DK2004196T3 - Okulære allergibehandlinger - Google Patents
Okulære allergibehandlinger Download PDFInfo
- Publication number
- DK2004196T3 DK2004196T3 DK07759365.5T DK07759365T DK2004196T3 DK 2004196 T3 DK2004196 T3 DK 2004196T3 DK 07759365 T DK07759365 T DK 07759365T DK 2004196 T3 DK2004196 T3 DK 2004196T3
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- DK
- Denmark
- Prior art keywords
- compound
- pharmaceutically acceptable
- eye
- acceptable salts
- polymorphs
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Rheumatology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (64)
1. Alcaftadin, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et klinisk symptom af øjenallergi, fremgangsmåden omfattende administration til en patients øje en effektiv mængde af alcraftdinen, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
2. Alcraftdin, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et klinisk symptom af øjeninflammation, fremgangsmåden omfattende administration til en patients øje en effektiv mængde af alcraftdinen, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
3. Alcraftdin, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et mekanistisk symptom associeret med øjenallergi eller øjeninflammation, fremgangsmåden omfattende administration til en patients øje en effektiv mængde af alcraftdinen, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
4. Alcraftdin, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et nasalt symptom af øjenallergi, fremgangsmåden omfattende administration til en patients næse en effektiv mængde af alcraftdinen, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
5. Alcraftdin, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et klinisk symptom af øjenallergi, fremgangsmåden omfattende administration til en patients øje en ophthalmisk sammensætning omfattende alcraftdinen, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
6. Forbindelse af
formel II dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et klinisk symptom af øjenallergi, fremgangsmåden omfattende administration til en patients øje en effektiv mængde af forbindelsen med formlen II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
7. Forbindelse af
formel II dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et klinisk symptom af øjeninflammation, fremgangsmåden omfattende administration til en patients øje en effektiv mængde af forbindelsen med formlen II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
8. Forbindelse af
formel II dets farmaceutisk acceptable salte, N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et mekanistisk symptom associeret med øjenallergi eller øjeninflammation, fremgangsmåden omfattende administration til en patients øje en effektiv mængde af forbindelsen med formlen II, dets farmaceutisk acceptable salte, N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
9. Forbindelse af
formel II dets farmaceutisk acceptable salte, N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et næsesymptom af øjenallergi, fremgangsmåden omfattende administration til en patients næse en effektiv mængde af forbindelsen med formlen II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
10, Forbindelse af
formel II dets farmaceutisk acceptable salte, N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et klinisk symptom af øjenallergi, fremgangsmåden omfattende administration til en patients øje en ophthalmisk sammensætning omfattende forbindelsen med formel II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
11. Forbindelse af
formel II dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et mekanistisk symptom af øjenallergi, fremgangsmåden omfattende administration til en patients øje en ophthalmisk sammensætning omfattende forbindelsen med formel II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
12. Forbindelse af
formel II dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et klinisk symptom af øjeninflammation, fremgangsmåden omfattende administration til en patients øje en ophthalmisk sammensætning omfattende forbindelsen med formel II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
13. Forbindelse af
formel II dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af et mekanistisk symptom af øjeninflammation, fremgangsmåden omfattende administration til en patients øje en ophthalmisk sammensætning omfattende forbindelsen med formlen II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
14. Forbindelsen til anvendelse ifølge et af kravene 1, 5, 6, 10 eller 11 hvor øjenallergien er allergisk konjunktivitis.
15. Forbindelsen til anvendelse ifølge et af kravene 1, 2, 6 eller 7 hvor det kliniske symptom er valgt fra gruppen bestående af øjenkløe, røde øjne, opsvulmning af øjenlåg, væskeansamling, tårer, og næseinflammation, næsekongestion, rhinorrhea, næsepruritis, øre/palate pruritis, og nysen.
16. Forbindelsen til anvendelse ifølge et af kravene 1, 2 eller 6 hvor det kliniske symptom er øjenkløe.
17. Forbindelsen til anvendelse ifølge et af kravene 1, 2 eller 6 hvor det kliniske symptom er røde øjne.
18. Forbindelsen til anvendelse ifølge et af kravene 1, 2, 6 eller 7 yderligere omfattende behandling eller forebyggelse af mindst to kliniske symptomer.
19. Forbindelsen til anvendelse ifølge krav 18 hvor de mindst to kliniske symptomer er øjenkløe og røde øjne.
20. Forbindelsen til anvendelse ifølge et af kravene 1, 2, 6 eller 7 yderligere omfattende behandling eller forebyggelse af mindst tre kliniske symptomer valgt fra gruppen bestående af øjenkløe, røde øjne, opsvulmning af øjenlåg, væskeansamling, og tårer.
