DK200001171A - Farmaceutiske sammensætninger - Google Patents

Farmaceutiske sammensætninger Download PDF

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Publication number
DK200001171A
DK200001171A DK200001171A DKPA200001171A DK200001171A DK 200001171 A DK200001171 A DK 200001171A DK 200001171 A DK200001171 A DK 200001171A DK PA200001171 A DKPA200001171 A DK PA200001171A DK 200001171 A DK200001171 A DK 200001171A
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Denmark
Prior art keywords
pharmaceutical composition
inorganic salt
pharmaceutical compositions
cation
multivalent
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DK200001171A
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English (en)
Inventor
Joseph Richard Creekmore
Norman Alfred Wiggins
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Astrazeneca Ab
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Publication of DK200001171A publication Critical patent/DK200001171A/da
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Publication of DK178242B1 publication Critical patent/DK178242B1/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

PATENTKRAY 1. Farmaceutisk sammensætning omfattende (E)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R, 5S)-3,5-dihydroxyhept-6-ensyre eller et farmaceutisk acceptabelt salt deraf som den aktive bestanddel og et uorganisk salt, hvori kationen er multivalent. 2. Farmaceutisk sammensætning ifølge krav 1, hvori kationen af det uorganiske salt er valgt blandt calcium, magnesium, zink, aluminium og jem. 3. Farmaceutisk sammensætning ifølge krav 1, hvori det uorganiske salt er valgt blandt aluminiummagnesiummetasilicat, tribasisk calciumphosphat, tribasisk magnesiumphos-phat og tribasisk aluminiumphosphat. 4. Farmaceutisk sammensætning ifølge krav 3, hvori det uorganiske salt er aluminiummagnesiummetasilicat. 5. Farmaceutisk sammensætning ifølge ethvert af kravene 1-4, som er en tablet eller et pulver. 6. Farmaceutisk sammensætning ifølge ethvert af kravene 1-5, hvori der er mere end 5 mg aktiv bestanddel til stede. 7. Farmaceutisk sammensætning ifølge ethvert af kravene 1- 6, hvori der er mere end 10 mg aktiv bestanddel til stede. 8. Farmaceutisk sammensætning ifølge ethvert af kravene 1-7, hvori det uorganiske salt, hvori kationen er multivalent, ikke er syntetisk hydrotalcit. 9. Farmaceutisk sammensætning ifølge ethvert af kravene 1 -8, hvori forholdet mellem uorganisk salt og aktiv bestanddel er i området fra 1:80 til 50:1 på vægtbasis. 10. Farmaceutisk sammensætning ifølge ethvert af de foregående krav, som yderligere omfatter et eller flere fyldstoffer, bindemidler, desintegreringsmidler eller smøremidler. 11. Farmaceutisk sammensætning ifølge ethvert af kravene 1-6, hvori den aktive bestanddel er til stede i en mængde på 1 til 50 vægt% af sammensætningen. 12. Farmaceutisk sammensætning ifølge ethvert af kravene 1-6, hvori det uorganiske salt er til stede i en mængde på 1 til 50 vægt% af sammensætningen. 13. Farmaceutisk sammensætning ifølge krav 10, hvori fyldstoffet er til stede i en mængde fra 30 til 90 vægt% af sammensætningen. 14. Farmaceutisk sammensætning ifølge krav 10 eller 13, hvori bindemidlet er til stede i en mængde fra 2 til 90 vægt% af sammensætningen. 15. Farmaceutisk sammensætning ifølge krav 10,13 eller 14, hvori desintegrermgsmid-let er til stedet i en mængde fra 2 til 10 vægt% af sammensætningen. 16. Farmaceutisk sammensætning ifølge krav 10,13,14 eller 15, hvori smøremidlet er til stede i en mængde fra 0,5 til 3 vægt%. 17. Farmaceutisk sammensætning ifølge ethvert af de foregående krav, hvori den aktive bestanddel er calcramsaltet af (E)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methyl-sulfonyl)amino]pyrimidin-5-yl]-(3R, 5S)-3,5-dihydroxyhept-6-ensyre. 18. Anvendelse af et uorganisk salt, hvori kationen er multivalent, til stabilisering af forbindelsen (E)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyri- midin-5-yl]-(3R, 5S)-3,5-dihydroxyhept-6-ensyre eller et farmaceutisk acceptabelt salt deraf. 19. Anvendelse ifølge krav 18, hvori det uorganiske salt, hvori kationen er multivalent, er valgt blandt aluminiummagnesiummetasilicat, tribasisk calciumphosphat, tribasisk magnesiumphosphat og tribasisk aluminiumphosphat. 20. Anvendelse ifølge krav 19, hvori det uorganiske salt, hvori kationen er multivalent, er aluminiummagnesiummetasilicat. 21. Fremgangsmåde til fremstilling af en stabiliseret farmaceutisk sammensætning, som omfatter inkorporering af et uorganisk salt, hvori kationen er multivalent, i en farmaceutisk sammensætning indeholdende forbindelsen (E)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R, 5S)-3,5-dihydroxyhept-6-ensyre eller et farmaceutisk acceptabelt salt deraf. 22. Fremgangsmåde ifølge krav 21, hvori det uorganiske salt, hvori kationen er multivalent, er aluminiummagnesiummetasilicat.
DK200001171A 2000-01-26 2000-08-04 Farmaceutiske sammensætninger DK178242B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0001621 2000-01-26
GBGB0001621.2A GB0001621D0 (en) 2000-01-26 2000-01-26 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
DK200001171A true DK200001171A (da) 2001-07-27
DK178242B1 DK178242B1 (da) 2015-09-28

