pt not_active Application Discontinuation
- 2002-10-31 CN CNA2007101051509A patent/CN101156948A/zh active Pending
- 2002-10-31 US US10/494,004 patent/US20050048027A1/en not_active Abandoned
- 2002-10-31 EA EA201000386A patent/EA201000386A1/ru unknown
- 2002-10-31 WO PCT/EP2002/012204 patent/WO2003037363A2/de not_active Ceased
2004
- 2004-04-30 ZA ZA200403285A patent/ZA200403285B/en unknown
- 2004-06-01 NO NO20042262A patent/NO329789B1/no not_active IP Right Cessation
2005
- 2005-12-20 US US11/311,475 patent/US20060142195A1/en not_active Abandoned
2008
- 2008-06-27 US US12/163,828 patent/US8071091B2/en not_active Expired - Fee Related
- 2008-08-22 US US12/196,785 patent/US8119597B2/en not_active Expired - Fee Related
- 2008-10-23 CY CY20081101193T patent/CY1108446T1/el unknown
2009
- 2009-01-05 JP JP2009000322A patent/JP2009137983A/ja not_active Withdrawn
- 2009-11-19 CY CY20091101206T patent/CY1109648T1/el unknown
2010
- 2010-05-11 IL IL205695A patent/IL205695A0/en unknown
2012
- 2012-02-10 US US13/370,706 patent/US20130039902A1/en not_active Abandoned
- 2012-04-30 CY CY20121100407T patent/CY1112957T1/el unknown
2014
- 2014-01-09 US US14/151,390 patent/US20140199287A1/en not_active Abandoned
2016
- 2016-03-24 US US15/079,550 patent/US20170051268A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2005519025A (ja)	2005-06-30
US8119597B2 (en)	2012-02-21
JP5004407B2 (ja)	2012-08-22
HRP20040383A2 (en)	2005-08-31
US20140199287A1 (en)	2014-07-17
EA200801714A1 (ru)	2008-12-30
CA2465792C (en)	2014-04-01
PT1441757E (pt)	2008-11-03
DE50115077D1 (de)	2009-10-08
EP1997510B1 (de)	2012-02-29
ATE401910T1 (de)	2008-08-15
DK1308166T3 (da)	2009-12-14
BR0213856A (pt)	2004-08-31
DE50212548D1 (de)	2008-09-04
PL369872A1 (en)	2005-05-02
US20090263373A1 (en)	2009-10-22
EP1308166B1 (de)	2009-08-26
MXPA04004155A (es)	2005-03-31
NO20042262D0 (no)	2004-06-01
SI1997510T1 (sl)	2012-06-29
HK1057328A1 (zh)	2004-04-02
HUP0402165A2 (hu)	2005-01-28
JP2009137983A (ja)	2009-06-25
EP1441757A2 (de)	2004-08-04
EA201000386A1 (ru)	2011-06-30
US20090004176A1 (en)	2009-01-01
DK1441757T3 (da)	2008-11-17
CA2465792A1 (en)	2003-05-08
AU2002350660C1 (en)	2008-10-09
US20170051268A1 (en)	2017-02-23
ZA200403285B (en)	2005-07-27
PL208343B1 (pl)	2011-04-29
ES2382224T3 (es)	2012-06-06
NO20042262L (no)	2004-06-01
US20050048027A1 (en)	2005-03-03
EP1441757B1 (de)	2008-07-23
ES2332576T3 (es)	2010-02-09
EP1997510A1 (de)	2008-12-03
CN101156948A (zh)	2008-04-09
EP1308166A1 (de)	2003-05-07
EP2368567A1 (de)	2011-09-28
ATE440614T1 (de)	2009-09-15
KR100816221B1 (ko)	2008-03-24
EA010858B1 (ru)	2008-12-30
ES2311070T3 (es)	2009-02-01
CN1592634A (zh)	2005-03-09
CY1112957T1 (el)	2016-04-13
SG148034A1 (en)	2008-12-31
HUP0402165A3 (en)	2010-01-28
EP1997510A8 (de)	2011-04-13
EA013707B1 (ru)	2010-06-30
KR20090128583A (ko)	2009-12-15
IL205695A0 (en)	2010-11-30
HRP20040383B1 (hr)	2012-08-31
PT1308166E (pt)	2009-11-27
SI1441757T1 (sl)	2009-02-28
CN100446810C (zh)	2008-12-31
ATE547115T1 (de)	2012-03-15
NZ532903A (en)	2006-10-27
NZ545414A (en)	2008-09-26
KR20070087248A (ko)	2007-08-27
EA200400624A1 (ru)	2004-10-28
US20130039902A1 (en)	2013-02-14
PT1997510E (pt)	2012-05-21
WO2003037363A2 (de)	2003-05-08
DE10153601A1 (de)	2003-05-22
NO329789B1 (no)	2010-12-20
KR20050042234A (ko)	2005-05-06
WO2003037363A3 (de)	2003-09-18
US20060142195A1 (en)	2006-06-29
CY1109648T1 (el)	2014-08-13
HU230163B1 (hu)	2015-09-28
AU2002350660B2 (en)	2008-04-10
CY1108446T1 (el)	2014-04-09
US8071091B2 (en)	2011-12-06

Publication	Publication Date	Title
IL205695A0 (en)	2010-11-30	Compositions containing dspa alpha 1 for the treatment of stroke
DK1232254T3 (da)	2008-12-15	Fremgangsmåde til fremstilling af en reversibelt inaktiv syrnet plasminkomponent
DE60218633D1 (de)	2007-04-19	Inhibitoren von cruzipain und anderen cysteinproteasen
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NO910811L (no)	1991-02-28	Vevsplasminogen-aktivator med zymogeniske- eller fibrinspesifikke egenskaper.
DK0691858T3 (da)	2000-05-08	Tokomponent fibrinklæber
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TW337997B (en)	1998-08-11	Pharmaceutical preparation containing plasminogen activators
ES2088128T3 (es)	1996-08-01	Aminosulfonilureas inhibidoras de acat.
TWI262794B (en)	2006-10-01	Catheter composition and uses thereof
DK0768892T3 (da)	2004-03-15	Thrombolytisk præparat
JPS6434921A (en)	1989-02-06	Preventive and remedy for thrombosis