21. Forbindelsen til anvendelse ifølge et af kravene 1, 2, 6 eller 7 hvor en effektiv mængde er mindre end ca. 0,25 mg til over ca. 0,015 mg.
22. Forbindelsen til anvendelse ifølge krav 1 eller krav 6, hvor den effektive mængde er mellem ca. 0,075 mg og ca. 0,125 mg.
23. Forbindelsen til anvendelse ifølge et af kravene 1, 2 eller 3 hvor effektiv mængde er mellem ca. 0,075 mg og ca. 0,125 mg.
24. Forbindelsen til anvendelse ifølge et af kravene 1, 2 eller 3 hvor effektiv mængde er mellem mindre end ca. 0,25 mg til over ca. 0,015 mg.
25. Forbindelsen til anvendelse ifølge et af kravene 1, 2 eller 3 hvor det kliniske symptom er øjenkløe.
26. Forbindelsen til anvendelse ifølge et af kravene 1, 2 eller 3 hvor det kliniske symptom er røde øjne.
27. Forbindelsen til anvendelse ifølge et af kravene 1, 2 eller 3 yderligere omfattende behandling eller forebyggelse af mindst to kliniske symptomer.
28. Forbindelsen til anvendelse ifølge krav 27 hvor de mindst to kliniske symptomer er øjenkløe og røde øjne.
29. Forbindelsen til anvendelse ifølge et af kravene 1, 2 eller 3, yderligere omfattende behandling eller forebyggelse af mindst tre kliniske symptomer valgt fra gruppen bestående af øjenkløe, røde øjne, opsvulmning af øjenlåg, væskeansamling, og tårer.
30. Forbindelsen til anvendelse ifølge krav 2 hvor effektiv mængde er mellem mindre end ca. 7.1 pg/kg pr. dag og ca. 3,5 pg/kg pr. dag.
31. Forbindelsen til anvendelse ifølge krav 3, hvor det mekanistiske symptom er valgt fra gruppen bestående af vaskulær lækage, en reduktion i integritet af den konjunktivitiske epiteltætte forbindelse, modulation af hU-receptoren, og mastcellenedbrydning.
32. Forbindelsen til anvendelse ifølge krav 4 eller krav 9, hvor allergi-nasalcellesymptomet er valgt fra gruppen bestående af næseinflammation, næsekongestion, rhinorrhea, næsepruritis, og nysen.
33. Forbindelsen til anvendelse ifølge krav 4 eller krav 9 yderligere omfattende behandling eller forebyggelse af mindst to næsesymptomer af allergi.
34. Forbindelsen til anvendelse ifølge krav 32, hvor en effektiv mængde er mindre end ca. 0,25 mg til over ca. 0,015 mg.
35. Forbindelsen til anvendelse ifølge krav 32, hvor den effektive mængde er mellem ca. 0,075 mg og ca. 0,125 mg.
36. Forbindelsen til anvendelse ifølge krav 5, hvor den ophthalmiske sammensætning omfatter fra ca. 0,005 til ca. 10 vægtprocent alcraftdin.
37. Forbindelsen til anvendelse ifølge krav 5, hvor den ophthalmiske sammensætning omfatter fra ca. 0,2 til ca. 0,35 vægtprocent alcraftdin.
38. Forbindelsen til anvendelse ifølge krav 5 yderligere omfattende behandling eller forebyggelse af mindst to kliniske symptomer af øjenallergi valgt fra gruppen bestående af øjenkløe, røde øjne, opsvulmning af øjenlåg, væskeansamling, tårer, og næseinflammation, næsekongestion, rhinorrhea, næsepruritis, øre/gane pruritis, og nysen.
39. Forbindelsen til anvendelse ifølge et af kravene 6, 7, 8, 9, eller 11, hvor den effektive mængde er mellem ca. 0,075 mg og ca. 0,125 mg.
40. Forbindelsen til anvendelse ifølge et af kravene 6, 7, 8, 9, eller 11 hvor effektiv mængde er mellem mindre end ca. 0,25 mg til over ca. 0,015 mg.
41. Forbindelsen til anvendelse ifølge et af kravene 6, 7, 8, 9, eller 11 yderligere omfattende behandling eller forebyggelse af mindst to kliniske symptomer.
42. Forbindelsen til anvendelse ifølge krav 41, hvor de mindst to kliniske symptomer er øjenkløe og røde øjne
43. Forbindelsen til anvendelse ifølge et af kravene 6, 7, 8, 9, eller 11, yderligere omfattende behandling eller forebyggelse af mindst tre kliniske symptomer valgt fra gruppen bestående af øjenkløe, røde øjne, opsvulmning af øjenlåg, væskeansamling, og tårer.