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ID=9884259

Family Applications (3)

Application Number Title Priority Date Filing Date
DK200001170A DK200001170A (da) 2000-01-26 2000-08-04 Farmaceutiske sammensætninger
DK00953283T DK1223918T3 (da) 2000-01-26 2000-08-04 Farmaceutiske præparater omfattende en HMG-CoA-reductaseinhibitor
DK200001171A DK178242B1 (da) 2000-01-26 2000-08-04 Farmaceutiske sammensætninger

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DK200001170A DK200001170A (da) 2000-01-26 2000-08-04 Farmaceutiske sammensætninger
DK00953283T DK1223918T3 (da) 2000-01-26 2000-08-04 Farmaceutiske præparater omfattende en HMG-CoA-reductaseinhibitor

Country Status (48)

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US (2) US6316460B1 (da)
EP (6) EP2133070A1 (da)
JP (3) JP4800467B2 (da)
KR (3) KR100388713B1 (da)
CN (3) CN101028268A (da)
AP (2) AP1879A (da)
AR (3) AR025055A1 (da)
AT (3) AT412063B (da)
AU (5) AU6580000A (da)
BE (2) BE1013414A5 (da)
BG (4) BG65234B1 (da)
BR (2) BR0003364A (da)
CA (3) CA2639407C (da)
CH (2) CH700184B1 (da)
CL (1) CL2007001807A1 (da)
CR (3) CR6568A (da)
CZ (3) CZ290167B6 (da)
DE (3) DE10038110B4 (da)
DK (3) DK200001170A (da)
EE (3) EE05221B1 (da)
ES (2) ES2155043B1 (da)
FI (3) FI121365B (da)
FR (2) FR2804025B1 (da)
GB (3) GB0001621D0 (da)
HK (4) HK1047052A1 (da)
HR (3) HRP20080525A2 (da)
HU (2) HUP0003111A3 (da)
IL (4) IL150513A0 (da)
IS (3) IS1940B (da)
IT (2) ITTO20000779A1 (da)
ME (4) ME00191B (da)
MY (2) MY123650A (da)
NL (2) NL1015859C2 (da)
NO (4) NO327675B1 (da)
NZ (2) NZ531474A (da)
PL (2) PL196808B1 (da)
PT (3) PT1223918E (da)
RS (1) RS50201B (da)
RU (2) RU2206324C1 (da)
SE (2) SE523471C2 (da)
SI (1) SI1223918T1 (da)
SK (2) SK283872B6 (da)
TR (3) TR200200270T2 (da)
TW (2) TW553749B (da)
UA (2) UA51853C2 (da)
WO (2) WO2001054668A1 (da)
YU (1) YU52902A (da)
ZA (2) ZA200003998B (da)

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