DK2013221T3 - Sammensætninger og fremgangsmåder til cellulær billedgengivelse og terapi - Google Patents
Sammensætninger og fremgangsmåder til cellulær billedgengivelse og terapi Download PDFInfo
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- DK2013221T3 DK2013221T3 DK06769952.0T DK06769952T DK2013221T3 DK 2013221 T3 DK2013221 T3 DK 2013221T3 DK 06769952 T DK06769952 T DK 06769952T DK 2013221 T3 DK2013221 T3 DK 2013221T3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0493—Steroids, e.g. cholesterol, testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Claims (17)
1. Forbindelse defineret som formlen:
hvor - A-ι, A2, A3j og A4 hver især uafhængigt er -(CH2)X-, hvor x = 2-4; - R-ι, R2 og R3 hver især uafhængigt er hydrogen eller
2. Forbindelse ifølge krav 1, hvor forbindelsen er cheleret til et metalatom.
3. Forbindelse ifølge krav 2, hvor metalatomet ikke er radioaktivt.
4. Forbindelse ifølge krav 3, hvor metalatomet er kobber, kobolt, platin, jern, arsen, rhenium eller germanium.
5. Forbindelse ifølge krav 1, hvor forbindelsen er cheleret til et radionuklid.
6. Forbindelse ifølge krav 5, hvor radionuklidet er 99mTc, 188Re, 186Re, 183Sm, 166Ho, 90Y, 89Sr, 67Ga, 68Ga, 111ln, 183Gd, 59Fe, 225Ac, 212Bi, 211At, 45Ti, 60Cu, 61Cu, 67Cu, 64Cu, eller 62Cu; 68Ga, 90Y, 68Ga, og 188Re er foretrukket; og 99mTc især er foretrukket.
7. Farmaceutisk sammensætning omfattende forbindelsen ifølge krav 1.
8. Forbindelse ifølge krav 1 eller 6 til anvendelse i en fremgangsmåde til behandling af cancer eller i en fremgangsmåde til billedgengivelse.
9. Forbindelse til anvendelse ifølge krav 8, hvor fremgangsmåden til behandling af cancer eller fremgangsmåden til billedgengivelse skal udføres i et pattedyr, især i et menneske.
10. Forbindelse til anvendelse ifølge krav 8, hvor fremgangsmåden til behandling af cancer skal udføres i kombination med en anden anti-cancer-forbindelse.
11. Forbindelse til anvendelse ifølge krav 8, hvor behandlingen af cancer skal udføres i kombination med strålebehandling eller operation.
12. Forbindelse til anvendelse ifølge krav 8, hvor billedgengivelsen er PET-eller SPET-billedgengivelse.
13. Kit omfattende en forbindelse ifølge krav 1 og et reduktionsmiddel.
14. Kit ifølge krav 13, hvor kittet yderligere omfatter et radionuklid, især et radionuklid, såsom 99mTc, 188Re, 186Re, 183Sm, 166Ho, 90Y, 89Sr, 67Ga, 68Ga, 111 In, 183Gd,59Fe,225Ac, 212Bi, 211At, 45Ti, 60Cu, 61Cu, 67Cu, 64Cu eller 62Cu.
15. Kit ifølge krav 13, hvor kittet yderligere omfatter en antioxidant, især en antioxidant som vitamin C, tocopherol, pyridoxin, thiamin eller rutin.
16. Kit ifølge krav 13, hvor kittet yderligere omfatter en overgangschelator, især en overgangschelator, såsom glucoheptonat, gluconat, glucarat, citrate eller tartarat.