44. Forbindelsen til anvendelse ifølge et af kravene 8, 11 eller 13, hvor det mekanistiske symptom er valgt fra gruppen bestående af vaskulær lækage, en reduktion i integritet af den konjunktivitiske epiteltætte forbindelse, og mastcellenedbrydning.
45. Forbindelsen til anvendelse ifølge krav 10 eller krav 12, hvor den ophthalmiske sammensætning omfatter fra ca. 0,005 til ca. 10 vægtprocent af forbindelse med formel II.
46. Forbindelsen til anvendelse ifølge krav 10 eller krav 12, hvor den ophthalmiske sammensætning omfatter fra ca. 0,2 til ca. 0,35 vægtprocent af forbindelse med formel II.
47. Forbindelsen til anvendelse ifølge krav 10 eller krav 12 yderligere omfattende behandling eller forebyggelse af mindst to kliniske symptomer af øjenallergi valgt fra gruppen bestående af øjenkløe, røde øjne, opsvulmning af øjenlåg, væskeansamling, tårer, og næseinflammation, næsekongestion, rhinorrhea, næsepruritis, øre/palate pruritis, og nysen.
48. Ophthalmisk sammensætning omfattende alcraftdin eller forbindelse med formel II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf, hvor den ophthalmiske sammensætning omfattende alcraftdin omfatter fra ca. 0,005 til ca. 10 vægtprocent alcraftdin.
49. Den opthalmiske sammensætning ifølge krav 48, yderligere omfattende et vehikel.
50. Den opthalmiske sammensætning ifølge krav 48, omfattende alcraftdin og et farmaceutisk acceptabelt vehikel, eller forbindelse med formel II og et farmaceutisk acceptabelt vehikel.
51. Den opthalmiske sammensætning ifølge krav 48, hvor den ophthalmiske sammensætning omfatter fra ca. 0,005 til ca. 0,4 vægtprocent alcraftdin eller forbindelse med formel II.
52. Den opthalmiske sammensætning ifølge krav 48, hvor den ophthalmiske sammensætning omfatter fra ca. 0,2 til ca. 0,35 vægtprocent alcraftdin eller forbindelse med formel II.
53. Kit omfattende ophthalmisk sammensætning omfattende alcraftdin eller forbindelse med formel II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf indeholdt inde i en beholder fremstillet af et farmaceutisk acceptabelt pakningsmateriale, hvor den ophthalmiske sammensætning omfattende alcraftdin omfatter fra ca. 0,005 til ca. 10 vægtprocent alcraftdin.
54. Kittet ifølge krav 53, hvor den ophthalmiske sammensætning er i form af en ophthalmisk opløsning eller suspension.
55. Kittet ifølge krav 53, hvor den ophthalmiske opløsning omfatter mellem ca. 0,1 vægtprocent og ca. 0,4 vægtprocent alcraftdin eller forbindelse med formel II.
56. Kittet ifølge krav 53, hvor det farmaceutisk acceptable pakningsmateriale er lavdensitetspolyethylen eller højdensitetspolyethylen.
57. Kittet ifølge krav 53, hvor beholderen er steriliseret med ethylenoxid før fyldning med den opthalmiske opløsning.
58. Ophthalmisk sammensætning til anvendelse i behandlingen eller forebyggelse af et klinisk symptom af øjenallergi, den ophthalmiske sammensætning omfattende alcraftdin eller forbindelse med formel II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf og et vehikel.
59. Ophthalmisk sammensætning til anvendelse i behandlingen eller forebyggelse af et klinisk symptom af øjeninflammation, den ophthalmiske sammensætning omfattende alcraftdin eller forbindelse med formel II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
60. Ophthalmisk sammensætning til anvendelse i behandlingen eller forebyggelse af et klinisk symptom af allergisk konjunktivitis, den ophthalmiske sammensætning omfattende alcraftdin eller forbindelse med formel II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
61. Ophthalmisk sammensætning til anvendelse i behandlingen eller forebyggelse af et mekanistisk symptom af øjeninflammation, den ophthalmiske sammensætning omfattende alcraftdin eller forbindelse med formel II, dets farmaceutisk acceptable salte, dets N-oxider, hydrater, solvater, polymorfe, eller blandinger deraf.
62. Ophthalmisk sammensætning til anvendelse ifølge et hvilket som helst af kravene 58 til 61, hvor behandling eller forebyggelse omfatter øje- eller næseadministration af sammensætningen.
63. Ophthalmisk sammensætning til anvendelse ifølge krav 62, hvor behandling eller forebyggelse omfatter administrationen på mindre end ca. 0,25 mg til over ca. 0,015 mg alcraftdin eller af forbindelse med formel II.
