DK200101419A - Process for coating particles - Google Patents

Description

CLAIMS 1. A process for coating particles by circulating the particles upwards through a first zone and downwards through a second zone adjacent to the first zone, atomizing a coating liquid into the first zone, introducing a first stream of gas into the bottom part of said first zone in an amount and at a velocity sufficient for creating a gas flow in the first zone carrying the particles upwards through this zone while they are wetted by the atomized coating liquid and partly dried, introducing a second stream of gas into the bottom portion of the second zone in an amount and at a velocity insufficient to form a gas flow in the second zone which would blow particles received from the top of the first zone out of said second zone, but sufficient to increase the flowability of the particles in the second zone, characterized in introducing said second stream of gas at a temperature below the temperature at which said first stream of gas is introduced. 2. The process of claim 1, characterized in establishing said first zone within a vertical duct and said second zone in an area surrounding the duct and defined downwards by a perforated gas distribution plate, and passing the particles to be coated from the bottom of the second zone to the bottom of the first zone through a spacing between said duct and said plate. 3. The process of anyone of claim 1 or 2, characterized in introducing said first stream of gas into said first zone at a direction providing an upwardly swirling flow of gas and entrained particles in the first zone. 4. The process of anyone of the preceding claims, characterized in that the coating liquid is atomized by means of a nozzle upwards from the centre of the bottom portion of the first zone. 5. The process of anyone of the preceding claims, characterized in that said first stream of gas is introduced into the bottom part of the first zone through an annular aperture encircling the nozzle . 6. The process of anyone of the preceding claims, characterized in using a coating liquid containing a substance which in dry or moist condition is sticky at the gas temperature prevailing in the upper portion of the first zone but less sticky at the temperature prevailing in the second zone. 7. The process of anyone of the preceding claims, characterized in using a coating liquid containing a pharmaceutically active, heat-sensitive component. 8. The process of anyone of the preceding claims, characterized in using an aqueous dispersion of a metacrylic acid-methyl methacrylate copolymer as coating liquid and introducing said first stream of gas at a temperature above 35° C and said second gas stream at a temperature below 35° C. 9. The process of anyone of the preceding claims, characterized in passing particles partly coated by circulation through said first and second zones to at least one further first atomizing zone for circulation through this and through at least one second zone, which may form a continuum with the first-mentioned second zone or may be separated therefrom. 10. The process of anyone of the preceding claims, characterized in applying consecutively on each particle two or more layers of different composition.