17. Kit ifølge krav 13, hvor reduktionsmidlet er tin-(ll)-chlorid eller triphenyl-phosphin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US74514806P | 2006-04-19 | 2006-04-19 | |
| PCT/US2006/016784 WO2007120153A1 (en) | 2006-04-19 | 2006-05-04 | Compositions and methods for cellular imaging and therapy |
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| DK2013221T3 true DK2013221T3 (da) | 2015-09-28 |
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| EP (1) | EP2013221B1 (da) |
| JP (1) | JP2009534381A (da) |
| KR (2) | KR101653182B1 (da) |
| CN (1) | CN101516899B (da) |
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| CA (1) | CA2649869C (da) |
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| IL (1) | IL194826A (da) |
| NO (1) | NO341574B1 (da) |
| WO (1) | WO2007120153A1 (da) |
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| US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
| EP2114461A2 (en) * | 2007-01-19 | 2009-11-11 | Mallinckrodt Inc. | Diagnostic and therapeutic cyclooxygenase-2 binding ligands |
| US9585841B2 (en) | 2013-10-22 | 2017-03-07 | Tyme, Inc. | Tyrosine derivatives and compositions comprising them |
| WO2019018536A1 (en) * | 2017-07-18 | 2019-01-24 | Vyripharm Enterprises, Llc | COMPOSITIONS CONTAINING CONJUGATES OF CANNABINOID ANALOGUES AND METHODS OF USE THEREOF |
| US11378564B2 (en) | 2014-02-05 | 2022-07-05 | Vyripharm Enterprises, Llc | Systems and methods for integrated and comprehensive management of cannabis products |
| WO2015152128A1 (ja) * | 2014-03-31 | 2015-10-08 | 長瀬産業株式会社 | アミノ酸前駆体、アミノ酸およびその製造方法、ならびに該アミノ酸を用いたｐｅｔ診断用トレーサー |
| GB201417067D0 (en) | 2014-09-26 | 2014-11-12 | South African Nuclear Energy | Radiopharmaceutical conjugate |
| KR20190089191A (ko) * | 2016-11-30 | 2019-07-30 | 타임, 인크. | 티로신 유도체 및 이들을 포함하는 조성물 |
| US11090395B2 (en) * | 2018-09-14 | 2021-08-17 | SeeCure Taiwan Co., Ltd. | Composition for cross talk between estrogen receptors and cannabinoid receptors |
| EP3968785A4 (en) | 2019-05-14 | 2023-01-11 | Tyme, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER |
| US10905698B1 (en) | 2020-05-14 | 2021-02-02 | Tyme, Inc. | Methods of treating SARS-COV-2 infections |
| US11554184B2 (en) | 2021-03-26 | 2023-01-17 | Vyripharm Enterprises, Inc. | Synthetic cannabinoid combination therapy compositions and methods for personalized and targeted therapies including the treatment of infectious diseases |
| CN117088825A (zh) * | 2023-10-12 | 2023-11-21 | 成都威斯津生物医药科技有限公司 | 一种可离子化脂质、含该可离子化脂质的药物组合物及其用途 |
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| US4988496A (en) * | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5650133A (en) * | 1990-01-19 | 1997-07-22 | Nycomed Salutar | Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality |
| US5684149A (en) * | 1993-01-22 | 1997-11-04 | Research Foundation Of State University Of New York | Metal complexes for promoting catalytic cleavage of RNA by transesterification |
| US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| WO2000035887A2 (en) * | 1998-12-18 | 2000-06-22 | Du Pont Pharm Co | Vitronectin receptor antagonist pharmaceuticals |
| US6673333B1 (en) * | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| ES2221903T3 (es) * | 2000-05-12 | 2005-01-16 | University Hospital | Agentes pro-quelantes para la preparacion de moleculas marcadas con metales radiactivos que tienen propiedades biologicas mejoradas. |
| EP2022787B1 (en) * | 2000-09-29 | 2012-11-28 | Genzyme Corporation | Process for the preparation of N-1 protected N ring nitrogen containing cyclic polyamines and products thereof |
| DE10135356C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
| US20050255038A1 (en) * | 2002-04-12 | 2005-11-17 | A And D Bioscience, Inc. | Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof |
| AU2003303714B2 (en) * | 2003-01-13 | 2009-02-19 | Bracco Imaging S.P.A. | Improved linkers for radiopharmaceutical compounds |
| CA2593256A1 (en) * | 2005-01-05 | 2006-07-13 | Board Of Regents, The University Of Texas System | Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications |
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- 2006-05-04 KR KR1020087028323A patent/KR20090014164A/ko not_active Ceased
- 2006-05-04 JP JP2009506472A patent/JP2009534381A/ja active Pending
- 2006-05-04 BR BRPI0621580A patent/BRPI0621580B8/pt active IP Right Grant
- 2006-05-04 DK DK06769952.0T patent/DK2013221T3/da active
- 2006-05-04 EP EP06769952.0A patent/EP2013221B1/en active Active
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2008
- 2008-10-22 IL IL194826A patent/IL194826A/en active IP Right Grant
- 2008-11-18 NO NO20084821A patent/NO341574B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101516899B (zh) | 2016-07-06 |
| AU2006342202C1 (en) | 2013-09-26 |
| BRPI0621580A2 (pt) | 2011-05-10 |
| IL194826A0 (en) | 2009-08-03 |
| WO2007120153A1 (en) | 2007-10-25 |
| EP2013221A4 (en) | 2010-12-15 |
| AU2006342202A1 (en) | 2007-10-25 |
| CN101516899A (zh) | 2009-08-26 |
| KR101653182B1 (ko) | 2016-09-01 |
| NO341574B1 (no) | 2017-12-04 |
| IL194826A (en) | 2013-08-29 |
| KR20140099557A (ko) | 2014-08-12 |
| BRPI0621580B1 (pt) | 2021-05-11 |
| EP2013221B1 (en) | 2015-06-24 |
| KR20090014164A (ko) | 2009-02-06 |
| ES2544244T3 (es) | 2015-08-28 |
| EP2013221A1 (en) | 2009-01-14 |
| CA2649869C (en) | 2014-11-18 |
| CA2649869A1 (en) | 2007-10-25 |
| HK1123306A1 (en) | 2009-06-12 |
| JP2009534381A (ja) | 2009-09-24 |
| BRPI0621580B8 (pt) | 2021-05-25 |
| NO20084821L (no) | 2009-01-16 |
| AU2006342202B2 (en) | 2013-03-07 |
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