64. Ophthalmisk sammensætning til anvendelse ifølge krav 62, omfattende mellem ca. 0,1 vægtprocent og ca. 0,4 vægtprocent alcraftdin eller af forbindelse med formel II.
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| PL3150209T3 (pl) | 2006-03-31 | 2020-03-31 | Vistakon Pharmaceuticals, Llc | Leczenie alergii oczu |
| WO2007127333A2 (en) | 2006-04-26 | 2007-11-08 | Aciex, Inc. | Compositions for the treatment and prevention of eyelid swelling |
| EP2219630A2 (en) * | 2007-11-08 | 2010-08-25 | Aciex Therapeutics, Inc. | Compositions for the treatment and prevention of eyelid swelling comprising an osmotically active ingredient and a vasoconstrictor |
| EP2408453B1 (en) | 2009-03-17 | 2022-01-05 | Nicox Ophthalmics, Inc. | Ophthalmic formulations of cetirizine and methods of use |
| US8569273B2 (en) | 2009-03-17 | 2013-10-29 | Aciex Therapeutics, Inc. | Ophthalmic formulations of cetirizine and methods of use |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| EP2664329A1 (de) * | 2012-05-15 | 2013-11-20 | F. Holzer GmbH | Ophthalmologisches Vehikelsystem |
| WO2014080259A1 (en) * | 2012-11-21 | 2014-05-30 | Enaltec Labs Pvt. Ltd. | Novel polymorphic forms of alcaftadine |
| WO2014087208A2 (en) * | 2012-12-06 | 2014-06-12 | Enaltec Labs Pvt. Ltd. | A process of preparing alcaftadine |
| KR102275012B1 (ko) | 2016-08-12 | 2021-07-07 | 실크 테크놀로지스 리미티드 | 염증 치료용 실크 유래 단백질 |
| JP7191022B2 (ja) * | 2017-07-28 | 2022-12-16 | 参天製薬株式会社 | アルカフタジン又はその塩を含有する水性医薬組成物 |
| KR20200035047A (ko) * | 2017-08-03 | 2020-04-01 | 산텐 세이야꾸 가부시키가이샤 | 클로르헥시딘을 함유하는 의약 조성물 |
| PT3740191T (pt) * | 2018-01-18 | 2021-07-09 | Faes Farma Sa | Composições oftálmicas compreendendo bilastina, uma beta-ciclodextrina e pelo menos um agente gelificante |
| EP4057941A4 (en) | 2019-11-15 | 2024-05-29 | Silk Technologies Ltd. | Stable formulations of silk-derived protein |
| CN115701988A (zh) * | 2020-06-15 | 2023-02-14 | 阿尔克姆实验室有限公司 | 阿卡他定和皮质类固醇的组合 |
| CN117222382B (zh) | 2021-02-24 | 2025-06-10 | 视尔普斯眼科公司 | 小管内储器插入器装置 |
| WO2022208146A1 (en) | 2021-04-01 | 2022-10-06 | Alkem Laboratories Limited | Nasal compositions comprising alcaftadine |
| WO2024010044A1 (ja) * | 2022-07-06 | 2024-01-11 | ロート製薬株式会社 | 眼科組成物 |
| TW202408472A (zh) * | 2022-07-06 | 2024-03-01 | 日商樂敦製藥股份有限公司 | 眼科組成物 |
| CN116473937A (zh) * | 2022-11-29 | 2023-07-25 | 嘉兴学院 | 一种具有抗恶性黑素瘤作用的仿生纳米颗粒及制备方法和应用 |
| TW202448475A (zh) * | 2023-03-31 | 2024-12-16 | 日商樂敦製藥股份有限公司 | 眼科組成物 |
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| DE3134672A1 (de) * | 1981-09-02 | 1983-03-17 | Boehringer Ingelheim KG, 6507 Ingelheim | Heterocyclische verbindungen, ihre herstellung und verwendung |
| GB8900380D0 (en) | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
| US5393753A (en) | 1990-10-10 | 1995-02-28 | Schering Corporation | Substituted imidazobenzazepines |
| IT1248014B (it) * | 1991-06-07 | 1995-01-05 | Inverni Della Beffa Spa | Preparazioni oftalmiche a rilascio protratto |
| IL101850A (en) | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them |
| US5641805A (en) | 1995-06-06 | 1997-06-24 | Alcon Laboratories, Inc. | Topical ophthalmic formulations for treating allergic eye diseases |
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| PL3150209T3 (pl) | 2006-03-31 | 2020-03-31 | Vistakon Pharmaceuticals, Llc | Leczenie alergii oczu |
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